| Structural basis for the mutation-induced dysfunction of the human IL-15/IL-15alpha receptor complex. | Structural basis for the mutation-induced dysfunction of the human IL-15/IL-15α receptor complex.
Batool Z, Qureshi U, Mushtaq M, Ahmed S, Nur-E-Alam M, Ul-Haq Z. | 02/11/2023 |
| miRNA-binding site polymorphism in IL-15RA gene in rheumatoid arthritis and systemic lupus erythematosus: correlation with disease risk and clinical characteristics. | miRNA-binding site polymorphism in IL-15RA gene in rheumatoid arthritis and systemic lupus erythematosus: correlation with disease risk and clinical characteristics.
Jadidi N, Alesaeidi S, Arab F, Pakzad B, Siasi E, Esmaeilzadeh E. | 10/22/2022 |
| Schizophrenia Patient Shows a Rare Interleukin 15 Receptor alpha Variant Disrupting Signal Transduction. | Schizophrenia Patient Shows a Rare Interleukin 15 Receptor alpha Variant Disrupting Signal Transduction.
Pan Y, Wang Z, Zhang G, Guo J, Zhu X, Zhou J, Zhang Z, Sun Z, Yang J, Kastin AJ, Pan W, Wu X, Zhang J, Wang X, Wang C, He Y. | 11/22/2021 |
| Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor alpha Chain Foster Local Environment for Type 1 Innate Like T Cell Development. | Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development.
Tao H, Li L, Liao NS, Schluns KS, Luckhart S, Sleasman JW, Zhong XP., Free PMC Article | 09/18/2021 |
| Tumor cell-expressed IL-15Ralpha drives antagonistic effects on the progression and immune control of gastric cancer and is epigenetically regulated in EBV-positive gastric cancer. | Tumor cell-expressed IL-15Rα drives antagonistic effects on the progression and immune control of gastric cancer and is epigenetically regulated in EBV-positive gastric cancer.
Wei J, Guo C, An X, Miao W, Zhang C, Wang B, Cai W, Li M, Zhang F. | 08/7/2021 |
| RUNX2 and IL-15RA Polymorphisms associated with OPLL in the Han and Mongolian population. | RUNX2 and IL-15RA Polymorphisms associated with OPLL in the Han and Mongolian population.
Li P, Liu Z, Liu J, Xing W, Fu H, Zhu S. | 07/17/2021 |
| The expression levels of CHI3L1 and IL15Ralpha correlate with TGM2 in duodenum biopsies of patients with celiac disease. | The expression levels of CHI3L1 and IL15Rα correlate with TGM2 in duodenum biopsies of patients with celiac disease.
Catrogiovanni P, Musumeci G, Giunta S, Imbesi R, Di Rosa M. | 07/10/2021 |
| IL-15 and IL15RA in Osteoarthritis: Association With Symptoms and Protease Production, but Not Structural Severity. | IL-15 and IL15RA in Osteoarthritis: Association With Symptoms and Protease Production, but Not Structural Severity.
Warner SC, Nair A, Marpadga R, Chubinskaya S, Doherty M, Valdes AM, Scanzello CR., Free PMC Article | 04/13/2021 |
| IL-15 is a particularly important regulator of natural killer development, differentiation, homeostasis, and activation. | Lung Dendritic Cells Drive Natural Killer Cytotoxicity in Chronic Obstructive Pulmonary Disease via IL-15Rα.
Finch DK, Stolberg VR, Ferguson J, Alikaj H, Kady MR, Richmond BW, Polosukhin VV, Blackwell TS, McCloskey L, Curtis JL, Freeman CM., Free PMC Article | 09/28/2019 |
| Data show that the response of NK cells activated by ULBP2 was augmented by an interaction between NKG2D ligand 2 protein (ULBP2)-bound natural killer group 2D (NKG2D) and IL- interleukin 15 receptor (IL-15R). | A nanoscale reorganization of the IL-15 receptor is triggered by NKG2D in a ligand-dependent manner.
Bálint Š, Lopes FB, Davis DM., Free PMC Article | 09/21/2019 |
| the combination of the oncolytic immunotherapy with anti-PD-1 antibody dramatically improves the therapeutic outcome compared to either anti-PD-1 alone or vvDD-IL15-Ralpha alone | Superagonist IL-15-Armed Oncolytic Virus Elicits Potent Antitumor Immunity and Therapy That Are Enhanced with PD-1 Blockade.
Kowalsky SJ, Liu Z, Feist M, Berkey SE, Ma C, Ravindranathan R, Dai E, Roy EJ, Guo ZS, Bartlett DL., Free PMC Article | 08/17/2019 |
| Men with the IL-15Ralpha 1775AA genotype spent more time in light intensity physical activity (39.4 +/- 2.4 hr/week) than men with the CC genotype (28.6 +/- 2.3 hr/week, (p = .009). | A genetic variant in IL-15Rα correlates with physical activity among European-American adults.
Bruneau M Jr, Walsh S, Selinsky E, Ash G, Angelopoulos TJ, Clarkson P, Gordon P, Moyna N, Visich P, Zoeller R, Thompson P, Gordish-Dressman H, Hoffman E, Devaney J, Pescatello LS., Free PMC Article | 10/20/2018 |
| circulating IL-15 and IL-15Ralpha concentrations are reduced in lean and obese physically active people | Serum IL-15 and IL-15Rα levels are decreased in lean and obese physically active humans.
