| IL-2RG as a possible immunotherapeutic target in CRC predicting poor prognosis and regulated by miR-7-5p and miR-26b-5p. | IL-2RG as a possible immunotherapeutic target in CRC predicting poor prognosis and regulated by miR-7-5p and miR-26b-5p.
Gharib E, Rejali L, Piroozkhah M, Zonoobi E, Nasrabadi PN, Arabsorkhi Z, Baghdar K, Shams E, Sadeghi A, Kuppen PJK, Salehi Z, Nazemalhosseini-Mojarad E., Free PMC Article | 05/13/2024 |
| PD-1 signaling negatively regulates the common cytokine receptor gamma chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity. | PD-1 signaling negatively regulates the common cytokine receptor γ chain via MARCH5-mediated ubiquitination and degradation to suppress anti-tumor immunity.
Liu R, Zeng LW, Li HF, Shi JG, Zhong B, Shu HB, Li S., Free PMC Article | 04/8/2024 |
| Somatic Genetic Reversion of a Duplication Event in IL2RG in Siblings. | Somatic Genetic Reversion of a Duplication Event in IL2RG in Siblings.
Cruz PD, Rylaarsdam S, Torgerson TR, Hagin D, Allenspach EJ. | 11/22/2023 |
| NFAT1 and NFkappaB regulates expression of the common gamma-chain cytokine receptor in activated T cells. | NFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells.
Shim JA, Lee SM, Jeong JW, Kim H, Son WJ, Park JH, Song P, Im SH, Bae S, Park JH, Jo Y, Hong C., Free PMC Article | 11/3/2023 |
| Keratinocytes activated by IL-4/IL-13 express IL-2Rgamma with consequences on epidermal barrier function. | Keratinocytes activated by IL-4/IL-13 express IL-2Rγ with consequences on epidermal barrier function.
Progneaux A, Evrard C, De Glas V, Fontaine A, Dotreppe C, De Vuyst E, Nikkels AF, García-González V, Dumoutier L, Lambert de Rouvroit C, Poumay Y. | 05/5/2023 |
| Somatic Reversion of a Novel IL2RG Mutation Resulting in Atypical X-Linked Combined Immunodeficiency. | Somatic Reversion of a Novel IL2RG Mutation Resulting in Atypical X-Linked Combined Immunodeficiency.
Hou Y, Gratz HP, Ureña-Bailén G, Gratz PG, Schilbach-Stückle K, Renno T, Güngör D, Mader DA, Malenke E, Antony JS, Handgretinger R, Mezger M., Free PMC Article | 02/26/2022 |
| Survival-Assured Liver Injury Preconditioning (SALIC) Enables Robust Expansion of Human Hepatocytes in Fah(-/-) Rag2(-/-) IL2rg(-/-) Rats. | Survival-Assured Liver Injury Preconditioning (SALIC) Enables Robust Expansion of Human Hepatocytes in Fah(-/-) Rag2(-/-) IL2rg(-/-) Rats.
Zhang L, Ge JY, Zheng YW, Sun Z, Wang C, Peng Z, Wu B, Fang M, Furuya K, Ma X, Shao Y, Ohkohchi N, Oda T, Fan J, Pan G, Li D, Hui L., Free PMC Article | 02/12/2022 |
| Case Report: A Novel IL2RG Frame-Restoring Rescue Mutation Mimics Early T Cell Engraftment Following Haploidentical Hematopoietic Stem Cell Transplantation in a Patient With X-SCID. | Case Report: A Novel IL2RG Frame-Restoring Rescue Mutation Mimics Early T Cell Engraftment Following Haploidentical Hematopoietic Stem Cell Transplantation in a Patient With X-SCID.
