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    IL2 interleukin 2 [ Homo sapiens (human) ]

    Gene ID: 3558, updated on 12-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Association of CTACK, IL-2, and IL-13 with increased risk of lung cancer: A Mendelian randomization study.

    Association of CTACK, IL-2, and IL-13 with increased risk of lung cancer: A Mendelian randomization study.
    Liu Z, Zheng Y, Yuan M, Zhang G, Yang G.

    11/6/2024
    CD38 in SLE CD4 T cells promotes Ca[2+] flux and suppresses interleukin-2 production by enhancing the expression of GM2 on the surface membrane.

    CD38 in SLE CD4 T cells promotes Ca(2+) flux and suppresses interleukin-2 production by enhancing the expression of GM2 on the surface membrane.
    Katsuyama E, Humbel M, Suarez-Fueyo A, Satyam A, Yoshida N, Kyttaris VC, Tsokos MG, Tsokos GC., Free PMC Article

    10/5/2024
    Plasma Levels of Interleukin 2 (IL-2) Associated with Hearing Loss Evaluation in the Elderly.

    Plasma Levels of Interleukin 2 (IL-2) Associated with Hearing Loss Evaluation in the Elderly.
    Cordeiro FP, Marchiori LLM, Teixeira DC, Andraus RAC, Poli-Frederico RC., Free PMC Article

    06/30/2024
    Differential requirement for IL-2 and IL-23 in the differentiation and effector functions of Th17/ILC3-like cells in a human T cell line.

    Differential requirement for IL-2 and IL-23 in the differentiation and effector functions of Th17/ILC3-like cells in a human T cell line.
    Momtazkari S, Dev Choudhury A, Yong ZWE, Le DT, Nguyen Canh H, Harada K, Toshiyuki H, Osato M, Takahashi C, Koh CP, Voon DC.

    06/5/2024
    PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function.

    PGE(2) inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function.
    Morotti M, Grimm AJ, Hope HC, Arnaud M, Desbuisson M, Rayroux N, Barras D, Masid M, Murgues B, Chap BS, Ongaro M, Rota IA, Ronet C, Minasyan A, Chiffelle J, Lacher SB, Bobisse S, Murgues C, Ghisoni E, Ouchen K, Bou Mjahed R, Benedetti F, Abdellaoui N, Turrini R, Gannon PO, Zaman K, Mathevet P, Lelievre L, Crespo I, Conrad M, Verdeil G, Kandalaft LE, Dagher J, Corria-Osorio J, Doucey MA, Ho PC, Harari A, Vannini N, Böttcher JP, Dangaj Laniti D, Coukos G., Free PMC Article

    06/3/2024
    IL2RA rs2104286 and IL2 rs2069762 polymorphisms may be associated with bipolar disorder and its clinical findings.

    IL2RA rs2104286 and IL2 rs2069762 polymorphisms may be associated with bipolar disorder and its clinical findings.
    Pehlivan S, Aytac HM, Nursal AF, Tuncel FC, Pehlivan M.

    04/29/2024
    Tumor-infiltrating mast cells stimulate ICOS[+] regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression.

    Tumor-infiltrating mast cells stimulate ICOS(+) regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression.
    Lv Y, Tian W, Teng Y, Wang P, Zhao Y, Li Z, Tang S, Chen W, Xie R, Lü M, Zhuang Y., Free PMC Article

    03/4/2024
    Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.

    Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue.
    Martinez HA, Koliesnik I, Kaber G, Reid JK, Nagy N, Barlow G, Falk BA, Medina CO, Hargil A, Zihsler S, Vlodavsky I, Li JP, Pérez-Cruz M, Tang SW, Meyer EH, Wrenshall LE, Lord JD, Garcia KC, Palmer TD, Steinman L, Nepom GT, Wight TN, Bollyky PL, Kuipers HF., Free PMC Article

    02/23/2024
    The soluble IL-2 receptor alpha/CD25 as a modulator of IL-2 function.

    The soluble IL-2 receptor α/CD25 as a modulator of IL-2 function.
    Lokau J, Petasch LM, Garbers C.

    02/12/2024
    The Effect of Interleukin-2 -330 T/G Polymorphism in People with Schizophrenia Among The Batak and Javanese Ethnic Groups.

    The Effect of Interleukin-2 -330 T/G Polymorphism in People with Schizophrenia Among The Batak and Javanese Ethnic Groups.
    Amin MM, Husada MS, Idaiani S, Effendy E, Nasution S, Purnama SD., Free PMC Article

    02/2/2024
    Evaluation of gene-gene interaction between the interleukin (IL)-2 and IL-2RA gene polymorphisms in schizophrenia patients in the Turkish Population.

    Evaluation of gene-gene interaction between the interleukin (IL)-2 and IL-2RA gene polymorphisms in schizophrenia patients in the Turkish Population.
    Ozdilli K, Mervan Aytac H, Ceren Tuncel F, Oyaci Y, Pehlivan M, Pehlivan S., Free PMC Article

    01/12/2024
    Intestinal flora altered and correlated with interleukin-2/4 in patients with primary immune thrombocytopenia.

    Intestinal flora altered and correlated with interleukin-2/4 in patients with primary immune thrombocytopenia.
    Wang H, Bi H, Yang M, Wang X, Song C, Yang W, Wang Y, Xie D, Li H, Zhou Z.

    11/10/2023
    Down-regulation of interleukin-2 predicts poor prognosis and associated with immune escape in lung adenocarcinoma.

    Down-regulation of interleukin-2 predicts poor prognosis and associated with immune escape in lung adenocarcinoma.
    Hou Y, Xiang B, Yang Z, Liu J, Xu D, Geng L, Zhan M, Xu Y, Zhang B., Free PMC Article

    11/7/2023
    The Important Role of Interleukin-2 in COVID-19.

