| Molecular dynamics simulations corroborate recombinant expression studies carried out on three alphaIIb beta-propeller mutations reported in Indian Glanzmann thrombasthenia patients. | Molecular dynamics simulations corroborate recombinant expression studies carried out on three αIIb β-propeller mutations reported in Indian Glanzmann thrombasthenia patients.
Chandrasekaran FP, Vishal A, Arora U, Kumar S U, George C PD, Nelson EJR. | 07/24/2023 |
| Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood. | Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood.
Landsem A, Emblem Å, Lau C, Christiansen D, Gerogianni A, Karlsen BO, Mollnes TE, Nilsson PH, Brekke OL., Free PMC Article | 01/14/2023 |
| New alphaIIbbeta3 variants in 28 Turkish Glanzmann patients; structural hypothesis for complex activation by residues variations in I-EGF domains. | New αIIbβ3 variants in 28 Turkish Glanzmann patients; structural hypothesis for complex activation by residues variations in I-EGF domains.
Koker MY, Sarper N, Albayrak C, Zulfikar B, Zengin E, Saraymen B, Albayrak D, Koc B, Avcilar H, Karakükcü M, Chenet C, Bianchi F, de Brevern AG, Petermann R, Jallu V. | 06/18/2022 |
| Ectopic Expression of FVIII in HPCs and MSCs Derived from hiPSCs with Site-Specific Integration of ITGA2B Promoter-Driven BDDF8 Gene in Hemophilia A. | Ectopic Expression of FVIII in HPCs and MSCs Derived from hiPSCs with Site-Specific Integration of ITGA2B Promoter-Driven BDDF8 Gene in Hemophilia A.
Zhao J, Zhou M, Wang Z, Wu L, Hu Z, Liang D., Free PMC Article | 02/26/2022 |
| Nonsense-mediated mRNA decay efficiency influences bleeding severity in ITGA2B c.2659C > T (p.Q887X) knock-in mice. | Nonsense-mediated mRNA decay efficiency influences bleeding severity in ITGA2B c.2659C > T (p.Q887X) knock-in mice.
Xie Z, Jiang J, Cao L, Jiang M, Yang F, Ma Z, Wang Z, Ruan C, Liu H, Zhou L. | 01/1/2022 |
| Identification of three novel pathogenic ITGA2B and one novel pathogenic ITGB3 mutations in patients with hereditary Glanzmann's thrombasthenia living in Eastern Turkey. | Identification of three novel pathogenic ITGA2B and one novel pathogenic ITGB3 mutations in patients with hereditary Glanzmann's thrombasthenia living in Eastern Turkey.
Karaman K, Yürektürk E, Geylan H, Yaşar AŞ, Karaman S, Aymelek HS, Çetin M, Oner AF. | 12/25/2021 |
| An alternate covalent form of platelet alphaIIbbeta3 integrin that resides in focal adhesions and has altered function. | An alternate covalent form of platelet αIIbβ3 integrin that resides in focal adhesions and has altered function.
Pijning AE, Blyth MT, Coote ML, Passam F, Chiu J, Hogg PJ., Free PMC Article | 12/11/2021 |
| ITGA2, LAMB3, and LAMC2 may be the potential therapeutic targets in pancreatic ductal adenocarcinoma: an integrated bioinformatics analysis. | ITGA2, LAMB3, and LAMC2 may be the potential therapeutic targets in pancreatic ductal adenocarcinoma: an integrated bioinformatics analysis.
Islam S, Kitagawa T, Baron B, Abiko Y, Chiba I, Kuramitsu Y., Free PMC Article | 11/13/2021 |
| Genetic Confirmation and Identification of Novel Variants for Glanzmann Thrombasthenia and Other Inherited Platelet Function Disorders: A Study by the Korean Pediatric Hematology Oncology Group (KPHOG). | Genetic Confirmation and Identification of Novel Variants for Glanzmann Thrombasthenia and Other Inherited Platelet Function Disorders: A Study by the Korean Pediatric Hematology Oncology Group (KPHOG).
