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    LBP lipopolysaccharide binding protein [ Homo sapiens (human) ]

    Gene ID: 3929, updated on 17-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis.

    Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis.
    Zhang Q, Shen X, Yuan X, Huang J, Zhu Y, Zhu T, Zhang T, Wu H, Wu Q, Fan Y, Ni J, Meng L, He A, Shi C, Li H, Hu Q, Wang J, Chang C, Huang F, Li F, Chen M, Liu A, Ye S, Zheng M, Fang H., Free PMC Article

    04/19/2024
    Gastric cancer-derived LBP promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formation.

    Gastric cancer-derived LBP promotes liver metastasis by driving intrahepatic fibrotic pre-metastatic niche formation.
    Xie L, Qiu S, Lu C, Gu C, Wang J, Lv J, Fang L, Chen Z, Li Y, Jiang T, Xia Y, Wang W, Li B, Xu Z., Free PMC Article

    10/5/2023
    Lipopolysaccharide-binding protein and future Parkinson's disease risk: a European prospective cohort.

    Lipopolysaccharide-binding protein and future Parkinson's disease risk: a European prospective cohort.
    Zhao Y, Walker DI, Lill CM, Bloem BR, Darweesh SKL, Pinto-Pacheco B, McNeil B, Miller GW, Heath AK, Frissen M, Petrova D, Sánchez MJ, Chirlaque MD, Guevara M, Zibetti M, Panico S, Middleton L, Katzke V, Kaaks R, Riboli E, Masala G, Sieri S, Zamora-Ros R, Amiano P, Jenab M, Peters S, Vermeulen R., Free PMC Article

    07/25/2023
    Lipopolysaccharide-binding protein as a biomarker in oral and maxillofacial tumors.

    Lipopolysaccharide-binding protein as a biomarker in oral and maxillofacial tumors.
    Qiao B, Chen Z, Huang J, Lam AK, Mei Z, Li Y, Qiao J.

    03/22/2023
    Identification of CD14 and lipopolysaccharide-binding protein as novel biomarkers for sarcoidosis using proteomics of serum extracellular vesicles.

    Identification of CD14 and lipopolysaccharide-binding protein as novel biomarkers for sarcoidosis using proteomics of serum extracellular vesicles.
    Futami Y, Takeda Y, Koba T, Narumi R, Nojima Y, Ito M, Nakayama M, Ishida M, Yoshimura H, Naito Y, Fukushima K, Takimoto T, Edahiro R, Matsuki T, Nojima S, Hirata H, Koyama S, Iwahori K, Nagatomo I, Shirai Y, Suga Y, Satoh S, Futami S, Miyake K, Shiroyama T, Inoue Y, Adachi J, Tomonaga T, Ueda K, Kumanogoh A., Free PMC Article

    06/18/2022
    A Genetic Variation of Lipopolysaccharide Binding Protein Affects the Inflammatory Response and Is Associated with Improved Outcome during Sepsis.

    A Genetic Variation of Lipopolysaccharide Binding Protein Affects the Inflammatory Response and Is Associated with Improved Outcome during Sepsis.
    Kumpf O, Gürtler K, Sur S, Parvin M, Zerbe LK, Eckert JK, Weber ANR, Oh DY, Lundvall L, Hamann L, Schumann RR.

    05/14/2022
    SWATH-MS identification of CXCL7, LBP, TGFbeta1 and PDGFRbeta as novel biomarkers in human systemic mastocytosis.

    SWATH-MS identification of CXCL7, LBP, TGFβ1 and PDGFRβ as novel biomarkers in human systemic mastocytosis.
    Graham RLJ, McMullen AA, Moore G, Dempsey-Hibbert NC, Myers B, Graham C., Free PMC Article

    05/14/2022
    Shift Work Predicts Increases in Lipopolysaccharide-Binding Protein, Interleukin-10, and Leukocyte Counts in a Cross-Sectional Study of Healthy Volunteers Carrying Low-Grade Systemic Inflammation.

