| Mechanisms underlying morphological and functional changes of cilia in fibroblasts derived from patients bearing ARL3[T31A] and ARL3[T31A/C118F] mutations. | Mechanisms underlying morphological and functional changes of cilia in fibroblasts derived from patients bearing ARL3(T31A) and ARL3(T31A/C118F) mutations.
Zhang X, Yao S, Zhang L, Yang L, Yang M, Guo Q, Li Y, Wang Z, Lei B, Jin X. | 03/13/2024 |
| Human Mutations in Arl3, a Small GTPase Involved in Lipidated Cargo Delivery to the Cilia, Cause Retinal Dystrophy. | Human Mutations in Arl3, a Small GTPase Involved in Lipidated Cargo Delivery to the Cilia, Cause Retinal Dystrophy.
Travis AM, Pearring JN. | 09/1/2023 |
| ARL3 activation requires the co-GEF BART and effector-mediated turnover. | ARL3 activation requires the co-GEF BART and effector-mediated turnover.
ElMaghloob Y, Sot B, McIlwraith MJ, Garcia E, Yelland T, Ismail S., Free PMC Article | 01/29/2022 |
| Expression patterns of ciliopathy genes ARL3 and CEP120 reveal roles in multisystem development. | Expression patterns of ciliopathy genes ARL3 and CEP120 reveal roles in multisystem development.
Powell L, Barroso-Gil M, Clowry GJ, Devlin LA, Molinari E, Ramsbottom SA, Miles CG, Sayer JA., Free PMC Article | 10/2/2021 |
| Mechanism of Guanosine Triphosphate Hydrolysis by the Visual Proteins Arl3-RP2: Free Energy Reaction Profiles Computed with Ab Initio Type QM/MM Potentials. | Mechanism of Guanosine Triphosphate Hydrolysis by the Visual Proteins Arl3-RP2: Free Energy Reaction Profiles Computed with Ab Initio Type QM/MM Potentials.
Khrenova MG, Bulavko ES, Mulashkin FD, Nemukhin AV., Free PMC Article | 07/17/2021 |
| Low ARL3 expression predicted poor prognosis and contributed to antiangiogenesis and the proportion of infiltrating immune cells in the GBM microenvironment. Thus, ARL3 may be a prognostic marker and therapeutic target for glioma. | ARL3 is downregulated and acts as a prognostic biomarker in glioma.
Wang Y, Zhao W, Liu X, Guan G, Zhuang M., Free PMC Article | 07/4/2020 |
| Our study confirms that the ARL3 missense variant p.(Tyr90Cys) causes retinitis pigmentosa. | Dominant ARL3-related retinitis pigmentosa.
Holtan JP, Teigen K, Aukrust I, Bragadóttir R, Houge G. | 03/14/2020 |
| Our study uncovers an additional cone rod dystrophy (CRD) gene and assigns the CRD phenotype to a variant of ARL3. The results imply that cargo transportation in photoreceptors as mediated by the ARL3 pathway is essential for cone and rod cell survival and vision in humans. | Homozygous Variant in ARL3 Causes Autosomal Recessive Cone Rod Dystrophy.
Sheikh SA, Sisk RA, Schiavon CR, Waryah YM, Usmani MA, Steel DH, Sayer JA, Narsani AK, Hufnagel RB, Riazuddin S, Kahn RA, Waryah AM, Ahmed ZM., Free PMC Article | 02/1/2020 |
| We utilized a structure-based approach to pinpoint the binding interface to a strictly conserved cluster of residues on the surface of RP2 that spans both the C- and N-terminal domains of the protein, and which is structurally distinct from the ARL3-binding site.RP2 is a positive regulator of cell motility in vitro, recruiting OSTF1 to the cell membrane and preventing its interaction with the migration regulator Myo1E. | Characterization of a novel RP2-OSTF1 interaction and its implication for actin remodelling.
Lyraki R, Lokaj M, Soares DC, Little A, Vermeren M, Marsh JA, Wittinghofer A, Hurd T., Free PMC Article | 09/7/2019 |
| ARL3 provides a potential hub in the network of proteins implicated in ciliopathies. | ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition.
Alkanderi S, Molinari E, Shaheen R, Elmaghloob Y, Stephen LA, Sammut V, Ramsbottom SA, Srivastava S, Cairns G, Edwards N, Rice SJ, Ewida N, Alhashem A, White K, Miles CG, Steel DH, Alkuraya FS, Ismail S, Sayer JA., Free PMC Article | 05/18/2019 |
| By molecular functional analysis, we observed that ARL3 promotes the aggregation of GFP-LC3, up-regulation of LC3-II/LC3-I and down-regulation of SQSMT1/BECN1, and knocking down of ARL3 inbibits autophagy, which suggested that ARL3 is necessary for autophagy. | ARL3 subcellular localization and its suspected role in autophagy.
