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    ITGB3 integrin subunit beta 3 [ Homo sapiens (human) ]

    Gene ID: 3690, updated on 13-Apr-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Endometrial BMP2 Deficiency Impairs ITGB3-Mediated Trophoblast Invasion in Women With Repeated Implantation Failure.

    Endometrial BMP2 Deficiency Impairs ITGB3-Mediated Trophoblast Invasion in Women With Repeated Implantation Failure.
    Hu C, Deng J, Liu M, Ni T, Chen ZJ, Yan J, Li Y.

    02/5/2024
    The role of thrombomodulin in modulating ITGB3 expression and its implications for triple-negative breast cancer progression.

    The role of thrombomodulin in modulating ITGB3 expression and its implications for triple-negative breast cancer progression.
    Chang YJ, Prince GMSH, Wei PL, Batzorig U, Huang CY, Hung CS, Chang TC.

    01/26/2024
    Integrin-alphavbeta3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance.

    Integrin-αvβ3 is a Therapeutically Targetable Fundamental Factor in Medulloblastoma Tumorigenicity and Radioresistance.
    Echavidre W, Durivault J, Gotorbe C, Blanchard T, Pagnuzzi M, Vial V, Raes F, Broisat A, Villeneuve R, Amblard R, Garnier N, Ortholan C, Faraggi M, Serrano B, Picco V, Montemagno C., Free PMC Article

    12/21/2023
    Effect of c.1431C > T mutation, a causative mutation of Glanzmann's thrombasthenia, on ITGB3 splicing, gene and protein expression.

    Effect of c.1431C > T mutation, a causative mutation of Glanzmann's thrombasthenia, on ITGB3 splicing, gene and protein expression.
    Wang D, Lai P, Lu Q, El-Magd MA, Li X.

    10/10/2023
    A single F153Sbeta3 mutation causes constitutive integrin alphaIIbbeta3 activation in a variant form of Glanzmann thrombasthenia.

    A single F153Sβ3 mutation causes constitutive integrin αIIbβ3 activation in a variant form of Glanzmann thrombasthenia.
    Koukouritaki SB, Thinn AMM, Ashworth KJ, Fang J, Slater HS, Du LM, Nguyen HTT, Pillois X, Nurden AT, Ng CJ, Di Paola J, Zhu J, Wilcox DA., Free PMC Article

    09/12/2023
    Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin alphavbeta3.

    Molecular basis for the recognition of 24-(S)-hydroxycholesterol by integrin αvβ3.
    Gc JB, Chen J, Pokharel SM, Mohanty I, Mariasoosai C, Obi P, Panipinto P, Bandyopadhyay S, Bose S, Natesan S., Free PMC Article

    06/8/2023
    ITGB3 promotes cisplatin resistance in osteosarcoma tumors.

    ITGB3 promotes cisplatin resistance in osteosarcoma tumors.
    Li Q, Chen G, Jiang H, Dai H, Li D, Zhu K, Zhang K, Shen H, Xu H, Li S., Free PMC Article

    05/3/2023
    Genetic screening of PLA1/PLA2 polymorphous marker of integrin beta 3 (ITGB3) GP IIIA gene in adolescent girls with puberty menorrhagia.

    Genetic screening of PLA1/PLA2 polymorphous marker of integrin beta 3 (ITGB3) GP IIIA gene in adolescent girls with puberty menorrhagia.
    Tsysar YV, Andriiets OA, Dubyk LV, Dyak KV, Radu RM., Free PMC Article

    03/27/2023
    Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood.

    Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood.
    Landsem A, Emblem Å, Lau C, Christiansen D, Gerogianni A, Karlsen BO, Mollnes TE, Nilsson PH, Brekke OL., Free PMC Article

    01/14/2023
    A Novel Frameshift Mutation in the ITGB3 Gene Leading to Glanzmann's Thrombasthenia in a Saudi Arabian Family.

    A Novel Frameshift Mutation in the ITGB3 Gene Leading to Glanzmann's Thrombasthenia in a Saudi Arabian Family.
    Alharbi A, Hashmi JA, Alharby E, Albalawi AM, Ramzan K, Basit S.

    12/3/2022
    Relation among EGFL7, ITGB3, and KLF2 and their clinical implication in multiple myeloma patients: a prospective study.

    Relation among EGFL7, ITGB3, and KLF2 and their clinical implication in multiple myeloma patients: a prospective study.
    Li Y, Zhang L, Gong J., Free PMC Article

    10/1/2022
    Positive feedback regulation of lncRNA TPT1-AS1 and ITGB3 promotes cell growth and metastasis in pancreatic cancer.

    Positive feedback regulation of lncRNA TPT1-AS1 and ITGB3 promotes cell growth and metastasis in pancreatic cancer.
    Cheng C, Liu D, Liu Z, Li M, Wang Y, Sun B, Kong R, Chen H, Wang G, Li L, Hu J, Li Y, Chen H, Zhao Z, Zhang T, Zhu S, Pan S., Free PMC Article

    09/24/2022
    microRNA-25-3p suppresses osteogenic differentiation of BMSCs in patients with osteoporosis by targeting ITGB3.

    microRNA-25-3p suppresses osteogenic differentiation of BMSCs in patients with osteoporosis by targeting ITGB3.
    Yu D, Li Z, Cao J, Shen F, Wei G.

