| PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the beta5 integrin. | PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the β5 integrin.
Datta R, Mukherjee D, Podolsky MJ, Yang CD, Alba DL, Singh S, Arnold TD, Koliwad S, Lizama CO, Atabai K., Free PMC Article | 02/27/2024 |
| Assessment Of Endometrial Integrin Beta 5 In Women With Unexplained Recurrent Pregnancy Loss. | Assessment Of Endometrial Integrin Beta 5 In Women With Unexplained Recurrent Pregnancy Loss.
Fathy AM, Rizk AY, El Azeez Nosair NA, Abdelkarim AM, Ellakany MF. | 07/27/2023 |
| Integrin alphavbeta5 heterodimer is a specific marker of human pancreatic beta cells. | Integrin αvβ5 heterodimer is a specific marker of human pancreatic beta cells.
Schiesser JV, Loudovaris T, Thomas HE, Elefanty AG, Stanley EG., Free PMC Article | 01/15/2022 |
| Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells. | Scavenger receptor MARCO contributes to macrophage phagocytosis and clearance of tumor cells.
Xing Q, Feng Y, Sun H, Yang S, Sun T, Guo X, Ji F, Wu B, Zhou D. | 12/11/2021 |
| Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin alphavbeta5 Axis. | Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin α(v)β(5) Axis.
Zhu Z, Mesci P, Bernatchez JA, Gimple RC, Wang X, Schafer ST, Wettersten HI, Beck S, Clark AE, Wu Q, Prager BC, Kim LJY, Dhanwani R, Sharma S, Garancher A, Weis SM, Mack SC, Negraes PD, Trujillo CA, Penalva LO, Feng J, Lan Z, Zhang R, Wessel AW, Dhawan S, Diamond MS, Chen CC, Wechsler-Reya RJ, Gage FH, Hu H, Siqueira-Neto JL, Muotri AR, Cheresh DA, Rich JN., Free PMC Article | 05/8/2021 |
| Findings indicate integrin inhibition as a promising strategy to block both aryl hydrocarbon receptor (AhR) and transforming growth factor beta (TGF-beta)-controlled features of malignancy in glioblastoma. | The aryl hydrocarbon receptor links integrin signaling to the TGF-β pathway.
Silginer M, Burghardt I, Gramatzki D, Bunse L, Leske H, Rushing EJ, Hao N, Platten M, Weller M, Roth P. | 09/16/2017 |
| High ITGB5 expression is associated with cervical cancer. | Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin α2/β5/FAK signaling pathway.
Liu F, Tong D, Li H, Liu M, Li J, Wang Z, Cheng X., Free PMC Article | 01/14/2017 |
| Data suggest that the binding, but not the internalization of photoreceptor outer segments (POS) confers protective effects on retinal pigment epithelium (RPE) cells through the alphavbeta5 integrin/focal adhesion kinase (FAK)/PGC-1alpha pathway. | αvβ5 Integrin/FAK/PGC-1α Pathway Confers Protective Effects on Retinal Pigment Epithelium.
Roggia MF, Ueta T., Free PMC Article | 05/14/2016 |
| ITGA3, ITGA6, ITGB3,ITGB4 and ITGB5 are associated with GC susceptibility (rs2675), ITGA3, ITGA6, ITGB3, ITGB4 and ITGB5 are associated with gastric cancer susceptibility tumor stage and lymphatic metastasis in Chinese Han population | Association between polymorphisms of microRNA-binding sites in integrin genes and gastric cancer in Chinese Han population.
Song X, Zhong H, Zhou J, Hu X, Zhou Y, Ye Y, Lu X, Wang J, Ying B, Wang L. | 07/25/2015 |
| FAK activity regulates beta5 integrin expression and anchorage-independent cell growth in ovarian carcinoma. | FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth.
Tancioni I, Uryu S, Sulzmaier FJ, Shah NR, Lawson C, Miller NL, Jean C, Chen XL, Ward KK, Schlaepfer DD., Free PMC Article | 05/16/2015 |
| Integrins alphavbeta5 and alphavbeta3 both control myofibroblast differentiation by activating latent TGF-beta1 | Integrins αvβ5 and αvβ3 promote latent TGF-β1 activation by human cardiac fibroblast contraction.
Sarrazy V, Koehler A, Chow ML, Zimina E, Li CX, Kato H, Caldarone CA, Hinz B., Free PMC Article | 03/7/2015 |
| FRMD5 regulates tumor cell motility via a dual pathway involving FRMD5 binding to integrin beta5 tail and to ROCK1 | FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin β5 subunit and ROCK1.
Hu J, Niu M, Li X, Lu D, Cui J, Xu W, Li G, Zhan J, Zhang H. | 01/31/2015 |
| Immunohistochemical analysis for alphavbeta3, alphavbeta5 and alphavbeta6 integrin subunits was performed and correlated with Ki67 and hypoxia-inducible factor (HIF)-1alpha indexes | αvβ3, αvβ5 and αvβ6 integrins in brain metastases of lung cancer.
