| Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication. | Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication.
Xiao RW, Wang F, Wang TM, Zhang JB, Wu ZY, Deng CM, Liao Y, Zhou T, Yang DW, Dong SQ, Xue WQ, He YQ, Zheng XH, Li XZ, Zhang PF, Zhang SD, Hu YZ, Liu YY, Xia YF, Gao S, Mu JB, Feng L, Jia WH., Free PMC Article | 10/22/2022 |
| Next-Generation Sequencing-Based Analysis of the Roles of DNA Polymerases nu and theta in the Replicative Bypass of 8-Oxo-7,8-dihydroguanine in Human Cells. | Next-Generation Sequencing-Based Analysis of the Roles of DNA Polymerases ν and θ in the Replicative Bypass of 8-Oxo-7,8-dihydroguanine in Human Cells.
Liu Y, Zhu X, Wang Z, Dai X, You C. | 08/27/2022 |
| Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction. | Multiple deprotonation paths of the nucleophile 3'-OH in the DNA synthesis reaction.
Gregory MT, Gao Y, Cui Q, Yang W., Free PMC Article | 12/4/2021 |
| DNA polymerases eta and kappa bypass N(2)-guanine-O(6)-alkylguanine DNA alkyltransferase cross-linked DNA-peptides. | DNA polymerases η and κ bypass N(2)-guanine-O(6)-alkylguanine DNA alkyltransferase cross-linked DNA-peptides.
Ghodke PP, Guengerich FP., Free PMC Article | 11/27/2021 |
| Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase eta. | Translesion synthesis of the major nitrogen mustard-induced DNA lesion by human DNA polymerase η.
Jung H, Rayala NK, Lee S., Free PMC Article | 03/13/2021 |
| The roles of polymerases nu and theta in replicative bypass of O (6)- and N (2)-alkyl-2'-deoxyguanosine lesions in human cells. | The roles of polymerases ν and θ in replicative bypass of O(6)- and N(2)-alkyl-2'-deoxyguanosine lesions in human cells.
Du H, Wang P, Wu J, He X, Wang Y., Free PMC Article | 01/2/2021 |
| Crystallographic evidence for two-metal-ion catalysis in human pol eta. | Crystallographic evidence for two-metal-ion catalysis in human pol η.
Wang J, Smithline ZB., Free PMC Article | 01/25/2020 |
| the Poleta-oxaliplatin-GpG structure provides a structural basis for TLS-mediated bypass of the major oxaliplatin-DNA adducts and insights into resistance to platinum-based chemotherapy in humans. | Structural basis for the bypass of the major oxaliplatin-DNA adducts by human DNA polymerase η.
Ouzon-Shubeita H, Baker M, Koag MC, Lee S., Free PMC Article | 12/21/2019 |
| These results suggest that hpol eta is one of the major reverse transcriptases involved in physiological processes in human cells. | Human DNA polymerase η has reverse transcriptase activity in cellular environments.
Su Y, Ghodke PP, Egli M, Li L, Wang Y, Guengerich FP., Free PMC Article | 10/19/2019 |
| Data suggest that translesion DNA synthesis mediated by (1) POLI-dependent pathway (2) REV1- and POLN-dependent pathway, or (3) POLtheta-dependent pathway occur in predominantly error-free manner in human cells. (POLI = DNA polymerase iota; REV1 = DNA repair protein-REV1; POLN = DNA polymerase nu; POLtheta = DNA polymerase theta) | Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct.
Yoon JH, Hodge RP, Hackfeld LC, Park J, Roy Choudhury J, Prakash S, Prakash L., Free PMC Article | 12/22/2018 |
| The structural data are consistent with the observed tendency of hpol eta to insert both dC and dT opposite the O(6)-MeG lesion with similar efficiencies. | Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase η.
Patra A, Zhang Q, Guengerich FP, Egli M., Free PMC Article | 05/27/2017 |
| Five x-ray crystal structures of hpol eta ternary complexes were determined, three at the insertion and two at the extension stage. | Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase η.
Patra A, Su Y, Zhang Q, Johnson KM, Guengerich FP, Egli M., Free PMC Article | 11/19/2016 |
| The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase eta Mediates Its Interaction with the C-terminal Domain of Rev1. | The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1.
