| miRNA-137-5p improves spatial memory and cognition in Alzheimer's mice by targeting ubiquitin-specific peptidase 30. | miRNA-137-5p improves spatial memory and cognition in Alzheimer's mice by targeting ubiquitin-specific peptidase 30.
Jiang Y, Bian W, Chen J, Cao X, Dong C, Xiao Y, Xu B, Sun X., Free PMC Article | 01/5/2024 |
| Intratumoral Restoration of miR-137 Plus Cholesterol Favors Homeostasis of the miR-137/Coactivator p160/AR Axis and Negatively Modulates Tumor Progression in Advanced Prostate Cancer. | Intratumoral Restoration of miR-137 Plus Cholesterol Favors Homeostasis of the miR-137/Coactivator p160/AR Axis and Negatively Modulates Tumor Progression in Advanced Prostate Cancer.
Pimenta R, Mioshi CM, Gonçalves GL, Candido P, Camargo JA, Guimarães VR, Chiovatto C, Ghazarian V, Romão P, da Silva KS, Dos Santos GA, Silva IA, Srougi M, Nahas WC, Leite KR, Viana NI, Reis ST., Free PMC Article | 06/15/2023 |
| Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia. | Mitochondrial, exosomal miR137-COX6A2 and gamma synchrony as biomarkers of parvalbumin interneurons, psychopathology, and neurocognition in schizophrenia.
Khadimallah I, Jenni R, Cabungcal JH, Cleusix M, Fournier M, Beard E, Klauser P, Knebel JF, Murray MM, Retsa C, Siciliano M, Spencer KM, Steullet P, Cuenod M, Conus P, Do KQ., Free PMC Article | 05/14/2022 |
| MicroRNA-137-3p Improves Nonalcoholic Fatty Liver Disease through Activating AMPKalpha. | MicroRNA-137-3p Improves Nonalcoholic Fatty Liver Disease through Activating AMPKα.
Yu Y, He C, Tan S, Huang M, Guo Y, Li M, Zhang Q., Free PMC Article | 04/2/2022 |
| miR-137 and miR-122, two outer subventricular zone non-coding RNAs, regulate basal progenitor expansion and neuronal differentiation. | miR-137 and miR-122, two outer subventricular zone non-coding RNAs, regulate basal progenitor expansion and neuronal differentiation.
Tomasello U, Klingler E, Niquille M, Mule N, Santinha AJ, de Vevey L, Prados J, Platt RJ, Borrell V, Jabaudon D, Dayer A., Free PMC Article | 03/5/2022 |
| LncRNA GAS5/miR-137 Is a Hypoxia-Responsive Axis Involved in Cardiac Arrest and Cardiopulmonary Cerebral Resuscitation. | LncRNA GAS5/miR-137 Is a Hypoxia-Responsive Axis Involved in Cardiac Arrest and Cardiopulmonary Cerebral Resuscitation.
Jing W, Tuxiu X, Xiaobing L, Guijun J, Lulu K, Jie J, Lu Y, Liying Z, Xiaoxing X, Jingjun L., Free PMC Article | 02/26/2022 |
| Microglia exosomal miRNA-137 attenuates ischemic brain injury through targeting Notch1. | Microglia exosomal miRNA-137 attenuates ischemic brain injury through targeting Notch1.
Zhang D, Cai G, Liu K, Zhuang Z, Jia K, Pei S, Wang X, Wang H, Xu S, Cui C, Sun M, Guo S, Song W, Cai G., Free PMC Article | 08/21/2021 |
| Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits. | Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits.
Tamming RJ, Dumeaux V, Jiang Y, Shafiq S, Langlois L, Ellegood J, Qiu LR, Lerch JP, Bérubé NG., Free PMC Article | 05/1/2021 |
| miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke. | miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke.
