| A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer. | A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer.
Xiong L, Liu HS, Zhou C, Yang X, Huang L, Jie HQ, Zeng ZW, Zheng XB, Li WX, Liu ZZ, Kang L, Liang ZX., Free PMC Article | 05/4/2023 |
| Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression. | Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression.
Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale M, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A., Free PMC Article | 01/22/2022 |
| Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2alpha-ATF4 axis. | Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK-eIF2α-ATF4 axis.
Watanabe Y, Sasaki T, Miyoshi S, Shimizu M, Yamauchi Y, Sato R., Free PMC Article | 12/4/2021 |
| The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity. | The Propensity of the Human Liver to Form Large Lipid Droplets Is Associated with PNPLA3 Polymorphism, Reduced INSIG1 and NPC1L1 Expression and Increased Fibrogenetic Capacity.
Ferri F, Carotti S, Carpino G, Mischitelli M, Cantafora A, Molinaro A, Argenziano ME, Parisse S, Corsi A, Riminucci M, Lai Q, Mennini G, Spadetta G, Pugliese F, Rossi M, Morini S, Gaudio E, Ginanni Corradini S., Free PMC Article | 07/17/2021 |
| Investigation of the association between obesity and insulin-induced gene 1 polymorphism at 7q36.3 region in Uygur population in Xinjiang, China. | Investigation of the association between obesity and insulin-induced gene 1 polymorphism at 7q36.3 region in Uygur population in Xinjiang, China.
Tao J, Abudoukelimu M, Shen X, Liu J, Wang FX, Yuan J, Gu PP, Zhu W, Zhang XT, Wang Z, Ma YT, Li GQ., Free PMC Article | 10/24/2020 |
| the gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis; findings highlight the importance of the protein kinase activity of PCK1 in the activation of SREBPs, lipogenesis and the development of hepatocellular carcinoma | The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, Hung MC, Lu Z. | 06/6/2020 |
| INSIG1 functions as a sentinel responsive to HIV-1 production and inhibits HIV-1 replication by degrading Gag, a process occurring at intracellular membrane sites such as the endoplasmic reticulum and endosomes where both INSIG1 and Gag may be located. | Insulin-induced gene 1 (INSIG1) inhibits HIV-1 production by degrading Gag via activity of the ubiquitin ligase TRC8.
Zhang Y, Lu J, Ma J, Liu X., Free PMC Article | 06/29/2019 |
| Knock down of FADS1 did not significantly change cholesterol efflux (p=0.70), but knockdown of INSIG1 and LDLR resulted in highly significant reduction of the efflux to HDL (67% and 75% of control, respectively, p<0.001). | HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages.
Orekhov AN, Pushkarsky T, Oishi Y, Nikiforov NG, Zhelankin AV, Dubrovsky L, Makeev VJ, Foxx K, Jin X, Kruth HS, Sobenin IA, Sukhorukov VN, Zakiev ER, Kontush A, Le Goff W, Bukrinsky M., Free PMC Article | 01/19/2019 |
| INSIG1 variation may contribute to statin-induced changes in plasma triglycerides in a sex-specific manner. | Statin-induced expression change of INSIG1 in lymphoblastoid cell lines correlates with plasma triglyceride statin response in a sex-specific manner.
Theusch E, Kim K, Stevens K, Smith JD, Chen YI, Rotter JI, Nickerson DA, Medina MW., Free PMC Article | 01/6/2018 |
| argue that precursor miR-122 molecules modulate polyadenylation site usage in Insig1 mRNAs, resulting in down-regulation of Insig1 protein abundance | Precursor microRNA-122 inhibits synthesis of Insig1 isoform mRNA by modulating polyadenylation site usage.
Norman KL, Chen TC, Zeiner G, Sarnow P., Free PMC Article | 12/9/2017 |
| Our findings suggest that miR-92a may affect cholesterol metabolism by repressing insig1, resulting in raised intracellular cholesterol levels and Golgi volume and hence enhanced protein secretion. | miR-92a enhances recombinant protein productivity in CHO cells by increasing intracellular cholesterol levels.
Loh WP, Yang Y, Lam KP. | 04/29/2017 |
| identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect. | The gene-gene interaction of INSIG-SCAP-SREBP pathway on the risk of obesity in Chinese children.
