| NBR1-mediated autophagic degradation of caspase 8 protects vascular endothelial cells against arsenite-induced apoptotic cell death. | NBR1-mediated autophagic degradation of caspase 8 protects vascular endothelial cells against arsenite-induced apoptotic cell death.
Hu S, Wang F, Mao L, Jiang X, Luo Y, Qin X, Zou Z, Chen C, Yu C, Zhang J. | 07/3/2024 |
| NBR1 mediates autophagic degradation of IRF3 to negatively regulate type I interferon production. | NBR1 mediates autophagic degradation of IRF3 to negatively regulate type I interferon production.
Cai Y, Zhu Y, Zheng J, Zhang Y, Chen W. | 09/3/2022 |
| Germline mutation in the NBR1 gene involved in autophagy detected in a family with renal tumors. | Germline mutation in the NBR1 gene involved in autophagy detected in a family with renal tumors.
Adolphe F, Ferlicot S, Verkarre V, Posseme K, Couvé S, Garnier P, Droin N, Deloger M, Job B, Giraud S, Paillerets BB, Gardie B, Richard S, Renaud F, Gad S. | 12/25/2021 |
| Identification of putative phenotype-modifying genetic factors associated with phenotypic diversity in Brooke-Spiegler syndrome. | Identification of putative phenotype-modifying genetic factors associated with phenotypic diversity in Brooke-Spiegler syndrome.
Pap ÉM, Farkas K, Széll M, Németh G, Rajan N, Nagy N. | 10/30/2021 |
| Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation. | Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation.
Turco E, Savova A, Gere F, Ferrari L, Romanov J, Schuschnig M, Martens S., Free PMC Article | 09/25/2021 |
| The influence of rs139416141 in neighbor of Brca1 gene (NBR1) on bone mineral density in postmenopausal Chinese women. | The influence of rs139416141 in neighbor of Brca1 gene (NBR1) on bone mineral density in postmenopausal Chinese women.
Zhang Y, Zhang Z, Zhang Z, Zhao L, Xue Y, Wu H, Hou J. | 02/6/2021 |
| An increase in p62/NBR1 levels in melioidosis patients of Sri Lanka exhibit a characteristic of potential host biomarker. | An increase in p62/NBR1 levels in melioidosis patients of Sri Lanka exhibit a characteristic of potential host biomarker.
Saikh KU, Ranji CM, Ulrich RG, Corea E, De Silva AD, Natesan M., Free PMC Article | 11/21/2020 |
| Depletion of NBR1 in urothelial carcinoma cells enhances rapamycin-induced apoptosis through impaired autophagy and mitochondrial dysfunction. | Depletion of NBR1 in urothelial carcinoma cells enhances rapamycin-induced apoptosis through impaired autophagy and mitochondrial dysfunction.
Kim MJ, Hwang GY, Cho MJ, Chi BH, Park SI, Chang IH, Whang YM. | 09/12/2020 |
| NBR1 is not required for PARK2-dependent mitophagy. | NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1.
Shi J, Fung G, Deng H, Zhang J, Fiesel FC, Springer W, Li X, Luo H., Free PMC Article | 09/17/2016 |
| The NBR1 depletion impairs FA turnover and decreases targeting of autophagosomes to FAs, whereas ectopic expression of autophagy-competent, but not autophagy-defective, NBR1 enhances FA disassembly and reduces FA lifetime during migration. | NBR1 enables autophagy-dependent focal adhesion turnover.
Kenific CM, Stehbens SJ, Goldsmith J, Leidal AM, Faure N, Ye J, Wittmann T, Debnath J., Free PMC Article | 07/16/2016 |
| NBR1 positively correlates with adipose inflammation in human obese patients. | A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity.
Hernandez ED, Lee SJ, Kim JY, Duran A, Linares JF, Yajima T, Müller TD, Tschöp MH, Smith SR, Diaz-Meco MT, Moscat J., Free PMC Article | 05/23/2015 |
| Analysis of muscle biopsies of sporadic inclusion body myositis (sIBM) patients revealed a strong decrease of NBR1 phosphorylation in muscles of sIBM patients that directly correlated with the severity of protein aggregation. | Phosphorylation of NBR1 by GSK3 modulates protein aggregation.
