| Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE. | Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.
Grk M, Miskovic R, Jeremic I, Basaric M, Dusanovic Pjevic M, Jekic B, Miljanovic D, Lazarevic I, Despotovic A, Cirkovic A, Banko A., Free PMC Article | 08/7/2023 |
| Interleukin-10 receptor signaling promotes the maintenance of a PD-1(int) TCF-1(+) CD8(+) T cell population that sustains anti-tumor immunity. | Interleukin-10 receptor signaling promotes the maintenance of a PD-1(int) TCF-1(+) CD8(+) T cell population that sustains anti-tumor immunity.
Hanna BS, Llaó-Cid L, Iskar M, Roessner PM, Klett LC, Wong JKL, Paul Y, Ioannou N, Öztürk S, Mack N, Kalter V, Colomer D, Campo E, Bloehdorn J, Stilgenbauer S, Dietrich S, Schmidt M, Gabriel R, Rippe K, Feuerer M, Ramsay AG, Lichter P, Zapatka M, Seiffert M. | 02/19/2022 |
| IL-10 receptor expression on lymphocytes and monocytes in children with food allergy. | IL-10 receptor expression on lymphocytes and monocytes in children with food allergy.
Nedelkopoulou N, Taparkou A, Agakidis C, Mavroudi A, Xinias I, Farmaki E. | 09/4/2021 |
| Characterization of novel and large fragment deletions in exon 1 of the IL10RA gene in Chinese children with very early onset inflammatory bowel diseases. | Characterization of novel and large fragment deletions in exon 1 of the IL10RA gene in Chinese children with very early onset inflammatory bowel diseases.
Tang Z, Zhang P, Ji M, Yin C, Zhao R, Huang Z, Huang Y., Free PMC Article | 06/26/2021 |
| Intestinal dysbiosis in pediatric Crohn's disease patients with IL10RA mutations. | Intestinal dysbiosis in pediatric Crohn's disease patients with IL10RA mutations.
Xue AJ, Miao SJ, Sun H, Qiu XX, Wang SN, Wang L, Ye ZQ, Zheng CF, Huang ZH, Wang YH, Huang Y., Free PMC Article | 06/26/2021 |
| IL-10 suppresses IFN-gamma-mediated signaling in lung adenocarcinoma. | IL-10 suppresses IFN-γ-mediated signaling in lung adenocarcinoma.
Gao Y, Lu J, Zeng C, Yang J, Huang B, Zhang N, Li L, Fu X. | 05/29/2021 |
| [Relationship between gene polymorphism at rs2228055 locus in the exon region of interleukin-10 receptor A and susceptibility to food allergy in children]. | [Relationship between gene polymorphism at rs2228055 locus in the exon region of interleukin-10 receptor A and susceptibility to food allergy in children].
Sun JB, Li ZL. | 11/21/2020 |
| Identification of a novel signaling complex containing host chemokine receptor CXCR4, Interleukin-10 receptor, and human cytomegalovirus US27. | Identification of a novel signaling complex containing host chemokine receptor CXCR4, Interleukin-10 receptor, and human cytomegalovirus US27.
Tu CC, O'Connor CM, Spencer JV., Free PMC Article | 10/24/2020 |
| Erythema Nodosum Leprosum Neutrophil Subset Expressing IL-10R1 Transmigrates into Skin Lesions and Responds to IL-10. | Erythema Nodosum Leprosum Neutrophil Subset Expressing IL-10R1 Transmigrates into Skin Lesions and Responds to IL-10.
Pacheco FS, Prata RBDS, Brandão SS, Ferreira H, Rodrigues TF, Brandão Dos Santos J, da Silva CO, Tavares IF, Mendes MA, Rodrigues ACDP, Machado AM, Nery JADC, Amadeu TP, Moraes MO, Sarno EN, Schmitz V. | 10/10/2020 |
| Two SNPs, rs3024490 and rs1800871, were found to be significantly different between breast cancer patients and healthy women. These SNPs also increased the risk of breast cancer in co-dominant and dominant models. Another SNP, rs1554286, was significantly associated with an increased risk of breast cancer in the co-dominant model. | The effect of interleukin 10 polymorphisms on breast cancer susceptibility in Han women in Shaanxi Province.
