| Data reported the first genome-wide analysis and transcriptome profiling of the new mib(nn2002) in Zebrafish. These results suggested that the defects in the somitogenesis were related to the down-regulated segmentation genes, such as foxc1a, smyhc1, myod1 and mylpfa. | Comparative transcriptomic characterization of a new mib mutant allele, mib(nn2002), in zebrafish.
Lai KP, Li JW, Hsu CH, You MS, Chan TF, Tse WKF, Jiang YJ. | 12/23/2017 |
| Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons. | Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons.
Matsuda M, Rand K, Palardy G, Shimizu N, Ikeda H, Dalle Nogare D, Itoh M, Chitnis AB., Free PMC Article | 09/9/2017 |
| indicate that miR-10 regulates the angiogenic behaviour in a Notch-dependent manner by directly targeting mib1 | MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis.
Wang X, Ling CC, Li L, Qin Y, Qi J, Liu X, You B, Shi Y, Zhang J, Jiang Q, Xu H, Sun C, You Y, Chai R, Liu D. | 12/31/2016 |
| forms of DeltaD that have the MID can activate Notch in trans and suppress early neurogenesis when mRNA encoding it is ectopically expressed in zebrafish embryos. | Identification of the Mind Bomb1 Interaction Domain in Zebrafish DeltaD.
Palardy G, Chitnis AB., Free PMC Article | 04/2/2016 |
| Mib and Mib2 interact with Fih-1 that is involved in the hypoxia signaling pathway. | New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens.
Tseng LC, Zhang C, Cheng CM, Xu H, Hsu CH, Jiang YJ., Free PMC Article | 11/29/2014 |
| Data indicate a general down-regulation of Notch signaling genes necessary for proper brain development in mind bomb-mutant zebrafish embryos. | Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish.
Hortopan GA, Baraban SC., Free PMC Article | 12/10/2011 |
| mind bomb mutants have downregulation of several genes necessary for GABA-mediated signaling. Spontaneous seizures are seen in these animals. | Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish.
Hortopan GA, Dinday MT, Baraban SC., Free PMC Article | 11/6/2010 |
| Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions | Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions.
Yamamoto M, Morita R, Mizoguchi T, Matsuo H, Isoda M, Ishitani T, Chitnis AB, Matsumoto K, Crump JG, Hozumi K, Yonemura S, Kawakami K, Itoh M., Free PMC Article | 08/30/2010 |
| The mib ( ta52b ) mutation may affect not only neurogenesis but also mesoderm development. These results provide new insights into Notch signaling pathway. | Transcriptome analysis of the zebrafish mind bomb mutant.
Hwang J, Kim HS, Seok JW, Kim JD, Koun S, Park SY, Lee J, Kim HS, Kim HS, Kim KS, Chang KT, Ryoo ZY, Wang SM, Huh TL, Lee S. | 01/21/2010 |
| Mib encodes a RING ubiquitin ligase that promotes ubiquitylation and internalization of Delta. | Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.
Itoh M, Kim CH, Palardy G, Oda T, Jiang YJ, Maust D, Yeo SY, Lorick K, Wright GJ, Ariza-McNaughton L, Weissman AM, Lewis J, Chandrasekharappa SC, Chitnis AB. | 02/9/2009 |
| Zebrafish Mib and Mib2 are colocalized in transfected cells and function redundantly in regulating Notch signaling in embryos. | The characterization of zebrafish antimorphic mib alleles reveals that Mib and Mind bomb-2 (Mib2) function redundantly.
Zhang C, Li Q, Lim CH, Qiu X, Jiang YJ. | 01/21/2010 |
| Here we further demonstrated that zebrafish Mib and Mib2, similar to their mouse orthologs, have a C-terminal-most RING finger-dependent E3 ubiquitin ligase activity. Mib and Mib2 are reciprocal E3 ubiquitin ligases and substrates. | Zebrafish Mib and Mib2 are mutual E3 ubiquitin ligases with common and specific delta substrates.
Zhang C, Li Q, Jiang YJ. | 01/21/2010 |
| The three functionally distinct modules of Mind bomb work cooperatively to regulate Notch signaling by associating with, ubiquitinating, and internalizing Delta. | Three modules of zebrafish Mind bomb work cooperatively to promote Delta ubiquitination and endocytosis.
Chen W, Casey Corliss D. | 01/21/2010 |
| Mosaic analysis indicates that the bronchiomotor neurons patterning and fusion defects in the mib hindbrain arise non-cell autonomously. | Neurogenic phenotype of mind bomb mutants leads to severe patterning defects in the zebrafish hindbrain.
Bingham S, Chaudhari S, Vanderlaan G, Itoh M, Chitnis A, Chandrasekhar A., Free PMC Article | 01/21/2010 |