| Circ_0061140 Contributes to Ovarian Cancer Progression by Targeting miR-761/LETM1 Signaling. | Circ_0061140 Contributes to Ovarian Cancer Progression by Targeting miR-761/LETM1 Signaling.
Ma L, Liu W, Li M. | 04/6/2023 |
| LETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) silence reduces the proliferation, invasion, migration and angiogenesis in esophageal squamous cell carcinoma via KIF14 (kinesin family member 14). | LETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) silence reduces the proliferation, invasion, migration and angiogenesis in esophageal squamous cell carcinoma via KIF14 (kinesin family member 14).
Zhao Q, Chen S, Chen L., Free PMC Article | 02/26/2022 |
| Suppression of LETM1 inhibits the proliferation and stemness of colorectal cancer cells through reactive oxygen species-induced autophagy. | Suppression of LETM1 inhibits the proliferation and stemness of colorectal cancer cells through reactive oxygen species-induced autophagy.
Che N, Yang Z, Liu X, Li M, Feng Y, Zhang C, Li C, Cui Y, Xuan Y., Free PMC Article | 09/25/2021 |
| The leucine zipper EF-hand containing transmembrane protein-1 EF-hand is a tripartite calcium, temperature, and pH sensor. | The leucine zipper EF-hand containing transmembrane protein-1 EF-hand is a tripartite calcium, temperature, and pH sensor.
Lin QT, Lee R, Feng AL, Kim MS, Stathopulos PB., Free PMC Article | 08/14/2021 |
| The mitochondrial inner membrane protein LETM1 modulates cristae organization through its LETM domain. | The mitochondrial inner membrane protein LETM1 modulates cristae organization through its LETM domain.
Nakamura S, Matsui A, Akabane S, Tamura Y, Hatano A, Miyano Y, Omote H, Kajikawa M, Maenaka K, Moriyama Y, Endo T, Oka T., Free PMC Article | 06/19/2021 |
| Wholeexome sequencing identifies a novel mutation of SLC20A2 (c.C1849T) as a possible cause of hereditary multiple exostoses in a Chinese family. | Whole‑exome sequencing identifies a novel mutation of SLC20A2 (c.C1849T) as a possible cause of hereditary multiple exostoses in a Chinese family.
Li Y, Lin X, Zhu M, Li J, Yuan Z, Xu H., Free PMC Article | 05/1/2021 |
| MiR-613 blocked the progression of cervical cancer by targeting LETM1. | MiR-613 blocked the progression of cervical cancer by targeting LETM1.
Ji H, Hu NJ. | 04/17/2021 |
| LETM1 could serve as a potential prognostic biomarker and a therapeutic target for the better clinical management of gastric adenocarcinoma | LETM1 is a potential biomarker that predicts poor prognosis in gastric adenocarcinoma.
Li H, Piao L, Xu D, Xuan Y. | 07/18/2020 |
| LETM1 is a potential prognostic biomarker of lung non-small cell carcinoma. | LETM1 is a potential biomarker of prognosis in lung non-small cell carcinoma.
Piao L, Yang Z, Feng Y, Zhang C, Cui C, Xuan Y., Free PMC Article | 02/29/2020 |
| LETM1 expression was remarkably upregulated in human fetal sagittal sections and colorectal adenocarcinoma tissues. The expression of LETM1 in colorectal adenocarcinoma tissue was correlated with clinical stage, lymph node metastasis, distant metastasis, and microvessel density. | LETM1 is a potential cancer stem-like cell marker and predicts poor prognosis in colorectal adenocarcinoma.
Piao L, Feng Y, Yang Z, Qi W, Li H, Han H, Xuan Y. | 01/18/2020 |
| High expression of LETM1 indicates poor prognosis and may be a potential cancer stem cell marker in esophageal squamous cell carcinoma. | Identification of LETM1 as a marker of cancer stem-like cells and predictor of poor prognosis in esophageal squamous cell carcinoma.
Yang Z, Ni W, Cui C, Qi W, Piao L, Xuan Y. | 10/26/2019 |
| Here, the authors show that LETM1 is associated with mitochondrial ribosomes, is required for mitochondrial DNA distribution and expression, and regulates the activity of an ancillary metabolic enzyme, pyruvate dehydrogenase. | LETM1 couples mitochondrial DNA metabolism and nutrient preference.
Durigon R, Mitchell AL, Jones AW, Manole A, Mennuni M, Hirst EM, Houlden H, Maragni G, Lattante S, Doronzio PN, Dalla Rosa I, Zollino M, Holt IJ, Spinazzola A., Free PMC Article | 05/4/2019 |
| Data show that LETM1 is a transporter protein localized to the inner mitochondrial membrane shown to have a Ca(2+)/H exchanger activity. The role of LETM1 to Ca(2+) regulation is evident from Wolf-Hirschhorn syndrome patients that harbor a haploinsuficiency in LETM1 expression, leading to dysfunctional mitochondrial Ca(2+) handling and from many types of cancer cells that show an upregulation of its expression. [review] | Molecular Mechanisms of Leucine Zipper EF-Hand Containing Transmembrane Protein-1 Function in Health and Disease.
