| Systematic analysis of the prognostic value and immunological function of LTBR in human cancer. | Systematic analysis of the prognostic value and immunological function of LTBR in human cancer.
Wu Y, Zhao S, Guo W, Liu Y, Requena Mullor MDM, Rodrìguez RA, Wei R., Free PMC Article | 01/29/2024 |
| A LIGHT-HVEM/LTbetaR axis contributes to the fibrosis of intrauterine adhesion. | A LIGHT-HVEM/LTβR axis contributes to the fibrosis of intrauterine adhesion.
Abudukeyoumu A, Lai ZZ, Lu JJ, Zhang X, Hou DY, Dong J, Wu JN, Li MQ, Xie F. | 10/8/2022 |
| LIGHT (TNFSF14) enhances osteogenesis of human bone marrow-derived mesenchymal stem cells. | LIGHT (TNFSF14) enhances osteogenesis of human bone marrow-derived mesenchymal stem cells.
Heo SK, Choi Y, Jeong YK, Ju LJ, Yu HM, Kim DK, Seo HJ, Lee YJ, Cheon J, Koh S, Min YJ, Noh EK, Jo JC., Free PMC Article | 08/28/2021 |
| Clathrin- and dynamin-dependent endocytosis limits canonical NF-kappaB signaling triggered by lymphotoxin beta receptor. | Clathrin- and dynamin-dependent endocytosis limits canonical NF-κB signaling triggered by lymphotoxin β receptor.
Maksymowicz M, Miączyńska M, Banach-Orłowska M., Free PMC Article | 08/14/2021 |
| LIGHT/LTbetaR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells. | LIGHT/LTβR signaling regulates self-renewal and differentiation of hematopoietic and leukemia stem cells.
Höpner SS, Raykova A, Radpour R, Amrein MA, Koller D, Baerlocher GM, Riether C, Ochsenbein AF., Free PMC Article | 02/27/2021 |
| Inhibition of LTbetaR signalling activates WNT-induced regeneration in lung. | Inhibition of LTβR signalling activates WNT-induced regeneration in lung.
Conlon TM, John-Schuster G, Heide D, Pfister D, Lehmann M, Hu Y, Ertüz Z, Lopez MA, Ansari M, Strunz M, Mayr C, Angelidis I, Ciminieri C, Costa R, Kohlhepp MS, Guillot A, Günes G, Jeridi A, Funk MC, Beroshvili G, Prokosch S, Hetzer J, Verleden SE, Alsafadi H, Lindner M, Burgstaller G, Becker L, Irmler M, Dudek M, Janzen J, Goffin E, Gosens R, Knolle P, Pirotte B, Stoeger T, Beckers J, Wagner D, Singh I, Theis FJ, de Angelis MH, O'Connor T, Tacke F, Boutros M, Dejardin E, Eickelberg O, Schiller HB, Königshoff M, Heikenwalder M, Yildirim AÖ., Free PMC Article | 02/6/2021 |
| The Nuclear Protein HOXB13 Enhances Methylmercury Toxicity by Inducing Oncostatin M and Promoting Its Binding to TNFR3 in Cultured Cells. | The Nuclear Protein HOXB13 Enhances Methylmercury Toxicity by Inducing Oncostatin M and Promoting Its Binding to TNFR3 in Cultured Cells.
Toyama T, Xu S, Nakano R, Hasegawa T, Endo N, Takahashi T, Lee JY, Naganuma A, Hwang GW., Free PMC Article | 09/19/2020 |
| Cutting Edge: The RNA-Binding Protein Ewing Sarcoma Is a Novel Modulator of Lymphotoxin beta Receptor Signaling. | Cutting Edge: The RNA-Binding Protein Ewing Sarcoma Is a Novel Modulator of Lymphotoxin β Receptor Signaling.
Virgen-Slane R, Correa RG, Ramezani-Rad P, Steen-Fuentes S, Detanico T, DiCandido MJ, Li J, Ware CF., Free PMC Article | 09/12/2020 |
| These data provide the first evidence of overexpression of LIGHT and its receptors HVEM and LT beta receptor in systemic sclerosis and suggest that the LIGHT axis might contribute to the pathogenesis of systemic sclerosis. | Increased expression of the TNF superfamily member LIGHT/TNFSF14 and its receptors (HVEM and LTßR) in patients with systemic sclerosis.
Gindzienska-Sieskiewicz E, Distler O, Reszec J, Jordan S, Bielecki P, Sieskiewicz A, Sulik A, Lukasik M, Bielecki M, Kowal K, Kowal-Bielecka O. | 01/11/2020 |
| Authors found that knockdown of Rab7a or HOPS components led to sequestration of LTbetaR in intraluminal vesicles of endosomes, thus precluding NF-kappaB signaling. This was in contrast to the LTbetaR localization on the outer endosomal membrane that was seen after ESCRT depletion and was permissive for signaling. | The topology of the lymphotoxin β receptor that accumulates upon endolysosomal dysfunction dictates the NF-κB signaling outcome.
Banach-Orłowska M, Jastrzębski K, Cendrowski J, Maksymowicz M, Wojciechowska K, Korostyński M, Moreau D, Gruenberg J, Miaczynska M. | 01/11/2020 |
| the lymphotoxin beta receptor (LTbetaR) to elicit the fast release of NF-kappaB inducing kinase (NIK) from the receptor complex leading to non-canonical NF-kappaB signaling. | Helicobacter pylori induces direct activation of the lymphotoxin beta receptor and non-canonical nuclear factor-kappa B signaling.
