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    LRP1 LDL receptor related protein 1 [ Homo sapiens (human) ]

    Gene ID: 4035, updated on 19-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.

    Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.
    Zhou J, Zhang L, Peng J, Zhang X, Zhang F, Wu Y, Huang A, Du F, Liao Y, He Y, Xie Y, Gu L, Kuang C, Ou W, Xie M, Tu T, Pang J, Zhang D, Guo K, Feng Y, Yin S, Cao Y, Li T, Jiang Y.

    09/12/2024
    LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer.

    LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer.
    Lin H, Fu L, Zhou X, Yu A, Chen Y, Liao W, Shu G, Zhang L, Tan L, Liang H, Wang Z, Deng Q, Wang J, Jin M, Chen Z, Wei J, Cao J, Chen W, Li X, Li P, Lu J, Luo J.

    09/5/2024
    LRP1 is the cell-surface endocytosis receptor for vaspin in adipocytes.

    LRP1 is the cell-surface endocytosis receptor for vaspin in adipocytes.
    Tindall CA, Möhlis K, Rapöhn I, Dommel S, Riedl V, Schneekönig M, Höfling C, Roßner S, Stichel J, Beck-Sickinger AG, Weiner J, Heiker JT.

    08/9/2024
    LRP-1 Binds Fibrinogen in a Sialylation-Dependent Manner: A Quartz Crystal Microbalance Study.

    LRP-1 Binds Fibrinogen in a Sialylation-Dependent Manner: A Quartz Crystal Microbalance Study.
    Gao DL, Johal MS.

    07/19/2024
    Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation.

    Apolipoprotein E-containing lipoproteins and their extracellular interactions with LRP1 affect LPS-induced inflammation.
    Akahane S, Matsuura H, Kaido T, Usami Y, Ishimine N, Uehara T, Yamauchi K.

    06/7/2024
    A reactive monocyte subset characterized by low expression of CD91 is expanded during sterile and septic inflammation.

    A reactive monocyte subset characterized by low expression of CD91 is expanded during sterile and septic inflammation.
    Gosset C, Foguenne J, Simul M, Layios N, Massion PB, Damas P, Gothot A.

    06/5/2024
    Apolipoprotein E isoforms and their Cys-thiol modifications impact LRP1-mediated metabolism of triglyceride-rich lipoproteins.

    Apolipoprotein E isoforms and their Cys-thiol modifications impact LRP1-mediated metabolism of triglyceride-rich lipoproteins.
    Matsuura H, Akahane S, Kaido T, Kamijo T, Sakamoto K, Yamauchi K.

    02/20/2024
    ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells.

    ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells.
    Lee J, Lee H, Lee H, Shin M, Shin MG, Seo J, Lee EJ, Park SA, Park S., Free PMC Article

    01/3/2024
    Jun-APOE-LRP1 axis promotes tumor metastasis in colorectal cancer.

    Jun-APOE-LRP1 axis promotes tumor metastasis in colorectal cancer.
    He L, Shi M, Ren S, Zhang J, Tian Y, Yang X, Liu H., Free PMC Article

    11/8/2023
    The endocytic receptor protein LRP-1 modulate P-glycoprotein mediated drug resistance in MCF-7 cells.

    The endocytic receptor protein LRP-1 modulate P-glycoprotein mediated drug resistance in MCF-7 cells.
    Henry A, Mauperin M, Devy J, Dedieu S, Chazee L, Hachet C, Terryn C, Duca L, Martiny L, Devarenne-Charpentier E, Btaouri HE., Free PMC Article

    10/5/2023
    LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4.

    LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4.
    Oue H, Yamazaki Y, Qiao W, Yuanxin C, Ren Y, Kurti A, Shue F, Parsons TM, Perkerson RB, Kawatani K, Wang N, Starling SC, Roy B, Mosneag IE, Aikawa T, Holm ML, Liu CC, Inoue Y, Sullivan PM, Asmann YW, Kim BY, Bu G, Kanekiyo T., Free PMC Article

    08/10/2023
    Exome-wide analysis reveals role of LRP1 and additional novel loci in cognition.

    Exome-wide analysis reveals role of LRP1 and additional novel loci in cognition.
    Chakraborty S, Kahali B., Free PMC Article

    06/21/2023
    Peripheral apolipoprotein E proteins and their binding to LRP1 antagonize Alzheimer's disease pathogenesis in the brain during peripheral chronic inflammation.

    Peripheral apolipoprotein E proteins and their binding to LRP1 antagonize Alzheimer's disease pathogenesis in the brain during peripheral chronic inflammation.
    Na H, Yang JB, Zhang Z, Gan Q, Tian H, Rajab IM, Potempa LA, Tao Q, Qiu WQ., Free PMC Article

    05/22/2023
    Low-density lipoprotein receptor-related protein 1 (LRP1) as an auxiliary host factor for RNA viruses.

