| GRP78 recognizes EV-F 3D protein and activates NF-kappaB to repress virus replication by interacting with CHUK/IKBKB. | GRP78 recognizes EV-F 3D protein and activates NF-κB to repress virus replication by interacting with CHUK/IKBKB.
Chang X, Guo Y, Zhang Q, Zheng X, Cui X, Hu J, Zhang Z, Zhang F, Wang X., Free PMC Article | 07/17/2024 |
| IkappaB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation. | IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation.
Iguchi Y, Takahashi Y, Li J, Araki K, Amakusa Y, Kawakami Y, Kobayashi K, Yokoi S, Katsuno M., Free PMC Article | 06/24/2024 |
| Novel association between single-nucleotide polymorphisms of IKKbeta at rs17875746 and rs12676482 and periodontitis. | Novel association between single-nucleotide polymorphisms of IKKβ at rs17875746 and rs12676482 and periodontitis.
Mahmood AA, Abbas RF, Hussein HM. | 01/3/2024 |
| IKKbeta Inhibition Attenuates Epithelial Mesenchymal Transition of Human Stem Cell-Derived Retinal Pigment Epithelium. | IKKβ Inhibition Attenuates Epithelial Mesenchymal Transition of Human Stem Cell-Derived Retinal Pigment Epithelium.
Sripathi SR, Hu MW, Turaga RC, Mikeasky R, Satyanarayana G, Cheng J, Duan Y, Maruotti J, Wahlin KJ, Berlinicke CA, Qian J, Esumi N, Zack DJ., Free PMC Article | 05/23/2023 |
| SARS-CoV-2 ORF3a positively regulates NF-kappaB activity by enhancing IKKbeta-NEMO interaction. | SARS-CoV-2 ORF3a positively regulates NF-κB activity by enhancing IKKβ-NEMO interaction.
Nie Y, Mou L, Long Q, Deng D, Hu R, Cheng J, Wu J., Free PMC Article | 04/4/2023 |
| The expression levels of NF-kappaB and IKKbeta in epithelial ovarian cancer and their correlation with drug resistance-related genes MDR1, TOPOII, and ERCC1. | The expression levels of NF-κB and IKKβ in epithelial ovarian cancer and their correlation with drug resistance-related genes MDR1, TOPOII, and ERCC1.
Hu Z, Cang R, Zhang H, Gao Y, Zhang X, Chen X, Rong Y, Luo B, Gao Y. | 03/30/2023 |
| The inhibitor of kappaB kinase beta (IKKbeta) phosphorylates IkappaBalpha twice in a single binding event through a sequential mechanism. | The inhibitor of κB kinase β (IKKβ) phosphorylates IκBα twice in a single binding event through a sequential mechanism.
Stephenson AA, Taggart DJ, Xu G, Fowler JD, Wu H, Suo Z., Free PMC Article | 02/4/2023 |
| IKKbeta primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network. | IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network.
Schmacke NA, O'Duill F, Gaidt MM, Szymanska I, Kamper JM, Schmid-Burgk JL, Mädler SC, Mackens-Kiani T, Kozaki T, Chauhan D, Nagl D, Stafford CA, Harz H, Fröhlich AL, Pinci F, Ginhoux F, Beckmann R, Mann M, Leonhardt H, Hornung V., Free PMC Article | 01/14/2023 |
| NF-kappaB-inducing kinase (NIK) is activated in pancreatic beta-cells but does not contribute to the development of diabetes. | NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes.
Xiao P, Takiishi T, Violato NM, Licata G, Dotta F, Sebastiani G, Marselli L, Singh SP, Sze M, Van Loo G, Dejardin E, Gurzov EN, Cardozo AK., Free PMC Article | 05/28/2022 |
| IKKbeta Alleviates Neuron Injury in Alzheimer's Disease via Regulating Autophagy and RIPK1-Mediated Necroptosis. | IKKβ Alleviates Neuron Injury in Alzheimer's Disease via Regulating Autophagy and RIPK1-Mediated Necroptosis.
Wang W, Gu X, Cheng Z, Lu X, Xie S, Liu X. | 04/30/2022 |
| Enterovirus 2C Protein Suppresses IKKalpha Phosphorylation by Recruiting IKKbeta and IKKalpha into Viral Inclusion Bodies. | Enterovirus 2C Protein Suppresses IKKα Phosphorylation by Recruiting IKKβ and IKKα into Viral Inclusion Bodies.
Ji L, Yang E, He S, Jin Y, Chen D. | 03/19/2022 |
| Basal and IL-1beta enhanced chondrocyte chemotactic activity on monocytes are co-dependent on both IKKalpha and IKKbeta NF-kappaB activating kinases. | Basal and IL-1β enhanced chondrocyte chemotactic activity on monocytes are co-dependent on both IKKα and IKKβ NF-κB activating kinases.
Olivotto E, Minguzzi M, D'Adamo S, Astolfi A, Santi S, Uguccioni M, Marcu KB, Borzì RM., Free PMC Article | 01/29/2022 |
| Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-kappaB/bone remodeling factors signaling. | Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-κB/bone remodeling factors signaling.
