| FOXK2 amplification promotes breast cancer development and chemoresistance. | FOXK2 amplification promotes breast cancer development and chemoresistance.
Yu Y, Cao WM, Cheng F, Shi Z, Han L, Yi J, da Silva EM, Dopeso H, Chen H, Yang J, Wang X, Zhang C, Zhang H., | 08/1/2024 |
| FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration. | FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin mediated degradation modulates mitochondrial respiration.
El-Mergawy R, Chafin L, Ovando-Ricardez JA, Rosas L, Tsai M, Rojas M, Mora AL, Mallampalli RK., Free PMC Article | 07/23/2024 |
| FOXK2 regulates PFKFB3 in promoting glycolysis and tumorigenesis in multiple myeloma. | FOXK2 regulates PFKFB3 in promoting glycolysis and tumorigenesis in multiple myeloma.
Liu X, Tang N, Liu Y, Fu J, Zhao Y, Wang H, Wang H, Hu Z. | 09/6/2023 |
| CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg effect. | CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg effect.
Zheng J, Yan X, Lu T, Song W, Li Y, Liang J, Zhang J, Cai J, Sui X, Xiao J, Chen H, Chen G, Zhang Q, Liu Y, Yang Y, Zheng K, Pan Z., Free PMC Article | 03/22/2023 |
| FOXK2 affects cancer cell response to chemotherapy by promoting nucleotide de novo synthesis. | FOXK2 affects cancer cell response to chemotherapy by promoting nucleotide de novo synthesis.
Li Y, Chen J, Wang B, Xu Z, Wu C, Ma J, Song Q, Geng Q, Yu J, Pei H, Yao Y. | 02/24/2023 |
| FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway. | FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway.
Zhang Y, Wang Y, Zhao G, Tanner EJ, Adli M, Matei D., Free PMC Article | 05/21/2022 |
| Long non-coding RNA tumor protein 53 target gene 1 promotes cervical cancer development via regulating microRNA-33a-5p to target forkhead box K2. | Long non-coding RNA tumor protein 53 target gene 1 promotes cervical cancer development via regulating microRNA-33a-5p to target forkhead box K2.
Liao D, Liu X, Yuan X, Feng P, Ouyang Z, Liu Y, Li C., Free PMC Article | 04/30/2022 |
| Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network. | Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.
Xia YK, Zeng YR, Zhang ML, Liu P, Liu F, Zhang H, He CX, Sun YP, Zhang JY, Zhang C, Song L, Ding C, Tang YJ, Yang Z, Yang C, Wang P, Guan KL, Xiong Y, Ye D., Free PMC Article | 01/29/2022 |
| FOXK2 transcriptionally activating VEGFA induces apatinib resistance in anaplastic thyroid cancer through VEGFA/VEGFR1 pathway. | FOXK2 transcriptionally activating VEGFA induces apatinib resistance in anaplastic thyroid cancer through VEGFA/VEGFR1 pathway.
Feng H, Jin Z, Liang J, Zhao Q, Zhan L, Yang Z, Yan J, Kuang J, Cheng X, Qiu W. | 01/1/2022 |
| CircRNA circFOXK2 facilitates oncogenesis in breast cancer via IGF2BP3/miR-370 axis. | CircRNA circFOXK2 facilitates oncogenesis in breast cancer via IGF2BP3/miR-370 axis.
Zhang W, Liu H, Jiang J, Yang Y, Wang W, Jia Z., Free PMC Article | 12/11/2021 |
| The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation. | The forkhead transcription factor FOXK2 premarks lineage-specific genes in human embryonic stem cells for activation during differentiation.
Ji Z, Li Y, Liu SX, Sharrocks AD., Free PMC Article | 03/6/2021 |
| Circular RNA Circ-ITCH Inhibits the Malignant Behaviors of Cervical Cancer by microRNA-93-5p/FOXK2 Axis. | Circular RNA Circ-ITCH Inhibits the Malignant Behaviors of Cervical Cancer by microRNA-93-5p/FOXK2 Axis.
Li J, Guo R, Liu Q, Sun J, Wang H. | 12/12/2020 |
| CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA-Binding Proteins and Sponging MiR-942. | CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA-Binding Proteins and Sponging MiR-942.
Wong CH, Lou UK, Li Y, Chan SL, Tong JH, To KF, Chen Y. | 11/21/2020 |
| Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR. | Forkhead box K2 promotes human colorectal cancer metastasis by upregulating ZEB1 and EGFR.
Du F, Qiao C, Li X, Chen Z, Liu H, Wu S, Hu S, Qiu Z, Qian M, Tian D, Wu K, Fan D, Nie Y, Xia L., Free PMC Article | 09/19/2020 |
| CHK2-FOXK axis promotes transcriptional control of autophagy programs. | CHK2-FOXK axis promotes transcriptional control of autophagy programs.
