| Exosomal miR-493 suppresses MAD2L1 and induces chemoresistance to intraperitoneal paclitaxel therapy in gastric cancer patients with peritoneal metastasis. | Exosomal miR-493 suppresses MAD2L1 and induces chemoresistance to intraperitoneal paclitaxel therapy in gastric cancer patients with peritoneal metastasis.
Makinoya M, Miyatani K, Matsumi Y, Sakano Y, Shimizu S, Shishido Y, Hanaki T, Kihara K, Matsunaga T, Yamamoto M, Tokuyasu N, Takano S, Sakamoto T, Hasegawa T, Saito H, Nakayama Y, Osaki M, Okada F, Fujiwara Y., Free PMC Article | 05/22/2024 |
| MAD2 activates IGF1R/PI3K/AKT pathway and promotes cholangiocarcinoma progression by interfering USP44/LIMA1 complex. | MAD2 activates IGF1R/PI3K/AKT pathway and promotes cholangiocarcinoma progression by interfering USP44/LIMA1 complex.
Jiang W, Yang X, Shi K, Zhang Y, Shi X, Wang J, Wang Y, Chenyan A, Shan J, Wang Y, Chang J, Chen R, Zhou T, Zhu Y, Yu Y, Li C, Li X. | 11/8/2023 |
| CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma. | CAMK2D serves as a molecular scaffold for RNF8-MAD2 complex to induce mitotic checkpoint in glioma.
Chuah YH, Tay EXY, Grinchuk OV, Yoon J, Feng J, Kannan S, Robert M, Jakhar R, Liang Y, Lee BWL, Wang LC, Lim YT, Zhao T, Sobota RM, Lu G, Low BC, Crasta KC, Verma CS, Lin Z, Ong DST., Free PMC Article | 08/10/2023 |
| The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia. | The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia.
Zhu L, Li X, Liu D, Bai W, Yang H, Cheng Q, Xu L, Fang J. | 07/31/2023 |
| MAD2L1 is transcriptionally regulated by TEAD4 and promotes cell proliferation and migration in colorectal cancer. | MAD2L1 is transcriptionally regulated by TEAD4 and promotes cell proliferation and migration in colorectal cancer.
Li Q, Tong D, Jing X, Ma P, Li F, Jiang Q, Zhang J, Wen H, Cui M, Huang C, Zhang M. | 05/19/2023 |
| Upregulation of MAD2L1 mediated by ncRNA axis is associated with poor prognosis and tumor immune infiltration in hepatocellular carcinoma: A review. | Upregulation of MAD2L1 mediated by ncRNA axis is associated with poor prognosis and tumor immune infiltration in hepatocellular carcinoma: A review.
Liu S, Miao M, Kang L., Free PMC Article | 01/21/2023 |
| Inhibition of MAD2L1 Mediates Pulmonary Fibrosis through Impairment of Mitochondrial Function and Induction of Cell Senescence. | Inhibition of MAD2L1 Mediates Pulmonary Fibrosis through Impairment of Mitochondrial Function and Induction of Cell Senescence.
Wang L, Wan R, Chen X, Guo X, Li Z, Zhao W, Yan P, Yu G., Free PMC Article | 01/14/2023 |
| Association of mitotic checkpoint regulator MAD2L1 with fibrosis progression in chronic hepatitis C patients. | Association of mitotic checkpoint regulator MAD2L1 with fibrosis progression in chronic hepatitis C patients.
Khalid SS, Abdo AA, Al-Hamoudi W, Alswat K. | 08/27/2022 |
| Mad2 promotes Cyclin B2 recruitment to the kinetochore for guiding accurate mitotic checkpoint. | Mad2 promotes Cyclin B2 recruitment to the kinetochore for guiding accurate mitotic checkpoint.
Liu S, Yuan X, Gui P, Liu R, Durojaye O, Hill DL, Fu C, Yao X, Dou Z, Liu X., Free PMC Article | 06/11/2022 |
| Targeting of MAD2L1 by miR-515-5p involves the regulation of cell cycle arrest and apoptosis of colorectal cancer cells. | Targeting of MAD2L1 by miR-515-5p involves the regulation of cell cycle arrest and apoptosis of colorectal cancer cells.
Ding X, Fu Q, Chen W, Chen L, Zeng Q, Zhang S, He L. | 04/30/2022 |
| Identification of MAD2L1 as a Potential Biomarker in Hepatocellular Carcinoma via Comprehensive Bioinformatics Analysis. | Identification of MAD2L1 as a Potential Biomarker in Hepatocellular Carcinoma via Comprehensive Bioinformatics Analysis.
Chen Q, Yang S, Zhang Y, Li B, Xu H, Zuo S., Free PMC Article | 04/2/2022 |
| Single-cell sequencing reveals MYC targeting gene MAD2L1 is associated with prostate cancer bone metastasis tumor dormancy. | Single-cell sequencing reveals MYC targeting gene MAD2L1 is associated with prostate cancer bone metastasis tumor dormancy.
Wang X, Yu J, Yan J, Peng K, Zhou H., Free PMC Article | 03/26/2022 |
| MAD2L1 Functions As a Novel Diagnostic and Predictive Biomarker in Cholangiocarcinoma. | MAD2L1 Functions As a Novel Diagnostic and Predictive Biomarker in Cholangiocarcinoma.
