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    LRP6 LDL receptor related protein 6 [ Homo sapiens (human) ]

    Gene ID: 4040, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The inhibition of YTHDF3/m[6]A/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer.

    The inhibition of YTHDF3/m(6)A/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer.
    Zhong S, Guo Q, Chen X, Luo X, Long Y, Chong T, Ye M, He H, Lu A, Ao K, Yin M, Xu A, Li X, Hao Y, Guo X., Free PMC Article

    02/16/2024
    LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.

    LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.
    Li J, Liu Z, Ren Y, Shao H, Li S., Free PMC Article

    05/23/2023
    Overexpression of circRNAs LRP6 in gestational diabetes mellitus predicts foetal malformation and intrauterine death.

    Overexpression of circRNAs LRP6 in gestational diabetes mellitus predicts foetal malformation and intrauterine death.
    Hao H, Liu Q, Chen J, Zhou H.

    03/22/2023
    LRP6/filamentous-actin signaling facilitates osteogenic commitment in mechanically induced periodontal ligament stem cells.

    LRP6/filamentous-actin signaling facilitates osteogenic commitment in mechanically induced periodontal ligament stem cells.
    Wang J, Yang H, Ma X, Liu J, Li L, Chen L, Wei F., Free PMC Article

    02/4/2023
    A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.

    A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.
    Jones ME, Büchler J, Dufor T, Palomer E, Teo S, Martin-Flores N, Boroviak K, Metzakopian E, Gibb A, Salinas PC., Free PMC Article

    01/21/2023
    An LRP6 mutation (Arg360His) associated with low bone mineral density but not cardiovascular events in a Caucasian family.

    An LRP6 mutation (Arg360His) associated with low bone mineral density but not cardiovascular events in a Caucasian family.
    Puente N, Vega AI, Hernandez JL, Fernandez-Luna JL, Riancho JA., Free PMC Article

    10/22/2022
    Mutations in LRP6 highlight the role of WNT signaling in oral exostoses and dental anomalies.

    Mutations in LRP6 highlight the role of WNT signaling in oral exostoses and dental anomalies.
    Kantaputra P, Jatooratthawichot P, Chintakanon K, Intachai W, Pradermdutsadeeporn P, Adisornkanj P, Tongsima S, Ngamphiw C, Olsen B, Tucker AS, Ketudat Cairns JR.

    09/24/2022
    Variants in the Wnt co-receptor LRP6 are associated with familial exudative vitreoretinopathy.

    Variants in the Wnt co-receptor LRP6 are associated with familial exudative vitreoretinopathy.
    Li S, Yang M, He Y, Jiang X, Zhao R, Liu W, Huang L, Shi Y, Li X, Sun K, Yang Y, Sundaresan P, Zhao P, Yang Z, Zhu X.

    09/3/2022
    SIK2 maintains breast cancer stemness by phosphorylating LRP6 and activating Wnt/beta-catenin signaling.

    SIK2 maintains breast cancer stemness by phosphorylating LRP6 and activating Wnt/β-catenin signaling.
    Rong Z, Zhang L, Li Z, Xiao Z, Duan Y, Ren X, Zi Y, Gao J, Mu Y, Guan Y, Cao Z, Wang X, Pei Q, Zeng Y, Fan Q, Zeng Z, Ou D, He J, Nie Y, Tan R, Weng L, Li Y, Xiang R, Deng Y, Sun L.

    05/7/2022
    circLRP6 contributes to osteosarcoma progression by regulating the miR1413p/HDAC4/HMGB1 axis.

    circ‑LRP6 contributes to osteosarcoma progression by regulating the miR‑141‑3p/HDAC4/HMGB1 axis.
    Yu Y, Dong G, Li Z, Zheng Y, Shi Z, Wang G., Free PMC Article

    03/26/2022
    Lrp6 Genotype affects Individual Susceptibility to Nonalcoholic Fatty Liver Disease and Silibinin Therapeutic Response via Wnt/beta-catenin-Cyp2e1 Signaling.

    Lrp6 Genotype affects Individual Susceptibility to Nonalcoholic Fatty Liver Disease and Silibinin Therapeutic Response via Wnt/β-catenin-Cyp2e1 Signaling.
    Chen LJ, Lin XX, Guo J, Xu Y, Zhang SX, Chen D, Zhao Q, Xiao J, Lian GH, Peng SF, Guo D, Yang H, Shu Y, Zhou HH, Zhang W, Chen Y., Free PMC Article

    02/19/2022
    Transmembrane protein 97 exhibits oncogenic properties via enhancing LRP6-mediated Wnt signaling in breast cancer.

    Transmembrane protein 97 exhibits oncogenic properties via enhancing LRP6-mediated Wnt signaling in breast cancer.
    Zhu H, Su Z, Ning J, Zhou L, Tan L, Sayed S, Song J, Wang Z, Li H, Sun Q, Liu S, Sha O, Leng F, Chen X, Lu D., Free PMC Article

    02/5/2022
    The complex role of Wnt ligands in type 2 diabetes mellitus and related complications.

