| ING2 tumor suppressive protein translocates into mitochondria and is involved in cellular metabolism homeostasis. | ING2 tumor suppressive protein translocates into mitochondria and is involved in cellular metabolism homeostasis.
Ricordel C, Chaillot L, Blondel A, Archambeau J, Jouan F, Mouche A, Tiercin M, Burel A, Lena H, Desrues B, Guillaudeux T, Pedeux R. | 12/25/2021 |
| Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells. | Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.
Ma Y, Yan R, Wan Q, Lv B, Yang Y, Lv T, Xin W. | 02/6/2021 |
| Integrated analysis of DNA methylation and mRNA expression profiles to identify key genes involved in the regrowth of clinically non-functioning pituitary adenoma. | Integrated analysis of DNA methylation and mRNA expression profiles to identify key genes involved in the regrowth of clinically non-functioning pituitary adenoma.
Cheng S, Li C, Xie W, Miao Y, Guo J, Wang J, Zhang Y., Free PMC Article | 01/23/2021 |
| Findings provide evidence that ING2 is a direct target of miR92a. | miR‑92a contributes to cell proliferation, apoptosis and doxorubicin chemosensitivity in gastric carcinoma cells.
Tao XC, Zhang XY, Sun SB, Wu DQ. | 12/14/2019 |
| Our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration. | A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling.
Esmaeili M, Pungsrinont T, Schaefer A, Baniahmad A. | 10/28/2017 |
| ING2 may be involved in the repair and regeneration of organs or tissues and is associated with breast and gynecological carcinogenesis. | Expression profiles of inhibitor of growth protein 2 in normal and cancer tissues: An immunohistochemical screening analysis.
Zhao S, Yang XF, Gou WF, Lu H, Li H, Zhu ZT, Sun HZ, Zheng HC. | 11/5/2016 |
| Results suggest that ING2 acts as a tumor suppressor in osteosarcoma. | Nuclear ING2 expression is reduced in osteosarcoma.
Han XR, Bai XZ, Sun Y, Yang Y. | 10/31/2015 |
| It is thought that ING2 gene expression level could contribute to the development of BCC but not be associated with the stage and the prognosis of the tumor. | A novel tumor suppressor gene in basal cell carcinoma: inhibition of growth factor-2.
Temel M, Turkmen A, Dokuyucu R, Cevik C, Oztuzcu S, Cengiz B, Mutaf M. | 10/24/2015 |
| Decreased expression of ING2 gene is associated with non-small cell lung cancer. | Decreased expression of ING2 gene and its clinicopathological significance in Chinese NSCLC patients.
Pan YQ, Zhang X, Xu DP, Bao WG, Lin AF, Xu HH, Yan WH. | 09/27/2014 |
| It was concluded that ING2 not only plays an essential role in the growth and invasion of MGC-803 cells but also represents a potential approach to chemosensitization therapy in human gastric cancer. | Knockdown of inhibitor of growth protein 2 inhibits cell invasion and enhances chemosensitivity to 5-FU in human gastric cancer cells.
Zhong J, Yang L, Liu N, Zheng J, Lin CY. | 12/28/2013 |
| findings support a model in which PtdIns(5)P functions as a sub-nuclear trafficking factor that stabilizes ING2 at discrete genomic sites | Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage.
Bua DJ, Martin GM, Binda O, Gozani O., Free PMC Article | 10/19/2013 |
| Study establishes ING2 as a novel regulator of spermatogenesis functioning, and provides an animal model to study idiopathic and iatrogenic infertility in men. | Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas.
Saito M, Kumamoto K, Robles AI, Horikawa I, Furusato B, Okamura S, Goto A, Yamashita T, Nagashima M, Lee TL, Baxendale VJ, Rennert OM, Takenoshita S, Yokota J, Sesterhenn IA, Trivers GE, Hussain SP, Harris CC., Free PMC Article | 04/30/2011 |
| Data show that inhibition of ING2 expression accelerates progression of cells from G(1) to S-phase, and is accompanied by a decrease of p21 expression, and that regulation of p21 by ING2 is independent of p53. | ING2 controls the G1 to S-phase transition by regulating p21 expression.
Larrieu D, Ythier D, Brambilla C, Pedeux R. | 03/5/2011 |
| expression is downregulated in non-small cell lung carcinoma | Expression of candidate tumor suppressor gene ING2 is lost in non-small cell lung carcinoma.
