| [Clinical and bioinformatics analysis of the relationship between LAMA3 DNA methylation expression and platinum resistance and prognosis in epithelial ovarian cancer]. | [Clinical and bioinformatics analysis of the relationship between LAMA3 DNA methylation expression and platinum resistance and prognosis in epithelial ovarian cancer].
Chen CX, Zhang YL, Huang YZ, Li L. | 07/22/2024 |
| Correlation of laminin subunit alpha 3 expression in pancreatic ductal adenocarcinoma with tumor liver metastasis and survival. | Correlation of laminin subunit alpha 3 expression in pancreatic ductal adenocarcinoma with tumor liver metastasis and survival.
Xing Y, Jing X, Qing G, Jiang Y., Free PMC Article | 06/15/2024 |
| Lentiviral expression of wild-type LAMA3A restores cell adhesion in airway basal cells from children with epidermolysis bullosa. | Lentiviral expression of wild-type LAMA3A restores cell adhesion in airway basal cells from children with epidermolysis bullosa.
Lau CH, Rouhani MJ, Maughan EF, Orr JC, Kolluri KK, Pearce DR, Haughey EK, Sutton L, Flatau S, Balboa PL, Bageta ML, O'Callaghan C, Smith CM, Janes SM, Hewitt R, Petrof G, Martinez AE, McGrath JA, Butler CR, Hynds RE., | 05/23/2024 |
| LAMA3 Promotes Tumorigenesis of Oral Squamous Cell Carcinoma by METTL3-Mediated N6-Methyladenosine Modification. | LAMA3 Promotes Tumorigenesis of Oral Squamous Cell Carcinoma by METTL3-Mediated N6-Methyladenosine Modification.
Ning B, Mei Y. | 03/7/2024 |
| Phenotypic variability in LAMA3-associated amelogenesis imperfecta. | Phenotypic variability in LAMA3-associated amelogenesis imperfecta.
Wang SK, Zhang H, Wang YL, Seymen F, Koruyucu M, Simmer JP, Hu JC., Free PMC Article | 12/15/2023 |
| LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3. | LINC00936/microRNA-221-3p Regulates Tumor Progression in Ovarian Cancer by Interacting with LAMA3.
Shu C, Wang W, Wu L, Qi C, Yan W, Lu W, Tian J, Shang A. | 12/17/2022 |
| Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families. | Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families.
Wang R, Sun L, Habulieti X, Liu J, Guo K, Yang X, Ma D, Zhang X. | 11/26/2022 |
| Gene expression profiling of laminin alpha3-blocked keratinocytes reveals an immune-independent mechanism of blistering. | Gene expression profiling of laminin α3-blocked keratinocytes reveals an immune-independent mechanism of blistering.
Bao L, Perez White BE, Li J, Patel PM, Amber KT., Free PMC Article | 04/16/2022 |
| High expression of LAMA3/AC245041.2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis. | High expression of LAMA3/AC245041.2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis.
Tian C, Li X, Ge C., Free PMC Article | 01/15/2022 |
| LAMA3 DNA methylation and transcriptome changes associated with chemotherapy resistance in ovarian cancer. | LAMA3 DNA methylation and transcriptome changes associated with chemotherapy resistance in ovarian cancer.
Feng LY, Huang YZ, Zhang W, Li L., Free PMC Article | 11/22/2021 |
| Loss of the laminin subunit alpha-3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma. | Loss of the laminin subunit alpha-3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma.
Caley MP, Martins VL, Moore K, Lashari M, Nissinen L, Kähäri VM, Alexander S, Jones E, Harwood CA, Jones J, Donaldson M, Marshall JF, O'Toole EA. | 06/12/2021 |
| Laminin332 mediates proliferation, apoptosis, invasion, migration and epithelialtomesenchymal transition in pancreatic ductal adenocarcinoma. | Laminin‑332 mediates proliferation, apoptosis, invasion, migration and epithelial‑to‑mesenchymal transition in pancreatic ductal adenocarcinoma.
Huang C, Chen J., Free PMC Article | 05/1/2021 |
| The authors describe the natural history of JEB in three children with the same LAMA3 splice-site mutation. In spite of residual laminin 332, two of them died prematurely. | Natural history and clinical outcome of junctional epidermolysis bullosa generalized intermediate due to a LAMA3 mutation.
Reimer A, Schwieger-Briel A, He Y, Leppert J, Schauer F, Kiritsi D, Schneider H, Ott H, Bruckner-Tuderman L, Has C. | 09/14/2019 |
| We identified two pathogenic and 10 loss-of-function (LOF) candidate variants, accounting for 4.74% (12 out of 253) of all the. In burden tests, rare missense variants in three genes (CSF3R, DSP, and LAMA3) were identified that have a statistically significant relationship with Idiopathic pulmonary fibrosis | Targeted resequencing reveals genetic risks in patients with sporadic idiopathic pulmonary fibrosis.