Lin QT, Stathopulos PB., Free PMC Article | 04/27/2019 |
| these results revealed that the knockdown of LETM1 exhibited tumor suppressive effects, possibly by controlling the downstream Wnt/beta-catenin signaling pathway. | Suppression of LETM1 by siRNA inhibits cell proliferation and invasion of bladder cancer cells.
Huang B, Zhang J, Zhang X, Huang C, Hu G, Li S, Xie T, Liu M, Xu Y. | 07/7/2018 |
| Data indicate a positive association between LETM1 up-regulation, YAP1 nuclear localization and high PDGFB expression. | Coupling of LETM1 up-regulation with oxidative phosphorylation and platelet-derived growth factor receptor signaling via YAP1 transactivation.
Lee J, Lee WK, Seol MY, Lee SG, Kim D, Kim H, Park J, Jung SG, Chung WY, Lee EJ, Jo YS., Free PMC Article | 02/17/2018 |
| LETM1 plays an important role in the progression of breast cancer | LETM1 overexpression is correlated with the clinical features and survival outcome of breast cancer.
Li N, Zheng Y, Xuan C, Lin Z, Piao L, Liu S., Free PMC Article | 10/8/2016 |
| LETM1 protein overexpression is associated with Triple negative breast cancer progression, and may be a potential biomarker for poor prognostic evaluation of Triple negative breast cancer. | Clinical implication of leucine zipper/EF hand-containing transmembrane-1 overexpression in the prognosis of triple-negative breast cancer.
Wang CA, Liu Q, Chen Y, Liu S, Xu J, Cui X, Zhang Y, Piao L. | 06/20/2015 |
| LETM1 plays an important role in the progression of head and neck squamous cell carcinoma. | High expression of leucine zipper-EF-hand containing transmembrane protein 1 predicts poor prognosis in head and neck squamous cell carcinoma.
Chen L, Yang Y, Liu S, Piao L, Zhang Y, Lin Z, Li Z., Free PMC Article | 05/16/2015 |
| Letm1 expression is decreased in patients with intractable TLE and a rat model of epilepsy. Down-regulation of Letm1 leads to increases mitochondrial swelling and decreased MT-CYB expression, which is associated with susceptibility to seizures. | Association of mitochondrial letm1 with epileptic seizures.
Zhang X, Chen G, Lu Y, Liu J, Fang M, Luo J, Cao Q, Wang X. | 05/16/2015 |
| Reconstitution of LETM1 or antioxidant overexpression rescued mitochondrial Ca(2+) transport and bioenergetics | LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation.
Doonan PJ, Chandramoorthy HC, Hoffman NE, Zhang X, Cárdenas C, Shanmughapriya S, Rajan S, Vallem S, Chen X, Foskett JK, Cheung JY, Houser SR, Madesh M., Free PMC Article | 01/31/2015 |
| These findings identify novel cellular phenotypes in Wolf-Hirschhorn syndrome attributable to a 50% reduction in LETM1 expression level. | LETM1 haploinsufficiency causes mitochondrial defects in cells from humans with Wolf-Hirschhorn syndrome: implications for dissecting the underlying pathomechanisms in this condition.
Hart L, Rauch A, Carr AM, Vermeesch JR, O'Driscoll M., Free PMC Article | 12/20/2014 |
| Haploinsufficiency of WHSC1 and/or LETM1 contributes to Wolf-Hirschhorn Syndrome, but that loss of distinct and/or additional genes in 4p16.3 is necessary for the expression of the core Wolf-Hirschhorn Syndrome phenotype. | Deletions involving genes WHSC1 and LETM1 may be necessary, but are not sufficient to cause Wolf-Hirschhorn Syndrome.
Andersen EF, Carey JC, Earl DL, Corzo D, Suttie M, Hammond P, South ST., Free PMC Article | 11/22/2014 |
| NCLX, but not LETM1, mediates Ca(2+) extrusion from mitochondria. By controlling the duration of matrix Ca(2+) elevations, NCLX contributes to the regulation of NAD(P)H production and to the conversion of Ca(2+) signals into redox changes. | NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state.
De Marchi U, Santo-Domingo J, Castelbou C, Sekler I, Wiederkehr A, Demaurex N., Free PMC Article | 10/11/2014 |
| Functional properties of Letm1 described in study are remarkably similar to those of the H(+)-dependent Ca(2+) transport mechanism identified in intact mitochondria. | Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1.
Tsai MF, Jiang D, Zhao L, Clapham D, Miller C., Free PMC Article | 08/16/2014 |
| Data indicate that loss of Letm1 contributes to the pathology of Wolf-Hirschhorn syndrome and may contribute to seizure phenotypes by reducing glucose oxidation and other specific metabolic alterations. | Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome.
Jiang D, Zhao L, Clish CB, Clapham DE., Free PMC Article | 08/31/2013 |