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    LEPR leptin receptor [ Homo sapiens (human) ]

    Gene ID: 3953, updated on 29-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The Arg/Arg genotype of leptin receptor gene Gln223Arg polymorphism may be an independent risk factor for nonalcoholic fatty liver disease.

    The Arg/Arg genotype of leptin receptor gene Gln223Arg polymorphism may be an independent risk factor for nonalcoholic fatty liver disease.
    Navari M, Zarei F, Sayedsalehi S, Mahmoudi T, Rostami M, Mahban A, Rezamand G, Asadi A, Dabiri R, Nobakht H, Farahani H, Tabaeian SP, Zali MR.

    10/25/2024
    Role of Different Variants of Leptin Receptor in Human Adrenal Tumor Types.

    Role of Different Variants of Leptin Receptor in Human Adrenal Tumor Types.
    Klimont A, Ruciński M, Sawicka-Gutaj N, Szyszka M, Blatkiewicz M, Wierzbicki T, Karczewski M, Janicka-Jedyńska M, Ruchała M, Komarowska H., Free PMC Article

    08/31/2024
    Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.

    Association of leptin G2548A and leptin receptor Q223R polymorphisms and their serum levels with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.
    Kargasheh FB, Ansaripour S, Borumandnia N, Moradi N, Zandieh Z, Maleki M, Mokhtar S, Karimi A, Fatemi F, Kheirollahi A, Vatannejad A., Free PMC Article

    08/27/2024
    The Association of Plasma Leptin, Soluble Leptin Receptor and Total and High-Molecular Weight Adiponectin With the Risk of Perioperative Neurocognitive Disorders.

    The Association of Plasma Leptin, Soluble Leptin Receptor and Total and High-Molecular Weight Adiponectin With the Risk of Perioperative Neurocognitive Disorders.
    Feinkohl I, Janke J, Slooter AJC, Winterer G, Spies C, Pischon T.

    08/13/2024
    The Expression of Genes Related to Reverse Cholesterol Transport and Leptin Receptor Pathways in Peripheral Blood Mononuclear Cells Are Decreased in Morbid Obesity and Related to Liver Function.

    The Expression of Genes Related to Reverse Cholesterol Transport and Leptin Receptor Pathways in Peripheral Blood Mononuclear Cells Are Decreased in Morbid Obesity and Related to Liver Function.
    Jiménez-Cortegana C, López-Enríquez S, Alba G, Santa-María C, Martín-Núñez GM, Moreno-Ruiz FJ, Valdés S, García-Serrano S, Rodríguez-Díaz C, Ho-Plágaro A, Fontalba-Romero MI, García-Fuentes E, Garrido-Sánchez L, Sánchez-Margalet V., Free PMC Article

    08/3/2024
    A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers.

    A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers.
    Hu WQ, Zhou WG, Zhou GW, Liao JX, Shi JX, Xie F, Li SH, Wang Y, Feng XH, Gu XL, Chen BF.

    06/7/2024
    Association of polymorphism in leptin receptor gene with susceptibility of adolescent idiopathic scoliosis.

    Association of polymorphism in leptin receptor gene with susceptibility of adolescent idiopathic scoliosis.
    Araujo Junior AEP, de Azevedo GBL, Moliterno LAM, Tavares RH, Cardoso JV, de Souza GR, Guimarães JAM, Defino HLA, Perini JA.

    03/5/2024
    Leptin and Leptin Receptor Polymorphisms in Infants and Their Parents: Correlation with Preterm Birth.

    Leptin and Leptin Receptor Polymorphisms in Infants and Their Parents: Correlation with Preterm Birth.
    Savino F, Sardo A, Gambarino S, Dini M, Clemente A, Pau A, Galliano I, Bergallo M., Free PMC Article

    02/6/2024
    Immunomodulatory leptin receptor[+] sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis.

    Immunomodulatory leptin receptor(+) sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis.
    Haberman ER, Sarker G, Arús BA, Ziegler KA, Meunier S, Martínez-Sánchez N, Freibergerová E, Yilmaz-Özcan S, Fernández-González I, Zentai C, O'Brien CJO, Grainger DE, Sidarta-Oliveira D, Chakarov S, Raimondi A, Iannacone M, Engelhardt S, López M, Ginhoux F, Domingos AI.

    01/15/2024
    Genetic predisposition of LEPR (rs1137101) gene polymorphism related to type 2 diabetes mellitus - a meta-analysis.

    Genetic predisposition of LEPR (rs1137101) gene polymorphism related to type 2 diabetes mellitus - a meta-analysis.
    Veerabathiran R, P A, Bk I, D R, Rs AH., Free PMC Article

    01/12/2024
    GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population.

    GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population.
    Prodan A, Dzubanovsky I, Kamyshnyi O, Melnyk N, Pidruchna S, Voloshyn S.

    01/3/2024
    Association between leptin receptor polymorphisms and polycystic ovary syndrome risk: a meta-analysis based on 11 studies.

