| Novel role of LLGL2 silencing in autophagy: reversing epithelial-mesenchymal transition in prostate cancer. | Novel role of LLGL2 silencing in autophagy: reversing epithelial-mesenchymal transition in prostate cancer.
Hong GL, Kim KH, Kim YJ, Lee HJ, Cho SP, Han SY, Yang SW, Lee JS, Kang SK, Lim JS, Jung JY., Free PMC Article | 05/13/2024 |
| Co-expression effect of LLGL2 and SLC7A5 to predict prognosis in ERalpha-positive breast cancer. | Co-expression effect of LLGL2 and SLC7A5 to predict prognosis in ERα-positive breast cancer.
Hisada T, Kondo N, Wanifuchi-Endo Y, Osaga S, Fujita T, Asano T, Uemoto Y, Nishikawa S, Katagiri Y, Terada M, Kato A, Sugiura H, Okuda K, Kato H, Komura M, Morita S, Takahashi S, Toyama T., Free PMC Article | 10/8/2022 |
| A human cell polarity protein Lgl2 regulates influenza A virus nucleoprotein exportation from nucleus in MDCK cells. | A human cell polarity protein Lgl2 regulates influenza A virus nucleoprotein exportation from nucleus in MDCK cells.
Liu J, Wang H, Fang M, Chen X, Zeng X. | 04/3/2021 |
| Study and determination of the crystal structure of lethal giant larvae homolog 2 (Lgl2). | Solving the structure of Lgl2, a difficult blind test of unsupervised structure determination.
Ufimtsev IS, Almagor L, Weis WI, Levitt M., Free PMC Article | 04/4/2020 |
| The crystal structures of human lethal giant larvae homolog 2 (Lgl2) in both its unphosphorylated and atypical protein kinase C(aPKC) phosphorylated states are presented and investigated in this article. | Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2.
Almagor L, Ufimtsev IS, Ayer A, Li J, Weis WI., Free PMC Article | 04/4/2020 |
| LLGL2 functions as a promoter of tumour growth and not as a tumour suppressor in ER(+) breast cancer; beyond breast cancer, adaptation to nutrient stress is critically important, and findings identify an unexpected role for LLGL2 in this process | LLGL2 rescues nutrient stress by promoting leucine uptake in ER(+) breast cancer.
Saito Y, Li L, Coyaud E, Luna A, Sander C, Raught B, Asara JM, Brown M, Muthuswamy SK. | 01/25/2020 |
| The crystal structures of the Dlg4 GK domain in complex with two phosphor-Lgl2 peptides reveal the molecular mechanism underlying the specific and phosphorylation-dependent Dlg/Lgl complex formation. | Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl.
Zhu J, Shang Y, Wan Q, Xia Y, Chen J, Du Q, Zhang M., Free PMC Article | 05/30/2015 |
| It is correlated with lymphatic invasion and lymph node metastasis. | Localization of aPKC lambda/iota and its interacting protein, Lgl2, is significantly associated with lung adenocarcinoma progression.
Imamura N, Horikoshi Y, Matsuzaki T, Toriumi K, Kitatani K, Ogura G, Masuda R, Nakamura N, Takekoshi S, Iwazaki M. | 06/28/2014 |
| Loss or aberrant Lgl2 staining was useful in identifying Barrett gastric foveolar dysplasia | Distinguishing Barrett gastric foveolar dysplasia from reactive cardiac mucosa in gastroesophageal reflux disease.
Patil DT, Bennett AE, Mahajan D, Bronner MP. | 07/20/2013 |
| Hugl-2 induces MET and suppresses Snail tumorigenesis. | The human Lgl polarity gene, Hugl-2, induces MET and suppresses Snail tumorigenesis.
Kashyap A, Zimmerman T, Ergül N, Bosserhoff A, Hartman U, Alla V, Bataille F, Galle PR, Strand S, Strand D. | 05/4/2013 |
| Hugl1 and Hugl2 play an essential role in the maintenance of breast epithelial polarity and differentiated cell morphology, as well as growth control. | Hugl1 and Hugl2 in mammary epithelial cells: polarity, proliferation, and differentiation.
Russ A, Louderbough JM, Zarnescu D, Schroeder JA., Free PMC Article | 04/13/2013 |
| There is a role of Lgl2 immunohistochemistry as an adjunct in the diagnosis of foveolar-type gastric dysplasia. | Loss of cell polarity protein Lgl2 in foveolar-type gastric dysplasia: correlation with expression of the apical marker aPKC-zeta.
Lisovsky M, Ogawa F, Dresser K, Woda B, Lauwers GY. | 01/1/2011 |
| Lgl2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias. | Immunohistochemistry for cell polarity protein lethal giant larvae 2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias.
Lisovsky M, Dresser K, Woda B, Mino-Kenudson M. | 06/14/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesAssociation of genetic variants with hemorrhagic stroke in Japanese individuals.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y. | 12/2/2009 |
| We propose that Lgl2 may be a potential marker to rule out gastric epithelial dysplasia and adenocarcinoma in diagnostic specimens. | Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study.
Lisovsky M, Dresser K, Baker S, Fisher A, Woda B, Banner B, Lauwers GY. | 01/21/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study.
Yamada Y, Fuku N, Tanaka M, Aoyagi Y, Sawabe M, Metoki N, Yoshida H, Satoh K, Kato K, Watanabe S, Nozawa Y, Hasegawa A, Kojima T. | 05/17/2009 |
| The identification and functional characterization of the promoter region ( approximately 1.2kb) of the Hugl-2 gene are reported. | Cloning and characterization of the promoter of Hugl-2, the human homologue of Drosophila lethal giant larvae (lgl) polarity gene.
Zimmermann T, Kashyap A, Hartmann U, Otto G, Galle PR, Strand S, Strand D. | 01/21/2010 |
| Retention of Lgl2 expression is critical for the epithelial phenotype;its loss might be involved in metastasis. | The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer.
Spaderna S, Schmalhofer O, Wahlbuhl M, Dimmler A, Bauer K, Sultan A, Hlubek F, Jung A, Strand D, Eger A, Kirchner T, Behrens J, Brabletz T. | 01/21/2010 |
| binding between Lgl2 and LGN play a role in mitotic spindle organization through regulating formation of the LGN.NuMA complex; Lgl2 forms a Lgl2.Par-6.aPKC.LGN complex, which responds to mitotic signaling to establish normal cell division | Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division.
Yasumi M, Sakisaka T, Hoshino T, Kimura T, Sakamoto Y, Yamanaka T, Ohno S, Takai Y. | 01/21/2010 |