| Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis. | Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis.
Furue M., Free PMC Article | 02/20/2021 |
| Together, these results suggest that GR modulates involucrin expression of keratinocytes by regulating the intracellular signaling network in a ligand-independent manner. | Glucocorticoid receptor enhances involucrin expression of keratinocyte in a ligand-independent manner.
Yoon HK, Li ZJ, Choi DK, Sohn KC, Lim EH, Lee YH, Kim S, Im M, Lee Y, Seo YJ, Lee JH, Kim CD. | 12/6/2014 |
| over-expression of Nnat was evident along with involucrin and cytokeratin1 expression | Neuronatin is related to keratinocyte differentiation by up-regulating involucrin.
Dugu L, Nakahara T, Wu Z, Uchi H, Liu M, Hirano K, Yokomizo T, Furue M. | 10/18/2014 |
| involucrin is up-regulated in psoriatic keratinocytes | Regulation of involucrin in psoriatic epidermal keratinocytes: the roles of ERK1/2 and GSK-3β.
Chen JQ, Man XY, Li W, Zhou J, Landeck L, Cai SQ, Zheng M. | 03/8/2014 |
| KLF4 is part of a multiprotein complex that interacts that the hINV promoter distal regulatory region to drive differentiation-dependent hINV gene expression in epidermis. | Protein kinase C δ increases Kruppel-like factor 4 protein, which drives involucrin gene transcription in differentiating keratinocytes.
Chew YC, Adhikary G, Xu W, Wilson GM, Eckert RL., Free PMC Article | 08/31/2013 |
| Compared with the control, the level of expression of the IVL gene in NCTC 2544 cells was increased after 8 h of treatment with hyaluronic acid or Plantaricin A preparations. | The antimicrobial peptide pheromone Plantaricin A increases antioxidant defenses of human keratinocytes and modulates the expression of filaggrin, involucrin, β-defensin 2 and tumor necrosis factor-α genes.
Marzani B, Pinto D, Minervini F, Calasso M, Di Cagno R, Giuliani G, Gobbetti M, De Angelis M. | 03/9/2013 |
| Therefore, together with trichohyalin, the cross-linking due to involucrin is also responsible for the mechanical resistance of the corneous trabeculae present among the empty spaces of the medulla of the human hair. | Ultrastructural immunolocalization of involucrin in the medulla and inner root sheath of the human hair.
Alibardi L. | 12/22/2012 |
| The authors found that HPV 16 E6 but not E7 repressed IVL promoter activity in proliferating human foreskin keratinocyte cells. | Effects of human papillomavirus (HPV) type 16 oncoproteins on the expression of involucrin in human keratinocytes.
Gyöngyösi E, Szalmás A, Ferenczi A, Kónya J, Gergely L, Veress G., Free PMC Article | 05/12/2012 |
| higher expression in the fetal skin than in adult skin | Comparison between human fetal and adult skin.
Coolen NA, Schouten KC, Middelkoop E, Ulrich MM., Free PMC Article | 06/14/2010 |
| expression of the epidermal differentiation complex genes filaggrin and involucrin was strongly decreased directly by IL-13. | Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis.
Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, Buckmeier BK, Jameson SC, Greenberg A, Kaul A, Franciosi JP, Kushner JP, Martin LJ, Putnam PE, Abonia JP, Wells SI, Rothenberg ME., Free PMC Article | 05/3/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.
Stemmler S, Nothnagel M, Parwez Q, Petrasch-Parwez E, Epplen JT, Hoffjan S. | 09/16/2009 |
| Infection by HPV may alter the differentiation status of the epidermis, leading to earlier involucrin expression | Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis plane wart-type lesions.
Barcelos AC, Sotto MN. | 01/21/2010 |
| RT-PCR and western blot analysis revealed a delay in the expression of the differentiation markers K1, K10 and involucrin in HaCaT cells compared with normal human keratinocytes | Effects of extracellular calcium on the growth-differentiation switch in immortalized keratinocyte HaCaT cells compared with normal human keratinocytes.
Micallef L, Belaubre F, Pinon A, Jayat-Vignoles C, Delage C, Charveron M, Simon A. | 01/21/2010 |
| siRNA for PRKD1 resulted in reduction of mRNA levels of PKD1, altered cell phenotype and promotion of keratinocyte differentiation, demonstrated by increased expression of involucrin and keratin 10 mRNAs | Knockdown of PKD1 in normal human epidermal keratinocytes increases mRNA expression of keratin 10 and involucrin: early markers of keratinocyte differentiation.
