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    CXCR1 C-X-C motif chemokine receptor 1 [ Homo sapiens (human) ]

    Gene ID: 3577, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    IL-8 promotes lens capsular residual cells migration by down-regulates expression of E-cadherin and ZO-1 via the CXCR1/2-NF-kappaB-RhoA signal pathway.

    IL-8 promotes lens capsular residual cells migration by down-regulates expression of E-cadherin and ZO-1 via the CXCR1/2-NF-κB-RhoA signal pathway.
    Si W, Liu J, Wang Y, Mao Y, Zhang Y, Xu S, Guo K, Zhang Y, Hu Y, Zhang F.

    10/17/2024
    Interleukin-8/CXCR1 Signaling Contributes to the Progression of Pulmonary Adenocarcinoma Resulting in Malignant Pleural Effusion.

    Interleukin-8/CXCR1 Signaling Contributes to the Progression of Pulmonary Adenocarcinoma Resulting in Malignant Pleural Effusion.
    Chang YM, Huang WY, Yang SH, Jan CI, Nieh S, Lin YS, Chen SF, Lin YC., Free PMC Article

    07/17/2024
    CXCL8 and its cognate receptors CXCR1/CXCR2 in primary myelofibrosis.

    CXCL8 and its cognate receptors CXCR1/CXCR2 in primary myelofibrosis.
    Vermeersch G, Proost P, Struyf S, Gouwy M, Devos T., Free PMC Article

    07/11/2024
    VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract Infections in Women: Genetic Association Study.

    VDR, CXCR1, CXCR2, PSCA Polymorphisms and Recurrent Urinary Tract Infections in Women: Genetic Association Study.
    Sarker P, Pereira GMV, Khullar V, Yu J, Cartwright R., Free PMC Article

    05/7/2024
    Investigating the impact of the genetic variant CXCR1 (rs2234671) in individuals with urinary tract infections.

    Investigating the impact of the genetic variant CXCR1 (rs2234671) in individuals with urinary tract infections.
    Naser HH, Kadhim MJ, Almhanna H.

    04/11/2024
    Circ_0026579 knockdown ameliorates lipopolysaccharide-induced human lung fibroblast cell injury by regulating CXCR1 via miR-370-3p.

    Circ_0026579 knockdown ameliorates lipopolysaccharide-induced human lung fibroblast cell injury by regulating CXCR1 via miR-370-3p.
    Zhuang Y, Yang Y, Peng L.

    11/27/2023
    Exploring the role of miR-200 family in regulating CX3CR1 and CXCR1 in lung adenocarcinoma tumor microenvironment: implications for therapeutic intervention.

    Exploring the role of miR-200 family in regulating CX3CR1 and CXCR1 in lung adenocarcinoma tumor microenvironment: implications for therapeutic intervention.
    Sharma A, Singh P, Jha R, Almatroodi SA, Alrumaihi F, Rahmani AH, Alharbi HO, Dohare R, Syed MA., Free PMC Article

    10/2/2023
    [Roles of the CXCR1/CXCL8 axis in abnormal proliferation of bile duct epithelial cells in primary biliary cholangitis].

    [Roles of the CXCR1/CXCL8 axis in abnormal proliferation of bile duct epithelial cells in primary biliary cholangitis].
    Ai X, Fu HY, Xu JM, Yang WX, Tang YM.

    05/9/2023
    Analysis of the concentration of CXCL8 chemokine and its CXCR1 and CXCR2 receptors in peritoneal fluid of women with endometriosis.

    Analysis of the concentration of CXCL8 chemokine and its CXCR1 and CXCR2 receptors in peritoneal fluid of women with endometriosis.
    Smycz-Kubańska M, Mamrocha A, Wendlocha D, Królewska-Daszczyńska P, Strzelec A, Stępień S, Mielczarek-Palacz A.

    10/1/2022
    Analysis of CXCL8 and its receptors CXCR1/CXCR2 at the mRNA level in neoplastic tissue, as well as in serum and peritoneal fluid in patients with ovarian cance.

    Analysis of CXCL8 and its receptors CXCR1/CXCR2 at the mRNA level in neoplastic tissue, as well as in serum and peritoneal fluid in patients with ovarian cance.
    Smycz-Kubańska M, Stępień S, Gola JM, Kruszniewska-Rajs C, Wendlocha D, Królewska-Daszczyńska P, Strzelec A, Strzelczyk J, Szanecki W, Witek A, Mielczarek-Palacz A., Free PMC Article

    08/20/2022
    Association of single nucleotide polymorphisms in CXCR1, CXCR2 and CXCL5 with Behcet disease: a study in the Denizli province of Turkey.

    Association of single nucleotide polymorphisms in CXCR1, CXCR2 and CXCL5 with Behçet disease: a study in the Denizli province of Turkey.
    Arıkan S, Atalay A, Öztürk O, Duygulu Ş, Atalay EÖ.

    02/5/2022
    The role of circTMOD3 in regulating LPS-induced acute inflammation and injury in human lung fibroblast WI-38 cells.

    The role of circTMOD3 in regulating LPS-induced acute inflammation and injury in human lung fibroblast WI-38 cells.
    Ma K, Wang W, Gao C, He J.

    01/22/2022
    Long non-coding RNA PCED1B antisense RNA 1 promotes gastric cancer progression via modulating microRNA-215-3p / C-X-C motif chemokine receptor 1 axis.

