| miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure. | miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure.
Kang GJ, Xie A, Kim E, Dudley SC Jr., Free PMC Article | 05/3/2023 |
| An epilepsy-associated KV1.2 charge-transfer-center mutation impairs KV1.2 and KV1.4 trafficking. | An epilepsy-associated K(V)1.2 charge-transfer-center mutation impairs K(V)1.2 and K(V)1.4 trafficking.
Nilsson M, Lindström SH, Kaneko M, Wang K, Minguez-Viñas T, Angelini M, Steccanella F, Holder D, Ottolia M, Olcese R, Pantazis A., Free PMC Article | 06/18/2022 |
| Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH. | Human adrenal glomerulosa cells express K2P and GIRK potassium channels that are inhibited by ANG II and ACTH.
Enyeart JJ, Enyeart JA., Free PMC Article | 09/11/2021 |
| statistically significant association between the KCNA4 rs1323860 C/T transition and endurance running performance level | KCNA4 Gene Variant is Auxiliary in Endurance Running Performance Level.
Flecha-Velazquez K, Fahey TD, Martínez JL, Lopez-Taylor JR, Rivera MA. | 06/15/2019 |
| Expression of Kv1.4 appears to increase in the spinal cord of mice modelling remitting-relapsing experimental allergic encephalomyelitis (rrEAE) in peak and remitting phases. | K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.
Jukkola PI, Lovett-Racke AE, Zamvil SS, Gu C., Free PMC Article | 04/6/2013 |
| Detection of the methylation prevalence of KCNA4 and CYP26B1 together in serum demonstrated the good sensitivity and specificityin gastric cancer | Hypermethylated DNA as potential biomarkers for gastric cancer diagnosis.
Zheng Y, Chen L, Li J, Yu B, Su L, Chen X, Yu Y, Yan M, Liu B, Zhu Z. | 03/3/2012 |
| Data suggest that episodic ataxia type 1 mutations affect fast inactivation of Kv1.1/1.4 channels by a reduction in either subunit surface expression or altered affinity for the inactivation domain. | Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain.
Imbrici P, D'Adamo MC, Grottesi A, Biscarini A, Pessia M. | 08/27/2011 |
| Sialylated N-glycans uniquely impact gating of a mammalian Shaker family K(v) channel isoform, K(v)1.5, but have no effect on gating of a second Shaker isoform, K(v)1.4. | N-glycans modulate K(v)1.5 gating but have no effect on K(v)1.4 gating.
Schwetz TA, Norring SA, Bennett ES. | 05/3/2010 |
| Both arachidonic acid and Trolox potently modulate Kv1.4 and Kv4.2 channel alpha-subunits, thereby presumably tuning presynaptic transmitter release and postsynaptic somatodendritic excitability in synaptic transmission and plasticity. | Arachidonic acid potently inhibits both postsynaptic-type Kv4.2 and presynaptic-type Kv1.4 IA potassium channels.
Angelova PR, Müller WS. | 01/21/2010 |
| Novel role for GIP in regulating K(V)1.4 cell surface expression and modulation of A-type potassium currents | A novel mechanism for the suppression of a voltage-gated potassium channel by glucose-dependent insulinotropic polypeptide: protein kinase A-dependent endocytosis.
Kim SJ, Choi WS, Han JS, Warnock G, Fedida D, McIntosh CH. | 01/21/2010 |
| Thr-330 of Kv1.4 serves to interlock the voltage-sensing and gating domains of adjacent monomers, thereby yielding a structure competent for the surface expression of functional tetramers | Identification of an evolutionarily conserved extracellular threonine residue critical for surface expression and its potential coupling of adjacent voltage-sensing and gating domains in voltage-gated potassium channels.
Mckeown L, Burnham MP, Hodson C, Jones OT., Free PMC Article | 01/21/2010 |
| Ginsenoside Rg3 inhibits KV1.4 channel currents by interacting with the lysine531 residue. | Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue.
Lee JH, Lee BH, Choi SH, Yoon IS, Pyo MK, Shin TJ, Choi WS, Lim Y, Rhim H, Won KH, Lim YW, Choe H, Kim DH, Kim YI, Nah SY. | 01/21/2010 |
| N-type inactivation in hKv1.4 is regulated by pH(i) in the physiologic range through ionization of specific amino acid residues in the ball domain. | Molecular determinants of intracellular pH modulation of human Kv1.4 N-type inactivation.
Padanilam BJ, Lu T, Hoshi T, Padanilam BA, Shibata EF, Lee HC. | 01/21/2010 |
| Results describe an erbstatin (Erb) analogue as a small molecule inhibitor of the N-type inactivation in potassium channels Kv1.4 and Kv1.1+Kvbeta1. | Disinactivation of N-type inactivation of voltage-gated K channels by an erbstatin analogue.
Zhang ZH, Rhodes KJ, Childers WE, Argentieri TM, Wang Q. | 01/21/2010 |
| Fast inactivation in human Kv1.4 is modulated by structural elements in the C-terminus, suggesting that the process involves the concerted action of the N- and C-termini. | N type rapid inactivation in human Kv1.4 channels: functional role of a putative C-terminal helix.
Sankaranarayanan K, Varshney A, Mathew MK. | 01/21/2010 |
| The results demonstrate that the human Kvbeta1.1 and Kvbeta1.2 subunits regulate the proportion of wild-type Kv1.4-1.1 channels that are available to open. | Episodic ataxia type 1 mutations in the KCNA1 gene impair the fast inactivation properties of the human potassium channels Kv1.4-1.1/Kvbeta1.1 and Kv1.4-1.1/Kvbeta1.2.
Imbrici P, D'Adamo MC, Kullmann DM, Pessia M. | 01/21/2010 |