    The complex role of Wnt ligands in type 2 diabetes mellitus and related complications.
    Nie X, Wei X, Ma H, Fan L, Chen WD., Free PMC Article

    02/5/2022
    PUM1 modulates trophoblast cell proliferation and migration through LRP6.

    PUM1 modulates trophoblast cell proliferation and migration through LRP6.
    Wang Y, Sun L, Wang L, Yu H, Yu X, Zou Y.

    01/22/2022
    MicroRNA-513c-5p is involved in the pathogenesis of preeclampsia by regulating of low-density lipoprotein receptor-associated protein 6.

    MicroRNA-513c-5p is involved in the pathogenesis of preeclampsia by regulating of low-density lipoprotein receptor-associated protein 6.
    Zhou Q, Li H, Zhang Y, Peng W, Hou H, Gu M, Zhang F, Wang X, Gu X, Li L., Free PMC Article

    01/15/2022
    Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes.

    Low-Density Lipoprotein Receptor-Related Protein 6 Cell Surface Availability Regulates Fuel Metabolism in Astrocytes.
    Chow HM, Sun JK, Hart RP, Cheng KK, Hung CHL, Lau TM, Kwan KM., Free PMC Article

    12/25/2021
    Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis.

    Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis.
    Raisch J, Côté-Biron A, Langlois MJ, Leblanc C, Rivard N., Free PMC Article

    10/30/2021
    Clinical Phenotype and Relevance of LRP5 and LRP6 Variants in Patients With Early-Onset Osteoporosis (EOOP).

    Clinical Phenotype and Relevance of LRP5 and LRP6 Variants in Patients With Early-Onset Osteoporosis (EOOP).
    Stürznickel J, Rolvien T, Delsmann A, Butscheidt S, Barvencik F, Mundlos S, Schinke T, Kornak U, Amling M, Oheim R.

    09/18/2021
    Hsa_circ_0099198 facilitates the progression of retinoblastoma by regulating miR-1287/LRP6 axis.

    Hsa_circ_0099198 facilitates the progression of retinoblastoma by regulating miR-1287/LRP6 axis.
    Jiang Y, Xiao F, Wang L, Wang T, Chen L.

    09/18/2021
    Circ-LRP6 mediates epithelial-mesenchymal transition and autophagy in oral squamous cell carcinomas.

    Circ-LRP6 mediates epithelial-mesenchymal transition and autophagy in oral squamous cell carcinomas.
    Zhang Q, Jiang C, Ren W, Li S, Zheng J, Gao Y, Zhi K, Gao L.

    09/18/2021
    The rs2302685 polymorphism in the LRP6 gene is associated with bone mineral density and body composition in Iranian children.

    The rs2302685 polymorphism in the LRP6 gene is associated with bone mineral density and body composition in Iranian children.
    Montazeri-Najafabady N, Dabbaghmanesh MH, Mohammadian Amiri R.

    09/4/2021
    MiR-30a suppresses clear cell renal cell carcinoma proliferation and metastasis by targeting LRP6.

    MiR-30a suppresses clear cell renal cell carcinoma proliferation and metastasis by targeting LRP6.
    Ren Y, Zhang L, Zhang W, Gao Y.

    08/7/2021
    Low-density lipoprotein receptor-related protein 6 regulates cardiomyocyte-derived paracrine signaling to ameliorate cardiac fibrosis.

    Low-density lipoprotein receptor-related protein 6 regulates cardiomyocyte-derived paracrine signaling to ameliorate cardiac fibrosis.
    Wang X, Zou Y, Chen Z, Li Y, Pan L, Wang Y, Liu M, Yin C, Wu J, Yang C, Zhang L, Li C, Huang Z, Wang D, Qian J, Ge J, Zou Y, Gong H., Free PMC Article

    07/24/2021
    ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway.

    ERK1/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1/LRP6 pathway.
    Zeng P, Yang J, Liu L, Yang X, Yao Z, Ma C, Zhu H, Su J, Zhao Q, Feng K, Yang S, Zhu Y, Li X, Wang W, Duan Y, Han J, Chen Y., Free PMC Article

    07/24/2021
    MicroRNA590 inhibits migration, invasion and epithelialtomesenchymal transition of esophageal squamous cell carcinoma by targeting lowdensity lipoprotein receptorrelated protein 6.

    MicroRNA‑590 inhibits migration, invasion and epithelial‑to‑mesenchymal transition of esophageal squamous cell carcinoma by targeting low‑density lipoprotein receptor‑related protein 6.
    Guan H, Liu J, Lv P, Zhou L, Zhang J, Cao W., Free PMC Article

    07/10/2021
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