| Evaluation of the genetic diversity of KIR genes in patients with endometrial cancer. | Evaluation of the genetic diversity of KIR genes in patients with endometrial cancer.
Shiravani Z, Mirshekari K, Larki MH, Shafiee N, Haghshenas MR, Ghaderi A, Fattahi MJ. | 04/17/2024 |
| KIR2DS4 and Its Variant KIR1D in KIR-AA Genotype Donors Showed Differential Survival Impact in Patients with Lymphoid Disease after HLA-Matched Unrelated Hematopoietic Stem Cell Transplantation. | KIR2DS4 and Its Variant KIR1D in KIR-AA Genotype Donors Showed Differential Survival Impact in Patients with Lymphoid Disease after HLA-Matched Unrelated Hematopoietic Stem Cell Transplantation.
Gowdavally S, Tsamadou C, Platzbecker U, Sala E, Valerius T, Klein S, Kröger N, Wulf G, Einsele H, Thurner L, Schaefer-Eckart K, Freitag S, Casper J, Dürholt M, Kaufmann M, Hertenstein B, Ringhoffer M, Schmeller S, Neuchel C, Rode I, Amann EM, Richter A, Schrezenmeier H, Mytilineos J, Fuerst D. | 07/7/2023 |
| Association of KIR gene polymorphisms with COVID-19 disease. | Association of KIR gene polymorphisms with COVID-19 disease.
Hajeer A, Jawdat D, Massadeh S, Aljawini N, Abedalthagafi MS, Arabi YM, Alaamery M., Free PMC Article | 03/19/2022 |
| The impact of donor full-length KIR2DS4 in the development of acute and chronic GVHD after unrelated allogeneic HSCT. | The impact of donor full-length KIR2DS4 in the development of acute and chronic GVHD after unrelated allogeneic HSCT.
An K, Li B, Luo C, Wang J, Luo C, Chen J. | 09/4/2021 |
| Positive association of Bx genotype, KIR2L5, KIR2DS5 and full-length KIR2DS4 with the risk of meningioma. | Positive association of Bx genotype, KIR2L5, KIR2DS5 and full-length KIR2DS4 with the risk of meningioma.
Barani S, Taghipour M, Ghaderi A. | 05/29/2021 |
| Natural killer cell receptor variants and chronic hepatitis B virus infection in the Vietnamese population. | Natural killer cell receptor variants and chronic hepatitis B virus infection in the Vietnamese population.
Auer ED, Tong HV, Amorim LM, Malheiros D, Hoan NX, Issler HC, Petzl-Erler ML, Beltrame MH, Boldt ABW, Toan NL, Song LH, Velavan TP, Augusto DG. | 10/3/2020 |
| In head and neck squamous cell carcinoma (HNSCC), KIR2DL2 is positively while KIR2DS4 is negatively associated with advanced stage. The higher proportion of LNM in carriers of KIR2DL2 and carriers of 5 iKIRs, suggested that inhibitory KIRs are associated with metastatic risk | KIR2DS4, KIR2DL2, and KIR2DS4del are linked with basaloid tumors, lymph node metastasis, advanced stage and metastatic risk in head and neck squamous cell carcinoma.
Barani S, Khademi B, Ghaderi A. | 07/18/2020 |
| KIR2DS4 has a strong preference for rare peptides carrying a Trp at position 8 (p8) of 9-mer peptides bound to HLA-C*05:01. The complex of a peptide bound to HLA-C*05:01 with a Trp at p8 was sufficient for activation of primary KIR2DS4+ NK cells, independent of activation by other receptors and of prior NK cell licensing. Study predicts that over 1,000 bacterial species could activate NK cells through KIR2DS4. | Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C.
Sim MJW, Rajagopalan S, Altmann DM, Boyton RJ, Sun PD, Long EO., Free PMC Article | 04/11/2020 |
| The higher frequencies of KIR3DS1-Bw4 and homozygotic KIR2DS4- in patients compared with controls suggest they confer susceptibility to polycystic ovary syndrome. A lower frequency of KIR2DS4-full was observed in patients. | Killer-cell immunoglobulin-like receptors associated with polycystic ovary syndrome.
