| A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome. | A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome.
Kuzmuk V, Pranke I, Rollason R, Butler M, Ding WY, Beesley M, Waters AM, Coward RJ, Sessions R, Tuffin J, Foster RR, Mollet G, Antignac C, Edelman A, Welsh GI, Saleem MA. | 03/27/2024 |
| Keratin 8 is a scaffolding and regulatory protein of ERAD complexes. | Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.
Pranke IM, Chevalier B, Premchandar A, Baatallah N, Tomaszewski KF, Bitam S, Tondelier D, Golec A, Stolk J, Lukacs GL, Hiemstra PS, Dadlez M, Lomas DA, Irving JA, Delaunay-Moisan A, van Anken E, Hinzpeter A, Sermet-Gaudelus I, Edelman A. | 09/17/2022 |
| Keratin 8 Is an Inflammation-Induced and Prognosis-Related Marker for Pancreatic Adenocarcinoma. | Keratin 8 Is an Inflammation-Induced and Prognosis-Related Marker for Pancreatic Adenocarcinoma.
Xiong F, Guo T, Wang X, Wu G, Liu W, Wang Q, Wang B, Chen Y., Free PMC Article | 08/27/2022 |
| Autophagosome-lysosome fusion is facilitated by plectin-stabilized actin and keratin 8 during macroautophagic process. | Autophagosome-lysosome fusion is facilitated by plectin-stabilized actin and keratin 8 during macroautophagic process.
Son S, Baek A, Lee JH, Kim DE., Free PMC Article | 02/5/2022 |
| Association of Keratin 8 Level in Aqueous Humor With Outcomes of Intravitreal Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration. | Association of Keratin 8 Level in Aqueous Humor With Outcomes of Intravitreal Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration.
Shin JY, Lee J, Park J, Kim M, Chung H, Byeon SH., Free PMC Article | 01/29/2022 |
| The Role of Keratin-8 and Keratin-18 Polymorphisms and Protein Levels in the Occurrence and Progression of Vocal Leukoplakia. | The Role of Keratin-8 and Keratin-18 Polymorphisms and Protein Levels in the Occurrence and Progression of Vocal Leukoplakia.
Yang Y, Zhou J, He P, Wu H. | 05/29/2021 |
| Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18. | Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18.
Liu H, Duncan K, Helverson A, Kumari P, Mumm C, Xiao Y, Carlson JC, Darbellay F, Visel A, Leslie E, Breheny P, Erives AJ, Cornell RA., Free PMC Article | 05/8/2021 |
| KRT8 phosphorylation regulates the epithelial-mesenchymal transition in retinal pigment epithelial cells through autophagy modulation. | KRT8 phosphorylation regulates the epithelial-mesenchymal transition in retinal pigment epithelial cells through autophagy modulation.
Miao Q, Xu Y, Yin H, Zhang H, Ye J., Free PMC Article | 05/1/2021 |
| A multi-scale integrated analysis identifies KRT8 as a pan-cancer early biomarker. | A multi-scale integrated analysis identifies KRT8 as a pan-cancer early biomarker.
Scott MKD, Limaye M, Schaffert S, West R, Ozawa MG, Chu P, Nair VS, Koong AC, Khatri P., Free PMC Article | 04/24/2021 |
| KRT8 and KRT19, associated with EMT, are hypomethylated and overexpressed in lung adenocarcinoma and link to unfavorable prognosis. | KRT8 and KRT19, associated with EMT, are hypomethylated and overexpressed in lung adenocarcinoma and link to unfavorable prognosis.
Wang W, He J, Lu H, Kong Q, Lin S., Free PMC Article | 04/17/2021 |
| Keratin 8 Mutations Were Associated With Susceptibility to Chronic Hepatitis B and Related Progression. | Keratin 8 Mutations Were Associated With Susceptibility to Chronic Hepatitis B and Related Progression.
Ye J, Wu Y, Li M, Gong X, Zhong B. | 10/31/2020 |
| Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis. | Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis.
Strunz M, Simon LM, Ansari M, Kathiriya JJ, Angelidis I, Mayr CH, Tsidiridis G, Lange M, Mattner LF, Yee M, Ogar P, Sengupta A, Kukhtevich I, Schneider R, Zhao Z, Voss C, Stoeger T, Neumann JHL, Hilgendorff A, Behr J, O'Reilly M, Lehmann M, Burgstaller G, Königshoff M, Chapman HA, Theis FJ, Schiller HB., Free PMC Article | 09/12/2020 |
| Using a site-specific mutation assay, we identified K8-Lys108 and K18-Lys187/426 as acetylation sites, and K8-Arg47 and K18-Arg55 as methylation sites. Keratin mutation (Arg-to-Lys/Ala) at the methylation sites, but not the acetylation sites, led to decreased stability of the keratin protein. | Liver disease-associated keratin 8 and 18 mutations modulate keratin acetylation and methylation.
Jang KH, Yoon HN, Lee J, Yi H, Park SY, Lee SY, Lim Y, Lee HJ, Cho JW, Paik YK, Hancock WS, Ku NO., Free PMC Article | 06/6/2020 |
| Results identified self-antigens, Keratin 8, provoking a self-reactive T cell response suggesting its involvement in the immune-inflammatory mechanism of coronary artery disease. | Keratin 8 is a potential self-antigen in the coronary artery disease immunopeptidome: A translational approach.
