| Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis. | Cell-Specific and Variant-Linked Alterations in Expression of ERAP1, ERAP2, and LNPEP Aminopeptidases in Psoriasis.
Marusina AI, Ji-Xu A, Le ST, Toussi A, Tsoi LC, Li Q, Luxardi G, Nava J, Downing L, Leal AR, Kuzminykh NY, Kruglinskaya O, Brüggen MC, Adamopoulos IE, Merleev AA, Gudjonsson JE, Maverakis E. | 06/26/2023 |
| The role of LNPEP and ANPEP gene polymorphisms in the pathogenesis of pre-eclampsia. | The role of LNPEP and ANPEP gene polymorphisms in the pathogenesis of pre-eclampsia.
Khaliq OP, Konoshita T, Moodley J, Naicker T. | 07/3/2021 |
| LNPEP expression in the left atrium in mitral regurgitation patients significantly differed from those in aortic valve disease patients and normal controls. | Differential Gene Expression Profile of Renin-Angiotensin System in the Left Atrium in Mitral Regurgitation Patients.
Liu WH, Fang YN, Wu CC, Chen MC, Chang JP, Lin YS, Pan KL, Ho WC, Chang TH, Huang YK, Fang CY, Chen CJ, Lee WC., Free PMC Article | 04/13/2019 |
| This study shown that the schizophrenia patients, the numerical density of IRAP-expressing neurons in the paraventricular and the suprachiasmatic nuclei is significantly reduced, which might be associated with the reduction in neurophysin-containing neurons in these nuclei in schizophrenia. | Insulin-regulated aminopeptidase immunoreactivity is abundantly present in human hypothalamus and posterior pituitary gland, with reduced expression in paraventricular and suprachiasmatic neurons in chronic schizophrenia.
Bernstein HG, Müller S, Dobrowolny H, Wolke C, Lendeckel U, Bukowska A, Keilhoff G, Becker A, Trübner K, Steiner J, Bogerts B. | 02/3/2018 |
| Vasopressinase might be a potential early biomarker for acute kidney injury after cardiopulmonary bypass. | Vasopressinase Activity: A Potential Early Biomarker for Detecting Cardiopulmonary Bypass-Associated Acute Kidney Injury?
Kim N, Dai SY, Pang V, Mazer CD. | 07/22/2017 |
| Structural and biological characterization of three low molecular weight aryl sulfonamides: binding modes to human IRAP were explored by docking calculations combined with molecular dynamics simulations and binding affinity estimations using the linear interaction energy method. Two of these drug-like IRAP inhibitors can alter dendritic spine morphology and increase spine density in primary cultures of hippocampal neurons | Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures.
Diwakarla S, Nylander E, Grönbladh A, Vanga SR, Shamsudin Y, Gutiérrez-de-Terán H, Sävmarker J, Ng L, Pham V, Lundbäck T, Jenmalm-Jensen A, Svensson R, Artursson P, Zelleroth S, Engen K, Rosenström U, Larhed M, Åqvist J, Chai SY, Hallberg M. | 06/24/2017 |
| The PCR-RFLP is a simple and reliable method that allows a quick genotyping for the rs4869317 SNP of LNPEP gene. | A PCR-RFLP method for detection of the LNPEP encoding human insulin-regulated aminopeptidase (IRAP) rs4869317 polymorphism.
RamIrez-Expósito MJ, MartInez-Martos JM, Palomeque T, Lorite P., Free PMC Article | 06/24/2017 |
| This study describes a crystal structure of insulin-regulated aminopeptidase in complex with a recently developed bioactive and selective inhibitor at 2.53 A resolution. | Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.
Mpakali A, Saridakis E, Harlos K, Zhao Y, Kokkala P, Georgiadis D, Giastas P, Papakyriakou A, Stratikos E. | 04/29/2017 |
| The substrate Angiotensin II, the enzymes aminopeptidases-A, B, M as well as IRAP were detected in the jejunal mucosa. | Local expression of AP/AngIV/IRAP and effect of AngIV on glucose-induced epithelial transport in human jejunal mucosa.
Malinauskas M, Wallenius V, Fändriks L, Casselbrant A. | 10/1/2016 |
| Determined is the crystal structure of human IRAP revealing a closed, four domain arrangement with a large, mostly buried cavity abutting the active site. | Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.
Hermans SJ, Ascher DB, Hancock NC, Holien JK, Michell BJ, Chai SY, Morton CJ, Parker MW., Free PMC Article | 10/17/2015 |
| We identified the missense variant rs2303138 (p.Ala763Thr) within the LNPEP gene associated with psoriasis. | Identification of a missense variant in LNPEP that confers psoriasis risk.
Cheng H, Li Y, Zuo XB, Tang HY, Tang XF, Gao JP, Sheng YJ, Yin XY, Zhou FS, Zhang C, Chen G, Zhu J, Pan Q, Liang B, Zheng XD, Li P, Ding YT, Cheng F, Luo J, Chang RX, Pan GB, Fan X, Wang ZX, Zhang AP, Liu JJ, Yang S, Sun LD, Zhang XJ. | 03/29/2014 |
| Activities of aminopeptidases N and B and insulin-regulated aminopeptidase could be useful non-invasive biomarkers of Alzheimer's disease from the earliest stages. | Plasma renin-angiotensin system-regulating aminopeptidase activities are modified in early stage Alzheimer's disease and show gender differences but are not related to apolipoprotein E genotype.