Sala Elpidio LN, de Alencar JB, Tsuneto PY, Alves HV, Trento Toretta M, It Taura SK, Laguila Visentainer JE, Sell AM. | 11/2/2019 |
| Promoter methylation decreased and gene expression increased for KIR2DS4 after acute exercise. Chronic exercise resulted in a minor decrease of DNA methylation and did not alter gene expression. | Acute Exercise Increases the Expression of KIR2DS4 by Promoter Demethylation in NK Cells.
Schenk A, Pulverer W, Koliamitra C, Bauer CJ, Ilic S, Heer R, Schier R, Schick V, Böttiger BW, Gerhäuser C, Bloch W, Zimmer P. | 02/2/2019 |
| KIR2DS4 was associated with significant reduced incidence of relapse of hematological malignancies after hematopoietic stem cell transplantation from matched sibling | The effect of killer cell immunoglobulin-like receptor genotype on outcome of hematopoietic stem cell transplantation from matched sibling.
Elfishawi SM, Mossallam GI, El-Fattah RA, El-Haddad A, Kamel AM. | 07/7/2018 |
| KIR 2D (L1, L3, L4, S4) and KIR 3DL1 expression was correlated with poor prognosis in non-small cell lung carcinoma patients. | KIR 2D (L1, L3, L4, S4) and KIR 3DL1 protein expression in non-small cell lung cancer.
He Y, Bunn PA, Zhou C, Chan D., Free PMC Article | 02/17/2018 |
| KIR2DS4, KIR2DS1, and some alleles of KIR2DS5 contribute to successful pregnancy suggests that activation of uNK cells by KIR binding to HLA-C is a generic mechanism promoting trophoblast invasion into the decidua. | Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy.
Kennedy PR, Chazara O, Gardner L, Ivarsson MA, Farrell LE, Xiong S, Hiby SE, Colucci F, Sharkey AM, Moffett A., Free PMC Article | 07/29/2017 |
| Our findings suggest that KIR2DS4*00101 may offer a molecular biomarker to identify intrinsically milder forms of glioblastoma | Identification of a Natural Killer Cell Receptor Allele That Prolongs Survival of Cytomegalovirus-Positive Glioblastoma Patients.
Dominguez-Valentin M, Gras Navarro A, Rahman AM, Kumar S, Retière C, Ulvestad E, Kristensen V, Lund-Johansen M, Lie BA, Enger PØ, Njølstad G, Kristoffersen E, Lie SA, Chekenya M. | 07/22/2017 |
| Data indicate the allelic diversity of KIR2DS4 proteni among ethnic Hans from southern China, which may provide data for transplantation as well as studies on KIR-associated disease and evolution. | [Genetic polymorphisms of KIR2DS4 gene among ethnic Hans from southern China].
Zhen J, Zhang G, Yu Q, He L, Xu Y, Zou H, Deng Z. | 07/1/2017 |
| this study shows that the expression of full-length KIR2DS4 allele variants may contribute to a worse clinical outcome after hematopoietic stem cell transplantation | The impact of KIR2DS4 gene on clinical outcome after hematopoietic stem cell transplantation.
Burek Kamenaric M, Stingl Jankovic K, Grubic Z, Serventi Seiwerth R, Maskalan M, Nemet D, Mikulic M, Zunec R. | 03/18/2017 |
| Type 1 pediatric autoimmune hepatitis patients show increased frequency of KIR2DS4-Full Length, which in combination with HLA-DRB1*1301 revealed a strong synergistic effect. Adult autoimmune hepatitis cases have shown a weaker increased frequency of KIR2DS4-FL, a lack of synergistic effect with HLA class II antigens. | The early onset of type 1 autoimmune hepatitis has a strong genetic influence: role of HLA and KIR genes.
