| [Research Progress on the Role of Laminin Subunit Alpha 4 in Diseases]. | [Research Progress on the Role of Laminin Subunit Alpha 4 in Diseases].
Yu JJ, Zhang LJ, He CC, Cao YF, Yang J. | 03/3/2023 |
| Laminin-alpha4 Is Upregulated in Both Human and Murine Models of Obesity. | Laminin-α4 Is Upregulated in Both Human and Murine Models of Obesity.
Goddi A, Carmona A, Schroedl L, White JM, Piron MJ, De Leon A, Casimiro I, Hoffman A, Gonzalez Porras MA, Brey EM, Brady MJ, Cohen RN., Free PMC Article | 02/19/2022 |
| Effect of LAMA4 on Prognosis and Its Correlation with Immune Infiltration in Gastric Cancer. | Effect of LAMA4 on Prognosis and Its Correlation with Immune Infiltration in Gastric Cancer.
Wang M, Li C, Liu Y, Wang Z., Free PMC Article | 10/2/2021 |
| Laminin Subunit Alpha-4 and Osteopontin Are Glioblastoma-Selective Secreted Proteins That Are Increased in the Cerebrospinal Fluid of Glioblastoma Patients. | Laminin Subunit Alpha-4 and Osteopontin Are Glioblastoma-Selective Secreted Proteins That Are Increased in the Cerebrospinal Fluid of Glioblastoma Patients.
Kohata T, Ito S, Masuda T, Furuta T, Nakada M, Ohtsuki S. | 07/3/2021 |
| In diverse models, laminins alpha-4 (LAMA4) and alpha-5 (LAMA5) were differentially regulated. Immunity was associated with decreased LAMA4:LAMA5 ratio, while tolerance was associated with an increased ratio. LAMA4inhibited CD4+ T-cell proliferation and Th1, Th2, and Th17 polarization but favored Treg induction. LAMA4 and LAMA5 are coinhibitory and costimulatory ligands for human and mouse CD4 T cells, respectively. | Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node.
Simon T, Li L, Wagner C, Zhang T, Saxena V, Brinkman CC, Tostanoski LH, Ostrand-Rosenberg S, Jewell C, Shea-Donohue T, Hippen K, Blazar B, Abdi R, Bromberg JS., Free PMC Article | 06/20/2020 |
| Downregulation of the LAMA4 gene inhibits the proliferation, migration, and invasion of extravillous trophoblasts to suppress the expression of vascular factors, leading to the occurrence or development of preeclampsia. | Role of LAMA4 Gene in Regulating Extravillous Trophoblasts in Pathogenesis of Preeclampsia.
Ji Y, Zhou L, Wang G, Qiao Y, Tian Y, Feng Y., Free PMC Article | 05/23/2020 |
| High LAMA4 expression is associated with inflammation in asthma. | Laminin α4 contributes to airway remodeling and inflammation in asthma.
Prabhala P, Wright DB, Robbe P, Bitter C, Pera T, Ten Hacken NHT, van den Berge M, Timens W, Meurs H, Dekkers BGJ. | 04/11/2020 |
| High LAMA4 expression is associated with gastric cancer. | LAMA4 expression is activated by zinc finger E‑box‑binding homeobox 1 and independently predicts poor overall survival in gastric cancer.
Wang X, Hou Q, Zhou X. | 11/17/2018 |
| Disruption of LAMA4, LAMA5, and LAMB2 or the laminin-receptor interaction occurs in neuromuscular diseases including Pierson syndrome and Lambert-Eaton myasthenic syndrome (LEMS). (Review) | The role of laminins in the organization and function of neuromuscular junctions.
Rogers RS, Nishimune H., Free PMC Article | 01/6/2018 |
| highlight MCAM and LAMA4 as prime candidates for RCC prognosis and therapeutic targeting | MCAM and LAMA4 Are Highly Enriched in Tumor Blood Vessels of Renal Cell Carcinoma and Predict Patient Outcome.
Wragg JW, Finnity JP, Anderson JA, Ferguson HJ, Porfiri E, Bhatt RI, Murray PG, Heath VL, Bicknell R., Free PMC Article | 03/4/2017 |
| LAMA4-integrin signalling affects chondrocyte morphology and gene expression, contributing to cluster formation in osteoarthritic chondrocytes. | Effect of Laminin-A4 inhibition on cluster formation of human osteoarthritic chondrocytes.
Moazedi-Fuerst FC, Gruber G, Stradner MH, Guidolin D, Jones JC, Bodo K, Wagner K, Peischler D, Krischan V, Weber J, Sadoghi P, Glehr M, Leithner A, Graninger WB., Free PMC Article | 08/6/2016 |
| LAMA4 expression is lowered in preeclamptic placentas and promotes trophoblast cell invasion, migration, and angiogenesis. hypoxia-reoxygenation decreases LAMA4 expression and decouple the relationship between LAMA4 expression and p38 and ERK activation. | Laminin α4 (LAMA4) expression promotes trophoblast cell invasion, migration, and angiogenesis, and is lowered in preeclamptic placentas.
Shan N, Zhang X, Xiao X, Zhang H, Tong C, Luo X, Chen Y, Liu X, Yin N, Deng Q, Qi H. | 05/28/2016 |
| Oxidative stress plays a vital role in controlling expression of LAMA4 through MAPK signaling pathways, which suggests a possible pathological mechanism of pre-eclampsia. | The Role of Laminin α4 in Human Umbilical Vein Endothelial Cells and Pathological Mechanism of Preeclampsia.