Feige MH, Vieth M, Sokolova O, Täger C, Naumann M. | 06/2/2018 |
| these results suggest that the LTBR rs12354 polymorphism might be associated with the spontaneous resolution of hepatitis B virus infection | Association of LTBR polymorphisms with chronic hepatitis B virus infection and hepatitis B virus-related hepatocellular carcinoma.
Zhu Q, Li N, Li F, Sang J, Deng H, Han Q, Lv Y, Li C, Liu Z. | 05/5/2018 |
| LTBR and BCLAF1 showed higher DNA methylation percentages in the marsupialized OKCs, but this difference did not affect gene expression (P > .05). | DNA methylation profiles of 22 apoptosis-related genes in odontogenic keratocysts before and after marsupialization.
Pereira KMA, Costa SFDS, Pereira NB, Diniz MG, Castro WH, Gomes CC, Gomez RS. | 04/14/2018 |
| membrane-bound lymphotoxin-beta receptor (LTbetaR) and CXC chemokine receptor 2 (CXCR2), is involved in type B EAE development | An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage.
Inoue M, Chen PH, Siecinski S, Li QJ, Liu C, Steinman L, Gregory SG, Benner E, Shinohara ML., Free PMC Article | 09/9/2017 |
| LIGHT and LTBR interaction increases the survival and proliferation of human bone marrow-derived mesenchymal stem cells, and therefore, LIGHT might play an important role in stem cell therapy. | LIGHT (TNFSF14) Increases the Survival and Proliferation of Human Bone Marrow-Derived Mesenchymal Stem Cells.
Heo SK, Noh EK, Gwon GD, Kim JY, Jo JC, Choi Y, Koh S, Baek JH, Min YJ, Kim H., Free PMC Article | 06/24/2017 |
| We found that LTbetaR polymorphisms caused severe BPH. Thus, LTbetaR may contribute to the risk of BPH development. | Association of LTβR gene polymorphisms with prostate volume in benign prostatic hyperplasia in the Korean population.
Lee SH, Kim SK, Yoo KH, Chung JH, Chang SG. | 12/24/2016 |
| activation enhances the LPS-induced expression of IL-8 through NF-kappaB and IRF-1 | Activation of lymphotoxin-beta receptor enhances the LPS-induced expression of IL-8 through NF-κB and IRF-1.
Jang SW, Lim SG, Suk K, Lee WH. | 02/27/2016 |
| LIGHT, via LTbetaR signaling, may contribute to exacerbation of airway neutrophilic inflammation through cytokine and chemokine production by bronchial epithelial cells. | Lymphotoxin β receptor signaling induces IL-8 production in human bronchial epithelial cells.
Mikami Y, Matsuzaki H, Horie M, Noguchi S, Jo T, Narumoto O, Kohyama T, Takizawa H, Nagase T, Yamauchi Y., Free PMC Article | 12/19/2015 |
| Relative expression of HVEM and LTbetaR modulates canonical NF-kappaB and pro-apoptotic signals stimulated by LIGHT. | Herpesvirus entry mediator (HVEM) attenuates signals mediated by the lymphotoxin β receptor (LTβR) in human cells stimulated by the shared ligand LIGHT.
Bechill J, Muller WJ., Free PMC Article | 01/3/2015 |
| lymphotoxin-B-specific receptor. | Pillars article: A lymphotoxin-B-specific receptor. Science. 1994. 264: 707-710.
Crowe PD, Vanarsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA. | 04/19/2014 |
| Dimerization of LTbetaR by LTalpha1beta2 is necessary and sufficient for signal transduction. | Dimerization of LTβR by LTα1β2 is necessary and sufficient for signal transduction.
Sudhamsu J, Yin J, Chiang EY, Starovasnik MA, Grogan JL, Hymowitz SG., Free PMC Article | 02/8/2014 |
| Studies indicate roles for Lymphotoxin-alpha (LTalpha) and lymphotoxin-beta receptor (LTbetaR) pathway in innate and adaptive immune responses to microorganisms. | Lymphotoxin signalling in immune homeostasis and the control of microorganisms.
Upadhyay V, Fu YX., Free PMC Article | 05/18/2013 |
| Results suggest that blockade of lymphotoxin-beta receptor (LTBR) pathways may have therapeutic potential for treatment of Sjogren's syndrome. | Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome.
Fava RA, Kennedy SM, Wood SG, Bolstad AI, Bienkowska J, Papandile A, Kelly JA, Mavragani CP, Gatumu M, Skarstein K, Browning JL., Free PMC Article | 12/22/2012 |
| LTBR gene polymorphisms may be associated with risk of IgA nephropathy in Korean children | Association between lymphotoxin beta receptor gene polymorphisms and IgA nephropathy in Korean children.
Kim SK, Lee JY, Jeong Park H, Chung JH, Suh JS, Hahn WH, Cho BS, Kim MJ. | 10/13/2012 |
| show that a cognate interaction between LTalphabeta on CD4(+) helper T cells and LTbeta receptor on DCs results in unique signals that are necessary for optimal CD8(+) T-cell expansion via a type I IFN-dependent mechanism | LTβR signaling in dendritic cells induces a type I IFN response that is required for optimal clonal expansion of CD8+ T cells.
Summers deLuca L, Ng D, Gao Y, Wortzman ME, Watts TH, Gommerman JL., Free PMC Article | 03/26/2011 |