    Long non-coding RNA PCED1B antisense RNA 1 promotes gastric cancer progression via modulating microRNA-215-3p / C-X-C motif chemokine receptor 1 axis.
    Ren J, Xu N, Zhou R, Huang F, Zhang H, Li W., Free PMC Article

    12/18/2021
    [Diagnostic efficiency of determining CXCR1, CXCR2 and hyaluronic acid blood level in non-small cell lung cancer patients].", trans "Diagnosticheskaia effektivnost' opredeleniia urovnia retseptorov CXCR1, CXCR2 i gialuronovoi kisloty v krovi pri nemelkokletochnom rake legkogo.

    [Diagnostic efficiency of determining CXCR1, CXCR2 and hyaluronic acid blood level in non-small cell lung cancer patients].
    Murashka DI, Tahanovich AD, Kauhanka MM, Prokhorova VI, Gotko OV.

    11/22/2021
    CXCR1 correlates to poor outcomes of EGFR-TKI against advanced non-small cell lung cancer by activating chemokine and JAK/STAT pathway.

    CXCR1 correlates to poor outcomes of EGFR-TKI against advanced non-small cell lung cancer by activating chemokine and JAK/STAT pathway.
    Yang F, Zhang S, Meng Q, Zhou F, Pan B, Liu F, Yu Y.

    09/25/2021
    Conformational plasticity and dynamic interactions of the N-terminal domain of the chemokine receptor CXCR1.

    Conformational plasticity and dynamic interactions of the N-terminal domain of the chemokine receptor CXCR1.
    Kharche S, Joshi M, Chattopadhyay A, Sengupta D., Free PMC Article

    09/11/2021
    Impaired capillary tube formation induced by elevated secretion of IL8 involves altered signaling via the CXCR1/PI3K/MMP2 pathway.

    Impaired capillary tube formation induced by elevated secretion of IL8 involves altered signaling via the CXCR1/PI3K/MMP2 pathway.
    Levy YA, Ciaraldi TP, Henry RR.

    05/22/2021
    The rs1008562, rs2234671, and rs3138060 polymorphisms of the CXCR1 gene are associated with breast cancer risk in a Mexican population.

    The rs1008562, rs2234671, and rs3138060 polymorphisms of the CXCR1 gene are associated with breast cancer risk in a Mexican population.
    Gallegos-Arreola MP, Briseño-Zuno CJ, Figuera LE, Sánchez-López JY, Zúñiga-González GM, Puebla-Pérez AM, Gómez-Meda BC, Montoya-Fuentes H, Delgado-Saucedo JI.

    05/15/2021
    KLF2 regulates neutrophil migration by modulating CXCR1 and CXCR2 in asthma.

    KLF2 regulates neutrophil migration by modulating CXCR1 and CXCR2 in asthma.
    Zhu LM, Zeng D, Lei XC, Huang J, Deng YF, Ji YB, Liu J, Dai FF, Li YZ, Shi DD, Zhu YQ, Dai AG, Wang Z.

    01/23/2021
    Circular RNA circ_0067934 exhaustion expedites cell apoptosis and represses cell proliferation, migration and invasion in thyroid cancer via sponging miR-1304 and regulating CXCR1 expression.

    Circular RNA circ_0067934 exhaustion expedites cell apoptosis and represses cell proliferation, migration and invasion in thyroid cancer via sponging miR-1304 and regulating CXCR1 expression.
    Zhang H, Ma XP, Li X, Deng FS.

    12/19/2020
    The evaluation of the distribution of CD133, CXCR1 and the tumor associated macrophages in different molecular subtypes of breast cancer.

    The evaluation of the distribution of CD133, CXCR1 and the tumor associated macrophages in different molecular subtypes of breast cancer.
    Ilgın C, Çomut E, Sarıgül Ç, Korkmaz S, Vardar E, Müftüoğlu SF.

    11/21/2020
    Evaluated how secretoglobin family 1A member 1 (CC16), (which is present in sera from traumatized patients with or without pneumonia) will modify the functions of neutrophils. Results suggest an association of CC16 with C-X-C motif chemokine receptor 1 (CXCR1) and C-X-C motif chemokine receptor 2 (CXCR2.)

    Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2.
    Xu B, Janicova A, Vollrath JT, Störmann P, Martin L, Marzi I, Wutzler S, Hildebrand F, Ehnert S, Relja B., Free PMC Article

    07/11/2020
    that the IL-8/CXCR1 phenotype is associated with CSC-like properties in renal cancer

    IL-8 and CXCR1 expression is associated with cancer stem cell-like properties of clear cell renal cancer.
    Corrò C, Healy ME, Engler S, Bodenmiller B, Li Z, Schraml P, Weber A, Frew IJ, Rechsteiner M, Moch H., Free PMC Article

    04/11/2020
    The high frequency of CXCR2 CD8(+) T cells and the high levels of CXCR2 mRNA expression in myelopathy/tropical spastic paraparesis patients are associated with disease pathogenesis, while the high frequencies of CXCR1 T cells in asymptomatic carriers might suggest that these cells act as effector CD8 T cells and are involved in controlling the viral spread and modulation of the immune response.

    Different roles of CXCR1 and CXCR2 in HTLV-1 carriers and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients.
    Rajaei T, Farajifard H, Rezaee SA, Azarpazhooh MR, Mahmoudi M, Valizadeh N, Rafatpanah H.

    01/11/2020
    High serum CXCR1 levels are associated with Systemic Inflammatory Response Syndrome.

    A Preliminary Report of the Relationship Between Gene Polymorphism of IL-8 and Its Receptors and Systemic Inflammatory Response Syndrome Caused by Wasp Stings.
    Yao W, Sun Y, Sun Y, Chen P, Meng Z, Xiao M, Yang X.

    12/28/2019
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