| There is higher Period and Timeless and lower Cycle expression in the muscle of strains with delayed aging compared to the parental strain. | Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations.
Hunt LC, Jiao J, Wang YD, Finkelstein D, Rao D, Curley M, Robles-Murguia M, Shirinifard A, Pagala VR, Peng J, Fan Y, Demontis F., Free PMC Article | 02/1/2020 |
| experiments define the genetic architecture required to initiate circadian clock function in Drosophila, reveal mechanisms governing circadian activator stability that are conserved in perhaps all eukaryotes, and suggest that Clk, cyc, and cry expression is sufficient to drive clock expression in naive cells | CLOCK stabilizes CYCLE to initiate clock function in Drosophila.
Liu T, Mahesh G, Yu W, Hardin PE., Free PMC Article | 06/30/2018 |
| Here we demonstrate that the transcription factor CLOCKWORK ORANGE (CWO) antagonizes CLK-CYC E-box binding, thus enhancing the removal of CLK-CYC from E-boxes to maintain transcriptional repression. This process requires PER, which suggests that PER-TIM and CWO cooperate to maintain a transcriptionally repressed state by removing CLK-CYC from E-boxes | CLOCKWORK ORANGE Enhances PERIOD Mediated Rhythms in Transcriptional Repression by Antagonizing E-box Binding by CLOCK-CYCLE.
Zhou J, Yu W, Hardin PE., Free PMC Article | 05/6/2017 |
| Computational dissection of CLK/CYC context-specific binding sites reveals sequence motifs for putative partner factors, which are predictive for individual binding sites | cis-regulatory requirements for tissue-specific programs of the circadian clock.
Meireles-Filho ACA, Bardet AF, Yáñez-Cuna JO, Stampfel G, Stark A. | 08/23/2014 |
| findings show that Clk and cyc act during starvation to modulate the conflict of whether flies sleep or search for food | Clock and cycle limit starvation-induced sleep loss in Drosophila.
Keene AC, Duboué ER, McDonald DM, Dus M, Suh GS, Waddell S, Blau J., Free PMC Article | 11/6/2010 |
| a role of CYCLE in the post-translational regulation of the CLOCK protein. | Cytoplasmic interaction with CYCLE promotes the post-translational processing of the circadian CLOCK protein.
Maurer C, Hung HC, Weber F. | 01/21/2010 |
| Study shows that rhythmic transcription of per and tim involves time-of-day-specific binding of CLK-CYC and associated cycles in chromatin modifications. | Rhythmic E-box binding by CLK-CYC controls daily cycles in per and tim transcription and chromatin modifications.
Taylor P, Hardin PE., Free PMC Article | 01/21/2010 |
| Stress response genes protect against lethal effects of sleep deprivation in Drosophila | Stress response genes protect against lethal effects of sleep deprivation in Drosophila.
Shaw PJ, Tononi G, Greenspan RJ, Robinson DF. | 01/21/2010 |
| Cwo is rhythmically expressed and directly regulated by CLK-CYC through canonical E-box sequences. | A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock.
Matsumoto A, Ukai-Tadenuma M, Yamada RG, Houl J, Uno KD, Kasukawa T, Dauwalder B, Itoh TQ, Takahashi K, Ueda R, Hardin PE, Tanimura T, Ueda HR., Free PMC Article | 01/21/2010 |
| Here we examined the consequences of loss of clock function on reproductive fitness in Drosophila melanogaster with mutated period (per(0)), timeless (tim(0)), cycle (cyc(0)), and Clock (Clk(Jrk)) genes | Loss of circadian clock function decreases reproductive fitness in males of Drosophila melanogaster.
Beaver LM, Gvakharia BO, Vollintine TS, Hege DM, Stanewsky R, Giebultowicz JM., Free PMC Article | 01/21/2010 |
| findings suggest that Clockwork Orange (CWO) acts preferentially in the late night to help terminate CLK-CYC-mediated transcription of direct target genes including cwo itself | Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component.
Kadener S, Stoleru D, McDonald M, Nawathean P, Rosbash M., Free PMC Article | 01/21/2010 |
| cycle regulates rest and life span in male Drosophila | Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster.
Hendricks JC, Lu S, Kume K, Yin JC, Yang Z, Sehgal A. | 01/21/2010 |