| Upregulated expression of lamin B receptor increases cell proliferation and suppresses genomic instability: implications for cellular immortalization. | Upregulated expression of lamin B receptor increases cell proliferation and suppresses genomic instability: implications for cellular immortalization.
En A, Takemoto K, Yamakami Y, Nakabayashi K, Fujii M. | 08/9/2024 |
| Nuclear envelope protein lamin B receptor protects the genome from chromosomal instability and tumorigenesis. | Nuclear envelope protein lamin B receptor protects the genome from chromosomal instability and tumorigenesis.
Patil S, Deshpande S, Sengupta K. | 02/24/2023 |
| Differentiation-dependent changes in lamin B1 dynamics and lamin B receptor localization. | Differentiation-dependent changes in lamin B1 dynamics and lamin B receptor localization.
Wesley CC, Levy DL., Free PMC Article | 01/28/2023 |
| Natural history and genetic spectrum of the Turkish metaphyseal dysplasia cohort, including rare types caused by biallelic COL10A1, COL2A1, and LBR variants. | Natural history and genetic spectrum of the Turkish metaphyseal dysplasia cohort, including rare types caused by biallelic COL10A1, COL2A1, and LBR variants.
Tüysüz B, Kasap B, Sarıtaş M, Alkaya DU, Bozlak S, Kıykım A, Durmaz A, Yıldırım T, Akpınar E, Apak H, Vural M. | 01/14/2023 |
| Knockdown of Lamin B1 and the Corresponding Lamin B Receptor Leads to Changes in Heterochromatin State and Senescence Induction in Malignant Melanoma. | Knockdown of Lamin B1 and the Corresponding Lamin B Receptor Leads to Changes in Heterochromatin State and Senescence Induction in Malignant Melanoma.
Lämmerhirt L, Kappelmann-Fenzl M, Fischer S, Pommer M, Zimmermann T, Kluge V, Matthies A, Kuphal S, Bosserhoff AK., Free PMC Article | 08/13/2022 |
| Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome. | Lamin B receptor plays a key role in cellular senescence induced by inhibition of the proteasome.
En A, Takauji Y, Miki K, Ayusawa D, Fujii M., Free PMC Article | 01/8/2022 |
| Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor. | Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor.
Tiago T, Hummel B, Morelli FF, Basile V, Vinet J, Galli V, Mediani L, Antoniani F, Pomella S, Cassandri M, Garone MG, Silvestri B, Cimino M, Cenacchi G, Costa R, Mouly V, Poser I, Yeger-Lotem E, Rosa A, Alberti S, Rota R, Ben-Zvi A, Sawarkar R, Carra S., Free PMC Article | 10/16/2021 |
| Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis. | Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis.
Herman AB, Anerillas C, Harris SC, Munk R, Martindale JL, Yang X, Mazan-Mamczarz K, Zhang Y, Heckenbach IJ, Scheibye-Knudsen M, De S, Sen P, Abdelmohsen K, Gorospe M., Free PMC Article | 08/14/2021 |
| TMEM147 interacts with lamin B receptor, regulates its localization and levels, and affects cholesterol homeostasis. | TMEM147 interacts with lamin B receptor, regulates its localization and levels, and affects cholesterol homeostasis.
Christodoulou A, Maimaris G, Makrigiorgi A, Charidemou E, Lüchtenborg C, Ververis A, Georgiou R, Lederer CW, Haffner C, Brügger B, Santama N. | 07/3/2021 |
| A homozygous variant in the Lamin B receptor gene LBR results in a non-lethal skeletal dysplasia without Pelger-Huet anomaly. | A homozygous variant in the Lamin B receptor gene LBR results in a non-lethal skeletal dysplasia without Pelger-Huët anomaly.
Collins M, Miranda V, Rousseau J, Kratz LE, Campeau PM. | 06/26/2021 |
| The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP). | The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP).
En A, Takauji Y, Ayusawa D, Fujii M. | 12/12/2020 |
| Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally. | Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally.
Capell-Hattam IM, Sharpe LJ, Qian L, Hart-Smith G, Prabhu AV, Brown AJ., Free PMC Article | 10/24/2020 |
| MiR-222/LBR have key roles in controlling pro-progression influences of cancer-associated fibroblasts in breast cancer. | MicroRNA-222 reprogrammed cancer-associated fibroblasts enhance growth and metastasis of breast cancer.
Chatterjee A, Jana S, Chatterjee S, Wastall LM, Mandal G, Nargis N, Roy H, Hughes TA, Bhattacharyya A., Free PMC Article | 06/20/2020 |
| This report provides further evidence for a phenotypic spectrum of LBR-associated disorders and expands the genotypic spectrum by describing 3 novel disease-causing variants that have not been previously associated with a disease. | Lamin B receptor-related disorder is associated with a spectrum of skeletal dysplasia phenotypes.