Yang EJ, Shim YJ, Kim HS, Lim YT, Im HJ, Koh KN, Kim H, Suh JK, Park ES, Lee NH, Choi YB, Hah JO, Lee JM, Han JW, Lee JH, Lee YH, Jung HL, Ha JS, Ki CS, On Behalf Of The Benign Hematology Committee Of The Korean Pediatric Hematology Oncology Group Kphog., Free PMC Article | 09/4/2021 |
| Biphasic alpha2beta1 Integrin Expression in Breast Cancer Metastasis to Bone. | Biphasic α2β1 Integrin Expression in Breast Cancer Metastasis to Bone.
Moritz MNO, Merkel AR, Feldman EG, Selistre-de-Araujo HS, Rhoades Sterling JA., Free PMC Article | 07/31/2021 |
| Relationship of Platelet Glycoprotein IIb/IIIa and CD62P With Hypercoagulable State After Oncologic Surgery. | Relationship of Platelet Glycoprotein IIb/IIIa and CD62P With Hypercoagulable State After Oncologic Surgery.
Zhong X, Cao Z, Song J, Liu Y, Guo Q., Free PMC Article | 07/31/2021 |
| Nonredundant Roles of Platelet Glycoprotein VI and Integrin alphaIIbbeta3 in Fibrin-Mediated Microthrombus Formation. | Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbβ3 in Fibrin-Mediated Microthrombus Formation.
Perrella G, Huang J, Provenzale I, Swieringa F, Heubel-Moenen FCJI, Farndale RW, Roest M, van der Meijden PEJ, Thomas M, Ariëns RAS, Jandrot-Perrus M, Watson SP, Heemskerk JWM. | 06/5/2021 |
| Activated alphaIIbbeta3 on platelets mediates flow-dependent NETosis via SLC44A2. | Activated α(IIb)β(3) on platelets mediates flow-dependent NETosis via SLC44A2.
Constantinescu-Bercu A, Grassi L, Frontini M, Salles-Crawley II, Woollard K, Crawley JT., Free PMC Article | 04/3/2021 |
| Heterogeneity of Integrin alphaIIbbeta3 Function in Pediatric Immune Thrombocytopenia Revealed by Continuous Flow Cytometry Analysis. | Heterogeneity of Integrin α(IIb)β(3) Function in Pediatric Immune Thrombocytopenia Revealed by Continuous Flow Cytometry Analysis.
Martyanov AA, Morozova DS, Sorokina MA, Filkova AA, Fedorova DV, Uzueva SS, Suntsova EV, Novichkova GA, Zharkov PA, Panteleev MA, Sveshnikova AAN., Free PMC Article | 02/6/2021 |
| alphaIIbbeta3 variants in ten families with autosomal dominant macrothrombocytopenia: Expanding the mutational and clinical spectrum. | αIIbβ3 variants in ten families with autosomal dominant macrothrombocytopenia: Expanding the mutational and clinical spectrum.
Morais S, Oliveira J, Lau C, Pereira M, Gonçalves M, Monteiro C, Gonçalves AR, Matos R, Sampaio M, Cruz E, Freitas I, Santos R, Lima M., Free PMC Article | 01/16/2021 |
| Clinical significance of CD41-positive blasts in association with a monosomal karyotype in patients with myelodysplastic syndrome treated with azacitidine. | Clinical significance of CD41-positive blasts in association with a monosomal karyotype in patients with myelodysplastic syndrome treated with azacitidine.
Ogata K, Sei K, Kawahara N, Yamamoto Y. | 01/16/2021 |
| Association among PlA1/A2 gene polymorphism, laboratory aspirin resistance and clinical outcomes in patients with coronary artery disease: An updated meta-analysis. | Association among PlA1/A2 gene polymorphism, laboratory aspirin resistance and clinical outcomes in patients with coronary artery disease: An updated meta-analysis.
