| Genetic Screening of Haploid Neural Stem Cells Reveals that Nfkbia and Atp2b4 are Key Regulators of Oxidative Stress in Neural Precursors. | Genetic Screening of Haploid Neural Stem Cells Reveals that Nfkbia and Atp2b4 are Key Regulators of Oxidative Stress in Neural Precursors.
Nie S, Zhang W, Jin X, Li X, Sun S, Zhao Y, Jia Q, Li L, Liu Y, Liu D, Gao Q., Free PMC Article | 09/16/2024 |
| PMCA4 inhibition does not affect cardiac remodelling following myocardial infarction, but may reduce susceptibility to arrhythmia. | PMCA4 inhibition does not affect cardiac remodelling following myocardial infarction, but may reduce susceptibility to arrhythmia.
Stafford N, Zi M, Baudoin F, Mohamed TMA, Prehar S, De Giorgio D, Cartwright EJ, Latini R, Neyses L, Oceandy D., Free PMC Article | 09/11/2021 |
| Plasma membrane Ca(2+) ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca(2+) homeostasis in mice. | Plasma membrane Ca(2+) ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca(2+) homeostasis in mice.
Korthals M, Tech L, Langnaese K, Gottfried A, Hradsky J, Thomas U, Zenclussen AC, Brunner-Weinzierl MC, Tedford K, Fischer KD. | 08/21/2021 |
| PMCA4 gene expression is regulated by the androgen receptor in the mouse testis during spermatogenesis. | PMCA4 gene expression is regulated by the androgen receptor in the mouse testis during spermatogenesis.
Sun R, Liang H, Guo H, Wang Z, Deng Q., Free PMC Article | 05/8/2021 |
| the role of PMCA4 in the regulation of blood pressure was examined. | Acute inhibition of PMCA4, but not global ablation, reduces blood pressure and arterial contractility via a nNOS-dependent mechanism.
Lewis S, Little R, Baudoin F, Prehar S, Neyses L, Cartwright EJ, Austin C., Free PMC Article | 04/27/2019 |
| study provides evidence for the therapeutic potential of targeting PMCA4 to improve VEGF-based pro-angiogenic interventions. This goal will require the development of refined, highly selective versions of ATA, or the identification of novel PMCA4 inhibitors. | Selective inhibition of plasma membrane calcium ATPase 4 improves angiogenesis and vascular reperfusion.
Kurusamy S, López-Maderuelo D, Little R, Cadagan D, Savage AM, Ihugba JC, Baggott RR, Rowther FB, Martínez-Martínez S, Arco PG, Murcott C, Wang W, Francisco Nistal J, Oceandy D, Neyses L, Wilkinson RN, Cartwright EJ, Redondo JM, Armesilla AL. | 04/14/2018 |
| PMCA4 co-ordinates both Ca2+ and NO signaling in mammalian sperm, to control sperm motility. | Plasma membrane calcium ATPase 4 (PMCA4) co-ordinates calcium and nitric oxide signaling in regulating murine sperm functional activity.
Olli KE, Li K, Galileo DS, Martin-DeLeon PA., Free PMC Article | 10/14/2017 |
| the ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility | An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility.
Lessard S, Gatof ES, Beaudoin M, Schupp PG, Sher F, Ali A, Prehar S, Kurita R, Nakamura Y, Baena E, Ledoux J, Oceandy D, Bauer DE, Lettre G., Free PMC Article | 10/14/2017 |
| PMCA4 has no discernible role in normal renal Ca2+ handling as no urinary Ca2+ wasting was observed. Further investigation of the exact role of PMCA4 in the distal convoluted tubule and connecting tubule is required | Calcium Extrusion Pump PMCA4: A New Player in Renal Calcium Handling?
van Loon EP, Little R, Prehar S, Bindels RJ, Cartwright EJ, Hoenderop JG., Free PMC Article | 02/18/2017 |
| PMCA4 regulates the development of cardiac hypertrophy and provide proof of principle for a therapeutic approach to treat this condition. | The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy.
Mohamed TMA, Abou-Leisa R, Stafford N, Maqsood A, Zi M, Prehar S, Baudoin-Stanley F, Wang X, Neyses L, Cartwright EJ, Oceandy D., Free PMC Article | 09/3/2016 |
| Electron microscopy demonstrated Pmca4 localization in distal nephron cells at both the basolateral membrane and intracellular perinuclear compartments but not submembranous vesicles | Ultrastructural and immunohistochemical localization of plasma membrane Ca2+-ATPase 4 in Ca2+-transporting epithelia.
Alexander RT, Beggs MR, Zamani R, Marcussen N, Frische S, Dimke H. | 01/16/2016 |
| Findings indicate an important regulation of plasma membrane Ca(2+)-ATPase (PMCA) by Homer2 protein that has a central role on PMCA-mediated Ca(2+) signaling in parotid acinar cells. | Homer2 protein regulates plasma membrane Ca²⁺-ATPase-mediated Ca²⁺ signaling in mouse parotid gland acinar cells.
Yang YM, Lee J, Jo H, Park S, Chang I, Muallem S, Shin DM., Free PMC Article | 01/31/2015 |
| PMCA4 inhibits the activation of the calcineurin/NFAT pathway on VEGF stimulation of endothelial cells, leading to a significant attenuation of VEGF-mediated angiogenesis. | Plasma membrane calcium ATPase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin.
