| ING1 inhibits Twist1 expression to block EMT and is antagonized by the HDAC inhibitor vorinostat. | ING1 inhibits Twist1 expression to block EMT and is antagonized by the HDAC inhibitor vorinostat.
Yang Y, Ma B, Djamshidi M, Zhang Q, Sarkar A, Chanda A, Tran U, Soh J, Sandall C, Chen HM, MacDonald JA, Bonni S, Sensen CW, Zheng J, Riabowol K. | 09/25/2023 |
| ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer. | ING Tumour Suppressors and ING Splice Variants as Coregulators of the Androgen Receptor Signalling in Prostate Cancer.
Melekhova A, Baniahmad A., Free PMC Article | 03/19/2022 |
| CG7379 and ING1 suppress cancer cell invasion by maintaining cell-cell junction integrity. | CG7379 and ING1 suppress cancer cell invasion by maintaining cell-cell junction integrity.
Rusu AD, Cornhill ZE, Coutiño BC, Uribe MC, Lourdusamy A, Markus Z, May ST, Rahman R, Georgiou M., Free PMC Article | 02/12/2022 |
| miR-24-3p promotes colon cancer progression by targeting ING1. | miR-24-3p promotes colon cancer progression by targeting ING1.
Gao Z, Zhou L, Hua S, Wu H, Luo L, Li L, Wang S, Liu Y, Zhou Z, Chen X., Free PMC Article | 10/9/2021 |
| Emerging Role of C/EBPbeta and Epigenetic DNA Methylation in Ageing. | Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing.
Niehrs C, Calkhoven CF. | 05/29/2021 |
| Nitazoxanide as an autophagy inhibitor induces cell cycle arrest in glioblastoma via upregulated ING1. | Nitazoxanide, an antiprotozoal drug, inhibits late-stage autophagy and promotes ING1-induced cell cycle arrest in glioblastoma.
Wang X, Shen C, Liu Z, Peng F, Chen X, Yang G, Zhang D, Yin Z, Ma J, Zheng Z, Zhao B, Liu H, Wang L, Wu J, Han D, Wang K, Zhong C, Hou X, Zhao W, Shu M, Wang X, Zhao S., Free PMC Article | 11/16/2019 |
| ING1a induces these changes through strongly inhibiting endocytosis to block mitogen signaling by inducing the expression of intersectin 2, a key scaffolding protein of the endosomal pathway. | The ING1a model of rapid cell senescence.
Bertschmann J, Thalappilly S, Riabowol K. | 04/27/2019 |
| Over-expression of ING1 dramatically inhibited non-small cell lung cancer cells proliferation, migration and invasion. | Down-regulation of miR-500 and miR-628 suppress non-small cell lung cancer proliferation, migration and invasion by targeting ING1.
Jiang M, Zhou LY, Xu N, An Q. | 03/16/2019 |
| The p37 controls cortical NuMA levels via the phosphatase PP1 and its regulatory subunit Repo-Man, but it acts independently of Galphai, the kinase Aurora A, and the phosphatase PP2A. | p37/UBXN2B regulates spindle orientation by limiting cortical NuMA recruitment via PP1/Repo-Man.
Lee BH, Schwager F, Meraldi P, Gotta M., Free PMC Article | 12/22/2018 |
| Nuclear entrapment of p33ING1b by inhibition of exportin-1 triggers apoptosis in head and neck squamous cell cancer cells. | Nuclear entrapment of p33ING1b by inhibition of exportin-1: A trigger of apoptosis in head and neck squamous cell cancer.
Özdaş S. | 09/22/2018 |
| Results from a study on gene expression variability markers in early-stage human embryos shows that ING1 is a putative marker for the 3-day, 8-cell embryo stage. | Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
Hasegawa Y, Taylor D, Ovchinnikov DA, Wolvetang EJ, de Torrenté L, Mar JC., Free PMC Article | 07/23/2018 |
| Our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration. | A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling.
Esmaeili M, Pungsrinont T, Schaefer A, Baniahmad A. | 10/28/2017 |
| ING1 regulates the nucleolar epigenome and rDNA transcription suggesting that regulation of protein synthesis might serve as the basis for ING1 function as a type II tumor suppressor. | ING1 regulates rRNA levels by altering nucleolar chromatin structure and mTOR localization.