Podhorzer A, Paladino N, Cuarterolo ML, Fainboim HA, Paz S, Theiler G, Capucchio M, López SI, Machicote A, Montal S, Podesta G, Fainboim L. | 02/18/2017 |
| Collectively, our data suggest that the KIR 2DS4/1D allelic variance is associated with the outcome of sibling-related HLA-matched HSCT, and that donor subclassification of KIR 2DS4/1D alleles should be considered in this setting. | KIR2DS4 and Its Variant KIR1D Are Associated with Acute Graft-versus-Host Disease, Cytomegalovirus, and Overall Survival after Sibling-Related HLA-Matched Transplantation in Patients with Donors with KIR Gene Haplotype A.
Wu X, Yao Y, Bao X, Zhou H, Tang X, Han Y, Ma X, Liu Y, Chen J, Zhou H, Jing S, Gu B, Xu Y, Sun A, He J, Wu D. | 11/5/2016 |
| genetic polymorphism is associated with the course of Hepatitis C virus infection and the response to therapy | Genetic (KIR, HLA-C) and Some Clinical Parameters Influencing the Level of Liver Enzymes and Early Virologic Response in Patients with Chronic Hepatitis C.
Mozer-Lisewska I, Zwolińska K, Kowala-Piaskowska AE, Bura M, Rozpłochowski B, Pauli A, Żeromski J, Piasecki E, Kuśnierczyk P., Free PMC Article | 10/22/2016 |
| genetic association study in population in Eastern India: Data suggest that interactions between KIRs (KIR2DL2, KIR2DS4, KIR2DL3) and HLA ligands (HLAC1, HLAC2) contribute significantly toward susceptibility and protection toward type 1 diabetes. | Killer immunoglobulin receptor genes and their HLA-C ligand are associated with Type 1 diabetes in an Eastern Indian population.
Sanjeevi S, Sun C, Kanungo A, Sanjeevi CB. | 10/22/2016 |
| KIR2DS4 can induce the uptake of CCR7 by KIR2DS4(+) NKG2A(+) natural killer cell clones after interacting with CCR7(+) target cells expressing HLA-Cw4 and HLA-Cw6 alleles. | Uptake of CCR7 by KIR2DS4⁺ NK cells is induced upon recognition of certain HLA-C alleles.
Pesce S, Carlomagno S, Moretta A, Sivori S, Marcenaro E., Free PMC Article | 01/30/2016 |
| Study shows KIR3DL1 and KIR2DS4 gene variants are linked and that the gene KIR2DS5 is only present in the telomeric half of the KIR locus. Study revealed novel insights in the highly organized distribution of KIR genes. | Novel insights in the genomic organization and hotspots of recombination in the human KIR locus through analysis of intergenic regions.
Vendelbosch S, de Boer M, van Leeuwen K, Pourfarzad F, Geissler J, van den Berg TK, Kuijpers TW. | 01/16/2016 |
| These results highlight the impact of population allele frequency on viral control and identify a novel association between HLA-C04 : 01 in combination with KIR2DS4f and uncontrolled HIV infection. | The HLA-C*04: 01/KIR2DS4 gene combination and human leukocyte antigen alleles with high population frequency drive rate of HIV disease progression.
Olvera A, Pérez-Álvarez S, Ibarrondo J, Ganoza C, Lama JR, Lucchetti A, Cate S, Hildebrand W, Bernard N, Gomez L, Sanchez J, Brander C. | 10/31/2015 |
| KIR2DS4del presence in patients was associated with severity of endometriosis, which, due to strong negative linkage disequilibrium, may suggest an indirect effect of KIR2DS5 absence | KIR2DS5 in the presence of HLA-C C2 protects against endometriosis.
Nowak I, Płoski R, Barcz E, Dziunycz P, Kamiński P, Kostrzewa G, Milewski Ł, Roszkowski PI, Senitzer D, Malejczyk J, Kuśnierczyk P., Free PMC Article | 06/20/2015 |
| Response of rheumatoid arthritis patients with medium ESR values to methotrexate treatment may be dependent on the full-length KIR2DS4 gene. | Presence of the full-length KIR2DS4 gene reduces the chance of rheumatoid arthritis patients to respond to methotrexate treatment.
Majorczyk E, Pawlik A, Gendosz D, Kuśnierczyk P., Free PMC Article | 01/24/2015 |