| ZEB2 alleviates Hirschsprung's-associated enterocolitis by promoting the proliferation and differentiation of enteric neural precursor cells via the Notch-1/Jagged-2 pathway. | ZEB2 alleviates Hirschsprung's-associated enterocolitis by promoting the proliferation and differentiation of enteric neural precursor cells via the Notch-1/Jagged-2 pathway.
Feng Y, Zhou C, Zhao F, Ma T, Xiao Y, Peng K, Xia R. | 04/18/2024 |
| Ovarian tumor cell-derived JAGGED2 promotes omental metastasis through stimulating the Notch signaling pathway in the mesothelial cells. | Ovarian tumor cell-derived JAGGED2 promotes omental metastasis through stimulating the Notch signaling pathway in the mesothelial cells.
Islam SS, Al-Mohanna FH, Yousef IM, Al-Badawi IA, Aboussekhra A., Free PMC Article | 04/12/2024 |
| Splicing factor ESRP1 derived circ_0068162 promotes the progression of oral squamous cell carcinoma via the miR-186/JAG axis. | Splicing factor ESRP1 derived circ_0068162 promotes the progression of oral squamous cell carcinoma via the miR-186/JAG axis.
Chen S, Zong Y, Hou Z, Deng Z, Xia Z. | 03/12/2024 |
| miR-541 is associated with the prognosis of liver cirrhosis and directly targets JAG2 to inhibit the activation of hepatic stellate cells. | miR-541 is associated with the prognosis of liver cirrhosis and directly targets JAG2 to inhibit the activation of hepatic stellate cells.
Liu JP, Song SH, Shi PM, Qin XY, Zheng BN, Liu SQ, Ding CH, Zhang X, Xie WF, Shi YH, Xu WP., Free PMC Article | 03/8/2024 |
| Jagged2 progressively increased expression from Stage I to III of Bladder Cancer and Melatonin-mediated downregulation of Notch/Jagged2 suppresses the Bladder Tumorigenesis via inhibiting PI3K/AKT/mTOR/MMPs signaling. | Jagged2 progressively increased expression from Stage I to III of Bladder Cancer and Melatonin-mediated downregulation of Notch/Jagged2 suppresses the Bladder Tumorigenesis via inhibiting PI3K/AKT/mTOR/MMPs signaling.
Chen YT, Huang CR, Chang CL, Chiang JY, Luo CW, Chen HH, Yip HK., Free PMC Article | 11/27/2021 |
| A form of muscular dystrophy associated with pathogenic variants in JAG2. | A form of muscular dystrophy associated with pathogenic variants in JAG2.
Coppens S, Barnard AM, Puusepp S, Pajusalu S, Õunap K, Vargas-Franco D, Bruels CC, Donkervoort S, Pais L, Chao KR, Goodrich JK, England EM, Weisburd B, Ganesh VS, Gudmundsson S, O'Donnell-Luria A, Nigul M, Ilves P, Mohassel P, Siddique T, Milone M, Nicolau S, Maroofian R, Houlden H, Hanna MG, Quinlivan R, Beiraghi Toosi M, Ghayoor Karimiani E, Costagliola S, Deconinck N, Kadhim H, Macke E, Lanpher BC, Klee EW, Łusakowska A, Kostera-Pruszczyk A, Hahn A, Schrank B, Nishino I, Ogasawara M, El Sherif R, Stojkovic T, Nelson I, Bonne G, Cohen E, Boland-Augé A, Deleuze JF, Meng Y, Töpf A, Vilain C, Pacak CA, Rivera-Zengotita ML, Bönnemann CG, Straub V, Handford PA, Draper I, Walter GA, Kang PB., Free PMC Article | 07/3/2021 |
| Overexpression of JAG2 is related to poor outcomes in oral squamous cell carcinoma. | Overexpression of JAG2 is related to poor outcomes in oral squamous cell carcinoma.