Puertas Mdel C, Martínez-Martos JM, Cobo M, Lorite P, Sandalio RM, Palomeque T, Torres MI, Carrera-González MP, Mayas MD, Ramírez-Expósito MJ. | 11/16/2013 |
| An association between maternal common polymorphisms in LNPEP and susceptibility to preterm birth was observed. | Sequence variants in oxytocin pathway genes and preterm birth: a candidate gene association study.
Kim J, Stirling KJ, Cooper ME, Ascoli M, Momany AM, McDonald EL, Ryckman KK, Rhea L, Schaa KL, Cosentino V, Gadow E, Saleme C, Shi M, Hallman M, Plunkett J, Teramo KA, Muglia LJ, Feenstra B, Geller F, Boyd HA, Melbye M, Marazita ML, Dagle JM, Murray JC., Free PMC Article | 08/31/2013 |
| S1 specificity pocket of the aminopeptidases that generate antigenic peptides. | Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.
Zervoudi E, Papakyriakou A, Georgiadou D, Evnouchidou I, Gajda A, Poreba M, Salvesen GS, Drag M, Hattori A, Swevers L, Vourloumis D, Stratikos E., Free PMC Article | 09/17/2011 |
| The genetic variation in LNPEP (vasopressinase) is associated with 28-day mortality in septic shock and is associated with biologic effects on vasopressin clearance and serum sodium regulation | Leucyl/cystinyl aminopeptidase gene variants in septic shock.
Nakada TA, Russell JA, Wellman H, Boyd JH, Nakada E, Thain KR, Thair SA, Hirasawa H, Oda S, Walley KR. | 07/23/2011 |
| investigation of domain structure of IRAP; catalytic domains; inhibitor-binding domains; zinc binding sites | Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain.
Ascher DB, Cromer BA, Morton CJ, Volitakis I, Cherny RA, Albiston AL, Chai SY, Parker MW. | 06/4/2011 |
| Although PLAP has the necessary enzymatic properties to participate in generating or destroying major histocompatibility class I-presented peptides, its trimming behavior during antigen processing is distinct from that of ERAP1. | Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1.
Georgiadou D, Hearn A, Evnouchidou I, Chroni A, Leondiadis L, York IA, Rock KL, Stratikos E., Free PMC Article | 09/13/2010 |
| Expression of AT4R was increased in term placentae, with a significant reduction in pre-eclampsia placentae. | Expression of AT1R, AT2R and AT4R and their roles in extravillous trophoblast invasion in the human.
Williams PJ, Mistry HD, Innes BA, Bulmer JN, Broughton Pipkin F. | 08/9/2010 |
| The probable involvement of P-LAP in trophoblast invasion and development of preeclampsia. | Alteration of circulating Placental Leucine Aminopeptidase (P-LAP) activity in preeclampsia.
Landau R, Laverrière A, Bischof P, Irion O, Morales M, Cohen M. | 05/31/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.
Johnson MP, Roten LT, Dyer TD, East CE, Forsmo S, Blangero J, Brennecke SP, Austgulen R, Moses EK., Free PMC Article | 08/12/2009 |
| distinct biological effects of Angiotensin II 3-8 fragment, denoted as Angiotensin IV, and high affinity Ang IV binding to the AT(4) receptor. [review] | From angiotensin IV binding site to AT4 receptor.
Vanderheyden PM. | 01/21/2010 |
| study found a role for peptide trimming by IRAP in cross-presentation; in dendritic cells, IRAP was localized to a Rab14+ endosomal storage compartment in which it interacted with MHC class I molecules | IRAP identifies an endosomal compartment required for MHC class I cross-presentation.
Saveanu L, Carroll O, Weimershaus M, Guermonprez P, Firat E, Lindo V, Greer F, Davoust J, Kratzer R, Keller SR, Niedermann G, van Endert P. | 01/21/2010 |
| Triton-slowed APN as well as PLAP is present in the serum of pregnant women. | Identification of placental leucine aminopeptidase and triton-slowed aminopeptidase N in serum of pregnant women.
Kawai M, Araragi K, Shimizu Y, Hara Y. | 01/21/2010 |
| Data show that placental leucine aminopeptidase (P-LAP) plays important roles in the regulation of blood pressure under both the physiological and pathological conditions. | Biochemical and enzymatic properties of the M1 family of aminopeptidases involved in the regulation of blood pressure.
Tsujimoto M, Goto Y, Maruyama M, Hattori A. | 01/21/2010 |
| study identifies smooth muscle cell alpha actin positive ACE2 and AT4R in blood vessels as well as in angiogenic vessels, indicating a possible role for these enzymes in pathological disease | ACE2 and AT4R are present in diseased human blood vessels.
Zulli A, Burrell LM, Buxton BF, Hare DL. | 01/21/2010 |