| Tailup expression in Drosophila larval and adult cardiac valve cells. | Tailup expression in Drosophila larval and adult cardiac valve cells.
Meyer C, Bataillé L, Drechsler M, Paululat A. | 03/28/2023 |
| tup interacts with Chip to regulate the generation of different cardiac cell types. Tup directly regulates eve expression. | Chip/Ldb1 interacts with Tailup/islet1 to regulate cardiac gene expression in Drosophila.
Werner K, Donow C, Pandur P. | 04/29/2017 |
| Reinitiation of a transcriptional program previously employed for embryonic alary muscle development, in which the factors Org-1 and Tailup are key components, leads to the development of adult Drosophila ventral longitudinal heart muscles. | Org-1-dependent lineage reprogramming generates the ventral longitudinal musculature of the Drosophila heart.
Schaub C, März J, Reim I, Frasch M. | 12/5/2015 |
| An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila. | An Org-1-Tup transcriptional cascade reveals different types of alary muscles connecting internal organs in Drosophila.
Boukhatmi H, Schaub C, Bataillé L, Reim I, Frendo JL, Frasch M, Vincent A. | 11/29/2014 |
| Tailup is expressed in the main Drosophila cardiac outflow components, i.e., heart anchoring cells (HANC) and cardiac outflow muscles (COM) and that loss of its function and/or tissue-specific knockdowns dramatically affect cardiac outflow morphogenesis. | Tailup plays multiple roles during cardiac outflow assembly in Drosophila.
Zmojdzian M, Jagla K. | 06/7/2014 |
| These observations provide evidence for combinatorial activity of Isl and Lim3 in regulating ion channel gene expression | The transcription factors islet and Lim3 combinatorially regulate ion channel gene expression.
Wolfram V, Southall TD, Günay C, Prinz AA, Brand AH, Baines RA., Free PMC Article | 04/5/2014 |
| Tup/Islet1 integrates time and position to specify muscle identity in Drosophila. | Tup/Islet1 integrates time and position to specify muscle identity in Drosophila.
Boukhatmi H, Frendo JL, Enriquez J, Crozatier M, Dubois L, Vincent A. | 11/24/2012 |
| This study demonistratedt that therole of Islet on the excitability patterns characteristic of motoneuron subtypes. | The LIM-homeodomain protein islet dictates motor neuron electrical properties by regulating K(+) channel expression.
Wolfram V, Southall TD, Brand AH, Baines RA., Free PMC Article | 11/17/2012 |
| Tailup is required to activate achaete and scute at the dorsocentral region, probably by acting as an hexameric complex with the cofactor Chip and the transcriptional activator Sspd on the dorsocentral enhancer of the achaete-scute complex. | The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila.
de Navascués J, Modolell J. | 06/18/2011 |
| The early expression of Tup in the cardiac mesoderm suggests that Tup functions in cardiac specification. | The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis.
Mann T, Bodmer R, Pandur P., Free PMC Article | 01/21/2010 |
| role in the thoracic pre-patterning; in the dorso-central enhancer pro-neural cluster, Isl antagonizes Pnr activity both by dimerization with the DNA-binding domain of Pnr and via competitive inhibition of the Chip-bHLH interaction | The Drosophila LIM-homeo domain protein Islet antagonizes pro-neural cell specification in the peripheral nervous system.
Biryukova I, Heitzler P. | 01/21/2010 |
| the class III POU protein, Drifter (Ventral veinless), is co-expressed with Islet and Lim3 specifically in the ISNb motoneuron subclass | Specification of Drosophila motoneuron identity by the combinatorial action of POU and LIM-HD factors.
Certel SJ, Thor S. | 01/21/2010 |
| The data support a model in which the EGFR and Dpp signalling pathways, with their respective downstream Iro-C and tup genes, converge and cooperate to commit cells to the notum developmental fate. | tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification.
de Navascués J, Modolell J. | 01/21/2010 |
| Results establish Tailup as being a critical new transcription factor in dorsal vessel morphogenesis and lymph gland formation and place this regulator directly upstream of Hand in these developmental processes. | Requirement of the LIM homeodomain transcription factor tailup for normal heart and hematopoietic organ formation in Drosophila melanogaster.
Tao Y, Wang J, Tokusumi T, Gajewski K, Schulz RA., Free PMC Article | 01/21/2010 |