| In eosinophilic oesophagitis, serum Ig-fLC appeared higher in female than male children. | Serum immunoglobulin free light chain levels are higher in girls than boys during eosinophilic oesophagitis.
Knipping K, Colson D, Soulaines P, Redegeld F, Garssen J, Dupont C. | 02/14/2015 |
| the monomeric form of the Mcg immunoglobulin light chain variable domain as the quaternary unit required for amyloid fiber assembly. | Formation of amyloid fibers by monomeric light chain variable domains.
Brumshtein B, Esswein SR, Landau M, Ryan CM, Whitelegge JP, Phillips ML, Cascio D, Sawaya MR, Eisenberg DS., Free PMC Article | 12/20/2014 |
| The active center of A17lambda antibody is displaced, stabilized and made more rigid owing to interdomain interactions involving the complementarity determining region(CDR)s from the variable light (VL) chain and variable heavy (VH) chain domains. | Role of κ→λ light-chain constant-domain switch in the structure and functionality of A17 reactibody.
Ponomarenko N, Chatziefthimiou SD, Kurkova I, Mokrushina Y, Mokrushina Y, Stepanova A, Smirnov I, Avakyan M, Bobik T, Mamedov A, Mitkevich V, Belogurov A Jr, Fedorova OS, Dubina M, Golovin A, Lamzin V, Friboulet A, Makarov AA, Wilmanns M, Gabibov A., Free PMC Article | 08/23/2014 |
| Mutation of lambda 6 light chain is associated with amyloidogenesis. | Mutational and genetic determinants of λ6 light chain amyloidogenesis.
González-Andrade M, Becerril-Luján B, Sánchez-López R, Ceceña-Álvarez H, Pérez-Carreón JI, Ortiz E, Fernández-Velasco DA, del Pozo-Yauner L. | 01/25/2014 |
| The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus. | The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus.
Mraz M, Stano Kozubik K, Plevova K, Musilova K, Tichy B, Borsky M, Kuglik P, Doubek M, Brychtova Y, Mayer J, Pospisilova S. | 08/3/2013 |
| Study indicates the role of the differential analysis of monomeric and dimeric kappa- and lambda-immunoglobulin (Ig) free light chains (FLC) for the precise diagnosis of multiple sclerosis (MS). | Free light chain monomer-dimer patterns in the diagnosis of multiple sclerosis.
Kaplan B, Golderman S, Yahalom G, Yeskaraev R, Ziv T, Aizenbud BM, Sela BA, Livneh A. | 05/18/2013 |
| A humanized rat strain carries a chimeric human/rat IgH locus together with fully human IgL loci (variable kappas linked to Jkappa-Ckappa and Vlambdas linked to Jlambda-Clambda). | High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region.
Osborn MJ, Ma B, Avis S, Binnie A, Dilley J, Yang X, Lindquist K, Ménoret S, Iscache AL, Ouisse LH, Rajpal A, Anegon I, Neuberger MS, Buelow R, Brüggemann M., Free PMC Article | 03/30/2013 |
| Data indicate that serum free light chain kappa/lambda ratio (rFLC) showed the highest sensitivity (91.8%) to differentiate multiple myeloma (MM) from non-MM. | Combined analysis using extended renal reference range of serum free light chain ratio and serum protein electrophoresis improves the diagnostic accuracy of multiple myeloma in renal insufficiency.
Park JW, Kim YK, Bae EH, Ma SK, Kim SW. | 10/27/2012 |
| In survivors of chronic kidney failure, median serum levels of free kappa plus lambda immunoglobulin light chains are significantly higher compared with nonsurvivors. | Higher serum levels of free ĸ plus λ immunoglobulin light chains ameliorate survival of hemodialysis patients.
Thilo F, Caspari C, Scholze A, Tepel M. | 06/9/2012 |
| We present a CD5-positive, CCND1-negative B-cell lymphoma with a novel translocation involving CCND2 and the immunoglobulin lambda (IGL) gene. | CD5-positive, cyclinD1-negative mantle cell lymphoma with a translocation involving the CCND2 gene and the IGL locus.
Shiller SM, Zieske A, Holmes H 3rd, Feldman AL, Law ME, Saad R. | 07/23/2011 |
| Results have shown that RNA interference can markedly reduce LC synthesis and provide the basis for testing the therapeutic potential of this strategy using in vivo experimental models of multiple myeloma. | Inhibition of pathologic immunoglobulin-free light chain production by small interfering RNA molecules.
Phipps JE, Kestler DP, Foster JS, Kennel SJ, Donnell R, Weiss DT, Solomon A, Wall JS., Free PMC Article | 01/1/2011 |
| analysis of immunoglobulin light chain gene translocations in non-Hodgkin's lymphoma as assessed by fluorescence in situ hybridisation | Immunoglobulin light chain gene translocations in non-Hodgkin's lymphoma as assessed by fluorescence in situ hybridisation.
Fujimoto Y, Nomura K, Fukada S, Shimizu D, Shimura K, Matsumoto Y, Horiike S, Nishida K, Shimazaki C, Abe M, Taniwaki M. | 01/21/2010 |
| Selection into the productive Vlambda repertoire in principal might be driven mainly by autoantigens in the newborn, as well as in adulthood, since newborns have not been exposed to exogenous antigens. | The lambda gene immunoglobulin repertoire of human neonatal B cells.
Richl P, Stern U, Lipsky PE, Girschick HJ. | 01/21/2010 |
| Nomenclature of the human immunoglobulin lambda (IGL) genes. | Nomenclature of the human immunoglobulin lambda (IGL) genes.
Lefranc MP. | 01/21/2010 |
| Imprint of somatic hypermutation differs in immunoglobulin heavy and lambda chain variable gene segments. | Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments.
Boursier L, Su W, Spencer J. | 01/21/2010 |
| Isolated from multiple myeloma patients, this protein in crystal form may shed some light on the formation of fibrils common to certain storage diseases. | Four crystal forms of a Bence-Jones protein.
Makino DL, Henschen-Edman AH, McPherson A., Free PMC Article | 01/21/2010 |