| Scanning Electron-Assisted Dielectric Microscopy Reveals Autophagosome Formation by LC3 and ATG12 in Cultured Mammalian Cells. | Scanning Electron-Assisted Dielectric Microscopy Reveals Autophagosome Formation by LC3 and ATG12 in Cultured Mammalian Cells.
Okada T, Ogura T., Free PMC Article | 04/17/2021 |
| The aryl hydrocarbon receptor reduces LC3II expression and controls endoplasmic reticulum stress. | The aryl hydrocarbon receptor reduces LC3II expression and controls endoplasmic reticulum stress.
Guerrina N, Aloufi N, Shi F, Prasade K, Mehrotra C, Traboulsi H, Matthews J, Eidelman DH, Hamid Q, Baglole CJ. | 03/28/2021 |
| Our data presents evidence that AEG-1, LC3-II, Beclin-1, and HIF-1alpha are significantly up-regulated in T-NHL tissues, and hypoxia triggers AEG-1, LC3-II and Beclin-1 expression in T-NHL cells. | AEG-1 is involved in hypoxia-induced autophagy and decreases chemosensitivity in T-cell lymphoma.
Yan J, Zhang J, Zhang X, Li X, Li L, Li Z, Chen R, Zhang L, Wu J, Wang X, Sun Z, Fu X, Chang Y, Nan F, Yu H, Wu X, Feng X, Li W, Zhang M., Free PMC Article | 01/19/2019 |
| We found that both bafilomycin and chloroquine could significantly increase the autophagosome marker LC3-II and inhibit key parameters of mitochondrial function, and increase mtDNA damage. | Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons.
Redmann M, Benavides GA, Berryhill TF, Wani WY, Ouyang X, Johnson MS, Ravi S, Barnes S, Darley-Usmar VM, Zhang J., Free PMC Article | 12/2/2017 |
| treatment with an autophagy inhibitor decreased LC3II expression.However, miR-30b overexpression decreased Pi-induced expression of autophagy-related marker genes such as BECN1, ATG5, and LC3b, whereas miR-30b downregulation increased Pi-induced expression of these genes. In addition, we found that miR-30b | MicroRNA-30b Regulates High Phosphorus Level-Induced Autophagy in Vascular Smooth Muscle Cells by Targeting BECN1.
Wang J, Sun YT, Xu TH, Sun W, Tian BY, Sheng ZT, Sun L, Liu LL, Ma JF, Wang LN, Yao L. | 08/5/2017 |
| autophagy of cytoplasmic bulk cargo was completely LC3 independent. | Autophagy of cytoplasmic bulk cargo does not require LC3.
Engedal N, Seglen PO., Free PMC Article | 12/17/2016 |
| LC3B modulates Angiotensin II-induced cardiomyocyte hypertrophy in cultured ventricular cardiomyocytes. | LC3B, a Protein That Serves as an Autophagic Marker, Modulates Angiotensin II-induced Myocardial Hypertrophy.
Huang J, Pan W, Ou D, Dai W, Lin Y, Chen Y, Chen X. | 09/24/2016 |
| Our findings indicate that increased autophagy in the cerebellum of dogs naturally infected with CDV may play a role in transferring the virus from cell to cell. | Immunohistochemical detection of autophagy-related microtubule-associated protein 1 light chain 3 (LC3) in the cerebellums of dogs naturally infected with canine distemper virus.
Kabak YB, Sozmen M, Yarim M, Guvenc T, Karayigit MO, Gulbahar MY. | 09/17/2016 |
| Atg1/pULK and LC3 are key in the regulation of autophagy following cerebral ischemia reperfusion in the rat brain. | Activation of autophagy in rat brain cells following focal cerebral ischemia reperfusion through enhanced expression of Atg1/pULK and LC3.
Yu J, Bao C, Dong Y, Liu X., Free PMC Article | 05/7/2016 |
| the addition of amino acids to the starvation condition, a similar quick signal appeared by significant reduction of the LC3 ratio and bulk proteolysis. | A quick signal of starvation induced autophagy: transcription versus post-translational modification of LC3.
Karim MR, Kawanago H, Kadowaki M. | 10/3/2015 |
| The results of yhis study found that levels of autophagy markers such as LC3 and Beclin 1 are elevated in the GABAergic interneurons of the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain. | Expression of LC3 and Beclin 1 in the spinal dorsal horn following spinal nerve ligation-induced neuropathic pain.
Zhang E, Yi MH, Ko Y, Kim HW, Seo JH, Lee YH, Lee W, Kim DW. | 01/25/2014 |
| The protein expression level of the autophagy marker light chain 3/Atg8 exhibited a marked decline in aged kidneys. | Age-related changes in the function of autophagy in rat kidneys.
Cui J, Bai XY, Shi S, Cui S, Hong Q, Cai G, Chen X., Free PMC Article | 07/28/2012 |
| the effect of a single bout of running exercise, which augments cardiac work transiently and physiologically, on the expression of microtubule-associated protein 1 light chain 3 , an indicator of autophagy, in the rat cardiac muscle was studied. | Single bout of running exercise changes LC3-II expression in rat cardiac muscle.
Ogura Y, Iemitsu M, Naito H, Kakigi R, Kakehashi C, Maeda S, Akema T. | 01/7/2012 |
| These studies provided evidence that miR-204 played an important role in regulating autophagy through LC3-IIprotein during ischemia-reperfusion. | MiR-204 regulates cardiomyocyte autophagy induced by ischemia-reperfusion through LC3-II.
Xiao J, Zhu X, He B, Zhang Y, Kang B, Wang Z, Ni X., Free PMC Article | 10/8/2011 |
| p62 directly binds to the evolutionarily conserved cargo receptor-binding domain of Atg8/LC3 and selectively mediates the clearance of mutant Huntingtin. | The evolutionarily conserved interaction between LC3 and p62 selectively mediates autophagy-dependent degradation of mutant huntingtin.
Tung YT, Hsu WM, Lee H, Huang WP, Liao YF. | 09/20/2010 |
| These findings indicate that LC3 is involved in the lipid droplet formation regardless of the bulk degradation, and that LC3 has two pivotal roles in cellular homeostasis mediated by autophagy and lipid metabolism. | LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation.
Shibata M, Yoshimura K, Tamura H, Ueno T, Nishimura T, Inoue T, Sasaki M, Koike M, Arai H, Kominami E, Uchiyama Y. | 03/22/2010 |
| Data show that enhanced expression of CTGF in soft tissue tumors is fibronectin dependent and that LC3-mediated adhesion, invasion and proliferation are CTGF dependent. | LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor.
Ying L, Lau A, Alvira CM, West R, Cann GM, Zhou B, Kinnear C, Jan E, Sarnow P, Van de Rijn M, Rabinovitch M., Free PMC Article | 01/21/2010 |