| Hepatocyte polarity establishment and apical lumen formation are organized by Par3, Cdc42, and aPKC in conjunction with Lgl. | Hepatocyte polarity establishment and apical lumen formation are organized by Par3, Cdc42, and aPKC in conjunction with Lgl.
Tocan V, Hayase J, Kamakura S, Kohda A, Ohga S, Kohjima M, Sumimoto H., Free PMC Article | 01/29/2022 |
| LLGL1 Regulates Gemcitabine Resistance by Modulating the ERK-SP1-OSMR Pathway in Pancreatic Ductal Adenocarcinoma. | LLGL1 Regulates Gemcitabine Resistance by Modulating the ERK-SP1-OSMR Pathway in Pancreatic Ductal Adenocarcinoma.
Zhu YX, Li CH, Li G, Feng H, Xia T, Wong CH, Fung FKC, Tong JH, To KF, Chen R, Chen Y., Free PMC Article | 11/27/2021 |
| Scribble, Lgl1, and myosin II form a complex in vivo to promote directed cell migration. | Scribble, Lgl1, and myosin II form a complex in vivo to promote directed cell migration.
Abedrabbo M, Ravid S., Free PMC Article | 06/26/2021 |
| [MiR-665 Promotes the Biological Behavior of Small Cell Lung Cancer by Targeting LLGL1]. | [MiR-665 Promotes the Biological Behavior of Small Cell Lung Cancer by Targeting LLGL1].
Liu R, Zhang L, Xu Z, Cui Y., Free PMC Article | 02/2/2021 |
| LLGL1 is coexpressed with E-cadherin; loss of expression of either protein is associated with diffuse gastric cancer and peritoneal metastases. | Loss of LLGL1 Expression Correlates with Diffuse Gastric Cancer and Distant Peritoneal Metastases.
Desuki A, Staib F, Gockel I, Moehler M, Lang H, Biesterfeld S, Maderer A, Galle PR, Berger MR, Schimanski CC., Free PMC Article | 03/28/2020 |
| loss of Llgl1 results in EGFR mislocalization, promoting pre-neoplastic changes | Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.
Greenwood E, Maisel S, Ebertz D, Russ A, Pandey R, Schroeder J., Free PMC Article | 03/24/2018 |
| these results revealed that miR-652-3p execute a tumor-promoter function in non-small cell lung cancer through direct binding and regulating the expression of Lgl1 | MiR-652-3p is upregulated in non-small cell lung cancer and promotes proliferation and metastasis by directly targeting Lgl1.
Yang W, Zhou C, Luo M, Shi X, Li Y, Sun Z, Zhou F, Chen Z, He J., Free PMC Article | 12/9/2017 |
| Older age is a strong predictor of CNS involvement in patients seropositive for CASPR2-IgG or LGI1-IgG. Pain, peripheral manifestations, and stereotypic paroxysmal dizziness spells are common with LGI1-IgG. | Expanded phenotypes and outcomes among 256 LGI1/CASPR2-IgG-positive patients.
Gadoth A, Pittock SJ, Dubey D, McKeon A, Britton JW, Schmeling JE, Smith A, Kotsenas AL, Watson RE, Lachance DH, Flanagan EP, Lennon VA, Klein CJ. | 08/26/2017 |
| Reduced expression of Hugl 1 predicts poor survival in lung SqCC patients. The expression of Hugl 1 was inversely correlated with both overall survival rate and tumor stage. | Reduced Expression of Hugl 1 Contributes to the Progression of Lung Squamous Cell Carcinoma.
Matsuzaki T, Takekoshi S, Toriumi K, Kitatani K, Nitou M, Imamura N, Ogura G, Masuda R, Nakamura N, Iwazaki M. | 09/10/2016 |
| Our results support the growing appreciation that the tumour regulatory functions of Scribble, and other polarity protein family members, are context dependent. | Scribble acts as an oncogene in Eμ-myc-driven lymphoma.
Hawkins ED, Oliaro J, Ramsbottom KM, Newbold A, Humbert PO, Johnstone RW, Russell SM. | 08/6/2016 |
| this study provides the evidence that Hugl-1 inhibits glioma cell growth in intracranial model of nude mice, suggesting that Hugl-1 might be a potential tumor target for glioma therapy. | Hugl-1 inhibits glioma cell growth in intracranial model.
