| RhoB as a tumor suppressor: It's all about localization. | RhoB as a tumor suppressor: It's all about localization.
Zaoui K, Duhamel S. | 06/28/2023 |
| RhoB Promotes Endometrial Stromal Cells Decidualization Via Semaphorin3A/PlexinA4 Signaling in Early Pregnancy. | RhoB Promotes Endometrial Stromal Cells Decidualization Via Semaphorin3A/PlexinA4 Signaling in Early Pregnancy.
Xu L, Li YH, Zhao WJ, Sang YF, Chen JJ, Li DJ, Du MR. | 10/22/2022 |
| RhoB affects colitis through modulating cell signaling and intestinal microbiome. | RhoB affects colitis through modulating cell signaling and intestinal microbiome.
Yang J, Pei G, Sun X, Xiao Y, Miao C, Zhou L, Wang B, Yang L, Yu M, Zhang ZS, Keller ET, Yao Z, Wang Q., Free PMC Article | 10/8/2022 |
| A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry. | A CRISPR Activation Screen Identifies an Atypical Rho GTPase That Enhances Zika Viral Entry.
Luu AP, Yao Z, Ramachandran S, Azzopardi SA, Miles LA, Schneider WM, Hoffmann HH, Bozzacco L, Garcia G Jr, Gong D, Damoiseaux R, Tang H, Morizono K, Rudin CM, Sun R, Arumugaswami V, Poirier JT, MacDonald MR, Rice CM, Li MMH., Free PMC Article | 02/12/2022 |
| CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP. | CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP.
Nishiyama K, Maekawa M, Nakagita T, Nakayama J, Kiyoi T, Chosei M, Murakami A, Kamei Y, Takeda H, Takada Y, Higashiyama S., Free PMC Article | 01/15/2022 |
| Integrated Analysis of Prognostic Genes Associated With Ischemia-Reperfusion Injury in Renal Transplantation. | Integrated Analysis of Prognostic Genes Associated With Ischemia-Reperfusion Injury in Renal Transplantation.
Zhang D, Wang Y, Zeng S, Zhang M, Zhang X, Wang Y, Zhang Z, Wang X, Hu X., Free PMC Article | 12/18/2021 |
| RhoB is regulated by hypoxia and modulates metastasis in breast cancer. | RhoB is regulated by hypoxia and modulates metastasis in breast cancer.
Ju JA, Godet I, DiGiacomo JW, Gilkes DM., Free PMC Article | 12/4/2021 |
| A high expression ratio of RhoA/RhoB is associated with the migratory and invasive properties of basal-like Breast Tumors. | A high expression ratio of RhoA/RhoB is associated with the migratory and invasive properties of basal-like Breast Tumors.
Privat M, Cavard A, Zekri Y, Ponelle-Chachuat F, Molnar I, Sonnier N, Bignon YJ., Free PMC Article | 08/7/2021 |
| Endothelial RhoB and RhoC are dispensable for leukocyte diapedesis and for maintaining vascular integrity during diapedesis. | Endothelial RhoB and RhoC are dispensable for leukocyte diapedesis and for maintaining vascular integrity during diapedesis.
Schimmel L, de Ligt A, Tol S, de Waard V, van Buul JD., Free PMC Article | 07/17/2021 |
| An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli. | An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli.
Miao C, Yu M, Pei G, Ma Z, Zhang L, Yang J, Lv J, Zhang ZS, Keller ET, Yao Z, Wang Q., Free PMC Article | 06/5/2021 |
| CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity. | CSN5 inhibition triggers inflammatory signaling and Rho/ROCK-dependent loss of endothelial integrity.
Majolée J, Pronk MCA, Jim KK, van Bezu JSM, van der Sar AM, Hordijk PL, Kovačević I., Free PMC Article | 10/31/2020 |
| It findings identify a novel regulatory mechanism for RhoB localization and stability by Arf6 and establish the strict requirement of Arf6 for RhoB-specific subcellular targeting to endosomes and biological functions. | Arf6 regulates RhoB subcellular localization to control cancer cell invasion.
Zaoui K, Rajadurai CV, Duhamel S, Park M., Free PMC Article | 05/16/2020 |
| We found that RhoB, but not RhoA or RhoC, is in resting endothelium a negative regulator of permeability. Loss of RhoB accounted for an accumulation of VE-cadherin at cell-cell contacts. Thrombin-induced loss of endothelial integrity is mediated primarily by RhoA and RhoB. | RhoA, RhoB and RhoC differentially regulate endothelial barrier function.
Pronk MCA, van Bezu JSM, van Nieuw Amerongen GP, van Hinsbergh VWM, Hordijk PL., Free PMC Article | 04/25/2020 |
| Cytoplasmic p27(Kip1) promotes tumorigenesis by suppressing RhoB activity in non-small cell lung carcinoma cells. | Cytoplasmic p27(Kip1) promotes tumorigenesis via suppression of RhoB activity.