Nicot AS, Lo Verso F, Ratti F, Pilot-Storck F, Streichenberger N, Sandri M, Schaeffer L, Goillot E., Free PMC Article | 05/16/2015 |
| The C-terminal fragments of SQSTM1 and NBR1 exhibited a dominant-negative effect against native SQSTM1/NBR1, probably by competing for LC3 and ubiquitin chain binding. | Dominant-negative function of the C-terminal fragments of NBR1 and SQSTM1 generated during enteroviral infection.
Shi J, Fung G, Piesik P, Zhang J, Luo H., Free PMC Article | 04/25/2015 |
| structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin | Solution structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin.
Walinda E, Morimoto D, Sugase K, Konuma T, Tochio H, Shirakawa M., Free PMC Article | 12/20/2014 |
| results suggest that NBR1 is the specific autophagy receptor for pexophagy. | NBR1 acts as an autophagy receptor for peroxisomes.
Deosaran E, Larsen KB, Hua R, Sargent G, Wang Y, Kim S, Lamark T, Jauregui M, Law K, Lippincott-Schwartz J, Brech A, Johansen T, Kim PK. | 11/23/2013 |
| These findings suggest that NBR1 is involved in the formation of cytoplasmic inclusions in alpha-synucleinopathy. | Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in α-synucleinopathy.
Odagiri S, Tanji K, Mori F, Kakita A, Takahashi H, Wakabayashi K. | 12/22/2012 |
| The structural ensemble representing each of the two sequential folding transition transition states of the PB1 domain of NBR1 has been calculated using experimental Phi values and biased molecular dynamics simulations. | Structural insights into the two sequential folding transition states of the PB1 domain of NBR1 from Φ value analysis and biased molecular dynamics simulations.
Chen P, Evans CL, Hirst JD, Searle MS. | 12/8/2012 |
| Autophagy-related NBR1 protein is not involved in the formation/degradation of neuronal intranuclear inclusions in neurodegenerative diseases. | Autophagy-related proteins (p62, NBR1 and LC3) in intranuclear inclusions in neurodegenerative diseases.
Mori F, Tanji K, Odagiri S, Toyoshima Y, Yoshida M, Kakita A, Takahashi H, Wakabayashi K. | 11/17/2012 |
| Breast and ovarian cancer risk are high in Jewish women with BRCA1 genetic mutation. | Breast and ovarian cancer risk and risk reduction in Jewish BRCA1/2 mutation carriers.
Finkelman BS, Rubinstein WS, Friedman S, Friebel TM, Dubitsky S, Schonberger NS, Shoretz R, Singer CF, Blum JL, Tung N, Olopade OI, Weitzel JN, Lynch HT, Snyder C, Garber JE, Schildkraut J, Daly MB, Isaacs C, Pichert G, Neuhausen SL, Couch FJ, van't Veer L, Eeles R, Bancroft E, Evans DG, Ganz PA, Tomlinson GE, Narod SA, Matloff E, Domchek S, Rebbeck TR., Free PMC Article | 06/16/2012 |
| AtNBR1 is more similar to mammalian NBR1 than to p62 in domain architecture and amino acid sequence. | Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1.
Svenning S, Lamark T, Krause K, Johansen T., Free PMC Article | 12/31/2011 |
| Results indicate that the presence of a tryptophan residue in the LIR motif increases the binding affinity of GABARAPL-1/NBR1-LIR complex. | Characterization of the interaction of GABARAPL-1 with the LIR motif of NBR1.
Rozenknop A, Rogov VV, Rogova NY, Löhr F, Güntert P, Dikic I, Dötsch V. | 10/15/2011 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| findings suggest a critical function for NBR1 in the regulation of receptor trafficking and provide a mechanism for down-regulation of signaling by Spred2 via NBR1. | Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling.
Mardakheh FK, Yekezare M, Machesky LM, Heath JK., Free PMC Article | 01/21/2010 |
| NBR1 together with p62 promotes autophagic degradation of ubiquitinated targets and simultaneously regulates their aggregation when autophagy becomes limited. | NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets.
Kirkin V, Lamark T, Johansen T, Dikic I. | 01/21/2010 |
| The nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B chains. Nbr1 also binds to the autophagic effector protein LC3-A via a novel binding site. | Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover.
Waters S, Marchbank K, Solomon E, Whitehouse C, Gautel M. | 01/21/2010 |