Liu X, Lu D, Ma P, Liu H, Cao Y, Sang B, Zhu X, Shi Q, Hu J, Yu R, Zhou X. | 07/16/2016 |
| Lgl1 has a role in inhibiting glioblastoma | Inhibition of glioblastoma malignancy by Lgl1.
Gont A, Hanson JE, Lavictoire SJ, Daneshmand M, Nicholas G, Woulfe J, Kassam A, Da Silva VF, Lorimer IA., Free PMC Article | 09/26/2015 |
| PTEN loss leads to the phosphorylation and inactivation of Lgl by atypical protein kinase C in glioblastoma cells. | PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1.
Gont A, Hanson JE, Lavictoire SJ, Parolin DA, Daneshmand M, Restall IJ, Soucie M, Nicholas G, Woulfe J, Kassam A, Da Silva VF, Lorimer IA., Free PMC Article | 06/14/2014 |
| Suggest that Hugl-1 induces growth suppression and apoptosis in a human esophageal squamous cell carcinoma cell line both in vitro and in vivo. | Hugl-1 induces apoptosis in esophageal carcinoma cells both in vitro and in vivo.
Song J, Peng XL, Ji MY, Ai MH, Zhang JX, Dong WG., Free PMC Article | 01/4/2014 |
| inactivation of Llgl1 enhances hematopoietic stem cells self-renewal and fitness and is associated with unfavorable outcome in human acute myeloid leukemia | The cell fate determinant Llgl1 influences HSC fitness and prognosis in AML.
Heidel FH, Bullinger L, Arreba-Tutusaus P, Wang Z, Gaebel J, Hirt C, Niederwieser D, Lane SW, Döhner K, Vasioukhin V, Fischer T, Armstrong SA., Free PMC Article | 04/13/2013 |
| Hugl1 and Hugl2 play an essential role in the maintenance of breast epithelial polarity and differentiated cell morphology, as well as growth control. | Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation.
Russ A, Louderbough JM, Zarnescu D, Schroeder JA., Free PMC Article | 04/13/2013 |
| Preservation of HUGL-1 expression in pancreatic adenocarcinoma is a good prognostic factor that contributes to a better overall survival | Preservation of HUGL-1 expression as a favourable prognostic factor in pancreatic carcinoma.
Biesterfeld S, Kauhausen A, Kost C, Gockel I, Schimanski CC, Galle PR. | 10/20/2012 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Results provide the first evidence that Hugl-1 mRNA is frequently mutated by aberrant splicing exclusively in HCC, which may be involved in HCC progression. | Aberrant splicing of Hugl-1 is associated with hepatocellular carcinoma progression.
Lu X, Feng X, Man X, Yang G, Tang L, Du D, Zhang F, Yuan H, Huang Q, Zhang Z, Liu Y, Strand D, Chen Z. | 01/21/2010 |
| loss of Hugl-1 expression in endometrial cancer may contribute to lymph node metastasis and it can be a factor of poor prognosis. | Loss of Hugl-1 expression associates with lymph node metastasis in endometrial cancer.
Tsuruga T, Nakagawa S, Watanabe M, Takizawa S, Matsumoto Y, Nagasaka K, Sone K, Hiraike H, Miyamoto Y, Hiraike O, Minaguchi T, Oda K, Yasugi T, Yano T, Taketani Y. | 01/21/2010 |
| aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia | aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia.
Grifoni D, Garoia F, Bellosta P, Parisi F, De Biase D, Collina G, Strand D, Cavicchi S, Pession A. | 01/21/2010 |
| downregulation of Hugl-1 contributes to colorectal cancer progression | Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer.
Schimanski CC, Schmitz G, Kashyap A, Bosserhoff AK, Bataille F, Schäfer SC, Lehr HA, Berger MR, Galle PR, Strand S, Strand D. | 01/21/2010 |
| Hugl-1 can act as a tumour suppressor in Drosophila and thus is the functional homologue of lgl | The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo.
Grifoni D, Garoia F, Schimanski CC, Schmitz G, Laurenti E, Galle PR, Pession A, Cavicchi S, Strand D. | 01/21/2010 |
| loss of Hugl-1 expression contributes to melanoma progression | Expression of Hugl-1 is strongly reduced in malignant melanoma.
Kuphal S, Wallner S, Schimanski CC, Bataille F, Hofer P, Strand S, Strand D, Bosserhoff AK. | 01/21/2010 |