Xu Y, Zhang S, Liao X, Li M, Chen S, Li X, Wu X, Yang M, Tang M, Hu Y, Li Z, Yu R, Huang M, Song L, Li J., Free PMC Article | 01/29/2022 |
| Clinicopathological analysis and prognostic significance of NF-kappaB p65 and IKKbeta protein and mRNA expression in nasopharyngeal carcinoma. | Clinicopathological analysis and prognostic significance of NF-κB p65 and IKKβ protein and mRNA expression in nasopharyngeal carcinoma.
Zhou M, Zhao G, Zhou X, Xuan R, Chen Y, Wang Y., Free PMC Article | 01/15/2022 |
| MAP3K7-IKK Inflammatory Signaling Modulates AR Protein Degradation and Prostate Cancer Progression. | MAP3K7-IKK Inflammatory Signaling Modulates AR Protein Degradation and Prostate Cancer Progression.
Huang Z, Tang B, Yang Y, Yang Z, Shi L, Bai Y, Yan B, Karnes RJ, Zhang J, Jimenez R, Wang L, Wei Q, Yang J, Xu W, Jia Z, Huang H. | 01/8/2022 |
| Crosstalk of the IkappaB Kinase with Spliced X-Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial-Mesenchymal Transition. | Crosstalk of the IκB Kinase with Spliced X-Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial-Mesenchymal Transition.
Zhao Y, Zhang J, Sun H, Brasier AR., Free PMC Article | 08/14/2021 |
| Inhibition of kinase IKKbeta suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6. | Inhibition of kinase IKKβ suppresses cellular abnormalities induced by the human papillomavirus oncoprotein HPV 18E6.
Padash Barmchi M, Thomas M, Thatte JV, Vats A, Zhang B, Cagan RL, Banks L., Free PMC Article | 08/7/2021 |
| Heterozygous IKKbeta activation loop mutation results in a complex immunodeficiency syndrome. | Heterozygous IKKβ activation loop mutation results in a complex immunodeficiency syndrome.
Abbott J, Ehler AC, Jayaraman D, Reynolds PR, Otsu K, Manka L, Gelfand EW., Free PMC Article | 08/7/2021 |
| The IKKbeta-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis. | The IKKβ-USP30-ACLY Axis Controls Lipogenesis and Tumorigenesis.
Gu L, Zhu Y, Lin X, Lu B, Zhou X, Zhou F, Zhao Q, Prochownik EV, Li Y. | 06/19/2021 |
| The NF-kappaB regulator IkappaBbeta exhibits different molecular interactivity and phosphorylation status from IkappaBalpha in an IKK2-catalysed reaction. | The NF-κB regulator IκBβ exhibits different molecular interactivity and phosphorylation status from IκBα in an IKK2-catalysed reaction.
Shoji S, Hanada K, Takahashi M, Watanabe K, Yonemochi M, Tomabechi Y, Shirouzu M. | 05/8/2021 |
| A Novel Homozygous Mutation Destabilizes IKKbeta and Leads to Human Combined Immunodeficiency. | A Novel Homozygous Mutation Destabilizes IKKβ and Leads to Human Combined Immunodeficiency.
Qin T, Jia Y, Liu Y, Dai R, Zhou L, Okada S, Tsumura M, Ohnishi H, Kato Z, Kanegane H, Sun X, Zhao X., Free PMC Article | 05/1/2021 |
| IKKbeta activation promotes amphisome formation and extracellular vesicle secretion in tumor cells. | IKKβ activation promotes amphisome formation and extracellular vesicle secretion in tumor cells.
Peng X, Yang L, Ma Y, Li X, Yang S, Li Y, Wu B, Tang S, Zhang F, Zhang B, Liu J, Li H. | 04/17/2021 |
| Chrysin Inhibits NF-kappaB-Dependent CCL5 Transcription by Targeting IkappaB Kinase in the Atopic Dermatitis-Like Inflammatory Microenvironment. | Chrysin Inhibits NF-κB-Dependent CCL5 Transcription by Targeting IκB Kinase in the Atopic Dermatitis-Like Inflammatory Microenvironment.
Yeo H, Lee YH, Koh D, Lim Y, Shin SY., Free PMC Article | 02/27/2021 |
| Canonical, Non-Canonical and Atypical Pathways of Nuclear Factor small ka, Cyrillicb Activation in Preeclampsia. | Canonical, Non-Canonical and Atypical Pathways of Nuclear Factor кb Activation in Preeclampsia.
Sakowicz A, Bralewska M, Pietrucha T, Habrowska-Górczyńska DE, Piastowska-Ciesielska AW, Gach A, Rybak-Krzyszkowska M, Witas PJ, Huras H, Grzesiak M, Biesiada L., Free PMC Article | 02/20/2021 |
| IKKbeta Kinase Promotes Stemness, Migration, and Invasion in KRAS-Driven Lung Adenocarcinoma Cells. | IKKβ Kinase Promotes Stemness, Migration, and Invasion in KRAS-Driven Lung Adenocarcinoma Cells.
Rodrigues FS, Miranda VS, Carneiro-Lobo TC, Scalabrini LC, Kruspig B, Levantini E, Murphy DJ, Bassères DS., Free PMC Article | 02/20/2021 |