| Interaction of Integrin alphavbeta8 With Type I Collagen Promotes Squamous Cell Carcinoma Cell Motility via RAC1 Activation. | Interaction of Integrin αvβ8 With Type I Collagen Promotes Squamous Cell Carcinoma Cell Motility via RAC1 Activation.
Ishida Y, Shintani T, Nobumoto T, Sakurai S, Hamana T, Yanamoto S, Hayashido Y. | 11/3/2023 |
| Specificity of TGF-beta1 signal designated by LRRC33 and integrin alphaVbeta8. | Specificity of TGF-β1 signal designated by LRRC33 and integrin α(V)β(8).
Duan Z, Lin X, Wang L, Zhen Q, Jiang Y, Chen C, Yang J, Lee CH, Qin Y, Li Y, Zhao B, Wang J, Zhang Z., Free PMC Article | 09/3/2022 |
| Integrin subunit beta 8 contributes to lenvatinib resistance in HCC. | Integrin subunit beta 8 contributes to lenvatinib resistance in HCC.
Hou W, Bridgeman B, Malnassy G, Ding X, Cotler SJ, Dhanarajan A, Qiu W., Free PMC Article | 07/2/2022 |
| Paradoxical role of beta8 integrin on angiogenesis and vasculogenic mimicry in glioblastoma. | Paradoxical role of β8 integrin on angiogenesis and vasculogenic mimicry in glioblastoma.
Liu Y, Xu X, Zhang Y, Mo Y, Sun X, Shu L, Ke Y., Free PMC Article | 06/18/2022 |
| lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling. | lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling.
Lin X, Zhuang S, Chen X, Du J, Zhong L, Ding J, Wang L, Yi J, Hu G, Tang G, Luo X, Liu W, Ye F., Free PMC Article | 04/16/2022 |
| Circular RNA TTBK2 regulates cell proliferation, invasion and ferroptosis via miR-761/ITGB8 axis in glioma. | Circular RNA TTBK2 regulates cell proliferation, invasion and ferroptosis via miR-761/ITGB8 axis in glioma.
Zhang HY, Zhang BW, Zhang ZB, Deng QJ. | 03/20/2021 |
| The long non-coding RNA PVT1/miR-145-5p/ITGB8 axis regulates cell proliferation, apoptosis, migration and invasion in non-small cell lung cancer cells. | The long non-coding RNA PVT1/miR-145-5p/ITGB8 axis regulates cell proliferation, apoptosis, migration and invasion in non-small cell lung cancer cells.
Wei CM, Zhao XF, Qiu HB, Ming Z, Liu K, Yan J. | 11/21/2020 |
| Data uncovered that ITGB8 was a target gene of miR-106b. ITGB8 mRNA and protein levels decreased in colon cancer cells overexpressing miR-106b. | Has_circ_0055625 from circRNA profile increases colon cancer cell growth by sponging miR-106b-5p.
Zhang J, Liu H, Zhao P, Zhou H, Mao T. | 06/27/2020 |
| ITGB8 gene SNPs may be implicated in the risk of hemorrhagic event after a traumatic brain injury. | Effect of integrin AV and B8 gene polymorphisms in patients with traumatic brain injury.
Dardiotis E, Siokas V, Aloizou AM, Karampinis E, Brotis AG, Grigoriadis S, Paterakis K, Dardioti M, Komnos A, Kapsalaki E, Fountas K, Hadjigeorgiou GM. | 04/25/2020 |
| Lack of a binding site for one of three betaI domain divalent cations and a unique beta6-alpha7 loop conformation in beta8 facilitate movements of the alpha1 and alpha1' helices at the ligand binding pocket toward the high affinity state. | General structural features that regulate integrin affinity revealed by atypical αVβ8.
Wang J, Su Y, Iacob RE, Engen JR, Springer TA., Free PMC Article | 03/7/2020 |
| findings with the alphavbeta3 integrin suggests that our model of stabilizing the extended-closed conformation is generalizable to other integrins. | Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension.
Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y., Free PMC Article | 08/31/2019 |
| ITGB8 was significantly upregulated in ovarian cancer tissues compared to that in normal ovary tissues. High-grade Serous Ovarian Carcinoma patients with high ITGB8 expression had significantly shorter overall survival and recurrence-free survival compared to their low-expression counterparts. Increased ITGB8 expression might be an independent prognostic indicator of unfavorable overall survival | Integrin Subunit beta 8 (ITGB8) Upregulation Is an Independent Predictor of Unfavorable Survival of High-Grade Serous Ovarian Carcinoma Patients.
He J, Liu Y, Zhang L, Zhang H., Free PMC Article | 03/9/2019 |
| ITGB8 is identified as a novel target of miR-26a-5p. | MiR-26a-5p potentiates metastasis of human lung cancer cells by regulating ITGβ8- JAK2/STAT3 axis.
