| Identification of INSRR as an immune-related gene in the tumor microenvironment of glioblastoma by integrated bioinformatics analysis. | Identification of INSRR as an immune-related gene in the tumor microenvironment of glioblastoma by integrated bioinformatics analysis.
Zhang H, Bao M, Liao D, Zhang Z, Tian Z, Yang E, Luo P, Jiang X. | 05/1/2023 |
| Probing Structure and Function of Alkali Sensor IRR with Monoclonal Antibodies. | Probing Structure and Function of Alkali Sensor IRR with Monoclonal Antibodies.
Goryashchenko AS, Mozhaev AA, Serova OV, Erokhina TN, Orsa AN, Deyev IE, Petrenko AG., Free PMC Article | 02/13/2021 |
| ectoIRR's sensing of alkaline conditions involves additional molecular mechanisms, for example engagement of receptor juxtamembrane regions or the surrounding lipid environment. | The dimeric ectodomain of the alkali-sensing insulin receptor-related receptor (ectoIRR) has a droplike shape.
Shtykova EV, Petoukhov MV, Mozhaev AA, Deyev IE, Dadinova LA, Loshkarev NA, Goryashchenko AS, Bocharov EV, Jeffries CM, Svergun DI, Batishchev OV, Petrenko AG., Free PMC Article | 06/13/2020 |
| the extensive glycosylation of FnIII-2/3 provides steric hindrance for the alkali-induced rearrangement of the IRR ectodomain. | Site-Directed Mutagenesis of the Fibronectin Domains in Insulin Receptor-Related Receptor.
Deyev IE, Chachina NA, Zhevlenev ES, Petrenko AG., Free PMC Article | 08/18/2018 |
| IRR activation involves two separate centers of pH-dependent rearrangements that act synergistically to induce a major conformational change in the IRR molecule, resulting in internal kinase domains rapprochement and autophosphorylation. | Mapping of alkali-sensing sites of the insulin receptor-related receptor. The role of L2 and fibronectin domains.
Deyev IE, Chachina NA, Shayahmetova DM, Serova OV, Petrenko AG. | 12/5/2015 |
| IRR activation is not based on a single residue deprotonation in the IRR ectodomain but rather involves synergistic conformational changes at multiple points. | Structural determinants of the insulin receptor-related receptor activation by alkali.
Deyev IE, Mitrofanova AV, Zhevlenev ES, Radionov N, Berchatova AA, Popova NV, Serova OV, Petrenko AG., Free PMC Article | 02/8/2014 |
| Insulin receptor-related receptor as an extracellular pH sensor involved in the regulation of acid-base balance. (Review) | Insulin receptor-related receptor as an extracellular pH sensor involved in the regulation of acid-base balance.
Petrenko AG, Zozulya SA, Deyev IE, Eladari D. | 11/16/2013 |
| Analysis of structural determinants of alkali sensor IRR positive cooperativity. | Analysis of structural determinants of alkali sensor IRR positive cooperativity.
Popova NV, Deyev IE, Petrenko AG. | 09/21/2013 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesA large-scale candidate gene association study of age at menarche and age at natural menopause.
He C, Kraft P, Chasman DI, Buring JE, Chen C, Hankinson SE, Paré G, Chanock S, Ridker PM, Hunter DJ. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM. | 09/24/2008 |
| IRR mRNA expression was found in 25 (51%) neuroblastomas and correlated with stages 1, 2, 3, and 4S disease and with age. | Coexpression of insulin receptor-related receptor and insulin-like growth factor 1 receptor correlates with enhanced apoptosis and dedifferentiation in human neuroblastomas.
Weber A, Huesken C, Bergmann E, Kiess W, Christiansen NM, Christiansen H. | 01/21/2010 |
| Phosphotyrosine detection revealed a lack in the constitutive activation of the IRR described for analogous constructs of the two other members of the family | Comparative analysis of the signaling capabilities of the insulin receptor-related receptor.
Klammt J, Garten A, Barnikol-Oettler A, Beck-Sickinger AG, Kiess W. | 01/21/2010 |
| The IRR gene is expressed in the same ovarian compartment, IRR mRNA content increases strikingly in these cells in the afternoon of the first proestrus. | Expression of the insulin receptor-related receptor is induced by the preovulatory surge of luteinizing hormone in thecal-interstitial cells of the rat ovary.
Dissen GA, Garcia-Rudaz C, Tapia V, Parada LF, Hsu SY, Ojeda SR. | 01/21/2010 |