| CD137 expression and signal function drive pleiotropic gammadelta T-cell effector functions that inhibit intracellular M. tuberculosis growth. | CD137 expression and signal function drive pleiotropic γδ T-cell effector functions that inhibit intracellular M. tuberculosis growth.
Ji X, Huang G, Peng Y, Wang J, Cai X, Yang E, Zhu L, Wu Y, Sha W, Wang F, Shen L, Shen H. | 09/26/2024 |
| Multiplex spatial analysis reveals increased CD137 expression and m-MDSC neighboring tumor cells in refractory classical Hodgkin Lymphoma. | Multiplex spatial analysis reveals increased CD137 expression and m-MDSC neighboring tumor cells in refractory classical Hodgkin Lymphoma.
Solórzano JL, Menéndez V, Parra E, Solis L, Salazar R, García-Cosío M, Climent F, Fernández S, Díaz E, Francisco-Cruz A, Khoury J, Jiang M, Tamegnon A, Montalbán C, Melero I, Wistuba I, De Andrea C, F García J., Free PMC Article | 09/25/2024 |
| Soluble CD137: A Potential Prognostic Biomarker in Critically Ill Patients. | Soluble CD137: A Potential Prognostic Biomarker in Critically Ill Patients.
Räth U, Mester P, Schwarz H, Schmid S, Müller M, Buechler C, Pavel V., Free PMC Article | 01/11/2024 |
| Targeting neuropilin-1 abolishes anti-PD-1-upregulated regulatory T cells and synergizes with 4-1BB agonist for liver cancer treatment. | Targeting neuropilin-1 abolishes anti-PD-1-upregulated regulatory T cells and synergizes with 4-1BB agonist for liver cancer treatment.
Wu Q, Pan C, Zhou Y, Wang S, Xie L, Zhou W, Ding L, Chen T, Qian J, Su R, Gao X, Mei Z, Qiao Y, Yin S, Wu Y, Wang J, Zhou L, Zheng S. | 11/16/2023 |
| Epstein-Barr virus-induced ectopic CD137 expression helps nasopharyngeal carcinoma to escape immune surveillance and enables targeting by chimeric antigen receptors. | Epstein-Barr virus-induced ectopic CD137 expression helps nasopharyngeal carcinoma to escape immune surveillance and enables targeting by chimeric antigen receptors.
Prasad M, Ponnalagu S, Zeng Q, Luu K, Lang SM, Wong HY, Cheng MS, Wu M, Mallilankaraman K, Sobota RM, Lim YT, Wang LC, Goh CK, Tay KXJ, Loh KS, Wang CI, Lee WH, Goh BC, Lim CM, Schwarz H., Free PMC Article | 10/8/2022 |
| FBXL20-mediated ubiquitination triggers the proteasomal degradation of 4-1BB. | FBXL20-mediated ubiquitination triggers the proteasomal degradation of 4-1BB.
Sun R, Lim SO. | 08/6/2022 |
| Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB. | Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB.
Nielsen MA, Juul-Madsen K, Stegmayr J, Gao C, Mehta AY, Greisen SR, Kragstrup TW, Hvid M, Vorup-Jensen T, Cummings RD, Leffler H, Deleuran BW., Free PMC Article | 07/23/2022 |
| Early-Onset Parkinson's Disease: A Novel Deletion Comprising the DJ-1 and TNFRSF9 Genes. | Early-Onset Parkinson's Disease: A Novel Deletion Comprising the DJ-1 and TNFRSF9 Genes.
Güler S, Gül T, Güler Ş, Haerle MC, Başak AN. | 04/9/2022 |
| CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity. | CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity.
Stoll A, Bruns H, Fuchs M, Völkl S, Nimmerjahn F, Kunz M, Peipp M, Mackensen A, Mougiakakos D., Free PMC Article | 01/29/2022 |
| Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction. | Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction.
Lamarthée B, Marchal A, Charbonnier S, Blein T, Leon J, Martin E, Rabaux L, Vogt K, Titeux M, Delville M, Vinçon H, Six E, Pallet N, Michonneau D, Anglicheau D, Legendre C, Taupin JL, Nemazanyy I, Sawitzki B, Latour S, Cavazzana M, André I, Zuber J., Free PMC Article | 12/11/2021 |
| Early loss of T lymphocyte 4-1BB receptor expression is associated with higher short-term mortality in alcoholic hepatitis. | Early loss of T lymphocyte 4-1BB receptor expression is associated with higher short-term mortality in alcoholic hepatitis.
Eriksen LL, Nielsen MA, Laursen TL, Deleuran B, Vilstrup H, Støy S., Free PMC Article | 12/4/2021 |
| CD137 Ligand-CD137 Interaction is Required For Inflammasome-Associated Brain Injury Following Ischemic Stroke. | CD137 Ligand-CD137 Interaction is Required For Inflammasome-Associated Brain Injury Following Ischemic Stroke.
Fann DY, Nickles EP, Poh L, Rajeev V, Selvaraji S, Schwarz H, Arumugam TV. | 11/27/2021 |
| 4-1BB costimulation promotes CAR T cell survival through noncanonical NF-kappaB signaling. | 4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling.