Tian R, Wu B, Fu C, Guo K., Free PMC Article | 02/27/2021 |
| Serum secreted miR-137-containing exosomes affects oxidative stress of neurons by regulating OXR1 in Parkinson's disease. | Serum secreted miR-137-containing exosomes affects oxidative stress of neurons by regulating OXR1 in Parkinson's disease.
Jiang Y, Liu J, Chen L, Jin Y, Zhang G, Lin Z, Du S, Fu Z, Chen T, Qin Y, Sun X. | 10/24/2020 |
| Data show that miR-137 participates in prostate cancer progression by regulating NADPH oxidase 4 (NOX4), indicating NOX4 is a target gene of miR-137. | Downregulated NOX4 underlies a novel inhibitory role of microRNA-137 in prostate cancer.
Wu QQ, Zheng B, Weng GB, Yang HM, Ren Y, Weng XJ, Zhang SW, Zhu WZ. | 07/25/2020 |
| Results suggest that overexpression of miR-137 in the whole brain induces the several phenotypes that are relevant to aspects of psychiatric disorders, such as schizophrenia. Based on these findings, miR-137 transgenic mice may have the potential to become a useful tool in researching the pathophysiology of psychiatric disorders. | Transgenic mice overexpressing miR-137 in the brain show schizophrenia-associated behavioral deficits and transcriptome profiles.
Arakawa Y, Yokoyama K, Tasaki S, Kato J, Nakashima K, Takeyama M, Nakatani A, Suzuki M., Free PMC Article | 03/14/2020 |
| our results suggest that MIR137 plays essential roles in postnatal neurodevelopment and that dysregulation of miR-137 potentially contributes to neuropsychiatric disorders in humans. | Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a.
Cheng Y, Wang ZM, Tan W, Wang X, Li Y, Bai B, Li Y, Zhang SF, Yan HL, Chen ZL, Liu CM, Mi TW, Xia S, Zhou Z, Liu A, Tang GB, Liu C, Dai ZJ, Wang YY, Wang H, Wang X, Kang Y, Lin L, Chen Z, Xie N, Sun Q, Xie W, Peng J, Chen D, Teng ZQ, Jin P., Free PMC Article | 05/18/2019 |
| Synchronizing the expression of miR-124, miR-128, and miR-137 in a gene therapy approach displays significant anticancer synergism, abrogates this epigenesis-mediated, multi-protein tumor survival mechanism and results in a 5-fold increase in survival when combined with chemotherapy in murine glioblastoma models. | The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma.
Bhaskaran V, Nowicki MO, Idriss M, Jimenez MA, Lugli G, Hayes JL, Mahmoud AB, Zane RE, Passaro C, Ligon KL, Haas-Kogan D, Bronisz A, Godlewski J, Lawler SE, Chiocca EA, Peruzzi P., Free PMC Article | 02/16/2019 |
| Results suggest that elevated levels of miRNA-137 may exert an antiepileptic effect via a presynaptic neurotransmission mechanism. | Overexpression of miRNA-137 in the brain suppresses seizure activity and neuronal excitability: A new potential therapeutic strategy for epilepsy.
Wang W, Guo Y, He L, Chen C, Luo J, Ma Y, Li J, Yang Y, Yang Q, Du C, Zhang Y, Li Z, Xu X, Tian X, Wang X. | 02/16/2019 |
| we correlated the risk allele to expression of the genes in the MIR137 locus in human postmortem brain. Some evidence for increased MIR137HG expression was observed, especially in hippocampus of the disease-associated genotype. Second, in mouse hippocampal neurons, we confirmed previously observed changes in synaptic transmission upon miR-137 overexpression. | MIR137 schizophrenia-associated locus controls synaptic function by regulating synaptogenesis, synapse maturation and synaptic transmission.