Calvayrac O, Nowosad A, Cabantous S, Lin LP, Figarol S, Jeannot P, Serres MP, Callot C, Perchey RT, Creff J, Taranchon-Clermont E, Rouquette I, Favre G, Pradines A, Manenti S, Mazieres J, Lee H, Besson A. | 12/21/2019 |
| This data demonstrated that miR-19a promoted the invasion and EMT through targeting RhoB. It is suggested that miR-19a/RhoB axis may show a new way for the treatment of bladder cancer. | miR-19a promotes invasion and epithelial to mesenchymal transition of bladder cancer cells by targeting RhoB.
Li Z, Li Y, Wang Y. | 11/23/2019 |
| KIF13A-mediated endosomal trafficking modulates RhoB plasma membrane localization to control membrane blebbing and blebby amoeboid migration. | KIF13A-regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration.
Gong X, Didan Y, Lock JG, Strömblad S., Free PMC Article | 10/5/2019 |
| The authors propose a novel mechanism of TGFbeta/Smad signaling modulation by the small GTPase RhoB and show that this TGFbeta/RhoB signaling cross talk affects the nuclear and cytoplasmic responses to TGFbeta in opposite ways. | Modulation of TGFβ/Smad signaling by the small GTPase RhoB.
Livitsanou M, Vasilaki E, Stournaras C, Kardassis D. | 09/21/2019 |
| RhoB inhibits the proliferation, invasion, EMT, and PTEN/AKT signal pathway in breast tumor cells. | Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTEN/AKT Pathway via Promoting Ras Homolog Family Member B (RhoB).
Ma Q, Gao Y, Xu P, Li K, Xu X, Gao J, Qi Y, Xu J, Yang Y, Song W, He X, Liu S, Yuan X, Yin W, He Y, Pan W, Wei L, Zhang J., Free PMC Article | 08/17/2019 |
| Study demonstrated that expression of RhoB was decreased in osteosarcoma primary samples and cell lines. miR-19a, which exhibits abnormal expression in highly metastatic osteosarcoma cell lines, could inhibit the expression of RhoB and promote the lung metastasis of osteosarcoma cells in vivo. Results indicate that miR-19a-mediated RhoB is a critical regulator for the dephosphorylation of AKT1 in osteosarcoma cells. | miR-19a-mediated downregulation of RhoB inhibits the dephosphorylation of AKT1 and induces osteosarcoma cell metastasis.
Zou Q, Xiao X, Liang Y, Peng L, Guo Z, Li W, Yu W. | 08/10/2019 |
| Loss of FBXW7 indirectly modulates RhoB activity via alteration of the cholesterol biosynthesis pathway. | FBXW7 regulates endothelial barrier function by suppression of the cholesterol synthesis pathway and prenylation of RhoB.
Pronk MCA, Majolée J, Loregger A, van Bezu JSM, Zelcer N, Hordijk PL, Kovačević I., Free PMC Article | 06/29/2019 |
| the overexpression of miR223 reduced inflammation and suppressed the NLRP3 inflammasome and TLR4/NFkappaB signaling pathway via RHOB | MicroRNA‑223 attenuates LPS‑induced inflammation in an acute lung injury model via the NLRP3 inflammasome and TLR4/NF‑κB signaling pathway via RHOB.
Yan Y, Lu K, Ye T, Zhang Z., Free PMC Article | 06/1/2019 |
| High RHOB expression promotes skin tumor formation and invasion. | Loss of RhoA promotes skin tumor formation and invasion by upregulation of RhoB.
García-Mariscal A, Li H, Pedersen E, Peyrollier K, Ryan KM, Stanley A, Quondamatteo F, Brakebusch C. | 03/9/2019 |
| identified the RING E3 ligase complex Cullin-3-Rbx1-KCTD10 as key modulator of endothelial barrier integrity via its regulation of the ubiquitination, localization, and activity of RhoB. | The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB.
Kovačević I, Sakaue T, Majoleé J, Pronk MC, Maekawa M, Geerts D, Fernandez-Borja M, Higashiyama S, Hordijk PL., Free PMC Article | 02/23/2019 |
| Studies indicate mechanism for translocation of Tuberous Sclerosis Complex (TSC complex) protein to lysosomes in response to DNA damage, which depends on ATM and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1)-mediated rhoB GTP-binding protein (RhoB) phosphorylation and sumoylation. | ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage.
Liu M, Zeng T, Zhang X, Liu C, Wu Z, Yao L, Xie C, Xia H, Lin Q, Xie L, Zhou D, Deng X, Chan HL, Zhao TJ, Wang HR., Free PMC Article | 01/12/2019 |
| This article summarizes recent progress on the mechanisms that control the expression of the three members of the Rho-like subfamily (RhoA, RhoB, and RhoC) at the level of gene transcription as well as their post-transcriptional regulation by microRNAs. [review] | Transcriptional and post-transcriptional regulation of the genes encoding the small GTPases RhoA, RhoB, and RhoC: implications for the pathogenesis of human diseases.
Nomikou E, Livitsanou M, Stournaras C, Kardassis D. | 11/3/2018 |