Ivanova P, Atanasova G, Poumay Y, Mitev V. | 01/21/2010 |
| The expression of beta1-integrin was found to be significantly reduced in photoaged skin and ratios of the expressions of involucrin to beta1-integrin were increased 2.6-fold only in elderly subjects. | Photoaging-associated changes in epidermal proliferative cell fractions in vivo.
Kwon OS, Yoo HG, Han JH, Lee SR, Chung JH, Eun HC. | 01/21/2010 |
| PPAR gamma regulates involucrin expression by controlling the AP-1 signal and p38 activation in 1 alpha,25(OH)2D3-induced keratinocyte differentiation. | PPAR gamma is an important transcription factor in 1 alpha,25-dihydroxyvitamin D3-induced involucrin expression.
Dai X, Sayama K, Shirakata Y, Tokumaru S, Yang L, Tohyama M, Hirakawa S, Hanakawa Y, Hashimoto K. | 01/21/2010 |
| The expression of loricrin and involucrin in invovled and uninvolved skin of patients with atopic dermatitis is reported. | Loricrin and involucrin expression is down-regulated by Th2 cytokines through STAT-6.
Kim BE, Leung DY, Boguniewicz M, Howell MD., Free PMC Article | 01/21/2010 |
| These findings indicate that PKCdelta activity for activation of involucrin promoter requires Y(311) and a second tyrosine residue; however, any one of the several tyrosine residues can serve in the secondary role. | Multiple PKCdelta tyrosine residues are required for PKCdelta-dependent activation of involucrin expression--a key role of PKCdelta-Y311.
Zhu L, Brodie C, Balasubramanian S, Eckert RL., Free PMC Article | 01/21/2010 |
| a large multiprotein complex, which includes Fra-1, p300, P/CAF, junD, junB, and Sp1 acts at the AP1-5 site to produce a synergistic increase in hINV gene expression | Synergistic activation of human involucrin gene expression by Fra-1 and p300--evidence for the presence of a multiprotein complex.
Crish JF, Eckert RL., Free PMC Article | 01/21/2010 |
| BAG-1L also potentiated transactivation of known vitamin-D-responsive gene promoters, osteocalcin and 24-hydroxylase, and enhanced VDR-dependent transcription and protein expression of the keratinocyte differentiation marker, involucrin. | Subcellular localisation of BAG-1 and its regulation of vitamin D receptor-mediated transactivation and involucrin expression in oral keratinocytes: implications for oral carcinogenesis.
Lee SS, Crabb SJ, Janghra N, Carlberg C, Williams AC, Cutress RI, Packham G, Hague A. | 01/21/2010 |
| YY-1 and c-Jun transcription factors participate in the repression of the human involucrin promoter. | YY-1 and c-Jun transcription factors participate in the repression of the human involucrin promoter.
Alvarez-Salas LM, Benitez-Hess ML, Dipaolo JA. | 01/21/2010 |
| cascade regulates activator protein one, Sp1, and CCATT/enhancer-binding protein transcription factor DNA binding to two discrete involucrin promoter regions, the distal- and proximal-regulatory regions, to regulate involucrin gene expression. | Regulation of involucrin gene expression.
Eckert RL, Crish JF, Efimova T, Dashti SR, Deucher A, Bone F, Adhikary G, Huang G, Gopalakrishnan R, Balasubramanian S. | 01/21/2010 |
| Beta ig-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin alpha3beta1 and the phosphatidylinositol 3-kinase/Akt signaling pathway | Beta ig-h3 induces keratinocyte differentiation via modulation of involucrin and transglutaminase expression through the integrin alpha3beta1 and the phosphatidylinositol 3-kinase/Akt signaling pathway.
Oh JE, Kook JK, Min BM. | 01/21/2010 |
| cholesterol depletion alters involucrin gene expression through activation of p38alpha/beta. | Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38.
Jans R, Atanasova G, Jadot M, Poumay Y. | 01/21/2010 |
| role for AP1 transcription factors in the regulation of human corneal epithelial cell involucrin gene expression. | Regulation of involucrin expression in normal human corneal epithelial cells: a role for activator protein one.
Adhikary G, Crish J, Lass J, Eckert RL. | 01/21/2010 |