| Structure of human DPPA3 bound to the UHRF1 PHD finger reveals its functional and structural differences from mouse DPPA3. | Structure of human DPPA3 bound to the UHRF1 PHD finger reveals its functional and structural differences from mouse DPPA3.
Shiraishi N, Konuma T, Chiba Y, Hokazono S, Nakamura N, Islam MH, Nakanishi M, Nishiyama A, Arita K., Free PMC Article | 07/8/2024 |
| Stella employs a multilayered mechanism to achieve robust UHRF1 inhibition, which involves the dissociation from chromatin and cytoplasmic sequestration of UHRF1. | Stella protein facilitates DNA demethylation by disrupting the chromatin association of the RING finger-type E3 ubiquitin ligase UHRF1.
Du W, Dong Q, Zhang Z, Liu B, Zhou T, Xu RM, Wang H, Zhu B, Li Y., Free PMC Article | 02/22/2020 |
| Super-enhancers at the Nanog locus differentially regulate neighboring pluripotency-associated genes, in particular, DPPA3. | Super-Enhancers at the Nanog Locus Differentially Regulate Neighboring Pluripotency-Associated Genes.
Blinka S, Reimer MH Jr, Pulakanti K, Rao S., Free PMC Article | 11/18/2017 |
| We conclude that heterogeneous population of the HEK293T cells might be easily shifted towards expression of the pluripotency markers by ectopic expression of the SON factors or by growth in serum depleted media. | Pluripotency induction in HEK293T cells by concurrent expression of STELLA, OCT4 and NANOS2.
Farshchian M, Matin MM, Bahrami M, Geerts D, Dastpak M, Shahriyari M, Tajeran M, Mirahmadi M, Bahrami AR. | 06/3/2017 |
| Data suggest enforced expression of Stella into normal cells induces not only global DNA demethylation but also neoplastic transformation and increases metastatic ability; these changes involve altered regulation of neoplastic gene expression. | Global DNA hypomethylation coupled to cellular transformation and metastatic ability.
Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Okumura M, Oboki K, Matsumoto K, Saito H, Nakano T. | 05/14/2016 |
| Considering that impaired DNA methylation profiles are associated with various developmental or disease phenomena, Stella may be a powerful tool with which to study the biological effects of global DNA hypomethylation | Inhibition of maintenance DNA methylation by Stella.
Funaki S, Nakamura T, Nakatani T, Umehara H, Nakashima H, Nakano T. | 07/25/2015 |
| a role for STELLA in facilitating germline and endodermal differentiation of human ES cells | STELLA facilitates differentiation of germ cell and endodermal lineages of human embryonic stem cells.
Wongtrakoongate P, Jones M, Gokhale PJ, Andrews PW., Free PMC Article | 08/31/2013 |
| These results demonstrate that PGC7/Stella is indispensable for the maintenance of methylation involved in epigenetic reprogramming after fertilization. | PGC7/Stella protects against DNA demethylation in early embryogenesis.
Nakamura T, Arai Y, Umehara H, Masuhara M, Kimura T, Taniguchi H, Sekimoto T, Ikawa M, Yoneda Y, Okabe M, Tanaka S, Shiota K, Nakano T. | 01/21/2010 |
| human adult tissue-specific transcripts originate via retrotransposition of the pluripotent cell-specific gene, Dppa3 | Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin.
Elliman SJ, Wu I, Kemp DM. | 01/21/2010 |
| In mice, this gene may play a role in oogenesis and primordial germ cell development. | Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells.
Sato M, Kimura T, Kurokawa K, Fujita Y, Abe K, Masuhara M, Yasunaga T, Ryo A, Yamamoto M, Nakano T. | 09/20/2004 |
| In mice, a targeted mutation results in reduced female fertility and may function as a mammalian maternal effect gene. | Stella is a maternal effect gene required for normal early development in mice.
Payer B, Saitou M, Barton SC, Thresher R, Dixon JP, Zahn D, Colledge WH, Carlton MB, Nakano T, Surani MA. | 09/20/2004 |
| In mice, knockout experiments show this gene may be a maternal factor in cleavage stage embryogenesis. | Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice.
Bortvin A, Goodheart M, Liao M, Page DC., Free PMC Article | 09/20/2004 |