| Overexpression of smad7 inhibits the TGF-beta/Smad signaling pathway and EMT in NPHP1-defective MDCK cells. | Overexpression of smad7 inhibits the TGF-β/Smad signaling pathway and EMT in NPHP1-defective MDCK cells.
Wu X, Wang H, Chen H, Lin H, Li M, Yue Z, Sun L. | 01/1/2022 |
| Hypoxia disrupts polarized epithelial morphogenesis of MDCK cells in a HIF1alpha-dependent manner by modulating the transforming growth factor-beta1 signaling pathway. | BAMBI is a novel HIF1-dependent modulator of TGFβ-mediated disruption of cell polarity during hypoxia.
Raykhel I, Moafi F, Myllymäki SM, Greciano PG, Matlin KS, Moyano JV, Manninen A, Myllyharju J. | 11/2/2019 |
| he results of the present study suggested that USAG1 may be involved in the EMT process of MDCK cells induced by TGFbeta1, and febuxostat inhibited EMT by activating the Smad1/5/8 signaling pathway via downregulating the expression of USAG1 in MDCK cells. | Febuxostat inhibits TGF‑β1‑induced epithelial‑mesenchymal transition via downregulation of USAG‑1 expression in Madin‑Darby canine kidney cells in vitro.
Lu L, Zhu J, Zhang Y, Wang Y, Zhang S, Xia A., Free PMC Article | 05/25/2019 |
| Results suggested that CD61 (integrin-beta3) could induce canine adipose-derived mesenchymal stem cells (cADMSCs) to differentiate into primordial germ cell (PGC)-like cells by relying on the activation of transforming growth factor beta (TGF-beta) pathway. | CD61 promotes the differentiation of canine ADMSCs into PGC-like cells through modulation of TGF-β signaling.
Fang J, Wei Y, Lv C, Peng S, Zhao S, Hua J., Free PMC Article | 11/10/2018 |
| obstructive sleep apnea can accelerate the progression of pulmonary remodeling through TGF-beta/miR-185/CoLA1 signaling | Chronic obstructive sleep apnea accelerates pulmonary remodeling via TGF-β/miR-185/CoLA1 signaling in a canine model.
Ding X, Yu C, Liu Y, Yan S, Li W, Wang D, Sun L, Han Y, Li M, Zhang S, Yun F, Zhao H, Li Y., Free PMC Article | 02/24/2018 |
| TGFbeta1 signaling through the canonical SMAD pathway is increased in myxomatous mitral valves, but does not apparently mediate interstitial cell apoptosis in canine MMVD. | Apoptosis and abundance of Bcl-2 family and transforming growth factor β1 signaling proteins in canine myxomatous mitral valves.
Surachetpong S, Jiranantasak T, Rungsipipat A, Orton EC. | 04/12/2014 |
| IL-6 markedly decreased the nuclear concentration of a TGF-beta signaling transducer, Smad 2/3. | IL-6 restores dendritic cell maturation inhibited by tumor-derived TGF-β through interfering Smad 2/3 nuclear translocation.
Lin CS, Chen MF, Wang YS, Chuang TF, Chiang YL, Chu RM. | 02/1/2014 |
| celastrol downregulates Snail expression, thereby inhibiting TGF-beta1-induced EMT in MDCK and A549 cells | Celastrol inhibits TGF-β1-induced epithelial-mesenchymal transition by inhibiting Snail and regulating E-cadherin expression.
Kang H, Lee M, Jang SW. | 10/26/2013 |
| Ostectomy healing with or without platelet-rich plasma as indicated by radiography and expression of PDGF and TGF-beta expression are reported. | Healing and expression of growth factors (TGF-β and PDGF) in canine radial ostectomy gap containing platelet-rich plasma.
Souza TF, Andrade AL, Ferreira GT, Sakamoto SS, Albuquerque VB, Bonfim SR, Luvizotto MC, Louzada MJ. | 05/4/2013 |
| This study tested the hypothesis that cyclic strain and TGFbeta1 interact to modify mitral valve interstitial cell phenotype in 3D culture. | Interactions between TGFβ1 and cyclic strain in modulation of myofibroblastic differentiation of canine mitral valve interstitial cells in 3D culture.
Waxman AS, Kornreich BG, Gould RA, Moïse NS, Butcher JT., Free PMC Article | 09/29/2012 |
| PAK2 negatively modulate TGF-beta signaling by attenuating the receptor-Smad interaction and thus Smad activation | p21-Activated kinase 2 (PAK2) inhibits TGF-β signaling in Madin-Darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interaction.
Yan X, Zhang J, Sun Q, Tuazon PT, Wu X, Traugh JA, Chen YG., Free PMC Article | 07/21/2012 |
| This study showed a lack of an effect of recombinant inteferon-gamma on transforming growth factor-beta (TGF-beta) expression in keratinocytes. | Effect of recombinant canine interferon-γ on granulocyte-macrophage colony-stimulating factor, transforming growth factor-β and CC chemokine ligand 17 mRNA transcription in a canine keratinocyte cell line (CPEK).
Shibata S, Maeda S, Kondo N, Inoue A, Maeda S, Chimura N, Fukata T. | 07/27/2011 |
| Wnt-5a is involved during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition | Proteomics profiling of Madin-Darby canine kidney plasma membranes reveals Wnt-5a involvement during oncogenic H-Ras/TGF-beta-mediated epithelial-mesenchymal transition.
Chen YS, Mathias RA, Mathivanan S, Kapp EA, Moritz RL, Zhu HJ, Simpson RJ., Free PMC Article | 07/23/2011 |
| These results show basolateral domain specificity in localization of the TGFbeta receptor signaling apparatus. | Vectorial TGFbeta signaling in polarized intestinal epithelial cells.
Yakovich AJ, Huang Q, Du J, Jiang B, Barnard JA. | 06/28/2010 |
| These findings suggest that polyunsaturated fatty acids are able to influence proliferation of peripheral blood mononuclear cells in healthy and atopic dogs but do not seem to influence cytokine transcription. | Effects of polyunsaturated fatty acids on isolated canine peripheral blood mononuclear cells and cytokine expression (IL-4, IFN-gamma, TGF-beta) in healthy and atopic dogs.
Stehle ME, Hanczaruk M, Schwarz SC, Göbel TW, Mueller RS. | 06/14/2010 |
| TGFbeta1 might be associated with pulmonary vein stenosis after radiofrequency ablation in chronic atrial fibrillation of dogs | Expression of TGFbeta1 in pulmonary vein stenosis after radiofrequency ablation in chronic atrial fibrillation of dogs.
Li S, Li H, Mingyan E, Yu B. | 01/21/2010 |
| role played by TGF-beta in mediating the cyclosporine-induced activation of ERK1/2 and the resulting increase in transepithelial electric resistance | Role for TGF-beta in cyclosporine-induced modulation of renal epithelial barrier function.
Feldman G, Kiely B, Martin N, Ryan G, McMorrow T, Ryan MP. | 01/21/2010 |
| Transforming growth factor-beta 1 secreted by canine transmissible venereal tumor cells suppresses lymphokine-activated killer cytotoxicity. | Tumor-infiltrating lymphocyte secretion of IL-6 antagonizes tumor-derived TGF-beta 1 and restores the lymphokine-activated killing activity.
Hsiao YW, Liao KW, Hung SW, Chu RM. | 01/21/2010 |