Shan N, Zhang X, Xiao X, Zhang H, Chen Y, Luo X, Liu X, Zhuang B, Peng W, Qi H. | 03/26/2016 |
| Laminins 411 and 421 differentially promote tumor cell migration via alpha6beta1 integrin and MCAM (CD146). | Laminins 411 and 421 differentially promote tumor cell migration via α6β1 integrin and MCAM (CD146).
Ishikawa T, Wondimu Z, Oikawa Y, Gentilcore G, Kiessling R, Egyhazi Brage S, Hansson J, Patarroyo M. | 09/10/2015 |
| These results indicate that mAbs to the laminin a4 globular domain are able to inhibit tumor cell adhesion and migration on laminins 411 and 421, and that alpha6beta1 integrin and MCAM bind a4-laminins at very close sites on the globular domain | Monoclonal antibodies to human laminin α4 chain globular domain inhibit tumor cell adhesion and migration on laminins 411 and 421, and binding of α6β1 integrin and MCAM to α4-laminins.
Ishikawa T, Wondimu Z, Oikawa Y, Ingerpuu S, Virtanen I, Patarroyo M. | 04/18/2015 |
| Data from experiment with peptide fragments suggest laminin alpha4 (and laminin alpha5) may be part of host defense response and may protect tissues from invading pathogens. | Peptides derived from the human laminin alpha4 and alpha5 chains exhibit antimicrobial activity.
Senyürek I, Klein G, Kalbacher H, Deeg M, Schittek B. | 11/27/2010 |
| LAMC2, LAMA4, ITGB1, ITGB3, RSPA and MMP2) are overexpressed in angiotropic melanoma cells vs. non-angiotropic melanoma cells from the same tumor | Overexpression of malignancy-associated laminins and laminin receptors by angiotropic human melanoma cells in a chick chorioallantoic membrane model.
Lugassy C, Torres-Muñoz JE, Kleinman HK, Ghanem G, Vernon S, Barnhill RL. | 01/21/2010 |
| LM alpha4 and beta2 have roles in in vitro migration and in vivo tumorigenicity of prostate cancer cells | Senescence-induced alterations of laminin chain expression modulate tumorigenicity of prostate cancer cells.
Sprenger CC, Drivdahl RH, Woodke LB, Eyman D, Reed MJ, Carter WG, Plymate SR., Free PMC Article | 01/21/2010 |
| Concomitant changes take place in laminin- and collagen-binding receptors. Laminin-411 reduces adhesion to laminin-511 and fibronectin, suggesting that tumor cells could utilize laminin-411 in their invasive behavior | Epithelial-mesenchymal transition downregulates laminin alpha5 chain and upregulates laminin alpha4 chain in oral squamous carcinoma cells.
Takkunen M, Ainola M, Vainionpää N, Grenman R, Patarroyo M, García de Herreros A, Konttinen YT, Virtanen I. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesCommon polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population.
Wang Y, Fu W, Xie F, Wang Y, Chu X, Wang H, Shen M, Wang Y, Wang Y, Sun W, Lei R, Yang L, Wu H, Foo J, Liu J, Jin L, Huang W. Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.
Vieira AR, McHenry TG, Daack-Hirsch S, Murray JC, Marazita ML. | 11/16/2008 |
| LAMA4 is specifically up-regulated on both mRNA and protein levels in hepatocelluar carcinoma; potential role in hepatocarcinogenesis and tumor progression. | LAMA4, highly expressed in human hepatocellular carcinoma from Chinese patients, is a novel marker of tumor invasion and metastasis.
Huang X, Ji G, Wu Y, Wan B, Yu L. | 01/21/2010 |
| alpha4 chain Lms have a de-adhesive function and could thus play a role in detachment, migration and invasion of renal carcinoma cells in vivo. | Alpha4 chain laminins are widely expressed in renal cell carcinomas and have a de-adhesive function.
Vainionpää N, Lehto VP, Tryggvason K, Virtanen I. | 01/21/2010 |
| 2 novel mutations (2828C>T [Pro943Leu] & 3217C>T [Arg1073X]) in the integrin-interacting domain of the LAMA4 gene reduce its integrin binding, & cause endothelial cell loss and heart failure. | Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells.
Knöll R, Postel R, Wang J, Krätzner R, Hennecke G, Vacaru AM, Vakeel P, Schubert C, Murthy K, Rana BK, Kube D, Knöll G, Schäfer K, Hayashi T, Holm T, Kimura A, Schork N, Toliat MR, Nürnberg P, Schultheiss HP, Schaper W, Schaper J, Bos E, Den Hertog J, van Eeden FJ, Peters PJ, Hasenfuss G, Chien KR, Bakkers J. | 01/21/2010 |
| This suggests that G(1121-1139) peptide-containing proteins may perform their biological functions by interacting with alphavbeta3 integrin. | Identification of an active site on the laminin alpha4 chain globular domain that binds to alphavbeta3 integrin and promotes angiogenesis.
Lian J, Dai X, Li X, He F. | 01/21/2010 |
| Data report the identification of a splice variant of the human laminin alpha4 subunit transcript containing 21 extra nucleotides. | Identification and recombinant production of human laminin alpha4 subunit splice variants.
Hayashi Y, Kim KH, Fujiwara H, Shimono C, Yamashita M, Sanzen N, Futaki S, Sekiguchi K. | 01/21/2010 |