Gao Y, Liu Y, Sun L, Ouyang X, Zhu C, Qin X. | 03/5/2022 |
| [Dysregulation of MAD2L1/CAMK2A/PTTG1 Gene Cluster Maintains the Stemness Characteristics of Uterine Corpus Endometrial Carcinoma]. | [Dysregulation of MAD2L1/CAMK2A/PTTG1 Gene Cluster Maintains the Stemness Characteristics of Uterine Corpus Endometrial Carcinoma].
Zheng J, Zhang YW, Pan ZF. | 11/22/2021 |
| BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma. | BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma.
Busacca S, O'Regan L, Singh A, Sharkey AJ, Dawson AG, Dzialo J, Parsons A, Kumar N, Schunselaar LM, Guppy N, Nakas A, Sheaff M, Mansfield AS, Janes SM, Baas P, Fry AM, Fennell DA. | 10/23/2021 |
| Targeting MAD2 modulates stemness and tumorigenesis in human Gastric Cancer cell lines. | Targeting MAD2 modulates stemness and tumorigenesis in human Gastric Cancer cell lines.
Pajuelo-Lozano N, Alcalá S, Sainz B Jr, Perona R, Sanchez-Perez I., Free PMC Article | 06/5/2021 |
| Bioinformatic analysis revealing mitotic spindle assembly regulated NDC80 and MAD2L1 as prognostic biomarkers in non-small cell lung cancer development. | Bioinformatic analysis revealing mitotic spindle assembly regulated NDC80 and MAD2L1 as prognostic biomarkers in non-small cell lung cancer development.
Wei R, Wang Z, Zhang Y, Wang B, Shen N, E L, Li X, Shang L, Shang Y, Yan W, Zhang X, Ma W, Wang C., Free PMC Article | 05/15/2021 |
| Mitotic slippage is determined by p31(comet) and the weakening of the spindle-assembly checkpoint. | Mitotic slippage is determined by p31(comet) and the weakening of the spindle-assembly checkpoint.
Lok TM, Wang Y, Xu WK, Xie S, Ma HT, Poon RYC., Free PMC Article | 12/12/2020 |
| Analysis of TET2 and EZH2 gene functions in chromosome instability in acute myeloid leukemia. | Analysis of TET2 and EZH2 gene functions in chromosome instability in acute myeloid leukemia.
Wang J, He N, Wang R, Tian T, Han F, Zhong C, Zhang C, Hua M, Ji C, Ma D., Free PMC Article | 11/21/2020 |
| Downregulation of Mad2 and BubR1 increase the malignant behavior and nocodazole resistance of SiHa cells via causing spindle assembly checkpoint defect. | Downregulation of Mad2 and BubR1 increase the malignant potential and nocodazole resistance by compromising spindle assembly checkpoint signaling pathway in cervical carcinogenesis.
Wang L, Wang J, Jin Y, Zheng J, Yang Y, Xi X. | 06/6/2020 |
| human shugoshin 2, an essential protector of meiotic cohesin with unknown functions in the soma, is turned into a separase inhibitor upon association with spindle assembly checkpoint-activated MAD2 | Securin-independent regulation of separase by checkpoint-induced shugoshin-MAD2.
Hellmuth S, Gómez-H L, Pendás AM, Stemmann O. | 06/6/2020 |
| the present study revealed that PTEN knockdown resulted in MAD2 degradation via the ubiquitinproteasomal pathway, while restoration of MAD2 expression partially ameliorated the mitotic defects induced by PTEN loss. | Deficiency of PTEN leads to aberrant chromosome segregation through downregulation of MAD2.
Sun Z, Lu J, Wu M, Li M, Bai L, Shi Z, Hao L, Wu Y., Free PMC Article | 02/29/2020 |
| MAD2 and CDC20 are the most expressed in high grade dysplasia, suggesting their roles in the early stage of gastric carcinogenesis, whereas their overexpressions in gastric cancer are associated with intestinal histology and favorable clinicopathological parameters, which may be useful for immunohistochemical classification of chromosomal instability-type gastric cancer. | Spindle assembly checkpoint MAD2 and CDC20 overexpressions and cell-in-cell formation in gastric cancer and its precursor lesions.
Kim Y, Choi JW, Lee JH, Kim YS. | 11/30/2019 |
| we took advantage of a chemical and chemical-genetic approach to specifically inhibit Aurora A kinase activity in late prometaphase. We observed that a loss of Aurora A activity directly affects SAC function, that Aurora A is essential for maintaining the checkpoint protein Mad2 on unattached kinetochores and that inhibition of Aurora A leads to loss of the SAC, even in the presence of nocodazole or Taxol. | Aurora A kinase activity is required to maintain an active spindle assembly checkpoint during prometaphase.
Courtheoux T, Diallo A, Damodaran AP, Reboutier D, Watrin E, Prigent C. | 10/19/2019 |
| study provides insights into how specific substrates are recruited to AAA+ ATPases (like TRIP13) through adaptor proteins and suggests a model of how translocation through the axial pore of AAA+ ATPases is coupled to protein remodelling | Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13.
Alfieri C, Chang L, Barford D., Free PMC Article | 01/19/2019 |