Li M, Yue C, Zuo X, Jin G, Wang G, Guo H, Wu F, Huang S, Zhao X., Free PMC Article | 08/1/2020 |
| No gene-gene interaction was found between IL-10 and IL-10RA in terms of responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(-) mothers. | Association of IL-10 and IL-10RA single nucleotide polymorphisms with the responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(-) mothers: a nested case-control study.
Wen S, Wu Y, Pan Y, Cao M, Zhao D, Wang C, Wang C, Kong F, Li J, Niu J, Jiang J., Free PMC Article | 11/2/2019 |
| Very early onset inflammatory bowel disease is associated with IL-10RA mutation, usually with severe intestinal symptoms and significant extra-intestinal symptoms, as well as varied responses to conventional treatment. In our study, c.301C>T and c.537G>A are the most common mutations. | [Interleukin-10 receptor gene mutations induced very early onset inflammatory bowel disease in 6 infants].
Wang FP, Ma X, Zhu D, Gong YZ, Ning HJ, Zhong XM. | 04/6/2019 |
| Compound heterozygous mutations in IL10RA combined with a complement factor properdin mutation in infantile-onset inflammatory bowel disease. | Compound heterozygous mutations in IL10RA combined with a complement factor properdin mutation in infantile-onset inflammatory bowel disease.
Jung ES, Petersen BS, Mayr G, Cheon JH, Kang Y, Lee SJ, Che X, Kim WH, Kim S, Schreiber S, Franke A, Koh H. | 03/9/2019 |
| IL-10R expression and signaling are decreased in monocytes from patients with Crohn's disease. | Impaired IL-10 Receptor-mediated Suppression in Monocyte From Patients With Crohn Disease.
Nunberg MY, Werner L, Kopylov U, Haberman Y, Lahad A, Weiss B, Shouval DS. | 03/9/2019 |
| IL10R signaling regulates TH17 polarization and T-cell proliferation in humans but is not required for the generation and in vitro suppression of Tregs. Therapies targeting the TH17 axis might be beneficial for IL10- and IL10R-deficient patients as a bridge to allogeneic hematopoietic stem cell transplantation. | Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD.
Shouval DS, Konnikova L, Griffith AE, Wall SM, Biswas A, Werner L, Nunberg M, Kammermeier J, Goettel JA, Anand R, Chen H, Weiss B, Li J, Loizides A, Yerushalmi B, Yanagi T, Beier R, Conklin LS, Ebens CL, Santos FGMS, Sherlock M, Goldsmith JD, Kotlarz D, Glover SC, Shah N, Bousvaros A, Uhlig HH, Muise AM, Klein C, Snapper SB. | 06/16/2018 |
| This case report and case-control study explores the role of IL10RA and its deficiency in the development of the immune system and inflammatory bowel diseases. | Development and Function of Immune Cells in an Adolescent Patient With a Deficiency in the Interleukin-10 Receptor.
Veenbergen S, van Leeuwen MA, Driessen GJ, Kersseboom R, de Ruiter LF, Raatgeep RHC, Lindenbergh-Kortleve DJ, Simons-Oosterhuis Y, Biermann K, Halley DJJ, de Ridder L, Escher JC, Samsom JN. | 03/24/2018 |
| We identified 32 compound heterozygous mutations and 9 homozygous mutations in IL10 receptor subunit alpha and 1 homozygous mutation in IL10 receptor subunit beta. Among these mutations, 10 novel mutations were identified, and 6 pathogenic mutations had been previously described. In patients with IL10 receptor subunit alpha mutations, c.301C>T (p.R101RW) and c.537 G>A (p.T179T) were the most common mutations. | Mutations in Interleukin-10 Receptor and Clinical Phenotypes in Patients with Very Early Onset Inflammatory Bowel Disease: A Chinese VEO-IBD Collaboration Group Survey.