Mihailovic PM, Lio WM, Herscovici R, Chyu KY, Yano J, Zhao X, Zhou J, Zhou B, Freeman MR, Yang W, Shah PK, Cercek B, Dimayuga PC., Free PMC Article | 11/30/2019 |
| KRT8 is aberrantly expressed in lung adenocarcinoma tissues. KRT8 expression is an independent prognostic indicator for poor survival in lung adenocarcinoma patients. | High KRT8 Expression Independently Predicts Poor Prognosis for Lung Adenocarcinoma Patients.
Xie L, Dang Y, Guo J, Sun X, Xie T, Zhang L, Yan Z, Amin H, Guo X., Free PMC Article | 11/16/2019 |
| We found close association between changes in K8/K18 expression and cell death/cell survival events in the human granulosa cell lineage. Large secondary and early antral follicles and regressing corpora lutea showed low/absent K8/K18 expression. Conversely, early growing antral follicles, functional menstrual corpora lutea, as well as corpus luteum of pregnancy, where cell death was scarce, showed high K8/K18 expression. | Changes in keratin 8/18 expression in human granulosa cell lineage are associated to cell death/survival events: potential implications for the maintenance of the ovarian reserve.
Gaytan F, Morales C, Roa J, Tena-Sempere M. | 01/19/2019 |
| Cytokeratin 5/6 and CK8/18 immunohistochemistry on 150 cases of triple negative breast cancers was performed and association with various clinicopathological features was evaluated. | Cytokeratin 5/6 and cytokeratin 8/18 expression in triple negative breast cancers: clinicopathologic significance in South-Asian population.
Hashmi AA, Naz S, Hashmi SK, Hussain ZF, Irfan M, Bakar SMA, Faridi N, Khan A, Edhi MM., Free PMC Article | 10/13/2018 |
| KRT8 mRNA and protein are upregulated in anaplastic thyroid carcinoma. KRT8 protein binds to annexin A2. | Cytokeratin-8 in Anaplastic Thyroid Carcinoma: More Than a Simple Structural Cytoskeletal Protein.
Guo D, Xu Q, Pabla S, Koomen J, Biddinger P, Sharma A, Pabla S, Pacholczyk R, Chang CC, Friedrich K, Mohammed K, Smallridge RC, Copland JA, She JX, Weinberger PM., Free PMC Article | 08/11/2018 |
| K8/K18 variants are overrepresented in Chinese NAFLD patients and might accelerate liver fat storage through insulin resistance. | Association of keratin 8/18 variants with non-alcoholic fatty liver disease and insulin resistance in Chinese patients: A case-control study.
Li R, Liao XH, Ye JZ, Li MR, Wu YQ, Hu X, Zhong BH., Free PMC Article | 04/14/2018 |
| regulated enhancement of autophagy with concurrent increased expression of KRT8 and the inhibition of KRT8 phosphorylation serve to inhibit oxidative stress-induced epithelial-mesenchymal transitionof retinal pigment epithelium cells. | Autophagy and KRT8/keratin 8 protect degeneration of retinal pigment epithelium under oxidative stress.
Baek A, Yoon S, Kim J, Baek YM, Park H, Lim D, Chung H, Kim DE., Free PMC Article | 12/2/2017 |
| Histopathological differences between Magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU)-ablated tissue and radiofrequency (RF)-ablated tissue were demonstrated. CK-8 was more reliable for cell viability assessment than H&E when used directly after ablation | Histopathology of breast cancer after magnetic resonance-guided high-intensity focused ultrasound and radiofrequency ablation.
Knuttel FM, Waaijer L, Merckel LG, van den Bosch MA, Witkamp AJ, Deckers R, van Diest PJ. | 10/21/2017 |
| Loss of activating transcription factor 3 (ATF3) in knockout mice promotes the emergence of keratins CK5+CK8+ epithelial cells. | Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5(+)CK8(+) epithelial cells.
Wang Z, Kim J, Teng Y, Ding HF, Zhang J, Hai T, Cowell JK, Yan C., Free PMC Article | 09/16/2017 |
| notochord-specific marker during early intervertebral disc development | Spatiotemporal analysis of putative notochordal cell markers reveals CD24 and keratins 8, 18, and 19 as notochord-specific markers during early human intervertebral disc development.
Rodrigues-Pinto R, Berry A, Piper-Hanley K, Hanley N, Richardson SM, Hoyland JA., Free PMC Article | 09/2/2017 |
| Data show that the filament elongation of both desmin and keratin K8/K18 proceeds very similar to that of vimentin. | In Vitro Assembly Kinetics of Cytoplasmic Intermediate Filaments: A Correlative Monte Carlo Simulation Study.
Mücke N, Winheim S, Merlitz H, Buchholz J, Langowski J, Herrmann H., Free PMC Article | 07/29/2017 |
| New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8. | New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8.
Premchandar A, Kupniewska A, Bonna A, Faure G, Fraczyk T, Roldan A, Hoffmann B, Faria da Cunha M, Herrmann H, Lukacs GL, Edelman A, Dadlez M., Free PMC Article | 07/15/2017 |