Philipson BI, O'Connor RS, May MJ, June CH, Albelda SM, Milone MC., Free PMC Article | 11/6/2021 |
| Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis. | Regulatory T Cells Inhibit T Cell Activity by Downregulating CD137 Ligand via CD137 Trogocytosis.
Luu K, Patwardhan MV, Zeng Q, Wickström SL, Lundqvist A, Schwarz H., Free PMC Article | 10/16/2021 |
| PD-1 abrogates the prolonged persistence of CD8(+) CAR-T cells with 4-1BB co-stimulation. | PD-1 abrogates the prolonged persistence of CD8(+) CAR-T cells with 4-1BB co-stimulation.
Li F, Zhang Z, Xuan Y, Zhang D, Liu J, Li A, Wang S, Li T, Shi X, Zhang Y., Free PMC Article | 10/9/2021 |
| CD137 costimulation enhances the antiviral activity of Vgamma9Vdelta2-T cells against influenza virus. | CD137 costimulation enhances the antiviral activity of Vγ9Vδ2-T cells against influenza virus.
Pei Y, Wen K, Xiang Z, Huang C, Wang X, Mu X, Wen L, Liu Y, Tu W., Free PMC Article | 10/9/2021 |
| Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway. | Activating CD137 Signaling Promotes Sprouting Angiogenesis via Increased VEGFA Secretion and the VEGFR2/Akt/eNOS Pathway.
Li B, Zhang Y, Yin R, Zhong W, Chen R, Yan J., Free PMC Article | 10/2/2021 |
| Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting. | Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting.
Lee KY, Wong HY, Zeng Q, Le Lin J, Cheng MS, Kuick CH, Chang KTE, Loh AHP, Schwarz H., Free PMC Article | 08/7/2021 |
| T cells expanded from renal cell carcinoma display tumor-specific CD137 expression but lack significant IFN-gamma, TNF-alpha or IL-2 production. | T cells expanded from renal cell carcinoma display tumor-specific CD137 expression but lack significant IFN-γ, TNF-α or IL-2 production.
van Asten SD, de Groot R, van Loenen MM, Castenmiller SM, de Jong J, Monkhorst K, Haanen JBAG, Amsen D, Bex A, Spaapen RM, Wolkers MC., Free PMC Article | 08/7/2021 |
| Nuclear-localized costimulatory molecule 4-1BBL promotes colon cancer cell proliferation and migration by regulating nuclear Gsk3beta, and is linked to the poor outcomes associated with colon cancer. | Nuclear-localized costimulatory molecule 4-1BBL promotes colon cancer cell proliferation and migration by regulating nuclear Gsk3β, and is linked to the poor outcomes associated with colon cancer.
Ge Y, Chen W, Zhang X, Wang H, Cui J, Liu Y, Ju S, Tian X, Ju S., Free PMC Article | 05/29/2021 |
| 4-1BB Signaling Boosts the Anti-Tumor Activity of CD28-Incorporated 2(nd) Generation Chimeric Antigen Receptor-Modified T Cells. | 4-1BB Signaling Boosts the Anti-Tumor Activity of CD28-Incorporated 2(nd) Generation Chimeric Antigen Receptor-Modified T Cells.
Dai Q, Han P, Qi X, Li F, Li M, Fan L, Zhang H, Zhang X, Yang X., Free PMC Article | 05/1/2021 |
| Role of ADAM10 and ADAM17 in Regulating CD137 Function. | Role of ADAM10 and ADAM17 in Regulating CD137 Function.
Seidel J, Leitzke S, Ahrens B, Sperrhacke M, Bhakdi S, Reiss K., Free PMC Article | 04/24/2021 |
| 4-1BB Delineates Distinct Activation Status of Exhausted Tumor-Infiltrating CD8(+) T Cells in Hepatocellular Carcinoma. | 4-1BB Delineates Distinct Activation Status of Exhausted Tumor-Infiltrating CD8(+) T Cells in Hepatocellular Carcinoma.
Kim HD, Park S, Jeong S, Lee YJ, Lee H, Kim CG, Kim KH, Hong SM, Lee JY, Kim S, Kim HK, Min BS, Chang JH, Ju YS, Shin EC, Song GW, Hwang S, Park SH., Free PMC Article | 02/20/2021 |
| A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target. | A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target.
Freeman ZT, Nirschl TR, Hovelson DH, Johnston RJ, Engelhardt JJ, Selby MJ, Kochel CM, Lan RY, Zhai J, Ghasemzadeh A, Gupta A, Skaist AM, Wheelan SJ, Jiang H, Pearson AT, Snyder LA, Korman AJ, Tomlins SA, Yegnasubramanian S, Drake CG., Free PMC Article | 11/21/2020 |
| we report the first genetically well-documented case of EBV-driven T/NK cell lymphoproliferative disorder associated with homozygous mutations in PIK3CD and TNFRSF9, highlighting the potential role of these pathways in the immunity to EBV when EBV infects T cells. | Concomitant PIK3CD and TNFRSF9 deficiencies cause chronic active Epstein-Barr virus infection of T cells.
Rodriguez R, Fournier B, Cordeiro DJ, Winter S, Izawa K, Martin E, Boutboul D, Lenoir C, Fraitag S, Kracker S, Watts TH, Picard C, Bruneau J, Callebaut I, Fischer A, Neven B, Latour S., Free PMC Article | 06/20/2020 |