Song Q, Liu B, Li X, Zhang Q, Cao L, Xu M, Meng Z, Wu X, Xu K. | 10/27/2018 |
| our results indicate that miR-199a-3p enhances cisplatinsensitivity of ovarian cancer cells through downregulating ITGB8 expression, and miR-199a-3p may serve as a therapeutic target for the treatment of ovarian cancer patients with cisplatin-resistance. | miR-199a-3p enhances cisplatin sensitivity of ovarian cancer cells by targeting ITGB8.
Cui Y, Wu F, Tian D, Wang T, Lu T, Huang X, Zhang P, Qin L., Free PMC Article | 08/25/2018 |
| In cellular model, the microRNA-513a-3p was identified as a novel element targeting ITG-beta8, thereby controlling the protein level and its molecular function in the controlling of migration and pro-inflammatory environment. | Mir-513a-3p contributes to the controlling of cellular migration processes in the A549 lung tumor cells by modulating integrin β-8 expression.
da Silveira MB, Lima KF, da Silva AR, Dos Santos RAS, Moraes KCM. | 07/28/2018 |
| Among Greek and Polish patients with intracerebral hemorrhage, heterozygous individuals with the rs10251386 and the rs10239099 of the ITGB8 gene had significantly lower age of ICH onset compared to the wild-type genotypes. | Integrins AV and B8 Gene Polymorphisms and Risk for Intracerebral Hemorrhage in Greek and Polish Populations.
Dardiotis E, Siokas V, Zafeiridis T, Paterakis K, Tsivgoulis G, Dardioti M, Grigoriadis S, Simeonidou C, Deretzi G, Zintzaras E, Jagiella J, Hadjigeorgiou GM. | 06/2/2018 |
| Although Mn(2+) potently activates other integrins and increases affinity of alphaVbeta6 for pro-TGF-beta1 25- to 55-fold, it increases alphaVbeta8 affinity only 2- to 3-fold. | Atypical interactions of integrin α(V)β(8) with pro-TGF-β1.
Wang J, Dong X, Zhao B, Li J, Lu C, Springer TA., Free PMC Article | 05/19/2018 |
| The results demonstrated that the hsa_circ_0046701/miR-142-3p/ITGB8 axis might play critical regulatory roles in the pathogenesis and development of glioma. | A novel circular RNA, hsa_circ_0046701, promotes carcinogenesis by increasing the expression of miR-142-3p target ITGB8 in glioma.
Li G, Yang H, Han K, Zhu D, Lun P, Zhao Y. | 04/7/2018 |
| this study uncovers a novel pathway by which the TGFbeta-activating integrin alphavbeta8 is expressed in the human intestine on dendritic cell subsets, which is upregulated in patients with inflammatory bowel disease | Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.
Fenton TM, Kelly A, Shuttleworth EE, Smedley C, Atakilit A, Powrie F, Campbell S, Nishimura SL, Sheppard D, Levison S, Worthington JJ, Lehtinen MJ, Travis MA., Free PMC Article | 01/27/2018 |
| Integrins alphavbeta6 and alphavbeta8 were expressed in non-overlapping patterns by keratinocytes and maintained the epidermal residence of Langerhans cells and tissue resident memory T cells by activating latent TGF-beta. | Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.
Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH., Free PMC Article | 08/13/2016 |
| Integrin beta8 was differentially expressed between Fibromyalgia patients and healthy controls. | Genome-wide expression profiling in the peripheral blood of patients with fibromyalgia.
Jones KD, Gelbart T, Whisenant TC, Waalen J, Mondala TS, Iklé DN, Salomon DR, Bennett RM, Kurian SM., Free PMC Article | 07/16/2016 |
| Integrin Beta8 plays a role in the motility of prostate cancer cells. | The tumour-promoting receptor tyrosine kinase, EphB4, regulates expression of integrin-β8 in prostate cancer cells.
Mertens-Walker I, Fernandini BC, Maharaj MS, Rockstroh A, Nelson CC, Herington AC, Stephenson SA., Free PMC Article | 01/23/2016 |
| Herpes simplex virus entry is enabled by gH/gL interaction with alphavbeta6- or alphavbeta8-integrin receptors. | Dissociation of HSV gL from gH by αvβ6- or αvβ8-integrin promotes gH activation and virus entry.
Gianni T, Massaro R, Campadelli-Fiume G., Free PMC Article | 10/17/2015 |
| data show that integrin beta 8, but not integrin beta 5 or integrin beta 6, protein expression is increased in liver specimens of patients with biliary atresia | Integrin β-8, but not β-5 or -6, protein expression is increased in livers of children with biliary atresia.
Iordanskaia T, Koeck E, Rossi C, Mohan P, Schwarz K, Anders R, Nadler EP. | 07/25/2015 |
| overexpression of integrin alphav induces integrin alphavb8 heterodimer formation and the binding of integrin alphavbeta8 to type collagen might enhance the proliferation and invasion of SCC cells via the activation of the MEK/ERK signaling pathway. | Overexpression of integrin αv facilitates proliferation and invasion of oral squamous cell carcinoma cells via MEK/ERK signaling pathway that is activated by interaction of integrin αvβ8 with type Ⅰ collagen.
Hayashido Y, Kitano H, Sakaue T, Fujii T, Suematsu M, Sakurai S, Okamoto T. | 05/30/2015 |