    08/20/2022
    New alphaIIbbeta3 variants in 28 Turkish Glanzmann patients; structural hypothesis for complex activation by residues variations in I-EGF domains.

    New αIIbβ3 variants in 28 Turkish Glanzmann patients; structural hypothesis for complex activation by residues variations in I-EGF domains.
    Koker MY, Sarper N, Albayrak C, Zulfikar B, Zengin E, Saraymen B, Albayrak D, Koc B, Avcilar H, Karakükcü M, Chenet C, Bianchi F, de Brevern AG, Petermann R, Jallu V.

    06/18/2022
    Angiopoietin-like 3 (ANGPTL3) drives cell proliferation, migration and angiogenesis in cervical cancer via binding to integrin alpha v beta 3.

    Angiopoietin-like 3 (ANGPTL3) drives cell proliferation, migration and angiogenesis in cervical cancer via binding to integrin alpha v beta 3.
    Zhong L, Tang L, He X., Free PMC Article

    03/12/2022
    The Effects of alphavbeta3 Integrin Blockage in Breast Tumor and Endothelial Cells under Hypoxia In Vitro.

    The Effects of αvβ3 Integrin Blockage in Breast Tumor and Endothelial Cells under Hypoxia In Vitro.
    Casali BC, Gozzer LT, Baptista MP, Altei WF, Selistre-de-Araújo HS., Free PMC Article

    03/5/2022
    Overexpressed LINC00467 promotes the viability and proliferation yet inhibits apoptosis of gastric cancer cells via raising ITGB3 level.

    Overexpressed LINC00467 promotes the viability and proliferation yet inhibits apoptosis of gastric cancer cells via raising ITGB3 level.
    Xu L, Liu C, Ye Z, Wu C, Ding Y, Huang J.

    03/5/2022
    The VWF/LRP4/alphaVbeta3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells.

    The VWF/LRP4/αVβ3-axis represents a novel pathway regulating proliferation of human vascular smooth muscle cells.
    Lagrange J, Worou ME, Michel JB, Raoul A, Didelot M, Muczynski V, Legendre P, Plénat F, Gauchotte G, Lourenco-Rodrigues MD, Christophe OD, Lenting PJ, Lacolley P, Denis CV, Regnault V.

    03/5/2022
    A Novel Homozygous Frameshift Mutation in ITGB3 Causes Glanzmann's Thrombasthenia.

    A Novel Homozygous Frameshift Mutation in ITGB3 Causes Glanzmann's Thrombasthenia.
    Li X, Xu J, Li Z, Song Y, Fei Y, Yang G, Tang A.

    02/12/2022
    Genetic and epigenetic changes in the eutopic endometrium of women with endometriosis: association with decreased endometrial alphavbeta3 integrin expression.

    Genetic and epigenetic changes in the eutopic endometrium of women with endometriosis: association with decreased endometrial αvβ3 integrin expression.
    Joshi NR, Kohan-Ghadr HR, Roqueiro DS, Yoo JY, Fru K, Hestermann E, Yuan L, Ho SM, Jeong JW, Young SL, Lessey BA, Fazleabas AT., Free PMC Article

    01/22/2022
    Epigenetic induction of lipocalin 2 expression drives acquired resistance to 5-fluorouracil in colorectal cancer through integrin beta3/SRC pathway.

    Epigenetic induction of lipocalin 2 expression drives acquired resistance to 5-fluorouracil in colorectal cancer through integrin β3/SRC pathway.
    Zhang W, Pan R, Lu M, Zhang Q, Lin Z, Qin Y, Wang Z, Gong S, Lin H, Chong S, Lu L, Liao W, Lu X.

    01/1/2022
    Identification of three novel pathogenic ITGA2B and one novel pathogenic ITGB3 mutations in patients with hereditary Glanzmann's thrombasthenia living in Eastern Turkey.

    Identification of three novel pathogenic ITGA2B and one novel pathogenic ITGB3 mutations in patients with hereditary Glanzmann's thrombasthenia living in Eastern Turkey.
    Karaman K, Yürektürk E, Geylan H, Yaşar AŞ, Karaman S, Aymelek HS, Çetin M, Oner AF.

    12/25/2021
    An alternate covalent form of platelet alphaIIbbeta3 integrin that resides in focal adhesions and has altered function.

    An alternate covalent form of platelet αIIbβ3 integrin that resides in focal adhesions and has altered function.
    Pijning AE, Blyth MT, Coote ML, Passam F, Chiu J, Hogg PJ., Free PMC Article

    12/11/2021
    beta3-integrin Leu33Pro gain of function variant does not modulate inflammatory activity in human derived macrophages in diabetes.

    β3-integrin Leu33Pro gain of function variant does not modulate inflammatory activity in human derived macrophages in diabetes.
    Helmer P, Damm E, Schiekofer S, Roomp K, Schneider JG., Free PMC Article

    12/11/2021
    Overexpression and Activation of alphavbeta3 Integrin Differentially Affects TGFbeta2 Signaling in Human Trabecular Meshwork Cells.

    Overexpression and Activation of αvβ3 Integrin Differentially Affects TGFβ2 Signaling in Human Trabecular Meshwork Cells.
    Filla MS, Meyer KK, Faralli JA, Peters DM., Free PMC Article

    12/4/2021
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