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    MIR99B microRNA 99b [ Homo sapiens (human) ]

    Gene ID: 407056, updated on 10-Oct-2023

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Effect of the MiR-99b and MiR-135b on peritoneal carcinomatosis and liver metastasis in colorectal cancer.

    Effect of the MiR-99b and MiR-135b on peritoneal carcinomatosis and liver metastasis in colorectal cancer.
    Aziret M, Güney Eskiler G, Çakar GÇ, Özkan AD, Ercan M, Bilir C, Polat E, Koçer HB, Yıldırım EK, Duman M., Free PMC Article

    09/6/2023
    MiR-99b regulates cerebral ischemia neuronal injury through targeting IGF1R.

    MiR-99b regulates cerebral ischemia neuronal injury through targeting IGF1R.
    Qi D, Wang W, Zhang Y, Zhang T.

    03/16/2023
    Downregulation of miR-99b-5p and Upregulation of Nuclear mTOR Cooperatively Promotes the Tumor Aggressiveness and Drug Resistance in African American Prostate Cancer.

    Downregulation of miR-99b-5p and Upregulation of Nuclear mTOR Cooperatively Promotes the Tumor Aggressiveness and Drug Resistance in African American Prostate Cancer.
    Gujrati H, Ha S, Waseem M, Wang BD., Free PMC Article

    09/24/2022
    Human endothelial cell-derived exosomal microRNA-99a/b drives a sustained inflammatory response during sepsis by inhibiting mTOR expression.

    Human endothelial cell-derived exosomal microRNA-99a/b drives a sustained inflammatory response during sepsis by inhibiting mTOR expression.
    Fitzpatrick G, Nader D, Watkin R, McCoy CE, Curley GF, Kerrigan SW., Free PMC Article

    09/24/2022
    MicroRNA-99b-5p targets mTOR/AR axis, induces autophagy and inhibits prostate cancer cell proliferation.

    MicroRNA-99b-5p targets mTOR/AR axis, induces autophagy and inhibits prostate cancer cell proliferation.
    Niture S, Tricoli L, Qi Q, Gadi S, Hayes K, Kumar D.

    07/23/2022
    Human bone marrow mesenchymal stem cells-derived exosomes attenuated prostate cancer progression via the miR-99b-5p/IGF1R axis.

    Human bone marrow mesenchymal stem cells-derived exosomes attenuated prostate cancer progression via the miR-99b-5p/IGF1R axis.
    Jiang S, Chen H, He K, Wang J., Free PMC Article

    02/26/2022
    MicroRNA-99b inhibits NSCLC cell invasion and migration by directly targeting NIPBL.

    MicroRNA-99b inhibits NSCLC cell invasion and migration by directly targeting NIPBL.
    Xu JX, Liu CM, Ma CP.

    01/8/2022
    MiR-99b-5p suppressed proliferation of human osteoblasts by targeting FGFR3 in osteoporosis.

    MiR-99b-5p suppressed proliferation of human osteoblasts by targeting FGFR3 in osteoporosis.
    Ding M, Liu B, Chen X, Ouyang Z, Peng D, Zhou Y.

    01/1/2022
    Identification of miR-199a-5p, miR-214-3p and miR-99b-5p as Fibrosis-Specific Extracellular Biomarkers and Promoters of HSC Activation.

    Identification of miR-199a-5p, miR-214-3p and miR-99b-5p as Fibrosis-Specific Extracellular Biomarkers and Promoters of HSC Activation.
    Messner CJ, Schmidt S, Özkul D, Gaiser C, Terracciano L, Krähenbühl S, Suter-Dick L., Free PMC Article

    10/23/2021
    MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-kappaB pathway.

    MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.
    Lu Y, Liu L, Pan J, Luo B, Zeng H, Shao Y, Zhang H, Guan H, Guo D, Zeng C, Zhang R, Bai X, Zhang H, Cai D., Free PMC Article

    09/25/2021
    Identification of PBMC-expressed miRNAs for rheumatoid arthritis.

    Identification of PBMC-expressed miRNAs for rheumatoid arthritis.
    Zhu X, Wu L, Mo X, Xia W, Guo Y, Wang M, Zeng K, Wu J, Qiu Y, Lin X, Lu X, Deng F, Lei S., Free PMC Article

    05/15/2021
    Plasma level of miR-99b may serve as potential diagnostic and short-term prognostic markers in patients with acute cerebral infarction.

    Plasma level of miR-99b may serve as potential diagnostic and short-term prognostic markers in patients with acute cerebral infarction.
    Wu X, Zhang X, Li D, Zhu Z., Free PMC Article

    12/19/2020
    MicroRNA-99b-5p downregulates protein synthesis in human primary myotubes.

    MicroRNA-99b-5p downregulates protein synthesis in human primary myotubes.
    Zacharewicz E, Kalanon M, Murphy RM, Russell AP, Lamon S.

    10/24/2020
    aberrantly expressed miR-99b serves a prognostic biomarker for OS patients

    MicroRNA-99b predicts clinical outcome of osteosarcoma and suppresses tumor cell proliferation, migration and invasion.
    Shi X, Guan X., Free PMC Article

    04/18/2020
    Circulating MiR-99b-5p, in particular, may serve as a possible predictor for erosion progression in early rheumatoid arthritis.