Boehm EM, Powers KT, Kondratick CM, Spies M, Houtman JC, Washington MT., Free PMC Article | 10/8/2016 |
| This is the first crystal structure of a DNA polymerase with an incoming rNTP opposite a DNA lesion. | Mechanism of Ribonucleotide Incorporation by Human DNA Polymerase η.
Su Y, Egli M, Guengerich FP., Free PMC Article | 07/2/2016 |
| Pol nu catalyzes both correct and mispair formation with high catalytic efficiency. | Human DNA Polymerase ν Catalyzes Correct and Incorrect DNA Synthesis with High Catalytic Efficiency.
Gowda AS, Moldovan GL, Spratt TE., Free PMC Article | 10/3/2015 |
| WRN improves the efficiency and fidelity of hpol eta to promote more effective replication of DNA. | Enhancement of human DNA polymerase η activity and fidelity is dependent upon a bipartite interaction with the Werner syndrome protein.
Maddukuri L, Ketkar A, Eddy S, Zafar MK, Griffin WC, Eoff RL., Free PMC Article | 02/16/2013 |
| Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase eta recruitment to DNA damage sites | Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase η recruitment to DNA damage sites.
Whitehurst CB, Vaziri C, Shackelford J, Pagano JS., Free PMC Article | 11/24/2012 |
| Our finding suggests that polymorphisms in DNA repair genes, POLN and PRKDC, were associated with increased melanoma risk in melanoma families with and without CDKN2A mutations. | Genetic variants in DNA repair genes and the risk of cutaneous malignant melanoma in melanoma-prone families with/without CDKN2A mutations.
Liang XS, Pfeiffer RM, Wheeler W, Maeder D, Burdette L, Yeager M, Chanock S, Tucker MA, Goldstein AM, Yang XR., Free PMC Article | 05/19/2012 |
| both yeast and human pol eta synthesize past the 3'-(m)C CPD in a >99% error-free manner, consistent with the highly water-exposed nature of the active site. | Preparation of site-specific T=mCG cis-syn cyclobutane dimer-containing template and its error-free bypass by yeast and human polymerase η.
Song Q, Sherrer SM, Suo Z, Taylor JS., Free PMC Article | 05/5/2012 |
| The lower fidelity of POLN compared to that of Klenow fragment of Escherichia coli can be attributed to a much lower catalytic efficiency for correct dNTP incorporation, whereas both enzymes have similar kinetic parameters for G-dTTP misinsertion. | Kinetic analysis of the unique error signature of human DNA polymerase ν.
Arana ME, Potapova O, Kunkel TA, Joyce CM., Free PMC Article | 01/7/2012 |
| Described is a novel translesion DNA synthesis substrate specificity of pol nu, demonstrating that it is able to bypass exceptionally large DNA lesions whose linkages are through the DNA major groove. | Novel enzymatic function of DNA polymerase nu in translesion DNA synthesis past major groove DNA-peptide and DNA-DNA cross-links.
Yamanaka K, Minko IG, Takata K, Kolbanovskiy A, Kozekov ID, Wood RD, Rizzo CJ, Lloyd RS., Free PMC Article | 07/5/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The recently discovered polymerase POLN identified here is involved in repair of DNA cross-links. | DNA polymerase POLN participates in cross-link repair and homologous recombination.
Moldovan GL, Madhavan MV, Mirchandani KD, McCaffrey RM, Vinciguerra P, D'Andrea AD., Free PMC Article | 02/15/2010 |
| The DNA cross-linking agent mitomycin C hypersensitivity of PolN knockdown cells is rescued by overexpression of DNA polymerase-proficient PolN but not by DNA polymerase-deficient PolN. | Evidence for the involvement of human DNA polymerase N in the repair of DNA interstrand cross-links.
Zietlow L, Smith LA, Bessho M, Bessho T., Free PMC Article | 01/21/2010 |
| pol nu error rates for all 12 single base-base mismatches and for insertion and deletion errors | A unique error signature for human DNA polymerase nu.
Arana ME, Takata K, Garcia-Diaz M, Wood RD, Kunkel TA., Free PMC Article | 01/21/2010 |