Steininger J, Leiss-Piller A, Geier CB, Rossmanith R, Elfeky R, Bra D, Pichler H, Lawitschka A, Zubarovskaya N, Artacker G, Matthes-Leodolter S, Eibl MM, Wolf HM., Free PMC Article | 09/25/2021 |
| Atypical immune phenotype in severe combined immunodeficiency patients with novel mutations in IL2RG and JAK3. | Atypical immune phenotype in severe combined immunodeficiency patients with novel mutations in IL2RG and JAK3.
Goldberg L, Simon AJ, Lev A, Barel O, Stauber T, Kunik V, Rechavi G, Somech R. | 08/14/2021 |
| Novel Hemizygous IL2RG p.(Pro58Ser) Mutation Impairs IL-2 Receptor Complex Expression on Lymphocytes Causing X-Linked Combined Immunodeficiency. | Novel Hemizygous IL2RG p.(Pro58Ser) Mutation Impairs IL-2 Receptor Complex Expression on Lymphocytes Causing X-Linked Combined Immunodeficiency.
Tuovinen EA, Grönholm J, Öhman T, Pöysti S, Toivonen R, Kreutzman A, Heiskanen K, Trotta L, Toiviainen-Salo S, Routes JM, Verbsky J, Mustjoki S, Saarela J, Kere J, Varjosalo M, Hänninen A, Seppänen MRJ., Free PMC Article | 08/7/2021 |
| Value of serum soluble interleukin-2 receptor as a diagnostic and predictive biomarker in sarcoidosis. | Value of serum soluble interleukin-2 receptor as a diagnostic and predictive biomarker in sarcoidosis.
Schimmelpennink MC, Quanjel M, Vorselaars A, Wiertz I, Veltkamp M, Van Moorsel C, Grutters JC. | 03/20/2021 |
| Data indicate a nonsense mutation in exon 8 (p.R328X) of interleukin (IL)-2 receptor common gamma chain gene (IL2RG)in two brothers were diagnosed with X-Linked combined Immunodeficiency (X-SCID). | The IL-2RG R328X nonsense mutation allows partial STAT-5 phosphorylation and defines a critical region involved in the leaky-SCID phenotype.
Arcas-García A, Garcia-Prat M, Magallón-Lorenz M, Martín-Nalda A, Drechsel O, Ossowski S, Alonso L, Rivière JG, Soler-Palacín P, Colobran R, Sayós J, Martínez-Gallo M, Franco-Jarava C., Free PMC Article | 08/1/2020 |
| High IL2RG expression is associated with peripheral Tcell lymphoma expressing the ITKSYK fusion gene. | Genome profiling revealed the activation of IL2RG/JAK3/STAT5 in peripheral T‑cell lymphoma expressing the ITK‑SYK fusion gene.
Zhang LL, Pan HX, Wang YX, Guo T, Liu L., Free PMC Article | 03/14/2020 |
| sgammac was highly expressed in synovial fluid of rheumatoid arthritis patients and increased in established Collagen-Induced Arthritis mice. | Specific Inhibition of Soluble γc Receptor Attenuates Collagen-Induced Arthritis by Modulating the Inflammatory T Cell Responses.
Lee B, Jo Y, Kim G, Ali LA, Sohn DH, Lee SG, Kim K, Shin E, Ryu SH, Hong C., Free PMC Article | 02/29/2020 |
| excreted-secreted antigens (ESA) directly influenced the expression of IL-2Rgamma, rather than the availability of IL-2 indirectly. ESA suppressed the level of Foxp3 via inhibiting IL-2Rgamma/JAK3/Stats signaling pathway in EL4 cells. | Excreted-secreted antigens of Toxoplasma gondii inhibit Foxp3 via IL-2Rγ/JAK3/Stats pathway.
Chen J, Huang C, Zhu D, Chen L, Wang J, Sun X, Hu L, Duan Y. | 11/30/2019 |
| IL2RG/JAK3-deficient B cells remain intrinsically defective posttransplant despite follicular helper T-cell reconstitution. In vitro response of B cells to IL-21 is a potential biomarker for humoral immunity in patients with IL2RG/JAK3 SCID after transplantation. | B-cell differentiation and IL-21 response in IL2RG/JAK3 SCID patients after hematopoietic stem cell transplantation.
