| Immunoglobulin heavy constant gamma 1 silencing decreases tonicity-responsive enhancer-binding protein expression to alleviate diabetic nephropathy. | Immunoglobulin heavy constant gamma 1 silencing decreases tonicity-responsive enhancer-binding protein expression to alleviate diabetic nephropathy.
Hu Q, Yang Q, Gao H, Tian J, Che G., Free PMC Article | 05/8/2024 |
| CSTF2T up-regulates IGHG1 by binding to ZEB1 to promote melanoma cell proliferation, migration, and invasion. | CSTF2T up-regulates IGHG1 by binding to ZEB1 to promote melanoma cell proliferation, migration, and invasion.
Li Y, Yun X, Li J, Bai M. | 03/21/2023 |
| High expression of IGHG1 promotes breast cancer malignant development by activating the AKT pathway. | High expression of IGHG1 promotes breast cancer malignant development by activating the AKT pathway.
Jin Y, Qiu L, Bao W, Lu M, Cao F, Ni H, Zhao B., Free PMC Article | 03/3/2023 |
| An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment. | An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment.
Yang B, Zhang Z, Chen X, Wang XY, Qin S, Du L, Yang C, Zhu L, Sun W, Zhu Y, Zheng Q, Zhao S, Wang Q, Zhao L, Lin Y, Huang J, Wu F, Lu L, Wang F, Zheng W, Zhou XH, Zhao X, Wang Z, Xiao-Lin S, Ye Y, Wang S, Li Z, Qi H, Zhang Z, Kuang DM, Zhang L, Shen Z, Liu W., Free PMC Article | 06/18/2022 |
| Association of IgG1 Antibody Clearance with FcgammaRIIA Polymorphism and Platelet Count in Infliximab-Treated Patients. | Association of IgG1 Antibody Clearance with FcγRIIA Polymorphism and Platelet Count in Infliximab-Treated Patients.
Thibault G, Paintaud G, Sung HC, Lajoie L, Louis E, The Getaid, Desvignes C, Watier H, Gouilleux-Gruart V, Ternant D., Free PMC Article | 07/17/2021 |
| These findings suggest that IGHG1 play a crucial role during the development of prostate cancer and inhibition of IGHG1 may be a potential therapy in the treatment of prostate cancer (PCa). | IGHG1 Regulates Prostate Cancer Growth via the MEK/ERK/c-Myc Pathway.
Chu J, Li Y, Deng Z, Zhang Z, Xie Q, Zhang H, Zhong W, Pan B., Free PMC Article | 12/28/2019 |
| Results indicated that IgG1 and IgG3 autoantibodies in Immuno-related hemocytopenia (IRH) patients might play a key role in the IRH pathogenesis. | Demonstration of IgG Subclass (IgG1 and IgG3) in Immuno-Related Hemocytopenia.
Shao Y, Qi X, Fu R, Liu H, Wang Y, Ding S, Wang H, Li L, Shao Z. | 09/21/2019 |
| Here, the authors demonstrate that SBP is actually the constant region of immunoglobulin G that binds to the membrane, specifically interacts with hepatitis B virus pre-Surface antigen (preS1) peptides, and enables HepG2 cells to uptake HBsAg preS1 peptides. | The Hepatitis B Surface Antigen Binding Protein: An Immunoglobulin G Constant Region-Like Protein That Interacts With HBV Envelop Proteins and Mediates HBV Entry.
Sun Y, Wang S, Yi Y, Zhang J, Duan Z, Yuan K, Liu W, Li J, Zhu Y., Free PMC Article | 09/7/2019 |
| Structure of the Fc fragment of the IgG1 NIST reference antibody RM8671 has been reported. | Structure of the Fc fragment of the NIST reference antibody RM8671.
Gallagher DT, Galvin CV, Karageorgos I., Free PMC Article | 12/22/2018 |
| Our results show that immunoglobulin GM genes are risk factors for the development of schizophrenia | Immunoglobulin G genotypes and the risk of schizophrenia.
Pandey JP, Namboodiri AM, Elston RC., Free PMC Article | 05/20/2017 |
| Using these maps as a constraint, we derived 120 conformations of the antibody via structural flexible docking of the crystal structure to these maps by targeted molecular dynamics simulations. | 3D Structural Fluctuation of IgG1 Antibody Revealed by Individual Particle Electron Tomography.
Zhang X, Zhang L, Tong H, Peng B, Rames MJ, Zhang S, Ren G., Free PMC Article | 02/27/2016 |
| Down-regulation of IGHG1 expression may be related to the etiology of poor sleep quality and chronic abdominal pain. | Sleep quality, BDNF genotype and gene expression in individuals with chronic abdominal pain.
Reddy SY, Rasmussen NA, Fourie NH, Berger RS, Martino AC, Gill J, Longchamps R, Wang XM, Heitkemper MM, Henderson WA., Free PMC Article | 10/3/2015 |
| These results show distinct epistatic contributions of GM and FcgammaRIIIa alleles to the antibody-dependent cell-mediated cytotoxicity of neuroblastoma cells | Immunoglobulin GM and FcγRIIIa genotypes influence cytotoxicity of neuroblastoma cells.