Wang J, Liu J, Zhou Y, Wang F, Xu K, Kong D, Bai J, Chen J, Gong X, Meng H, Li C., Free PMC Article | 10/31/2020 |
| HPA3 polymorphism of alphaIIbbeta3 is associated with atherosclerosis in Sudanese patients, while HPA1 polymorphism is not | Association of Platelet Integrin α(IIb)β(3) Polymorphisms with Atherosclerotic Coronary Heart Disease in Sudanese Patients.
Elsidege Ali LA, Mahdi Hassan F. | 08/1/2020 |
| This is the first report of a family with AD thrombocytopenia with normal platelet size resulting from mutation in ITGA2B. ITGA2B mutations should therefore be included in the differential diagnosis of this latter disorder. | Genome-wide linkage analysis and whole-exome sequencing identifies an ITGA2B mutation in a family with thrombocytopenia.
Khoriaty R, Ozel AB, Ramdas S, Ross C, Desch K, Shavit JA, Everett L, Siemieniak D, Li JZ, Ginsburg D., Free PMC Article | 06/6/2020 |
| Alanine replacements in the heterodimer stalk interface destabilize the inactive conformation causing constitutive alphaIIbB activation. | Modulating Integrin αIIbβ3 Activity through Mutagenesis of Allosterically Regulated Intersubunit Contacts.
Tan SK, Fong KP, Polizzi NF, Sternisha A, Slusky JSG, Yoon K, DeGrado WF, Bennett JS., Free PMC Article | 05/30/2020 |
| strong association between rheumatological manifestations and HPA-3 polymorphism in hepatitis C patients | Human platelet antigen-3 polymorphism as a risk factor for rheumatological manifestations in hepatitis C.
Medolago NB, Ferrasi AC, Rocha OMD, Pardini MIMC, Grotto RMT, Galvani AF, Silva GF., Free PMC Article | 05/16/2020 |
| a new etiology for macrothrombocytopenia, in which increased RhoA activity is associated with disrupted FLNa/alphaIIbbeta3 interaction. | Disrupted filamin A/α(IIb)β(3) interaction induces macrothrombocytopenia by increasing RhoA activity.
Donada A, Balayn N, Sliwa D, Lordier L, Ceglia V, Baschieri F, Goizet C, Favier R, Tosca L, Tachdjian G, Denis CV, Plo I, Vainchenker W, Debili N, Rosa JP, Bryckaert M, Raslova H., Free PMC Article | 12/28/2019 |
| We identified a total of 43 different ITGA2B and ITGB3 variants, including 25 previously unidentified, in 45 patients. These variants included 14 missense, 4 nonsense, 4 frameshift, and 3 splicing site variants. Patients with the same genotype generally manifested the same GT type but presented with different bleeding severities | Clinical and molecular insights into Glanzmann's thrombasthenia in China.
Zhou L, Jiang M, Shen H, You T, Ding Z, Cui Q, Ma Z, Yang F, Xie Z, Shi H, Su J, Cao L, Lin J, Yin J, Dai L, Wang H, Wang Z, Yu Z, Ruan C, Xia L., Free PMC Article | 11/16/2019 |
| alphaIIbbeta3 binding to polymeric fibrin can be segregated into two binding regimes, one with weaker rupture forces of 30-60 pN and a second with stronger rupture forces >60 pN that peaked at 70-80 pN. | Strong Binding of Platelet Integrin αIIbβ3 to Fibrin Clots: Potential Target to Destabilize Thrombi.
Höök P, Litvinov RI, Kim OV, Xu S, Xu Z, Bennett JS, Alber MS, Weisel JW., Free PMC Article | 07/6/2019 |
| ERp5 triggers fibrinogen dissociation from aIIbb3 integrin. | Mechano-redox control of integrin de-adhesion.
Passam F, Chiu J, Ju L, Pijning A, Jahan Z, Mor-Cohen R, Yeheskel A, Kolšek K, Thärichen L, Aponte-Santamaría C, Gräter F, Hogg PJ., Free PMC Article | 04/13/2019 |