Hatano K, Saigo C, Kito Y, Shibata T, Takeuchi T., Free PMC Article | 06/19/2021 |
| Results showed that Jagged2 was highly expressed in paclitaxel-resistant triple negative breast cancer (TNBC) tissues and cells. Jagged2 expression was found to be associated with cancer stem cell (CSC) properties of TNBC cells. Jagged2 maintains CSC properties of TNBC cells and paclitaxel resistance via regulating microRNA-200. | Jagged2 promotes cancer stem cell properties of triple negative breast cancer cells and paclitaxel resistance via regulating microRNA-200.
Li CY, Miao KL, Chen Y, Liu LY, Zhao GB, Lin MH, Jiang C. | 01/18/2020 |
| The CT genotype of rs741859 could significantly reduce the risk for NSCLP to 65% (P< 0.05) and the risk for cleft lip with or without cleft palate (CL/P) to 62% (P< 0.05). | [Association between the JAG2 gene polymorphism and the occurrence of nonsyndromic cleft lip with or without cleft palate in northwest Chinese population].
Lei J, Shen X, Bi B, Zhao S, Liu R, Xie X. | 01/18/2020 |
| CD14(+) monocytes serve as Langerhans cell histiocytosis (LCH) cell precursor and JAG2-mediated activation of the Notch signaling pathway initiates a differentiation of monocytes toward LCH cells. | JAG2 signaling induces differentiation of CD14(+) monocytes into Langerhans cell histiocytosis-like cells.
Schwentner R, Jug G, Kauer MO, Schnöller T, Waidhofer-Söllner P, Holter W, Hutter C. | 10/19/2019 |
| Long noncoding RNA (lncRNA) ENST00000455974 was significantly associated with TNM stage and distant metastasis in patients with DNA mismatch repair-proficient colon cancer. ENST00000455974 was gradually increased across the colonic normal-adenoma-carcinoma-metastasis sequence. ENST00000455974 was mainly located in the nucleus of colon cancer cells and it promoted growth and metastasis through up-regulating JAG2. | Long noncoding RNA ENST00000455974 plays an oncogenic role through up-regulating JAG2 in human DNA mismatch repair-proficient colon cancer.
Lao Y, Li Q, Li N, Liu H, Liu K, Jiang G, Wei N, Wang C, Wang Y, Wu J. | 06/8/2019 |
| In CL+/-P Malay patients, the prevalence of mutations in the Jagged2 gene was 12.5%. Three variants (g.19779C>T, g.19547G>A, and g.19712C>T) were identified in the Jagged2 gene among nonsyndromic CL+/-P and noncleft patients. Only g.19712C>T showed a significant association with nonsyndromic CL+/-P patients (P = .039). | Screening of Transforming Growth Factor Beta 3 and Jagged2 Genes in the Malay Population With Nonsyndromic Cleft Lip With or Without Cleft Palate.
Ghazali N, Rahman NA, Kannan TP, Jaafar S. | 01/27/2018 |
| these results show that the Notch signaling pathway in T cells is crucial for the induction of TH2-mediated allergic airway inflammation in an house dust mite -driven asthma model but that expression of Jagged 1 or Jagged 2 on DCs is not required | Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable.
Tindemans I, Lukkes M, de Bruijn MJW, Li BWS, van Nimwegen M, Amsen D, KleinJan A, Hendriks RW. | 10/28/2017 |
| The authors present novel structures of human ligands Jagged2 and Delta-like4 and human Notch2, together with functional assays, which suggest that ligand-mediated coupling of membrane recognition and Notch binding is likely to be critical in establishing the optimal context for Notch signalling. | Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
Suckling RJ, Korona B, Whiteman P, Chillakuri C, Holt L, Handford PA, Lea SM., Free PMC Article | 08/12/2017 |
| Immunohistochemistry showed a reverse correlation between MUC2 and Notch3 or Jagged1 (P = 0.033 and P = 0.005, respectively) and between MUC5AC and Jagged1 or Hes1 | Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.