Pérez-López A, Valadés D, Vázquez Martínez C, de Cos Blanco AI, Bujan J, García-Honduvilla N. | 08/4/2018 |
| IL-15/IL-15Ralpha signaling pathway is activated in skeletal muscle in response to a session of resistance exercise. | Skeletal muscle IL-15/IL-15Rα and myofibrillar protein synthesis after resistance exercise.
Pérez-López A, McKendry J, Martin-Rincon M, Morales-Alamo D, Pérez-Köhler B, Valadés D, Buján J, Calbet JAL, Breen L. | 08/4/2018 |
| IL-15 and IL-15Ralpha genes in samples from the Spanish Consortium for Genetics of Celiac Disease (CEGEC) collection, identifying two regulatory single-nucleotide polymorphisms (SNP) that might be associated with celiac disease | Association of the IL-15 and IL-15Rα genes with celiac disease.
Escudero-Hernández C, Plaza-Izurieta L, Garrote JA, Bilbao JR, CEGEC, Arranz E. | 06/23/2018 |
| this work provides evidence that the sushi-IL-15Ralpha/IL-15 fusion protein RLI enhances antitumor activity of anti-PD-1 treatment and is a promising approach to stimulate host immunity | IL-15 Trans-Signaling with the Superagonist RLI Promotes Effector/Memory CD8+ T Cell Responses and Enhances Antitumor Activity of PD-1 Antagonists.
Desbois M, Le Vu P, Coutzac C, Marcheteau E, Béal C, Terme M, Gey A, Morisseau S, Teppaz G, Boselli L, Jacques Y, Béchard D, Tartour E, Cassard L, Chaput N. | 08/12/2017 |
| this study describes variants of splicing of IL-15Ra expressed in intestinal epithelial cells, and identifies those variants with the ability of binding IL-15 and following the secretory pathway, as well as determines if any of these variants are regulated by methylation of DNA | New IL-15 receptor-α splicing variants identified in intestinal epithelial Caco-2 cells.
Escudero-Hernández C, Martínez-Abad B, Ruipérez V, Garrote JA, Arranz E. | 07/1/2017 |
| 15Ralpha/15 complexes represent a potent adjuvant for augmenting the efficacy of adoptive immunotherapy. Such cell-bound or soluble 15Ralpha/15 complexes could be developed for use in combination immunotherapy approaches. | Soluble and membrane-bound interleukin (IL)-15 Rα/IL-15 complexes mediate proliferation of high-avidity central memory CD8(+) T cells for adoptive immunotherapy of cancer and infections.
Hasan AN, Selvakumar A, Shabrova E, Liu XR, Afridi F, Heller G, Riviere I, Sadelain M, Dupont B, O'Reilly RJ., Free PMC Article | 04/29/2017 |
| Report improved antitumoral NK-cell activity in DC-based vaccine strategies through the use of IL-15/IL-15Ralpha mRNA-engineered designer DC. | Transpresentation of interleukin-15 by IL-15/IL-15Rα mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity.
Van den Bergh J, Willemen Y, Lion E, Van Acker H, De Reu H, Anguille S, Goossens H, Berneman Z, Van Tendeloo V, Smits E., Free PMC Article | 11/12/2016 |
| The novel mechanism of IL-15 transfer to the surface of antigen-processing DCs may explain the enhanced potency of IL-15:IL-15Ralpha-coated nanoparticles for antigen delivery. | Configuration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity.
Hong E, Usiskin IM, Bergamaschi C, Hanlon DJ, Edelson RL, Justesen S, Pavlakis GN, Flavell RA, Fahmy TM., Free PMC Article | 11/5/2016 |
| significant association of rs2228059 with ossification of the posterior longitudinal ligament of the spine in Chinese Han population | Association between single nucleotide polymorphism of IL15RA gene with susceptibility to ossification of the posterior longitudinal ligament of the spine.
Guo Q, Lv SZ, Wu SW, Tian X, Li ZY., Free PMC Article | 01/16/2016 |
| Report Il15Ralpha levels in synovial fluid from rheumatoid arthritis patients. | Differential expression of pro-inflammatory cytokines IL-15Ralpha, IL-15, IL-6 and TNFalpha in synovial fluid from rheumatoid arthritis patients.
Santos Savio A, Machado Diaz AC, Chico Capote A, Miranda Navarro J, Rodríguez Alvarez Y, Bringas Pérez R, Estévez del Toro M, Guillen Nieto GE., Free PMC Article | 12/19/2015 |
| NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15Ralpha expression | NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15Rα expression.
Braun M, Björkström NK, Gupta S, Sundström K, Ahlm C, Klingström J, Ljunggren HG., Free PMC Article | 10/17/2015 |
| IRF-1 promotes LTx I/R injury via hepatocyte IL-15/IL-15Ralpha production and suggest that targeting IRF-1 and IL-15/IL-15Ralpha may be effective in reducing I/R injury associated with LTx. | IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15Rα production.
Yokota S, Yoshida O, Dou L, Spadaro AV, Isse K, Ross MA, Stolz DB, Kimura S, Du Q, Demetris AJ, Thomson AW, Geller DA., Free PMC Article | 08/22/2015 |
| Coexpression of IL15RA and IL15 was also sufficient to activate peripheral blood mononuclear cells. | IL15RA drives antagonistic mechanisms of cancer development and immune control in lymphocyte-enriched triple-negative breast cancers.
Marra P, Mathew S, Grigoriadis A, Wu Y, Kyle-Cezar F, Watkins J, Rashid M, De Rinaldis E, Hessey S, Gazinska P, Hayday A, Tutt A. | 03/21/2015 |