Berghoff AS, Kovanda AK, Melchardt T, Bartsch R, Hainfellner JA, Sipos B, Schittenhelm J, Zielinski CC, Widhalm G, Dieckmann K, Weller M, Goodman SL, Birner P, Preusser M. | 12/20/2014 |
| Myo7a interacts with integrin beta5 and selectively promotes integrin alphavbeta5-mediated cell migration | FERM domain-containing unconventional myosin VIIA interacts with integrin β5 subunit and regulates αvβ5-mediated cell adhesion and migration.
Liu Y, Guan L, Zhan J, Lu D, Wan J, Zhang H. | 10/18/2014 |
| findings suggest that Alpha(v)Beta5 integrins and their natural ligand VN are involved in P. fluorescens adherence and invasion in human epithelial cells | AlphaVBeta5 integrins mediates Pseudomonas fluorescens interaction with A549 cells.
Buommino E, Di Domenico M, Paoletti I, Fusco A, De Gregorio V, Cozza V, Rizzo A, Tufano MA, Donnarumma G. | 09/20/2014 |
| we demonstrated via antibody blocking experiments that aV b5 and a6 significantly promoted hESC attachment in 2%oxygen only, whereas blockage of CD44 inhibited cell attachment in 21% O2 alone | αV β5 and CD44 are oxygen-regulated human embryonic stem cell attachment factors.
Kumar D, Gupta S, Yang Y, Forsyth NR., Free PMC Article | 08/9/2014 |
| Brain metastases ITGB5 expression exhibits considerable heterogeneity according to tumor origin. | Comparing the expression of integrins αvβ3, αvβ5, αvβ6, αvβ8, fibronectin and fibrinogen in human brain metastases and their corresponding primary tumors.
Schittenhelm J, Klein A, Tatagiba MS, Meyermann R, Fend F, Goodman SL, Sipos B., Free PMC Article | 08/9/2014 |
| Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. | Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β.
Bianchi-Smiraglia A, Kunnev D, Limoge M, Lee A, Beckerle MC, Bakin AV., Free PMC Article | 06/7/2014 |
| molecular model of integrin b5 structure was prepared and stereo chemical model quality was checked. Integrin b5 active sites were identified based on insilico analysis tools. | Structural insights into the extra cellular segment of integrinβ5 and molecular interaction studies.
Setti A, Sankati HS, Devi TA, Sekhar AC, Rao JV, Pawar SC. | 05/10/2014 |
| BDNF enhances the migration of chondrosarcoma by increasing beta5 integrin expression through a signal transduction pathway that involves the TrkB receptor, PI3K, Akt, and NF-kappaB. | β5 integrin up-regulation in brain-derived neurotrophic factor promotes cell motility in human chondrosarcoma.
Lin CY, Chen HJ, Li TM, Fong YC, Liu SC, Chen PC, Tang CH., Free PMC Article | 03/1/2014 |
| Data suggest that the integrin alphaVbeta5 receptor is largely responsible for mediating the differentiation process in pancreatic cells. | The differentiation of pancreatic tumor-initiating cells by vitronectin can be blocked by cilengitide.
Cabarcas SM, Sun L, Mathews L, Thomas S, Zhang X, Farrar WL., Free PMC Article | 01/25/2014 |
| The top primary GWAS association of Airway hyperresponsiveness was in rs848788(P-value 7.2E-07) located within the ITGB5 genes. | ITGB5 and AGFG1 variants are associated with severity of airway responsiveness.
Himes BE, Qiu W, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF Jr, Zeiger RS, Strunk RC, Martinez FD, Boushey H, Chinchilli VM, Israel E, Mauger D, Koppelman GH, Nieuwenhuis MA, Postma DS, Vonk JM, Rafaels N, Hansel NN, Barnes K, Raby B, Tantisira KG, Weiss ST., Free PMC Article | 01/11/2014 |
| Depletion of integrin beta5 in triple-negative breast carcinoma cells markedly reduced tumor take, growth and tumor angiogenesis, whereas reexpression of integrin beta5 rescued this phenotype; findings show a critical role for integrin beta5 in the tumorigenic potential of breast carcinoma cells | Integrin β5 contributes to the tumorigenic potential of breast cancer cells through the Src-FAK and MEK-ERK signaling pathways.
Bianchi-Smiraglia A, Paesante S, Bakin AV., Free PMC Article | 08/31/2013 |
| integrin alphavbeta5 might play an important role in invasion and metastases of laryngeal squamous cell carcinoma | Elevated expression of integrin αv and β5 subunit in laryngeal squamous-cell carcinoma associated with lymphatic metastasis and angiogenesis.
Li F, Liu Y, Kan X, Li Y, Liu M, Lu JG. | 08/31/2013 |
| CTGF increased IL-6 production in osteoarthritic synovial fibroblasts via the alphavbeta5 integrin, ASK1, p38/JNK, and AP-1/NF-kappaB signaling pathways. | CTGF increases IL-6 expression in human synovial fibroblasts through integrin-dependent signaling pathway.
Liu SC, Hsu CJ, Chen HT, Tsou HK, Chuang SM, Tang CH., Free PMC Article | 05/25/2013 |