Pandey JP, Namboodiri AM. | 06/7/2014 |
| Data indicate the involvement of immunoglobulin allotypes immunoglobulin gamma and kappa chains in immunity to a cancer-testis antigen, which has important implications for XAGE-1b-based immunotherapeutic interventions in lung adenocarcinoma. | Genetic variants of immunoglobulin γ and κ chains influence humoral immunity to the cancer-testis antigen XAGE-1b (GAGED2a) in patients with non-small cell lung cancer.
Pandey JP, Namboodiri AM, Ohue Y, Oka M, Nakayama E., Free PMC Article | 05/3/2014 |
| Suppression of IGHG1 gene expression by siRNA leads to growth inhibition and apoptosis induction in human prostate cancer cell. | Suppression of IGHG1 gene expression by siRNA leads to growth inhibition and apoptosis induction in human prostate cancer cell.
Pan B, Zheng S, Liu C, Xu Y. | 06/15/2013 |
| The presence of IGHG1 in pancreatic cancer cells might constitute an important element responsible for tumor cell proliferation and immune evasion mechanisms. | The presence of IGHG1 in human pancreatic carcinomas is associated with immune evasion mechanisms.
Li X, Ni R, Chen J, Liu Z, Xiao M, Jiang F, Lu C. | 10/29/2011 |
| Immunoglobulin (Ig) GM genes - genetic markers of IgG heavy chains located on chromosome 14 - are functional risk and protective factors for AD. | Immunoglobulin GM genes as functional risk and protective factors for the development of Alzheimer's disease.
Pandey JP. | 09/27/2010 |
| Cotransfection of mesenchymal stem cells with the combination of the CTLA4Ig and the BMP2 gene stimulates osteoblastic cell differentiation in vitro. | Immunomodulatory and osteogenic differentiation effects of mesenchymal stem cells by adenovirus-mediated coexpression of CTLA4Ig and BMP2.
Zhang X, Zhang C, Tang T, Qu Z, Lou J, Dai K. | 01/21/2010 |
| The IGHG1 polymorphism does not seem to play a major role in the induction of antibodies-to-infliximab. | IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab.
Magdelaine-Beuzelin C, Vermeire S, Goodall M, Baert F, Noman M, Assche GV, Ohresser M, Degenne D, Dugoujon JM, Jefferis R, Rutgeerts P, Lefranc MP, Watier H, Magdelaine-Beuzelin C, Vermeire S, Goodall M, Baert F, Noman M, Assche GV, Ohresser M, Degenne D, Dugoujon JM, Jefferis R, Rutgeerts P, Lefranc MP, Watier H. | 01/21/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | IgG1 heavy chain-coding gene polymorphism (G1m allotypes) and development of antibodies-to-infliximab.
Magdelaine-Beuzelin C, Vermeire S, Goodall M, Baert F, Noman M, Assche GV, Ohresser M, Degenne D, Dugoujon JM, Jefferis R, Rutgeerts P, Lefranc MP, Watier H, Magdelaine-Beuzelin C, Vermeire S, Goodall M, Baert F, Noman M, Assche GV, Ohresser M, Degenne D, Dugoujon JM, Jefferis R, Rutgeerts P, Lefranc MP, Watier H. | 04/8/2009 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | See all PubMed (2) articles | 03/13/2008 |
| Observational study of genotype prevalence. (HuGE Navigator) | Immunoglobulin enhancer HS1,2 polymorphism: a new powerful anthropogenetic marker.
Giambra V, Martínez-Labarga C, Giufré M, Modiano D, Simporé J, Gisladottir BK, Francavilla R, Zhelezova G, Kilic SS, Crawford M, Biondi G, Rickards O, Frezza D. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (4) articlesImmunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathies.
O'Hanlon TP, Rider LG, Schiffenbauer A, Targoff IN, Malley K, Pandey JP, Miller FW. Immunoglobulin constant heavy G chain genes as risk factors in childhood allergies.
Oxelius VA, Bråbäck L, Ahlstedt S, Björkstén B. Immunoglobulin KM and GM gene polymorphisms modify the clinical presentation of primary Sjögren's syndrome.
Pertovaara M, Hurme M, Antonen J, Pasternack A, Pandey JP. TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis.
Pandey JP, Frederick M, ACCESS Research Group. A Case Control Etiologic Study of Sarcoidosis, Pandey JP, Frederick M, ACCESS Research Group. A Case Control Etiologic Study of Sarcoidosis. | 03/13/2008 |
| genotypes at Immunoglobulin G1M (G1M f,z) loci are significantly associated with Systemic Lupus Erthematosus | Immunoglobulin GM and KM genotypes in Korean patients with systemic lupus erythematosus.
Lee EB, Lee YJ, Shin DH, Choi YM, Park MH, Pandey JP, Song YW. | 01/21/2010 |
| TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis. | TNF-alpha, IL1-beta, and immunoglobulin (GM and KM) gene polymorphisms in sarcoidosis.
Pandey JP, Frederick M, ACCESS Research Group. A Case Control Etiologic Study of Sarcoidosis, Pandey JP, Frederick M, ACCESS Research Group. A Case Control Etiologic Study of Sarcoidosis. | 01/21/2010 |