    Association between leptin receptor polymorphisms and polycystic ovary syndrome risk: a meta-analysis based on 11 studies.
    Wang NN, Tang M, Zhang HY, Yang QZ, Yang GL.

    11/10/2023
    The leptin receptor has no role in delta-cell control of beta-cell function in the mouse.

    The leptin receptor has no role in delta-cell control of beta-cell function in the mouse.
    Zhang J, Katada K, Mosleh E, Yuhas A, Peng G, Golson ML., Free PMC Article

    10/30/2023
    High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor.

    High morbidity and mortality in children with untreated congenital deficiency of leptin or its receptor.
    Saeed S, Khanam R, Janjua QM, Manzoor J, Ning L, Hanook S, Canouil M, Ali M, Ayesha H, Khan WI, Farooqi IS, Yeo GSH, O'Rahilly S, Bonnefond A, Butt TA, Arslan M, Froguel P., Free PMC Article

    09/25/2023
    Leptin Receptor Gln223Arg Polymorphism of Human Spermatozoa Associated with Male Infertility in a Chinese Population.

    Leptin Receptor Gln223Arg Polymorphism of Human Spermatozoa Associated with Male Infertility in a Chinese Population.
    Mo Y, Liang F, Mehmood A, Shah S, Xie Y, Lin Z, Sun Y, Jiang H, Guo Y, Niu X, Mo D., Free PMC Article

    09/25/2023
    A National Multicenter Study of Leptin and Leptin Receptor Deficiency and Systematic Review.

    A National Multicenter Study of Leptin and Leptin Receptor Deficiency and Systematic Review.
    Besci Ö, Fırat SN, Özen S, Çetinkaya S, Akın L, Kör Y, Pekkolay Z, Özalkak Ş, Özsu E, Erdeve ŞS, Poyrazoğlu Ş, Berberoğlu M, Aydın M, Omma T, Akıncı B, Demir K, Oral EA.

    08/25/2023
    Deficient leptin receptor signaling in T cells of human SLE.

    Deficient leptin receptor signaling in T cells of human SLE.
    Liu T, Zheng M, Jia L, Wang M, Tang L, Wen Z, Zhang M, Yuan F., Free PMC Article

    08/10/2023
    Clinical Significance of Plasma Leptin and Its Receptors mRNA Expression in Craniopharyngiomas: A Prospective Study.

    Clinical Significance of Plasma Leptin and Its Receptors mRNA Expression in Craniopharyngiomas: A Prospective Study.
    Xiao Y, Wu W, Cai K, Jin L, Jia Y, Qiao N, Liu F, Ru S, Cao L, Gui S., Free PMC Article

    08/2/2023
    Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival.

    Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival.
    Du M, Wang Y, Vallis J, Shariati M, Parfrey PS, Mclaughlin JR, Wang PP, Zhu Y., Free PMC Article

    06/29/2023
    Antagonizing the Leptin Receptor in Obesity.

    Antagonizing the Leptin Receptor in Obesity.
    Rosen CJ.

    06/17/2023
    Correlation of Q223R and K109R polymorphisms in leptin receptor gene with susceptibility of breast cancer: A systematic review and meta-analysis.

    Correlation of Q223R and K109R polymorphisms in leptin receptor gene with susceptibility of breast cancer: A systematic review and meta-analysis.
    Zhu S, Tang Z, Tang Y, Tan T, Chen B, Xie D, Xie S, Luo H, Jiang W, Tang Y, Yang J.

    06/16/2023
    Congenital leptin and leptin receptor deficiencies in nine new families: identification of six novel variants and review of literature.

    Congenital leptin and leptin receptor deficiencies in nine new families: identification of six novel variants and review of literature.
    Mazen IH, El-Gammal MA, Elaidy AA, Anwar GM, Ashaat EA, Abdel-Ghafar SF, Abdel-Hamid MS.

    06/2/2023
    Placenta DNA methylation levels of the promoter region of the leptin receptor gene are associated with infant cortisol.

    Placenta DNA methylation levels of the promoter region of the leptin receptor gene are associated with infant cortisol.
    Reid BM, Aubuchon-Endsley NL, Tyrka AR, Marsit CJ, Stroud LR., Free PMC Article

    06/1/2023
    Association between genetic polymorphisms of leptin receptor and preeclampsia in Chinese women.

    Association between genetic polymorphisms of leptin receptor and preeclampsia in Chinese women.
    Zeng S, Wu Y, Zhou M, Bai H, Liu X, Fan P.

    05/9/2023
    Functional characterization of all missense variants in LEPR, PCSK1, and POMC genes arising from single-nucleotide variants.

    Functional characterization of all missense variants in LEPR, PCSK1, and POMC genes arising from single-nucleotide variants.
    Shah BP, Sleiman PM, Mc Donald J, Moeller IH, Kleyn P.

    04/12/2023
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