Deng Y, Li Z, Liu J, Wang Z, Cao Y, Mou Y, Fu B, Mo B, Wei J, Cheng Z, Luo L, Li J, Shu Y, Wang X, Luo G, Yang S, Wang Y, Zhu J, Yang J, Wu M, Xu X, Ge R, Chen X, Peng Q, Wei G, Li Y, Yang H, Fang S, Zhang X, Xiong W. | 07/27/2019 |
| The study has identified two mutations in two large consanguineous pedigrees. Identification of novel variants in the LAMA3 and PLEC genes will expand the mutation spectrum and also help in genetic counselling of patients in the Pakistani population. | Novel autosomal recessive LAMA3 and PLEC variants underlie junctional epidermolysis bullosa generalized intermediate and epidermolysis bullosa simplex with muscular dystrophy in two consanguineous families.
Ahmad F, Shah K, Umair M, Jan A, Irfanullah, Khan S, Muhammad D, Basit S, Wakil SM, Ramzan K, Ahmad W. | 12/22/2018 |
| Seventeen percent of the patients were compound heterozygous or homozygous for mutations in the gene LAMA3, 59% carried mutations in both alleles of LAMB3, and 12% were homozygous for mutations in LAMC2. In nine patients with severe generalized JEB, detection of two mutations in one of the genes LAMA3, LAMB3, or LAMC2 was not possible, so the molecular basis of disease could not be clarified completely | Genotype, Clinical Course, and Therapeutic Decision Making in 76 Infants with Severe Generalized Junctional Epidermolysis Bullosa.
Hammersen J, Has C, Naumann-Bartsch N, Stachel D, Kiritsi D, Söder S, Tardieu M, Metzler M, Bruckner-Tuderman L, Schneider H. | 09/16/2017 |
| Both parents had offspring affected with JEB and displayed subtle enamel pitting of secondary dentition without any sign of skin blistering. The reported enamel abnormality in LAMA3 mutation carriers could be attributed to a half dose effect of the laminin a3 chain | Carriers with functional null mutations in LAMA3 have localized enamel abnormalities due to haploinsufficiency.
Gostyńska KB, Yan Yuen W, Pasmooij AMG, Stellingsma C, Pas HH, Lemmink H, Jonkman MF., Free PMC Article | 07/29/2017 |
| Loss of the normal basement membrane organization of alpha3 laminin observed in fibrotic regions from the lungs of patients with pulmonary fibrosis contributes to their disease progression. | Lung-specific loss of α3 laminin worsens bleomycin-induced pulmonary fibrosis.
Morales-Nebreda LI, Rogel MR, Eisenberg JL, Hamill KJ, Soberanes S, Nigdelioglu R, Chi M, Cho T, Radigan KA, Ridge KM, Misharin AV, Woychek A, Hopkinson S, Perlman H, Mutlu GM, Pardo A, Selman M, Jones JC, Budinger GR., Free PMC Article | 03/5/2016 |
| Two of the six genes (LAMA3 and DST) validated by quantitative RT-PCR for tumor-specific alternative splicing events | Expression microarray analysis reveals alternative splicing of LAMA3 and DST genes in head and neck squamous cell carcinoma.
Li R, Ochs MF, Ahn SM, Hennessey P, Tan M, Soudry E, Gaykalova DA, Uemura M, Brait M, Shao C, Westra W, Bishop J, Fertig EJ, Califano JA., Free PMC Article | 12/19/2015 |
| LAMNA variants have been identified in atrial fibrillation cohort studies, demonstrating abnormalities in cardiac excitation - supra ventricular tachycardia and atrial fibrillation. | Risk factors and genetics of atrial fibrillation.
Anumonwo JM, Kalifa J. | 08/1/2015 |
| We established the LAMA3 gene as novel potential susceptibility gene for atopic dermatitis. | Association of variation in the LAMA3 gene, encoding the alpha-chain of laminin 5, with atopic dermatitis in a German case-control cohort.
Stemmler S, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S., Free PMC Article | 01/10/2015 |
| Expression of a3, beta3 and beta2 cannot predict the prognosis. However, high expression of beta2 mRNA in HCC/non-cancerous liver correlated significantly with the absence of complete encapsulation, which is an important tumor invasiveness factor. | The clinical relevance of the expression of the ratio of laminin-5 subchains messenger RNA of hepatocellular carcinoma to non-cancerous liver remnant: a prospective study.
Jeng KS, Jeng WJ, Sheen IS, Su JC. | 12/10/2014 |
| Results describe a new pedigree identifying a novel mutation of LAMA3 in LOC syndrome | A new homozygous nonsense mutation in LAMA3A underlying laryngo-onycho-cutaneous syndrome.
Barzegar M, Mozafari N, Kariminejad A, Asadikani Z, Ozoemena L, McGrath JA. | 08/30/2014 |
| A male patient with Herlitz junctional epidermolysis bullosa with a novel homozygosity for insertion LAMA3 Premature Termination Codon mutation is described. Both parents and his sibling were shown to be heterozygous carriers. | Detection of novel LAMA3 mutation in Herlitz junctional epidermolysis bullosa in a Jordanian family.
Badran EF, Battah HA, Akl KF, Khalil RW, Al Amori I. | 04/26/2014 |
| High LAMA3 expression is associated with gastric cancer. | The low-abundance transcriptome reveals novel biomarkers, specific intracellular pathways and targetable genes associated with advanced gastric cancer.
Bizama C, Benavente F, Salvatierra E, Gutiérrez-Moraga A, Espinoza JA, Fernández EA, Roa I, Mazzolini G, Sagredo EA, Gidekel M, Podhajcer OL. | 02/22/2014 |