Ythier D, Brambilla E, Binet R, Nissou D, Vesin A, de Fraipont F, Moro-Sibilot D, Lantuejoul S, Brambilla C, Gazzeri S, Pedeux R. | 02/5/2011 |
| sumoylation of ING2 enhances its binding to the Sin3A/HDAC complex and is required to regulate gene transcriptions | Sumoylation of ING2 regulates the transcription mediated by Sin3A.
Ythier D, Larrieu D, Binet R, Binda O, Brambilla C, Gazzeri S, Pedeux R. | 11/27/2010 |
| found that ING2 interacts with proliferating cell nuclear antigen and regulates its amount to the chromatin fraction, allowing normal replication progression and normal cell proliferation. | ING2 controls the progression of DNA replication forks to maintain genome stability.
Larrieu D, Ythier D, Binet R, Brambilla C, Brambilla E, Sengupta S, Pedeux R., Free PMC Article | 01/21/2010 |
| ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression. | ING2 is upregulated in colon cancer and increases invasion by enhanced MMP13 expression.
Kumamoto K, Fujita K, Kurotani R, Saito M, Unoki M, Hagiwara N, Shiga H, Bowman ED, Yanaihara N, Okamura S, Nagashima M, Miyamoto K, Takenoshita S, Yokota J, Harris CC., Free PMC Article | 01/21/2010 |
| ING2 loss of heterozygosity is associated with advanced staging in head and neck squamous cell carcinoma and determines survival rate. | Frequent deletion of ING2 locus at 4q35.1 associates with advanced tumor stage in head and neck squamous cell carcinoma.
Borkosky SS, Gunduz M, Nagatsuka H, Beder LB, Gunduz E, Ali MA, Rodriguez AP, Cilek MZ, Tominaga S, Yamanaka N, Shimizu K, Nagai N. | 01/21/2010 |
| ING2a knockdown suppressed cell growth only in the presence of p53, ING2b knockdown had no effect on cell growth, and knockdown of both induced cell cycle arrest and apoptosis independently of p53. | A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis.
Unoki M, Kumamoto K, Robles AI, Shen JC, Zheng ZM, Harris CC., Free PMC Article | 01/21/2010 |
| ING2 C-terminus recruits histone methyltransferase activity, which correlates with silencing function | ING2 recruits histone methyltransferase activity with methylation site specificity distinct from histone H3 lysines 4 and 9.
Goeman F, Otto K, Kyrylenko S, Schmidt O, Baniahmad A. | 01/21/2010 |
| ING2 collaborates with SnoN to mediate TGF-beta-induced Smad-dependent transcription and cellular responses | ING2 as a novel mediator of transforming growth factor-beta-dependent responses in epithelial cells.
Sarker KP, Kataoka H, Chan A, Netherton SJ, Pot I, Huynh MA, Feng X, Bonni A, Riabowol K, Bonni S., Free PMC Article | 01/21/2010 |
| p53-mediated mir34a, mir34b, and mir34c up-regulation and ING2 down-regulation may be involved in the senescence pathway. | Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence.
Kumamoto K, Spillare EA, Fujita K, Horikawa I, Yamashita T, Appella E, Nagashima M, Takenoshita S, Yokota J, Harris CC., Free PMC Article | 01/21/2010 |
| Decreased expression of ING2 gene is associated with hepatocellular carcinoma | Decreased expression of ING2 gene and its clinicopathological significance in hepatocellular carcinoma.
Zhang HK, Pan K, Wang H, Weng DS, Song HF, Zhou J, Huang W, Li JJ, Chen MS, Xia JC. | 01/21/2010 |
| the interaction between Alien and the tumor suppressors p33ING1 and p33ING2 reveals a novel cellular protein network | The tumor suppressors p33ING1 and p33ING2 interact with alien in vivo and enhance alien-mediated gene silencing.
Fegers I, Kob R, Eckey M, Schmidt O, Goeman F, Papaioannou M, Escher N, von Eggeling F, Melle C, Baniahmad A. | 01/21/2010 |
| molecular modeling and docking of the 5-methylenephosphonate or 5-phosphothionate analogues to the C-terminus PtdInsP-binding region of ING2 revealed a number of complementary surface and electrostatic contacts between the lipids and ING2 | Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling.
Huang W, Zhang H, Davrazou F, Kutateladze TG, Shi X, Gozani O, Prestwich GD., Free PMC Article | 01/21/2010 |