    Shift Work Predicts Increases in Lipopolysaccharide-Binding Protein, Interleukin-10, and Leukocyte Counts in a Cross-Sectional Study of Healthy Volunteers Carrying Low-Grade Systemic Inflammation.
    Atwater AQ, Immergluck LC, Davidson AJ, Castanon-Cervantes O., Free PMC Article

    01/8/2022
    Association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children.

    Association of serum lipopolysaccharide-binding protein level with sensitization to food allergens in children.
    Ha EK, Kim JH, Yon DK, Lee SW, Kim MA, Lee KS, Sung M, Jee HM, Shin YH, Han MY., Free PMC Article

    09/18/2021
    Lipopolysaccharide-binding protein is a distinctive biomarker of abnormal pain threshold in the general Japanese population.

    Lipopolysaccharide-binding protein is a distinctive biomarker of abnormal pain threshold in the general Japanese population.
    Kudoh K, Mizukami H, Itabashi C, Fuke N, Osonoi S, Takeuchi Y, Wada K, Igawa A, Ogasawara S, Ishibashi Y, Hakamada K, Yagihashi S, Nakaji S., Free PMC Article

    07/24/2021
    Postprandial Endotoxin Transporters LBP and sCD14 Differ in Obese vs. Overweight and Normal Weight Men during Fat-Rich Meal Digestion.

    Postprandial Endotoxin Transporters LBP and sCD14 Differ in Obese vs. Overweight and Normal Weight Men during Fat-Rich Meal Digestion.
    Laugerette F, Vors C, Alligier M, Pineau G, Drai J, Knibbe C, Morio B, Lambert-Porcheron S, Laville M, Vidal H, Michalski MC., Free PMC Article

    03/6/2021
    Plasma proteome profiling reveals differentially expressed lipopolysaccharide-binding protein among leptospirosis patients.

    Plasma proteome profiling reveals differentially expressed lipopolysaccharide-binding protein among leptospirosis patients.
    Fish-Low CY, Than LTL, Ling KH, Lin Q, Sekawi Z.

    10/24/2020
    Plasma levels of C-reactive protein, matrix metalloproteinase-7 and lipopolysaccharide-binding protein distinguish active pulmonary or extrapulmonary tuberculosis from uninfected controls in children.

    Plasma levels of C-reactive protein, matrix metalloproteinase-7 and lipopolysaccharide-binding protein distinguish active pulmonary or extrapulmonary tuberculosis from uninfected controls in children.
    Albuquerque VVS, Kumar NP, Fukutani KF, Vasconcelos B, Arriaga MB, Silveira-Mattos PS, Babu S, Andrade BB.

    09/12/2020
    The authors show here, using scanning electron microscopy and confocal microscopy, that platelet-poor-plasma from subjects with type 2 diabetes had a much greater propensity for hypercoagulability and for fibrin amyloidogenesis, and that these could both be reversed by LBP.

    Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular co-morbidities.
    Pretorius E, Mbotwe S, Kell DB., Free PMC Article

    05/4/2019
    rs2232618T allele of LBP significantly increased the risk of sepsis (Review)

    LBP rs2232618 polymorphism contributes to risk of sepsis after trauma.
    Lu HX, Sun JH, Wen DL, Du J, Zeng L, Zhang AQ, Jiang JX., Free PMC Article

    03/30/2019
    circulating LBP plasma concentration and hs-CRP were significantly increased in subjects with homeostatic model assessment of insulin resistance (HOMA-IR) >/=2.6 when compared with those with HOMA-IR<2.6 (P<.0001); there was no difference in TNF-alpha or IL-6 concentrations between groups

    Blood concentrations of lipopolysaccharide-binding protein, high-sensitivity C-reactive protein, tumor necrosis factor-α, and Interleukin-6 in relation to insulin resistance in young adolescents.
    Kim KE, Heo JS, Han S, Kwon SK, Kim SY, Kim JH, Baek KH, Sheen YH.