    Low-density lipoprotein receptor-related protein 1 (LRP1) as an auxiliary host factor for RNA viruses.
    Devignot S, Sha TW, Burkard TR, Schmerer P, Hagelkruys A, Mirazimi A, Elling U, Penninger JM, Weber F., Free PMC Article

    05/19/2023
    Contribution of LRP1 in Human Congenital Heart Disease Correlates with Its Roles in the Outflow Tract and Atrioventricular Cushion Development.

    Contribution of LRP1 in Human Congenital Heart Disease Correlates with Its Roles in the Outflow Tract and Atrioventricular Cushion Development.
    Arrigo AB, Zhu W, Williams KA, Guzman-Moreno C, Lo C, Lin JI., Free PMC Article

    05/5/2023
    Serum Exosomes From Epithelial Ovarian Cancer Patients Contain LRP1, Which Promotes the Migration of Epithelial Ovarian Cancer Cell.

    Serum Exosomes From Epithelial Ovarian Cancer Patients Contain LRP1, Which Promotes the Migration of Epithelial Ovarian Cancer Cell.
    Zhou W, Ma J, Zhao H, Wang Q, Guo X, Chen L, Cao Z, Xu J, Zhang B, Zhou X., Free PMC Article

    04/26/2023
    Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption.

    Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption.
    Zhu L, Tang Y, Li XY, Kerk SA, Lyssiotis CA, Sun X, Wang Z, Cho JS, Ma J, Weiss SJ., Free PMC Article

    03/9/2023
    LRP-1 links post-translational modifications to efficient presentation of celiac disease-specific T cell antigens.

    LRP-1 links post-translational modifications to efficient presentation of celiac disease-specific T cell antigens.
    Loppinet E, Besser HA, Sewa AS, Yang FC, Jabri B, Khosla C., Free PMC Article

    02/4/2023
    MT1-MMP Expression Levels and Catalytic Functions Dictate LDL Receptor-Related Protein-1 Ligand Internalization Capacity in U87 Glioblastoma Cells.

    MT1-MMP Expression Levels and Catalytic Functions Dictate LDL Receptor-Related Protein-1 Ligand Internalization Capacity in U87 Glioblastoma Cells.
    Pratt J, Haidara K, Annabi B., Free PMC Article

    12/10/2022
    Multitarget Activities of Muller Glial Cells and Low-Density Lipoprotein Receptor-Related Protein 1 in Proliferative Retinopathies.

    Multitarget Activities of Müller Glial Cells and Low-Density Lipoprotein Receptor-Related Protein 1 in Proliferative Retinopathies.
    Sanchez MC, Chiabrando GA., Free PMC Article

    11/5/2022
    A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage.

    A top-down approach to uncover the hidden ligandome of low-density lipoprotein receptor-related protein 1 in cartilage.
    Yamamoto K, Scavenius C, Meschis MM, Gremida AME, Mogensen EH, Thøgersen IB, Bonelli S, Scilabra SD, Jensen A, Santamaria S, Ahnström J, Bou-Gharios G, Enghild JJ, Nagase H.

    10/8/2022
    Soluble low density lipoprotein receptor-related protein-1 levels in the differential diagnosis of myopericarditis versus acute coronary syndrome.

    Soluble low density lipoprotein receptor-related protein-1 levels in the differential diagnosis of myopericarditis versus acute coronary syndrome.
    Agirbasli M, Bölen F, Konal O, Korkmaz R, Onur AI, Kartal I, Isman FK.

    10/8/2022
    Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts.

    Characterization of interaction between blood coagulation factor VIII and LRP1 suggests dynamic binding by alternating complex contacts.
    Chun H, Kurasawa JH, Olivares P, Marakasova ES, Shestopal SA, Hassink GU, Karnaukhova E, Migliorini M, Obi JO, Smith AK, Wintrode PL, Durai P, Park K, Deredge D, Strickland DK, Sarafanov AG., Free PMC Article

    10/8/2022
    LRP1 is a neuronal receptor for alpha-synuclein uptake and spread.

    LRP1 is a neuronal receptor for α-synuclein uptake and spread.
    Chen K, Martens YA, Meneses A, Ryu DH, Lu W, Raulin AC, Li F, Zhao J, Chen Y, Jin Y, Linares C, Goodwin M, Li Y, Liu CC, Kanekiyo T, Holtzman DM, Golde TE, Bu G, Zhao N., Free PMC Article

    09/24/2022
    Heterozygous LRP1 deficiency causes developmental dysplasia of the hip by impairing triradiate chondrocytes differentiation due to inhibition of autophagy.

    Heterozygous LRP1 deficiency causes developmental dysplasia of the hip by impairing triradiate chondrocytes differentiation due to inhibition of autophagy.
    Yan W, Zheng L, Xu X, Hao Z, Zhang Y, Lu J, Sun Z, Dai J, Shi D, Guo B, Jiang Q., Free PMC Article

    09/17/2022
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