Liu FH, Song JY, Shang XR, Meng XR, Ma J, Wang HJ., Free PMC Article | 03/21/2015 |
| Data show the essential role of PPARgamma and PPARgamma coactivator 1alpha (PGC-1alpha) in up-regulating Insig-1/2 expression, defining a mechanistic pathway triggered by CD36, and leading to cholesterol depletion in hepatocytes. | Scavenger receptor CD36 mediates inhibition of cholesterol synthesis via activation of the PPARγ/PGC-1α pathway and Insig1/2 expression in hepatocytes.
Rodrigue-Way A, Caron V, Bilodeau S, Keil S, Hassan M, Lévy E, Mitchell GA, Tremblay A. | 06/7/2014 |
| Our results indicated that the dysregulation of INSIG1 and SREBF1 caused by ART were observed not only in the fetus but also in the placenta, primarily in the ICSI group | Assisted reproductive technologies impair the expression and methylation of insulin-induced gene 1 and sterol regulatory element-binding factor 1 in the fetus and placenta.
Lou H, Le F, Zheng Y, Li L, Wang L, Wang N, Zhu Y, Huang H, Jin F. | 06/7/2014 |
| No significant associations were found between polymorphisms of INSIG1 gene and metabolic syndrome; however, INSIG1 and INSIG2 interactions were found in the significant 3-locus and 4-locus gene-gene interaction models. | Gene-gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics.
Liou YJ, Bai YM, Lin E, Chen JY, Chen TT, Hong CJ, Tsai SJ, Liou YJ, Bai YM, Lin E, Chen JY, Chen TT, Hong CJ, Tsai SJ. | 09/29/2012 |
| Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Gene-gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics.
Liou YJ, Bai YM, Lin E, Chen JY, Chen TT, Hong CJ, Tsai SJ, Liou YJ, Bai YM, Lin E, Chen JY, Chen TT, Hong CJ, Tsai SJ. | 12/5/2010 |
| From genetic association studies, SNPs in INSIG1 (including the promoter region) influence hypertriglyceridemia. | INSIG1 influences obesity-related hypertriglyceridemia in humans.
Smith EM, Zhang Y, Baye TM, Gawrieh S, Cole R, Blangero J, Carless MA, Curran JE, Dyer TD, Abraham LJ, Moses EK, Kissebah AH, Martin LJ, Olivier M., Free PMC Article | 10/23/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Common variation in INSIG1 is unlikely to have a major effect on risk of type 2 diabetes risk in white Europeans. | No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits.
Szopa M, Meirhaeghe A, Luan J, Moreno LA, Gonzalez-Gross M, Vidal-Puig A, Cooper C, Hagen R, Amouyel P, Wareham NJ, Loos RJ. | 07/12/2010 |
| These data suggest that p97 recruits proteasomes to polytopic ER proteins, such as Insig-1, even before they are extracted from membranes. | Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes.
Ikeda Y, Demartino GN, Brown MS, Lee JN, Goldstein JL, Ye J., Free PMC Article | 02/8/2010 |
| Studies define Insig-1 and Insig-2 as the minimal requirement for sterol-accelerated degradation of the membrane domain of reductase. | Insig-mediated, sterol-accelerated degradation of the membrane domain of hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase in insect cells.
Nguyen AD, Lee SH, DeBose-Boyd RA., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Interactions among genetic variants from SREBP2 activating-related pathway on risk of coronary heart disease in Chinese Han population.
Liu X, Li Y, Lu X, Wang L, Zhao Q, Yang W, Huang J, Cao J, Li H, Gu D. | 09/20/2009 |
| Unsaturated fatty acid-mediated stabilization of Insig-1 enhances the ability of sterols to inhibit proteolytic activation of SREBP-1, which activates transcription of genes involved in fatty acid synthesis | Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step.
Lee JN, Zhang X, Feramisco JD, Gong Y, Ye J., Free PMC Article | 01/21/2010 |
| Under conditions of mild steroid depletion, the failure to ubiquinate Insig-1 causes a delay in release of the Scap/sterol regulatory element binding protein-2, but it does not abolish it. | Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.
Gong Y, Lee JN, Lee PC, Goldstein JL, Brown MS, Ye J. | 01/21/2010 |
| The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. | The INSIG1 gene, not the INSIG2 gene, associated with coronary heart disease: tagSNPs and haplotype-based association study. The Beijing Atherosclerosis Study.
Liu X, Li Y, Wang L, Zhao Q, Lu X, Huang J, Fan Z, Gu D. | 01/21/2010 |