He E, Lozano MAG, Stringer S, Watanabe K, Sakamoto K, den Oudsten F, Koopmans F, Giamberardino SN, Hammerschlag A, Cornelisse LN, Li KW, van Weering J, Posthuma D, Smit AB, Sullivan PF, Verhage M., Free PMC Article | 02/16/2019 |
| miR-137 regulated the expression of the CACNA1C gene. | Micro-RNA-137 Inhibits Tau Hyperphosphorylation in Alzheimer's Disease and Targets the CACNA1C Gene in Transgenic Mice and Human Neuroblastoma SH-SY5Y Cells.
Jiang Y, Xu B, Chen J, Sui Y, Ren L, Li J, Zhang H, Guo L, Sun X., Free PMC Article | 11/10/2018 |
| MiR-137-3p was upregulated in Bv-injured DRGNs. MiR-137-3p downregulation rescued Bv-induced DRGN apoptosis and neurite retraction. MiR-137-3p and its downstream target LSD1 are inversely associated to regulate anesthetics-induced neurotoxicity in DRGN. | MicroRNA-137 and its downstream target LSD1 inversely regulate anesthetics-induced neurotoxicity in dorsal root ganglion neurons.
Chen L, Wang X, Huang W, Ying T, Chen M, Cao J, Wang M. | 07/7/2018 |
| miR-137 regulates neuronal levels of p55gamma, PTEN, Akt2, GSK3beta, mTOR, and rictor. miR-137 regulates neuronal responses to Nrg1alpha and BDNF through convergent mechanisms. | Inhibition of the Schizophrenia-Associated MicroRNA miR-137 Disrupts Nrg1α Neurodevelopmental Signal Transduction.
Thomas KT, Anderson BR, Shah N, Zimmer SE, Hawkins D, Valdez AN, Gu Q, Bassell GJ., Free PMC Article | 03/31/2018 |
| Taken together, these findings indicate that GAS5 may promote the progression of ischemic stroke through acting as a ceRNA for miR-137 to mediate the Notch1 signaling pathway, which contributes to an extensive understanding of ischemic stroke and may provide novel therapeutic options for this disease. | LncRNA GAS5 regulates ischemic stroke as a competing endogenous RNA for miR-137 to regulate the Notch1 signaling pathway.
Chen F, Zhang L, Wang E, Zhang C, Li X. | 02/17/2018 |
| ABETA 25-35 downregulated miR-137 and upregulated TNFAIP1 in cortical neurons and N2a cells. | miR-137 attenuates Aβ-induced neurotoxicity through inactivation of NF-κB pathway by targeting TNFAIP1 in Neuro2a cells.
He D, Tan J, Zhang J. | 08/19/2017 |
| MiR-137 played an important role in pancreatic cancer development. | microRNA-137 modulates pancreatic cancer cells tumor growth, invasion and sensitivity to chemotherapy.
Xiao J, Peng F, Yu C, Wang M, Li X, Li Z, Jiang J, Sun C., Free PMC Article | 04/15/2017 |
| miR-124, -128, and -137 act synergistically to regulate Sp1 expression. | miR-124, -128, and -137 Orchestrate Neural Differentiation by Acting on Overlapping Gene Sets Containing a Highly Connected Transcription Factor Network.
Santos MC, Tegge AN, Correa BR, Mahesula S, Kohnke LQ, Qiao M, Ferreira MA, Kokovay E, Penalva LO. | 12/17/2016 |
| This work demonstrated miR-137 and CDC42 are critical regulators in cardiomyocyte apoptosis. | MicroRNA-137 Negatively Regulates H₂O₂-Induced Cardiomyocyte Apoptosis Through CDC42.
Wang J, Xu R, Wu J, Li Z., Free PMC Article | 10/1/2016 |
| MicroRNA-124 and microRNA-137 cooperatively control caspase-3 activity through BCL2L13 in hippocampal neural stem cells. | MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells.
Schouten M, Fratantoni SA, Hubens CJ, Piersma SR, Pham TV, Bielefeld P, Voskuyl RA, Lucassen PJ, Jimenez CR, Fitzsimons CP., Free PMC Article | 05/28/2016 |