Rajarajacholan UK, Thalappilly S, Riabowol K., Free PMC Article | 10/7/2017 |
| a novel corepressor function of ING1b on various AR functions, thereby inhibiting prostate cancer cell growth. | The tumor suppressor ING1b is a novel corepressor for the androgen receptor and induces cellular senescence in prostate cancer cells.
Esmaeili M, Jennek S, Ludwig S, Klitzsch A, Kraft F, Melle C, Baniahmad A. | 09/30/2017 |
| ING1a acts as a novel link in the activation of the Rb pathway that can impose senescence in the absence of activating p53-mediated DNA damage signaling, and should prove useful in defining the molecular events contributing to Rb-induced senescence. | Aging with ING: a comparative study of different forms of stress induced premature senescence.
Rajarajacholan UK, Riabowol K., Free PMC Article | 08/27/2016 |
| These data indicate that stromal ING1 expression can predict the survival of patients with luminal breast cancer | Stromal ING1 expression induces a secretory phenotype and correlates with breast cancer patient survival.
Thakur S, Nabbi A, Klimowicz A, Riabowol K., Free PMC Article | 05/21/2016 |
| Overexpression of let-7b in gastric cancer can inhibit invasion and migration of gastric cancer cells through directly targeting the tumor metastasis-associated gene ING1. | MicroRNA let-7b suppresses human gastric cancer malignancy by targeting ING1.
Han X, Chen Y, Yao N, Liu H, Wang Z. | 01/16/2016 |
| Results show that ING1 expression is under-regulated in pancreatic duct adenocarcinoma (PDAC) and is a direct target of miR-371-5p involved in miR-371-5p inducing promotion of PDAC cells proliferation. | MiR-371-5p facilitates pancreatic cancer cell proliferation and decreases patient survival.
He D, Miao H, Xu Y, Xiong L, Wang Y, Xiang H, Zhang H, Zhang Z., Free PMC Article | 12/26/2015 |
| ING1b finely regulates the hypoxic response by triggering HIF1alpha proteasomal degradation. | ING1b negatively regulates HIF1α protein levels in adipose-derived stromal cells by a SUMOylation-dependent mechanism.
Bigot N, Guérillon C, Loisel S, Bertheuil N, Sensebé L, Tarte K, Pedeux R., Free PMC Article | 09/12/2015 |
| ING1b sumoylation regulates the binding of ING1b to the ISG15 and DGCR8 promoters, consequently regulating ISG15 and DGCR8 transcription. | SUMOylation of the ING1b tumor suppressor regulates gene transcription.
Satpathy S, Guérillon C, Kim TS, Bigot N, Thakur S, Bonni S, Riabowol K, Pedeux R., Free PMC Article | 05/16/2015 |
| Our results identify a novel functional relationship between cytoplasmic p33ING1b and oral squamous cell carcinoma patient survival | Tumor cell apoptosis mediated by cytoplasmic ING1 is associated with improved survival in oral squamous cell carcinoma patients.
Bose P, Thakur SS, Brockton NT, Klimowicz AC, Kornaga E, Nakoneshny SC, Riabowol KT, Dort JC., Free PMC Article | 01/24/2015 |
| Ing1b lacking cells showed decreased ability to repair the oxidized DNA. | Tumor suppressor Ing1b facilitates DNA repair and prevents oxidative stress induced cell death.
Rotte A, Li G, Bhandaru M. | 08/23/2014 |
| ING1 translocates to the mitochondria of primary fibroblasts and established epithelial cell lines in response to apoptosis inducing stimuli, independent of the cellular p53 status. | ING1 induces apoptosis through direct effects at the mitochondria.
Bose P, Thakur S, Thalappilly S, Ahn BY, Satpathy S, Feng X, Suzuki K, Kim SW, Riabowol K., Free PMC Article | 03/15/2014 |
| ING1 acts at early stages of the DNA damage response activating a variety of repair mechanisms. | Inhibitor of growth 1 (ING1) acts at early steps of multiple DNA repair pathways.
Ceruti JM, Ogara MF, Menéndez C, Palmero I, Cánepa ET. | 11/16/2013 |
| Src may play a major role in regulating ING1 levels during tumorigenesis in those cancers in which high levels of Src expression or activity are present. | Src regulates the activity of the ING1 tumor suppressor.
Yu L, Thakur S, Leong-Quong RY, Suzuki K, Pang A, Bjorge JD, Riabowol K, Fujita DJ., Free PMC Article | 10/26/2013 |