    The Important Role of Interleukin-2 in COVID-19.
    Ghanbari Naeini L, Abbasi L, Karimi F, Kokabian P, Abdi Abyaneh F, Naderi D., Free PMC Article

    09/22/2023
    Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells.

    Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells.
    Shapiro MR, Peters LD, Brown ME, Cabello-Kindelan C, Posgai AL, Bayer AL, Brusko TM., Free PMC Article

    09/20/2023
    Immune microenvironment of cervical cancer and the role of IL-2 in tumor promotion.

    Immune microenvironment of cervical cancer and the role of IL-2 in tumor promotion.
    Trujillo-Cirilo L, Weiss-Steider B, Vargas-Angeles CA, Corona-Ortega MT, Rangel-Corona R.

    09/13/2023
    Association of Interleukin-2 Gene Polymorphism with Henoch-schonlein Purpura Nephritis.

    Association of Interleukin-2 Gene Polymorphism with Henoch-schönlein Purpura Nephritis.
    Cao J, Zhang J, Xu H, Li W, Shi J, Ye Q.

    08/3/2023
    c-Kit signaling potentiates CAR T cell efficacy in solid tumors by CD28- and IL-2-independent co-stimulation.

    c-Kit signaling potentiates CAR T cell efficacy in solid tumors by CD28- and IL-2-independent co-stimulation.
    Xiong Y, Taleb M, Misawa K, Hou Z, Banerjee S, Amador-Molina A, Jones DR, Chintala NK, Adusumilli PS., Free PMC Article

    08/3/2023
    HIV-1 Transcriptional Activator Tat Inhibits IL2 Expression by Preventing the Presence of Pol II on the IL2 Promoter.

    HIV-1 Transcriptional Activator Tat Inhibits IL2 Expression by Preventing the Presence of Pol II on the IL2 Promoter.
    Anastasopoulou S, Georgakopoulos T, Mouzaki A., Free PMC Article

    07/5/2023
    Expression analysis of IL-2, TBX21 and SOCS1 in peripheral blood cells of celiac disease patients reveals the diagnostic potential of IL-2.

    Expression analysis of IL-2, TBX21 and SOCS1 in peripheral blood cells of celiac disease patients reveals the diagnostic potential of IL-2.
    Ganjali F, Asri N, Rostami-Nejad M, Hashemi M, Ainy E, Masotti A, Asadzadeh Aghdaei H.

    05/28/2023
    Inflammatory Response and Activation of Coagulation after COVID-19 Infection.

    Inflammatory Response and Activation of Coagulation after COVID-19 Infection.
    Teodoro AGF, Rodrigues WF, Farnesi-de-Assunção TS, Borges AVBE, Obata MMS, Neto JRDC, da Silva DAA, Andrade-Silva LE, Desidério CS, Costa-Madeira JC, Barbosa RM, Cunha ACCH, Pereira LQ, de Vito FB, Vaz Tanaka SCS, Helmo FR, Lemes MR, Barbosa LM, Trevisan RO, Mundim FV, Oliveira-Scussel ACM, Junior PRR, Monteiro IB, Ferreira YM, Machado GH, Ferreira-Paim K, Moraes-Souza H, de Oliveira CJF, Rodrigues Júnior V, Silva MVD., Free PMC Article

    05/12/2023
    TGF-beta2 antisense oligonucleotide enhances T-cell mediated anti-tumor activities by IL-2 via attenuation of fibrotic reaction in a humanized mouse model of pancreatic ductal adenocarcinoma.

    TGF-β2 antisense oligonucleotide enhances T-cell mediated anti-tumor activities by IL-2 via attenuation of fibrotic reaction in a humanized mouse model of pancreatic ductal adenocarcinoma.
    Lee HK, Nam MW, Go RE, Koo J, Kim TH, Park JE, Choi KC.

    02/25/2023
    Exploring the association of interleukin polymorphisms with aggression and internalizing behaviors in children and adolescents.

    Exploring the association of interleukin polymorphisms with aggression and internalizing behaviors in children and adolescents.
    Pouget JG, Bryushkova L, Koyama E, Zai CC, Fonseka TM, Mueller D, Kennedy JL, Beitchman JH., Free PMC Article

    11/19/2022
    Combined assessment of S- and N-specific IL-2 and IL-13 secretion and CD69 neo-expression for discrimination of post-infection and post-vaccination cellular SARS-CoV-2-specific immune response.

    Combined assessment of S- and N-specific IL-2 and IL-13 secretion and CD69 neo-expression for discrimination of post-infection and post-vaccination cellular SARS-CoV-2-specific immune response.
    Kratzer B, Schlax LC, Gattinger P, Waidhofer-Söllner P, Trapin D, Tauber PA, Sehgal ANA, Körmöczi U, Rottal A, Feichter M, Oberhofer T, Grabmeier-Pfistershammer K, Borochova K, Dorofeeva Y, Tulaeva I, Weber M, Mühl B, Kropfmüller A, Negrin B, Kundi M, Valenta R, Pickl WF., Free PMC Article

    11/5/2022
    The effect of serum IL-2 levels on the prognosis of primary biliary cholangitis-related liver failure and the preliminary exploration of its mechanism.

    The effect of serum IL-2 levels on the prognosis of primary biliary cholangitis-related liver failure and the preliminary exploration of its mechanism.
    Wang Q, Wang Y, Qiao W, Xu B, Liu Y, Zhang X, Li W, Zhao J, Liu M, Zhang Y, Chen D, Huang C, Jin R., Free PMC Article

    10/8/2022
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