    02/16/2019
    This study shows a remarkable reversal of amyloid fibrin formation by LBP addition to the plasma of Parkinson's Disease patients .

    Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease.
    Pretorius E, Page MJ, Mbotwe S, Kell DB., Free PMC Article

    06/30/2018
    Serum LBP levels are associated with arterial stiffness, independent of obesity and traditional cardiovascular risk factors, especially in men with type 2 diabetes.

    Lipopolysaccharide-binding protein is associated with arterial stiffness in patients with type 2 diabetes: a cross-sectional study.
    Sakura T, Morioka T, Shioi A, Kakutani Y, Miki Y, Yamazaki Y, Motoyama K, Mori K, Fukumoto S, Shoji T, Emoto M, Inaba M., Free PMC Article

    03/3/2018
    novel observation that sCD14 compared with lipopolysaccharide binding protein, offers a preferred target to ameliorate TLR especially TLR4-induced inflammation and insulin resistance in human obesity and metabolic syndrome

    The effect of the accessory proteins, soluble CD14 and lipopolysaccharide-binding protein on Toll-like receptor 4 activity in human monocytes and adipocytes.
    Pahwa R, Devaraj S, Jialal I.

    01/20/2018
    LBP, an endotoxemia associated protein might be used as an inflammatory biomarker of both infectious and non-infectious origins in HCV-infected subjects

    High Serum Lipopolysaccharide-Binding Protein Level in Chronic Hepatitis C Viral Infection Is Reduced by Anti-Viral Treatments.
    Nien HC, Hsu SJ, Su TH, Yang PJ, Sheu JC, Wang JT, Chow LP, Chen CL, Kao JH, Yang WS., Free PMC Article

    08/12/2017
    Data show that after matching for gender, age, and body mass index (BMI), serum lipopolysaccharide-binding protein (LBP) does not improve prediction of the development of type 2 diabetes mellitus (T2DM) independently.

    Lipopolysaccharide-binding protein cannot independently predict type 2 diabetes mellitus: A nested case-control study.
    Zhou H, Hu J, Zhu Q, Yang S, Zhang Y, Gao R, Liu L, Wang Y, Zhen Q, Lv Q, Li Q.

    12/17/2016
    The main findings of this study are that, in acute stroke patients, levels of LBP, IL-10, IL-6 and CRP show a different time course in patients with and without post-stroke infection.

    Lipopolysaccharide binding protein, interleukin-10, interleukin-6 and C-reactive protein blood levels in acute ischemic stroke patients with post-stroke infection.
    Worthmann H, Tryc AB, Dirks M, Schuppner R, Brand K, Klawonn F, Lichtinghagen R, Weissenborn K., Free PMC Article

    08/13/2016
    Serum LBP level is significantly elevated in polycystic ovary syndrome women and is associated with insulin resistance.

    Serum LBP Is Associated with Insulin Resistance in Women with PCOS.
    Zhu Q, Zhou H, Zhang A, Gao R, Yang S, Zhao C, Wang Y, Hu J, Goswami R, Gong L, Li Q., Free PMC Article

    07/16/2016
    LBP serves not only as an extracellular LPS shuttle but in addition facilitates intracellular transport of LPS.

    Lipopolysaccharide-binding protein is bound and internalized by host cells and colocalizes with LPS in the cytoplasm: Implications for a role of LBP in intracellular LPS-signaling.
    Kopp F, Kupsch S, Schromm AB.

    06/11/2016
    LBP level was not significantly different in neutropenic systemic inflammatory response syndrome patients and sepsis patients.

    Sepsis biomarkers in neutropaenic systemic inflammatory response syndrome patients on standard care wards.
    Ratzinger F, Haslacher H, Perkmann T, Schmetterer KG, Poeppl W, Mitteregger D, Dorffner G, Burgmann H.

    05/7/2016
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