Luo G, Sun Y, Feng R, Zhao Q, Wen T. | 12/1/2018 |
| this study identifies ARL3 as a key player in prenylated protein trafficking in rod photoreceptor cells and establishes the potential role for ARL3 dysregulation in the pathogenesis of RP2-related forms of XLRP | ARL3 regulates trafficking of prenylated phototransduction proteins to the rod outer segment.
Wright ZC, Singh RK, Alpino R, Goldberg AF, Sokolov M, Ramamurthy V., Free PMC Article | 07/29/2017 |
| Studies indicate that the binding of UNC119 and PDE6D, to the lipid-modified ciliary cargo and the specific release of the cargo in the cilia by the ciliary small G-protein Arl3 in a GTP-dependent manner. | Shuttling and sorting lipid-modified cargo into the cilia.
Stephen LA, Ismail S. | 07/15/2017 |
| Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).( | Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF).
Ivanova AA, Caspary T, Seyfried NT, Duong DM, West AB, Liu Z, Kahn RA., Free PMC Article | 07/8/2017 |
| Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3. | Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3.
Jaiswal M, Fansa EK, Kösling SK, Mejuch T, Waldmann H, Wittinghofer A., Free PMC Article | 05/20/2017 |
| These results indicate that ARL3 interacts with STAT3 and regulates the transcriptional activation of STAT3 by influencing its nuclear accumulation of STAT3. | A New STAT3-binding Partner, ARL3, Enhances the Phosphorylation and Nuclear Accumulation of STAT3.
Togi S, Muromoto R, Hirashima K, Kitai Y, Okayama T, Ikeda O, Matsumoto N, Kon S, Sekine Y, Oritani K, Matsuda T., Free PMC Article | 11/12/2016 |
| De Novo Occurrence of a Variant in ARL3 and Apparent Autosomal Dominant Transmission of Retinitis Pigmentosa. | De Novo Occurrence of a Variant in ARL3 and Apparent Autosomal Dominant Transmission of Retinitis Pigmentosa.
Strom SP, Clark MJ, Martinez A, Garcia S, Abelazeem AA, Matynia A, Parikh S, Sullivan LS, Bowne SJ, Daiger SP, Gorin MB., Free PMC Article | 08/6/2016 |
| Arl3 acts negatively in ciliogenesis but positively in cilia signaling (Review). | Molecular views of Arf-like small GTPases in cilia and ciliopathies.
Zhang Q, Hu J, Ling K., Free PMC Article | 10/26/2013 |
| When Arl3 binds UNC119, it allosterically displaces cargo by accelerating its release by 3 orders of magnitude. The N-terminal amphipathic helix of Arl3.GppNHp is not displaced by the interswitch toggle but remains bound on the surface of the protein. | Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119.
Ismail SA, Chen YX, Miertzschke M, Vetter IR, Koerner C, Wittinghofer A., Free PMC Article | 01/26/2013 |
| The G proteins Arl3 acts in a GTP-dependent manner as allosteric release factors for farnesylated cargo. | Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo.
Ismail SA, Chen YX, Rusinova A, Chandra A, Bierbaum M, Gremer L, Triola G, Waldmann H, Bastiaens PI, Wittinghofer A. | 02/4/2012 |
| We propose that RP2 regulation of Arl3 is important for maintaining Golgi cohesion, facilitating the transport and docking of vesicles and thereby carrying proteins to the base of the photoreceptor connecting cilium for transport to the outer segment. | The retinitis pigmentosa protein RP2 links pericentriolar vesicle transport between the Golgi and the primary cilium.
Evans RJ, Schwarz N, Nagel-Wolfrum K, Wolfrum U, Hardcastle AJ, Cheetham ME. | 05/31/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A., Free PMC Article | 12/2/2009 |
| Arl2 and Arl3 interactions were characterized. | Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.
Veltel S, Kravchenko A, Ismail S, Wittinghofer A. | 01/21/2010 |
| Knockdown of Arl3 by siRNA resulted in changes in cell morphology, increased acetylation of alpha-tubulin, failure of cytokinesis, and increased number of binucleated cells. | Arl2 and Arl3 regulate different microtubule-dependent processes.
Zhou C, Cunningham L, Marcus AI, Li Y, Kahn RA., Free PMC Article | 01/21/2010 |