Thompson E, Abdalla E, Superti-Furga A, McAlister W, Kratz L, Unger S, Royer-Bertrand B, Campos-Xavier B, Mittaz-Crettol L, Amin AK, DeSanto C, Wilson DB, Douglas G, Kozel B, Shinawi M. | 02/22/2020 |
| LBR represents an instructive example of one gene presenting with two different patterns of inheritance and at least three different clinical phenotypes. | A novel case of Greenberg dysplasia and genotype-phenotype correlation analysis for LBR pathogenic variants: An instructive example of one gene-multiple phenotypes.
Giorgio E, Sirchia F, Bosco M, Sobreira NLM, Baylor-Hopkins Center for Mendelian Genomics, Grosso E, Brussino A, Brusco A., Free PMC Article | 02/8/2020 |
| A common pathogenic mechanism in GMAP-210- and LBR-related diseases attributable to defective secretory trafficking at the Golgi apparatus. | A common pathomechanism in GMAP-210- and LBR-related diseases.
Wehrle A, Witkos TM, Schneider JC, Hoppmann A, Behringer S, Köttgen A, Elting M, Spranger J, Lowe M, Lausch E., Free PMC Article | 11/30/2019 |
| The c.893G>A (p.Gly298Glu) mutation in the LBR gene probably underlies the Pelger-Husmall io, Russiant anomaly in this pedigree | [Analysis of LBR gene mutation in a pedigree affected with Pelger-Huёt anomaly].
Luo X, Xu Q, Huang L, Yang N, Li Y, Zeng Q, An B, Huang S. | 09/28/2019 |
| These results suggested that decreased LBR function is involved in the induction of cellular senescence in human cells. | Lamin B receptor (LBR) is involved in the induction of cellular senescence in human cells.
Arai R, En A, Takauji Y, Maki K, Miki K, Fujii M, Ayusawa D. | 06/8/2019 |
| The authors demonstrate that human LBR is essential for cholesterol synthesis. | The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations.
Tsai PL, Zhao C, Turner E, Schlieker C., Free PMC Article | 11/25/2017 |
| These observations point to a new mechanism regulating the localization of LBR, which is governed by an ELYS-mediated phosphorylation network. | ELYS regulates the localization of LBR by modulating its phosphorylation state.
Mimura Y, Takagi M, Clever M, Imamoto N., Free PMC Article | 08/5/2017 |
| The primary response of cells to various stresses leading to senescence consists of the down-regulation of LBR and LB1 to attain reversal of the chromatin architecture. | Loss of lamin B receptor is necessary to induce cellular senescence.
Lukášová E, Kovarˇík A, Bacˇíková A, Falk M, Kozubek S. | 06/24/2017 |
| We have shown here that lamin B receptor (LBR) showed a change in localization in both BrdU-induced and replicative senescent cells. | Aberrant localization of lamin B receptor (LBR) in cellular senescence in human cells.
Arai R, En A, Ukekawa R, Miki K, Fujii M, Ayusawa D. | 05/13/2017 |
| Data indicate that proto-oncogene protein c-akt (Akt) phosphorylates distinct sites than SRPK1 protein within the arginine-serine (RS) domain of Lamin B Receptor (LBR). | SRPK1 and Akt Protein Kinases Phosphorylate the RS Domain of Lamin B Receptor with Distinct Specificity: A Combined Biochemical and In Silico Approach.
Voukkalis N, Koutroumani M, Zarkadas C, Nikolakaki E, Vlassi M, Giannakouros T., Free PMC Article | 04/1/2017 |
| Lamin B receptor mRNA expression was directly associated with tumor grade in breast cancer patients(grade 1 vs. grade 3 - 0.00 vs. 0.00; p = 0.0479) and Nottingham Prognostic Index (NPI1 vs. NPI3 - 0.00 vs. 0.00; p = 0.0551). | The clinicopathological significance of lamin A/C, lamin B1 and lamin B receptor mRNA expression in human breast cancer.
Wazir U, Ahmed MH, Bridger JM, Harvey A, Jiang WG, Sharma AK, Mokbel K., Free PMC Article | 09/13/2014 |
| Mutation in LBR gene is associated with pelger-huet anomaly and a mild skeletal phenotype. | Pelger-huet anomaly and a mild skeletal phenotype secondary to mutations in LBR.
Borovik L, Modaff P, Waterham HR, Krentz AD, Pauli RM. | 10/19/2013 |