    Circulating miR-99b-5p as a novel predictor of erosion progression on high-resolution peripheral quantitative computed tomography in early rheumatoid arthritis: A prospective cohort study.
    Yue J, Lau TCK, Griffith JF, Xu J, Xiao F, Shi L, Wang D, Wong PCH, Li EK, Tam LP, Li M, Li TK, Mak WY, Hung V, Qin L, Tam LS.

    02/22/2020
    MiR-99b targets IGF-1R and functions as a tumor suppressor in gastric cancer.

    MiR-99b-5p and miR-203a-3p Function as Tumor Suppressors by Targeting IGF-1R in Gastric Cancer.
    Wang Z, Zhao Z, Yang Y, Luo M, Zhang M, Wang X, Liu L, Hou N, Guo Q, Song T, Guo B, Huang C., Free PMC Article

    10/19/2019
    our findings identified the miR-125a~99b~let-7e cluster as a new key intracellular mediator used by the master anti-inflammatory cytokine IL-10 to dampen down the pro-inflammatory TLR pathway and provides a new perspective in the understanding of mechanisms by which the inflammatory response is regulated in phagocytes.

    Multi-Step Regulation of the TLR4 Pathway by the miR-125a~99b~let-7e Cluster.
    Curtale G, Renzi TA, Mirolo M, Drufuca L, Albanese M, De Luca M, Rossato M, Bazzoni F, Locati M., Free PMC Article

    10/19/2019
    Fractions enriched in nanosized RNAcarriers were separated from the plasma of young participants in this study with Down syndrome and their nontrisomic siblings and miRNAs were extracted. A microarraybased analysis on a small cohort of samples led to the identification of the three most abundant miRNAs, namely miR165p, miR99b5p and miR1443p.

    Analysis of a nanoparticle‑enriched fraction of plasma reveals miRNA candidates for Down syndrome pathogenesis.
    Salvi A, Vezzoli M, Busatto S, Paolini L, Faranda T, Abeni E, Caracausi M, Antonaros F, Piovesan A, Locatelli C, Cocchi G, Alvisi G, De Petro G, Ricotta D, Bergese P, Radeghieri A., Free PMC Article

    08/24/2019
    Low miR-99b-5p expression analyzed with sequencing methodology may correlate with tumor progression in tyrosine kinase inhibitorI-treated clear cell renal cell carcinoma patients patients.

    MiR-99b-5p expression and response to tyrosine kinase inhibitor treatment in clear cell renal cell carcinoma patients.
    Lukamowicz-Rajska M, Mittmann C, Prummer M, Zhong Q, Bedke J, Hennenlotter J, Stenzl A, Mischo A, Bihr S, Schmidinger M, Vogl U, Blume I, Karlo C, Schraml P, Moch H., Free PMC Article

    02/24/2018
    ARID3A was down-regulated by ZEB1 in a miR-99b/let-7e/miR-125a dependent mannerto promotes invasion and metastasis in esophageal squamous cell carcinoma.

    ZEB1 induced miR-99b/let-7e/miR-125a cluster promotes invasion and metastasis in esophageal squamous cell carcinoma.
    Ma J, Zhan Y, Xu Z, Li Y, Luo A, Ding F, Cao X, Chen H, Liu Z.

    08/26/2017
    Downregulation of miR-99b with concomitant upregulation of its target gene IGF-1R may over-induce the PI3K-AKT signaling pathway, leading to deregulated cell proliferation in Condyloma acuminatum.

    miR-99b suppresses IGF-1R expression and contributes to inhibition of cell proliferation in human epidermal keratinocytes.
    Li J, Fang R, Gong Q, Wang J.

    11/12/2016
    miR-99b-5p is differently expressed in primary colorectal cancer (CRC) and liver metastasis and functions as a tumor-suppressive microRNA in metastatic CRC

    miRNA-99b-5p suppresses liver metastasis of colorectal cancer by down-regulating mTOR.
    Li W, Chang J, Wang S, Liu X, Peng J, Huang D, Sun M, Chen Z, Zhang W, Guo W, Li J., Free PMC Article

    08/13/2016
    the expression of miR-99b was inversely correlated with CLDN11 levels . These findings suggest that a high level of miR-99b expression is an independent prognostic factor and correlates with poor survival of patients with Hepatocellular carcinoma (HCC)

    miR-99b promotes metastasis of hepatocellular carcinoma through inhibition of claudin 11 expression and may serve as a prognostic marker.
    Yang J, Liu X, Yuan X, Wang Z.

    05/14/2016
    Ionizing radiation promoted mTOR expression and activation in pancreatic cancer cells through reducing miR-99b expression, which negatively regulated mTOR.

    miR-99b-targeted mTOR induction contributes to irradiation resistance in pancreatic cancer.
    Wei F, Liu Y, Guo Y, Xiang A, Wang G, Xue X, Lu Z., Free PMC Article

    04/4/2015
    Low miR-99b expression is associated with cervical cancer.

    miR-99a and -99b inhibit cervical cancer cell proliferation and invasion by targeting mTOR signaling pathway.
    Wang L, Chang L, Li Z, Gao Q, Cai D, Tian Y, Zeng L, Li M.

    12/20/2014
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