Huang Z, Peng K, Li X, Zhao R, You J, Cheng X, Wang Z, Wang Y, Wu B, Wang H, Zeng H, Yu Z, Zheng C, Wang Y, Huang Y. | 02/24/2018 |
| these findings provide a novel mechanism by which microbial-derived butyrate promotes barrier through IL-10RA-dependent repression of claudin-2 | Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor-Dependent Repression of Claudin-2.
Zheng L, Kelly CJ, Battista KD, Schaefer R, Lanis JM, Alexeev EE, Wang RX, Onyiah JC, Kominsky DJ, Colgan SP., Free PMC Article | 11/4/2017 |
| Expression of IL10R subunits within the leukocyte population (CD45(+) cells) was significantly higher in primary brain tumors than in metastases. | Association Between Interleukin-10 Receptors and the CD45-Immunophenotype of Central Nervous System Tumors: A Preliminary Study.
Zadka L, Kram P, Koscinski J, Jankowski R, Kaczmarek M, Piatek K, Kulus M, Gomułkiewicz A, Piotrowska A, Dziegiel P. | 10/21/2017 |
| This study showed that lack of association with schizophrenia was detected for IL10 and IL10RA single polymorphisms and haplotypes. | Family-based association study of interleukin 10 (IL10) and interleukin 10 receptor alpha (IL10RA) functional polymorphisms in schizophrenia in Polish population.
Kapelski P, Skibinska M, Maciukiewicz M, Pawlak J, Zaremba D, Twarowska-Hauser J. | 08/19/2017 |
| The IL-10RA rs9610 A allele was increased in rheumatoid arthritis (RA) patient group compared with control subjects. Interestingly, significant differences were detected both in the allele and genotype frequencies of rs9610 between anti-CCP (anti-cyclic citrullinated peptide) positive patients and anti-CCP negative patients. The findings suggest that IL-10RA rs9610 polymorphism might contribute to RA susceptibility. | Genetic variant of IL-10RA and susceptibility to rheumatoid arthritis in a Chinese population.
Yang XK, Li P, Li S, Zhang C, Li BZ, Leng RX, Pan HF, Ye DQ. | 08/12/2017 |
| The quantitative methods used in this study have shown non-altered expression levels of different microglial markers (Iba-1, Cd11b and CD68), together with increased expression of IL6, IL10RA, colony stimulating factor 3 receptor and toll-like receptor 7 in the thalamus in FFI, which explains the seemingly contradictory results of the previous studies. | Identification of new molecular alterations in fatal familial insomnia.
Llorens F, Thüne K, Schmitz M, Ansoleaga B, Frau-Méndez MA, Cramm M, Tahir W, Gotzmann N, Berjaoui S, Carmona M, Silva CJ, Fernandez-Vega I, José Zarranz J, Zerr I, Ferrer I. | 07/15/2017 |
| These results suggest that S138G loss-of-function polymorphism of the IL-10R1 may be important risk factor in increasing susceptibility to multiple sclerosis. | Association of the IL-10 receptor A536G (S138G) loss-of-function variant with multiple sclerosis in Tunisian patients.
Ben Fredj N, Aissi M, Ben Selma W, Mahmoud I, Nefzi F, Frih-Ayed M, Boukadida J, Aouni M. | 07/1/2017 |
| Results reveal the structure of box1 from class II cytokine receptors IFNLR1 and IL10RA bound to the FERM-SH2 domain of human JAK1, identifying a consensus motif for JAK1 interaction. | The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.
Ferrao R, Wallweber HJ, Ho H, Tam C, Franke Y, Quinn J, Lupardus PJ., Free PMC Article | 07/1/2017 |
| Interleukin 10 and interleukin 10 receptor expression was also enriched in interferon gamma-expressing activated CD8(+) T cells. Treatment of anti-CD3/CD28-stimulated, purified CD8(+) T cells with interleukin 10 alone could significantly enhance CD8(+) T cell survival, an effect dependent on interleukin 10 receptor expression | Stimulatory role of interleukin 10 in CD8(+) T cells through STATs in gastric cancer.
Xi J, Xu M, Song Z, Li H, Xu S, Wang C, Song H, Bai J., Free PMC Article | 06/24/2017 |