Chen Y, Wu J, Liang G, Geng G, Zhao F, Yin P, Nowsheen S, Wu C, Li Y, Li L, Kim W, Zhou Q, Huang J, Liu J, Zhang C, Guo G, Deng M, Tu X, Gao X, Liu Z, Chen Y, Lou Z, Luo K, Yuan J., Free PMC Article | 09/19/2020 |
| Results identified FOXK2 as a functional target for miR-602 and its expression downregulated which is inversely correlated with that of miR-602 in esophageal squamous cell carcinoma (ESCC) tissue samples. | Epigenetically Upregulated MicroRNA-602 Is Involved in a Negative Feedback Loop with FOXK2 in Esophageal Squamous Cell Carcinoma.
Liu M, Yu J, Wang D, Niu Y, Chen S, Gao P, Yang Z, Wang H, Zhang J, Zhang C, Zhao Y, Hu W, Sun G., Free PMC Article | 06/20/2020 |
| in vitro and in vivo experiments, including studies of primary human cells, show how FOXK1 and/or FOXK2 are likely to act as important regulators that reprogram cellular metabolism to induce aerobic glycolysis | FOXK1 and FOXK2 regulate aerobic glycolysis.
Sukonina V, Ma H, Zhang W, Bartesaghi S, Subhash S, Heglind M, Foyn H, Betz MJ, Nilsson D, Lidell ME, Naumann J, Haufs-Brusberg S, Palmgren H, Mondal T, Beg M, Jedrychowski MP, Taskén K, Pfeifer A, Peng XR, Kanduri C, Enerbäck S. | 07/27/2019 |
| the findings of the present study demonstrated that FOXK2 functions as a tumor suppressor in gastric cancer; the loss of FOXK2 may induce the growth and invasion of gastric cancer cells. | Downregulation of FOXK2 is associated with poor prognosis in patients with gastric cancer.
Liu X, Wei X, Niu W, Wang D, Wang B, Zhuang H., Free PMC Article | 01/26/2019 |
| our results indicate that FOXK2 inhibits the malignant phenotype of clear-cell renal cell carcinoma and acts as a tumor suppressor possibly through the inhibition of EGFR. | FOXK2 suppresses the malignant phenotype and induces apoptosis through inhibition of EGFR in clear-cell renal cell carcinoma.
Zhang F, Ma X, Li H, Zhang Y, Li X, Chen L, Guo G, Gao Y, Gu L, Xie Y, Duan J, Zhang X. | 12/22/2018 |
| FOXK2, regulted by miR-1271-5p, promotes cell growth and indicates unfavorable prognosis in hepatocellular carcinoma | FOXK2, regulted by miR-1271-5p, promotes cell growth and indicates unfavorable prognosis in hepatocellular carcinoma.
Lin MF, Yang YF, Peng ZP, Zhang MF, Liang JY, Chen W, Liu XH, Zheng YL. | 12/2/2017 |
| SOX9 transcriptionally activated FOXK2 was involved in the pathogenesis of colorectal cancer.FOXK2 is highly expressed in colorectal cancer tissues. | Sox9 mediated transcriptional activation of FOXK2 is critical for colorectal cancer cells proliferation.
Qian Y, Xia S, Feng Z. | 06/24/2017 |
| Results show that Foxk2 expression was downregulated in lung adenocarcinoma tissues and non-small cell lung cancer cell (NSCLC) lines. Its overexpression suppresses epithelial-mesenchymal transition in NSCLC cells and inhibits cell migration and invasion. Also, the expression of Foxk2 seems to be regulated by miR-1271. | Foxk2 inhibits non-small cell lung cancer epithelial-mesenchymal transition and proliferation through the repression of different key target genes.
Chen S, Jiang S, Hu F, Xu Y, Wang T, Mei Q. | 04/22/2017 |
| FOXO3-dependent gene regulation is generally mediated not through uniquely bound regions but through regions occupied by both FOXK2 and FOXO3 where both factors play a regulatory role. | Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors.
Chen X, Ji Z, Webber A, Sharrocks AD., Free PMC Article | 08/6/2016 |
| FOXK2 might act as a negative regulator of ERalpha, and its association with both ERalpha and BRCA1/BARD1 could lead to the down-regulation of ERalpha transcriptional activity, effectively regulating the function of ERalpha. | FOXK2 transcription factor suppresses ERα-positive breast cancer cell growth through down-regulating the stability of ERα via mechanism involving BRCA1/BARD1.
Liu Y, Ao X, Jia Z, Bai XY, Xu Z, Hu G, Jiang X, Chen M, Wu H., Free PMC Article | 11/28/2015 |
| FOXK1 and FOXK2 positively regulate Wnt/beta-catenin signaling by translocating dishevelled proteins into the nucleus. | FOXKs promote Wnt/β-catenin signaling by translocating DVL into the nucleus.
Wang W, Li X, Lee M, Jun S, Aziz KE, Feng L, Tran MK, Li N, McCrea PD, Park JI, Chen J., Free PMC Article | 06/20/2015 |