Miggelbrink AM, Logan BR, Buckley RH, Parrott RE, Dvorak CC, Kapoor N, Abdel-Azim H, Prockop SE, Shyr D, Decaluwe H, Hanson IC, Gillio A, Dávila Saldaña BJ, Eibel H, Hopkins G, Walter JE, Whangbo JS, Kohn DB, Puck JM, Cowan MJ, Griffith LM, Haddad E, O'Reilly RJ, Notarangelo LD, Pai SY., Free PMC Article | 07/20/2019 |
| IL2RG mutations cause X-linked severe combined immunodeficiency in humans and mice that can be corrected by gene editing. | Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Alzubi J, Pallant C, Mussolino C, Howe SJ, Thrasher AJ, Cathomen T., Free PMC Article | 06/29/2019 |
| These data suggest that a fine balance between aberrant splicing and leaky production of normally spliced IL2RG mRNA resulted in late-onset combined immunodeficiency in these patients. | A synonymous splice site mutation in IL2RG gene causes late-onset combined immunodeficiency.
Yamashita M, Wakatsuki R, Kato T, Okano T, Yamanishi S, Mayumi N, Tanaka M, Ogura Y, Kanegane H, Nonoyama S, Imai K, Morio T. | 05/4/2019 |
| This study identifies one novel mutation in the IL2RG gene and another, previously described mutation in the CYBB genes. It is the first report establishing a diagnosis of X-SCID and X-CGD using WES in Chinese patients. | Identification of IL2RG and CYBB mutations in two Chinese primary immunodeficiency patients by whole-exome sequencing.
Xu S, Li Q, Wu J, Chen G, Zhu B, Gu W. | 09/8/2018 |
| New insights of common gamma chain in hematological malignancies. | New insights of common gamma chain in hematological malignancies.
Goh TS, Hong C. | 01/6/2018 |
| this study shows that downregulation of miR-3940-5p promotes T-cell activity by targeting the cytokine receptor IL-2R gamma on human cutaneous T-cell lines | Downregulation of miR-3940-5p promotes T-cell activity by targeting the cytokine receptor IL-2R gamma on human cutaneous T-cell lines.
Wang Y, Wang K, Dang N, Wang L, Zhang M. | 12/2/2017 |
| Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2- and IL-15-activated T-cells has been reported. | Characterization of Receptor-Associated Protein Complex Assembly in Interleukin (IL)-2- and IL-15-Activated T-Cell Lines.
Osinalde N, Sanchez-Quiles V, Akimov V, Aloria K, Arizmendi JM, Blagoev B, Kratchmarova I. | 10/21/2017 |
| systematic scoping review highlights the many potential uses of soluble interleukin-2 receptor measurement in the diagnosis and treatment of hemophagocytic syndromes. | Clinical utility of soluble interleukin-2 receptor in hemophagocytic syndromes: a systematic scoping review.
Lin M, Park S, Hayden A, Giustini D, Trinkaus M, Pudek M, Mattman A, Schneider M, Chen LYC. | 08/5/2017 |
| analysis of the contribution of IL2Rgamma to the dynamic formation of IL2-IL2R complexes | Quantitative Contribution of IL2Rγ to the Dynamic Formation of IL2-IL2R Complexes.
Ponce LF, García-Martínez K, León K., Free PMC Article | 07/29/2017 |
| A deletion mutation in IL2RG gene results in X-linked severe combined immunodeficiency with an atypical phenotype | A novel deletion mutation in IL2RG gene results in X-linked severe combined immunodeficiency with an atypical phenotype.
Mou W, He J, Chen X, Zhang H, Ren X, Wu X, Ni X, Xu B, Gui J. | 05/20/2017 |