Baggott RR, Alfranca A, López-Maderuelo D, Mohamed TM, Escolano A, Oller J, Ornes BC, Kurusamy S, Rowther FB, Brown JE, Oceandy D, Cartwright EJ, Wang W, Gómez-del Arco P, Martínez-Martínez S, Neyses L, Redondo JM, Armesilla AL. | 12/20/2014 |
| Oviductal exosomes play significant role in post-testicular sperm acquisition of PMCA4a which is essential for hyperactivated motility and fertility. | Expression and secretion of plasma membrane Ca2+-ATPase 4a (PMCA4a) during murine estrus: association with oviductal exosomes and uptake in sperm.
Al-Dossary AA, Strehler EE, Martin-Deleon PA., Free PMC Article | 08/16/2014 |
| this study concludes that Ca(2+) efflux activity of PMCA4 underlies G1 progression in vascular smooth muscle cells and that PMCA4a and PMCA4b differentially regulate specific downstream mediators. | Calcium efflux activity of plasma membrane Ca2+ ATPase-4 (PMCA4) mediates cell cycle progression in vascular smooth muscle cells.
Afroze T, Yang G, Khoshbin A, Tanwir M, Tabish T, Momen A, Husain M., Free PMC Article | 06/28/2014 |
| Both Ca2+-ATPase splice variants are expressed in the testis and throughout the epididymis. | Plasma membrane Ca2+-ATPase 4 in murine epididymis: secretion of splice variants in the luminal fluid and a role in sperm maturation.
Patel R, Al-Dossary AA, Stabley DL, Barone C, Galileo DS, Strehler EE, Martin-DeLeon PA., Free PMC Article | 03/8/2014 |
| Ca(2+) homeostasis in sperm is maintained by the relative ratios of CASK-PMCA4b and CASK-JAM-A interactions | CASK interacts with PMCA4b and JAM-A on the mouse sperm flagellum to regulate Ca2+ homeostasis and motility.
Aravindan RG, Fomin VP, Naik UP, Modelski MJ, Naik MU, Galileo DS, Duncan RL, Martin-Deleon PA., Free PMC Article | 07/7/2012 |
| Plasma membrane calcium pump (PMCA) isoform 4 is targeted to the apical membrane by the w-splice insert from PMCA2. | Plasma membrane calcium pump (PMCA) isoform 4 is targeted to the apical membrane by the w-splice insert from PMCA2.
Antalffy G, Mauer AS, Pászty K, Hegedus L, Padányi R, Enyedi A, Strehler EE., Free PMC Article | 06/9/2012 |
| Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain. | Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.
Mohamed TMA, Oceandy D, Zi M, Prehar S, Alatwi N, Wang Y, Shaheen MA, Abou-Leisa R, Schelcher C, Hegab Z, Baudoin F, Emerson M, Mamas M, Di Benedetto G, Zaccolo M, Lei M, Cartwright EJ, Neyses L., Free PMC Article | 01/28/2012 |
| expression of Atp2b4 significantly decreased in enamel organs from Mmp20(-/-) mice. A feedback mechanism regulates ion-responsive gene expression during enamel development. | Altered ion-responsive gene expression in Mmp20 null mice.
Tye CE, Sharma R, Smith CE, Bartlett JD., Free PMC Article | 01/1/2011 |
| the nNOS-PMCA4b complex regulates contractility via cAMP and phosphorylation of both PLB and cTnI. | Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium.
Mohamed TM, Oceandy D, Prehar S, Alatwi N, Hegab Z, Baudoin FM, Pickard A, Zaki AO, Nadif R, Cartwright EJ, Neyses L., Free PMC Article | 01/21/2010 |
| results suggest that the calcium removal function of PMCA4 in smooth muscle cells is dependent on its presence in intact caveolae | Calcium extrusion by plasma membrane calcium pump is impaired in caveolin-1 knockout mouse small intestine.
El-Yazbi AF, Cho WJ, Schulz R, Daniel EE. | 01/21/2010 |
| PMCA4 has a pivotal role in the regulation of sperm function and intracellular Ca(2+) levels | Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility.
Schuh K, Cartwright EJ, Jankevics E, Bundschu K, Liebermann J, Williams JC, Armesilla AL, Emerson M, Oceandy D, Knobeloch KP, Neyses L. | 01/21/2010 |
| results show that plasma membrane Ca2+-ATPase (PMCA)4 expression in the principle piece of the sperm tail is essential for hyperactivated motility and male fertility | Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4.
Okunade GW, Miller ML, Pyne GJ, Sutliff RL, O'Connor KT, Neumann JC, Andringa A, Miller DA, Prasad V, Doetschman T, Paul RJ, Shull GE. | 01/21/2010 |
| PMCA1 isoform is involved in overall Ca(2+) clearance, while PMCA4 is essential for [Ca(2+)](i) increase and contractile response to carbachol receptor-mediated signal transduction pathway. | Distinct roles of PMCA isoforms in Ca2+ homeostasis of bladder smooth muscle: evidence from PMCA gene-ablated mice.
Liu L, Ishida Y, Okunade G, Pyne-Geithman GJ, Shull GE, Paul RJ. | 01/21/2010 |