| LPA5-Dependent signaling regulates regeneration of the intestinal epithelium following irradiation. | LPA(5)-Dependent signaling regulates regeneration of the intestinal epithelium following irradiation.
McConnell BB, Liang Z, Xu C, Han Y, Yun CC., | 06/27/2024 |
| Autotaxin-lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling. | Autotaxin-lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling.
Janovicz A, Majer A, Kosztelnik M, Geiszt M, Chun J, Ishii S, Tigyi GJ, Benyó Z, Ruisanchez É., Free PMC Article | 01/6/2024 |
| Lysophosphatidic Acid Receptor 5 (LPA5) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In Vitro. | Lysophosphatidic Acid Receptor 5 (LPA(5)) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In Vitro.
Joshi L, Plastira I, Bernhart E, Reicher H, Koshenov Z, Graier WF, Vujic N, Kratky D, Rivera R, Chun J, Sattler W., Free PMC Article | 04/30/2022 |
| Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5. | Control of Intestinal Epithelial Permeability by Lysophosphatidic Acid Receptor 5.
Wang M, He P, Han Y, Dong L, Yun CC., Free PMC Article | 03/12/2022 |
| Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model. | Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model.
Joshi L, Plastira I, Bernhart E, Reicher H, Triebl A, Köfeler HC, Sattler W., Free PMC Article | 09/18/2021 |
| Lysophosphatidic Acid Receptor 5 Plays a Pathogenic Role in Brain Damage after Focal Cerebral Ischemia by Modulating Neuroinflammatory Responses. | Lysophosphatidic Acid Receptor 5 Plays a Pathogenic Role in Brain Damage after Focal Cerebral Ischemia by Modulating Neuroinflammatory Responses.
Sapkota A, Lee CH, Park SJ, Choi JW., Free PMC Article | 03/20/2021 |
| Lysophosphatidic Acid Receptor 5 Contributes to Imiquimod-Induced Psoriasis-Like Lesions through NLRP3 Inflammasome Activation in Macrophages. | Lysophosphatidic Acid Receptor 5 Contributes to Imiquimod-Induced Psoriasis-Like Lesions through NLRP3 Inflammasome Activation in Macrophages.
Gaire BP, Lee CH, Kim W, Sapkota A, Lee DY, Choi JW., Free PMC Article | 03/13/2021 |
| LPA5 Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling. | LPA(5) Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.
Mathew D, Kremer KN, Strauch P, Tigyi G, Pelanda R, Torres RM., Free PMC Article | 08/22/2020 |
| Lysophosphatidic acid did not activate NHE3 or fluid absorption in Lpar5 deficient mice. | Expression of lysophosphatidic acid receptor 5 is necessary for the regulation of intestinal Na(+)/H(+) exchanger 3 by lysophosphatidic acid in vivo.
Jenkin KA, He P, Yun CC., Free PMC Article | 08/17/2019 |
| These observations suggest that dietary lipid-induced ApoA-IV is associated with Cck synthesis in the duodenum and that ApoA-IV protein directly enhances CCK release through the activation of a LPAR5-dependent pathway. | Apolipoprotein A-IV enhances cholecystokinnin secretion.
Zhan J, Weng J, Hunt BG, Sean Davidson W, Liu M, Lo CC., Free PMC Article | 02/2/2019 |
| Findings suggest that lysophosphatidic acid receptor 5 antagonists elicit broad analgesic effects against both neuropathic and inflammatory pain. | Analgesic effects of novel lysophosphatidic acid receptor 5 antagonist AS2717638 in rodents.
Murai N, Hiyama H, Kiso T, Sekizawa T, Watabiki T, Oka H, Aoki T. | 06/16/2018 |
| It signaling may play a key role in the mechanisms underlying neuropathic pain following demyelination in the brain. | LPA5 signaling is involved in multiple sclerosis-mediated neuropathic pain in the cuprizone mouse model.
Tsukahara R, Yamamoto S, Yoshikawa K, Gotoh M, Tsukahara T, Neyama H, Ishii S, Akahoshi N, Yanagida K, Sumida H, Araki M, Araki K, Yamamura KI, Murakami-Murofushi K, Ueda H. | 04/28/2018 |
| These findings suggest that tumor and stromal LPA receptors, in particular LPA1 and LPA5, play different roles in invasion and the seeding of metastasis | Autotaxin and LPA1 and LPA5 receptors exert disparate functions in tumor cells versus the host tissue microenvironment in melanoma invasion and metastasis.
Lee SC, Fujiwara Y, Liu J, Yue J, Shimizu Y, Norman DD, Wang Y, Tsukahara R, Szabo E, Patil R, Banerjee S, Miller DD, Balazs L, Ghosh MC, Waters CM, Oravecz T, Tigyi GJ., Free PMC Article | 09/26/2015 |
| Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response | Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response.
Hu J, Oda SK, Shotts K, Donovan EE, Strauch P, Pujanauski LM, Victorino F, Al-Shami A, Fujiwara Y, Tigyi G, Oravecz T, Pelanda R, Torres RM., Free PMC Article | 08/23/2014 |
| These data expand the influences of LPA signaling in neuropathic pain through a second LPA receptor subtype, LPA(5), involving a mechanistically distinct downstream signaling pathway compared with LPA(1). | Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain.
Lin ME, Rivera RR, Chun J., Free PMC Article | 07/28/2012 |
| Lysophosphatidic acid (LPA) is a potent stimulant of NHE3 and fluid absorption in the intestine, signaling through LPA(5). Regulation by LPA(5) depends on its interaction with NHERF2. | Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2.
Lin S, Yeruva S, He P, Singh AK, Zhang H, Chen M, Lamprecht G, de Jonge HR, Tse M, Donowitz M, Hogema BM, Chun J, Seidler U, Yun CC., Free PMC Article | 04/12/2010 |
| GPR92 is highly expressed in the lymphocyte compartment of the gastrointestinal tract | Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes.
Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S, Owman C, Sillard R, Leeb-Lundberg LM, Olde B. | 01/21/2010 |
| Our data indicate that GPR93 can contribute to the observed induction of CCK expression and secretion by peptone and provide evidence that G protein-coupled receptors can transduce dietary luminal signals. | GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells.
Choi S, Lee M, Shiu AL, Yo SJ, Halldén G, Aponte GW. | 01/21/2010 |