Kang H, An HJ, Song JY, Kim TH, Heo JH, Ahn DH, Kim G. | 08/20/2016 |
| Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells | Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells.
Xishan Z, Bin Z, Haiyue Z, Xiaowei D, Jingwen B, Guojun Z., Free PMC Article | 08/20/2016 |
| Increased expression of JAG2, a target of miR-1280, is associated with high metastatic dissemination at diagnosis and a poor outcome in medulloblastoma. | A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma.
Wang F, Remke M, Bhat K, Wong ET, Zhou S, Ramaswamy V, Dubuc A, Fonkem E, Salem S, Zhang H, Hsieh TC, O'Rourke ST, Wu L, Li DW, Hawkins C, Kohane IS, Wu JM, Wu M, Taylor MD, Wu E., Free PMC Article | 12/5/2015 |
| Results show that tumor cell migration, invasion, and metastasis are dependent on JAGGED2 independently of NOTCH activation. | The NOTCH ligand JAGGED2 promotes pancreatic cancer metastasis independent of NOTCH signaling activation.
Hu Y, Su H, Li X, Guo G, Cheng L, Qin R, Qing G, Liu H. | 10/3/2015 |
| silencing prevents Notch2-driven osteoclast development and bone destruction in multiple myeloma | Notch signaling drives multiple myeloma induced osteoclastogenesis.
Colombo M, Thümmler K, Mirandola L, Garavelli S, Todoerti K, Apicella L, Lazzari E, Lancellotti M, Platonova N, Akbar M, Chiriva-Internati M, Soutar R, Neri A, Goodyear CS, Chiaramonte R., Free PMC Article | 08/1/2015 |
| Although Jag1 shares a high degree of homology with Jag2 in the ectodomain region, BACE1 fails to cleave Jag2 effectively, indicating a selective cleavage of Jag1. | β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.
He W, Hu J, Xia Y, Yan R., Free PMC Article | 02/14/2015 |
| This study demonistrated that NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma. | NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma.
Fiaschetti G, Schroeder C, Castelletti D, Arcaro A, Westermann F, Baumgartner M, Shalaby T, Grotzer MA., Free PMC Article | 12/20/2014 |
| Jagged2 expression status was closely correlated with important histopathologic characteristics (grades and stages) and the recurrence and metastasis of bladder urothelial carcinomas. | High expression of Notch ligand Jagged2 is associated with the metastasis and recurrence in urothelial carcinoma of bladder.
Li W, Liu M, Feng Y, Huang YF, Xu YF, Che JP, Wang GC, Zheng JH., Free PMC Article | 07/19/2014 |
| Notch-1 and Jagged-2 are not expressed in spastic colon segments, which may be associated with the pathogenesis of Hirschsprung disease. | [Expression and significance of Notch-1 and Jagged-2 in patients with Hirschsprung disease].
Jia HM, Han XF, Bai YZ, Wang WL. | 03/23/2013 |
| JAG2-mediated Notch activation confers phenotypic and functional aspects of Langerhans cell histiocytosis to dendritic cells. | Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells.
Hutter C, Kauer M, Simonitsch-Klupp I, Jug G, Schwentner R, Leitner J, Bock P, Steinberger P, Bauer W, Carlesso N, Minkov M, Gadner H, Stingl G, Kovar H, Kriehuber E. | 02/16/2013 |
| JAG2 is often expressed by CD138(+) primary cells. Our results indicate that spontaneous clonogenic growth of myeloma cells requires the expression of JAG2. | Critical role of the NOTCH ligand JAG2 in self-renewal of myeloma cells.
Chiron D, Maïga S, Descamps G, Moreau P, Le Gouill S, Marionneau S, Ouiller T, Moreaux J, Klein B, Bataille R, Amiot M, Pellat-Deceunynck C. | 07/21/2012 |